It is the tick borne disease caused by the bacterium Ehlrichia.The vector for this bacterium is the tick which are called as Ixodes scapularis and Ixodes pacificus.The Incubation period is 5-14 days.
It can occur at any age.But common age group is 40yrs.Men are mostly affected than women.It is more common among the northwest population.
Epidemiological Data should be collected.Questionnaire such as recent travel to endemic areas,occupational exposure with ticks,expose to the wooden materials should be considered.
It is acquired through tick bite and the bacterium is transmitted to the spleen and bone marrow.It gets multiplicated in the cytoplasmic vacuoles of the polymorphonuclear cells.It affects the progenitors of the myeloid and monocytic cells and invades the neutrophils.It leads to the deactivation of the neutrophils and release of cytokines leads to degranulation of the neutrophils.Intrrleukin 10 ,Interleukin 12 and IFN gamma plays an important role in the immune response.This cytokine released mechanism is manifested as the himan granulocytic ehlrichiosis.Pancytopenia(decrease in neutrophil count),liver damage and even shock may occur.
Signs and symptoms often begins within 1-2 weeks depending upon the immune system of an individual.
Early Illness-
Early signs and symptoms (days 1-5) are usually mild or moderate and may include:
Late Illness-
Rarely, if treatment is delayed or if there are other medical conditions present, ehlrichiosis can cause severe illness. Prompt treatment can reduce your risk of developing severe illness.
Signs and symptoms of severe (late stage) illness can include:
Risk factors for severe illness:
If you do find a tick attached to your skin, remove it within 24 hours. Follow these steps: