diease

Gout


Gout overview and Definition

It is termed as the deposition of the urate crystals in the joints that interrupts the normal activity of the human being affected with the gout. The term pseudogout is used to describe the deposition of the calcium pyrophosphate crystals at the joints.


Pathophysiology

Crystals include monosodium urate as in gout,disodium phosphoglycerate as in pseudo gout,calcium phosphate .these are termed as exogenous crstals.Endogenous crystals include corticosteroid crystals,polyethylene,methylacrylate and talcum.deposition of these crystals occurs in spaces between the articular joint.

  • Gout and gouty arthritis
  • Calcium pyrophosphate crystal deposition disease (pseudo-gout)


Clinical signs & symptoms

Pain during movement of the joints

Malaise and fatigue

Weight loss

Rashes

Muscle ache and pain

Tenderness

Numbness and tingling

Reduced range of motions


Differential Diagnosis

The normal uric acid level is checked. In women – 2.4 to 6 and in males 3.4 to 7.

Laboratory test:

Analysis of different types of body fluid is indicated.Fluids include blood,urine and joint fluids.

Synovial fluid:

It is the identification of the monosodium urate crystals in the synovial fluid or tophus. The fluid is removed by the process known as arthrocntesis. In polaried light it shows needle like biferinges.

Imaging:

Xrays-bone can show damage to cartilage,bone damage and bone spurs.but xray fails to show any arthritic damage

Computerized tomography:it shows cross sectional views of internal structures.

Magnetic resonance imaging:

Cross section studies of soft tissues such as cartilage ,tendons and ligaments are obtained.

Ultrasound:

Soft tissue image,cartilage and fluid structure are obtained.

Arthroscopy:

It is an 3D device used to visualize the joint images.

Dual-energy computerized tomography (DECT). This test combines X-ray images taken from many different angles to visualize urate crystals in joints


Prognosis

The gout gets subsided within 5-7 days.

 


Prevention

Take proper diet that does not causes increase in uric acid level

Do stretch exercises

Reduce the body weight

Eat fish or twice a week-since fish contains omega 3 fatty acids which can reduce inflammation in the bone.

Exercise regularly

Protect the joints and avoid joint injuries

 


Reference

https://en.wikipedia.org/wiki/Gout

https://www.medicalnewstoday.com/articles/144827

https://emedicine.medscape.com/article/329958-overview