Clinical signs & symptoms
The onset of symptoms is abrupt with general malaise, myalgia, arthralgia, fatigue and anorexia.
Nausea, vomiting, and diarrhea or constipation are frequent
Serum sickness seen early in acute hepatitis B.
Fever is low-grade.
There is a fall in pulse rate with the onset of jaundice.
Abdominal pain is present in right upper quadrant or epigastrium.
Hepatomegaly, Liver tenderness, and Splenomegaly is seen in 15% of patients
Jaundice occurs after 5–10 days of infection
The acute symptoms subside within 2–3 weeks.
< 1% will have a fulminant course and results in fulminant hepatitis
Hepatitis B may become chronic
It increases risk of hepatocellular carcinoma of liver
General – fever, night sweats
Skin – icteric skin, urticaria rash in
Oral cavity – yellowing mucosa of oral
Eyes – icteric sclera
Neurological – Dementia, mental
Abdomen cavity –
hepatosplenomegaly, lymph node enlargement
General Essentials of Diagnosis:
Prodrome period of anorexia, nausea, vomiting,
malaise and dislike the taste of smoking
Fever, enlarged and tender liver, jaundice.
Normal to low white blood cell count with
markedly elevated aminotransferases
Liver biopsy shows hepatocellular necrosis and