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INFORMATION ABOUT Anastrozole

Description Anastrozole


Anastrozole used to treat early-stage breast cancer in postmenopausal women and it is also used as a first-line treatment of advanced breast cancer that has spread to other parts of your body. It works by decreasing the amount of female hormone in the body and stops the growth of cancer cells that required estrogen to grow.

Uses and Benefits of Anastrozole


Breast cancer

It is a type of cancer that forms in the breast cells. It is common among women. Symptoms include breast lump, change in breast size, redness, pitting of the skin, color change, and peeling surrounding the breast skin or nipple. This medicine helps to inhibit the multiplication of cancer cells.

Mechanism of action of Anastrozole


Anastrozole is an anti-cancer medication, an aromatase inhibitor. In postmenopausal women, estrogen is derived from an aromatase enzyme that converts adrenal androgens to estrone and estradiol. Anastrozole is a non-steroidal aromatase inhibitor that reduces serum estrogen and its derivatives levels thus signaling process for the proliferation of abnormal cells is inhibited. Thus it shrinks the abnormal cells and minimizes metastasis thus treating and controlling cancers or tumors.

Contraindications of Anastrozole


  • Do not take this medicine if you are allergic to Anastrozole
  • It is not recommended to use in children
  • It is contraindicated to use this medicine during pregnancy

FAQs for Anastrozole


  • When can I plan a pregnancy if I am using the Anastrozole?

Avoid planning for pregnancy while you are receiving this medicine and also use an effective contraceptive for at least 3 months after taking the last medicine.

  • Does the Anastrozole cause hair loss?

Yes, one of the common side effects of this medicine is hair loss. Kindly consult with your doctor if your symptoms even persist after withdrawal of the medicines.

  • How to treat constipation during the treatment?

To treat constipation drink plenty of water a day and keep you active, add fiber to your diet. If you do not have a bowel movement for more than 3 days kindly consult with your doctor.

Driving or operating machinery


It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive, decrease alertness, and make you feel sleepy and drowsy. Kindly consult with your doctor.

Breast Feeding


The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

Liver Disease


Therapy should be administered with caution in patients who are having hepatic impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.

Use of Medicine in Adult:


It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor

Use of Anastrozole in Elderly Patients


Anastrozole should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

Talk to your doctor if


  • You are not responding to the treatment
  • You have experienced any allergic reaction like rashes and itching
  • You have a receiving any concomitant medication and disease

Drug Interaction of Anastrozole

Drug-Drug Interaction


Estradiol

It is contraindicated to use this medicine because the use of estradiol decreases the effect of anastrozole by pharmacodynamic antagonism.

Tamoxifen

It is contraindicated to use this medicine because the use of tamoxifen decreases the effect of anastrozole by unspecified interaction mechanism.

Palifermin

Use alternative drug because the use of palifermin increase the toxicity of the anastrozole by increasing the severity and duration of oral mucositis

Cholera vaccine

Therapy should be administered with caution because the use of anastrozole decreases the effect of the cholera vaccine by immunosuppressive effects and it also increases the risk of developing an infection

Drug-Disease Interaction


Cardiovascular events

Therapy should be administered with caution in women with a history of ischemic heart diseases because they have a higher incidence of ischemic cardiovascular events while using this medicine

Hepatic dysfunction

Therapy should be administered with caution in patients with severe hepatic impairment because the use of this medicine metabolized in the liver and cause hepatic cirrhosis

Osteoporosis

Therapy should be administered with caution in patients with osteoporosis because the use of this medicine decreases the lumbar spine and bone mineral density.

Over Dose:


Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Storage and Disposal


  • Stored at 30°C at room temperature.
  • Protect from light and heat.
  • Keep away from children and pets. Otherwise, it becomes toxic to them.
  • Disposed of properly in a suitable bag.

Uses of Anastrozole


It is used in the treatment of the following conditions as Breast cancer

Prescribed for Follow Indication


Anastrozole is prescribed in the following indications as breast cancer in postmenopausal women which is metastatic who has positive or negative estrogen receptors.

How to Anastrozole works


Anastrozole is an anti-cancer medication, an aromatase inhibitor. It produces its action by inhibiting estrogen receptors thus the signaling process for angiogenesis and proliferation of abnormal cells is inhibited. It minimizes the growth of abnormal cancer cells and terminates metastasis of tumors or cancers.

Side effects of Anastrozole


  • Hot flashes
  • Pain
  • Depression
  • Hypertension
  • Vasodilation
  • Mood disturbances
  • Abdominal pain
  • Diarrhea
  • Constipation
  • Chest pain

Precautions and general warning of Anastrozole

Alcohol


It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

pregnancy


The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

Kidney Problem


Therapy should be administered with caution in patients who are having a renal impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.

How to Take Medicine


The tablet can be taken with or without food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

Use of Anastrozole in children:


It is not recommended to use this medicine in children. Kindly consult with your doctor.

Other general warnings


  • The use of this medicine increases the incidence of developing ischemic cardiovascular events in women with a history of ischemic heart diseases.
  • The use of this medicine decreases the lumbar spine and total hip bone mineral density and it also increases the risk for developing fractures and osteoporosis,
  • Increased serum cholesterol was reported while you are using this medicine

General instructions


Anastrozole is used to treat early-stage breast cancer. It produces its action by inhibiting estrogen receptors thus the signaling process for angiogenesis and proliferation of abnormal cells is inhibited. It minimizes the growth of abnormal cancer cells and terminates metastasis of tumors or cancers.

Drug-Food Interaction


No data is available kindly consult with your doctor.

Missed Dose


Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

Fast Tag


  • Anastrozole is an anti-cancer medication, an aromatase inhibitor
  • It is used to treat breast cancer in postmenopausal women
  • Kindly avoid pregnancy while you are taking this medicine
  • Kindly check your vitamin D and bone mineral density if needed

AVAILABLE MEDICINE FOR Anastrozole

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Avantaz 1mg Tablet 1mg

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