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INFORMATION ABOUT Cisplatin

Description Cisplatin


Cisplatin used to treat ovarian cancer, bladder cancer, and testicular cancer. It works by inhibiting the growth of abnormal cells. It is used alone or with other combinations as chemotherapy.

Uses and Benefits of Cisplatin


Ovarian cancer

It is a type of cancer that occurs in an ovary a female reproductive system that produces women’s eggs and female hormones. The exact is not clear but if you have a history of ovarian cancer in your family. Symptoms include abdominal bloating, weight loss, discomfort in the pelvic area, fatigue, back pain, constipation, and frequent urination. This medicine helps to inhibit the multiplication of cancer cells.

Urothelial carcinoma

It is also called bladder cancer. It is a type of cancer that begins in the cells in the bladder. It usually occurs when changes occur in the DNA. Symptoms include back pain, blood in urine, frequent urination, and pain while urinating.

Testicular cancer

It is also called a malignant neoplasm of the testis. Cancer usually occurs in the testicles when compared with another type of cancer it is rare. Symptoms include testicle enlargement, abdomen and groin pain, enlargement of breast and back pain

Mechanism of action of Cisplatin


Cisplatin is an anti-cancer medication, a platinum coordination compound. It produces its action by inhibiting the synthesis of DNA, cross-links, and denatures the strands of DNA. This disrupts the function of DNA by binding to the DNA bases. It can also produce DNA intrastrand cross-linking and breakage and leads to cell death.

Contraindications of Cisplatin


  • Do not take this medicine if you are allergic to Cisplatin
  • It is contraindicated to use this medicine in patients with severe myelosuppression, bleeding, renal dysfunction, pregnancy, and lactation

FAQs for Cisplatin


  • Is Cisplatin safe?

Yes, the use of this medicine is considered safe if you have taken the medicine as per the dose and duration advised by the doctor.

  • Can I stop using the Cisplatin immediately or do I have to slowly wean off the use?

You should not withdraw the medicine immediately, you should taper the dose to avoid rebound effects.

  • Does Cisplatin cause hair loss?

Yes, one of the common side effects of this medicine is hair loss. This will get treated once you stop the treatment.

Driving or operating machinery


It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

Breast Feeding


The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

Liver Disease


It is considered safe to use this medicine in patients who are with hepatic impairment. Kindly consult with your doctor.

Use of Medicine in Adult:


It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.

Use of Cisplatin in Elderly Patients


Cisplatin should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

Talk to your doctor if


  • You are not responding to the treatment
  • You have experienced any allergic reaction like rashes and itching
  • You have a receiving any concomitant medication and disease
  • You develop shortness of breath

Drug Interaction of Cisplatin

Drug-Drug Interaction


Tofacitinib

Use alternative drug because the combination of this medicine either increase the toxicity of the other by immunosuppressive effect and it also increases the risk for developing an infection.

Palifermin

Use alternative drugs because the use of palifermin increases the toxicity of the cisplatin by increasing the severity and duration of oral mucositis

Amikacin

Therapy should be administered with caution because the combination of this medicine increases the nephrotoxicity and ototoxicity

Dichlorphenamide

Therapy should be administered with caution because the combination of this medicine decreases the serum potassium

Peramivir

Therapy should be administered with caution because the use of cisplatin increases the effect of peramivir by decreasing its renal clearance.

Drug-Disease Interaction


Infections

The use of this medicine is contraindicated in patients who are having infectious diseases because of their cytotoxic effect their induce myelosuppression.

Myelosuppression

Therapy should be administered with caution in patients with bone marrow suppression because the use of this medicine induces dose-related myelosuppression, leukopenia, thrombocytopenia, and anemia

Renal dysfunction

Therapy should be administered with caution in patients with renal impairment because the use of this medicine may cause nephrotoxicity

Hemolytic anemia

Therapy should be administered with caution in patients with a history of hemolytic syndromes because the use of this medicine may cause coomb’s hemolytic anemia

Over Dose:


Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Storage and Disposal


  • Stored at 30°C at room temperature.
  • Protect from light and heat.
  • Keep away from children and pets. Otherwise, it becomes toxic to them.
  • Disposed of properly in a suitable bag.

Uses of Cisplatin


It is used in the treatment of the following conditions ovarian cancer, bladder cancer, and testicular cancer.  

Prescribed for Follow Indication


The Cisplatin is prescribed in the following indications as ovarian cancer, bladder cancer, and testicular cancer.  

How to Cisplatin works


Cisplatin is an anti-cancer medication, a platinum coordination compound. It produces its action by damaging the DNA and RNA of the cancer cells which inhibit the growth and multiplication of cancer cells.

Side effects of Cisplatin


  • Leukopenia
  • Neutropenia
  • Nausea
  • vomiting
  • Anemia
  • Thrombocytopenia
  • Hair loss
  • Increased liver enzymes
  • Dehydration
  • Peripheral neuropathy

Precautions and general warning of Cisplatin

Alcohol


It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

pregnancy


The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

Kidney Problem


Therapy should be administered with caution in patients who are having a renal impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.

How to Take Medicine


This injection comes in a liquid solution as an intravenous. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.

Use of Cisplatin in children:


It is considered safe to use this medicine in children. Kindly consult with your doctor.

Other general warnings


  • The use of this medicine may cause irritant
  • Avoid using aluminum needles
  • Therapy should be administered with caution in patients with renal impairment, hearing impairment, neuropathy, neuromuscular diseases
  • The use of this medicine may increase the risk of developing cumulative nephrotoxicity
  • Myelosuppression, leukemia, cardiac abnormalities, ocular toxicity, renal toxicity, and peripheral neuropathy was reported

General instructions


Cisplatin is used to treat ovarian cancer, bladder cancer, and testicular cancer. It produces its action by damaging the DNA and RNA of the cancer cells which inhibit the growth and multiplication of cancer cells.

Drug-Food Interaction


No data available kindly consult with your doctor

Missed Dose


Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

Fast Tag


  • Cisplatin is an anti-cancer medication, an alkylating agent
  • It is used to treat ovarian cancer, bladder cancer, and testicular cancer.
  • Do not withdraw the medicine without consulting with a doctor
  • Kindly avoid pregnancy while you are receiving this medicine
  • Kindly consult with your doctor if you have experienced shortness of breath, chest pain, loss of appetite, and dark urine while you are receiving this medicine

AVAILABLE MEDICINE FOR Cisplatin

Uniplatin 50 Injection 50mg

Rs.0.00 Rs.0.00

Uniplatin 10 Injection 10mg

Rs.0.00

Kemoplat 10mg Injection 10mg

Rs.50.47 Rs.63.09

Platinex 10mg Injection 10mg

Rs.51.42 Rs.64.28

Stritin 10mg Injection 10mg

Rs.51.72 Rs.64.65

Celplat 10mg Injection 10mg

Rs.57.60 Rs.72.00

Planetica 10mg Injection 10mg

Rs.57.60 Rs.72.00

Planetica 10 Injection 10mg

Rs.61.20 Rs.72.00

Ciswel 10mg Injection 10mg

Rs.60.00 Rs.75.00

Ciszest 10mg Injection 10mg

Rs.64.12 Rs.75.00


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