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INFORMATION ABOUT Sorafenib

Description Sorafenib


Sorafenib used to treat renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid Cancer. It is not recommended in pediatric use

Uses and Benefits of Sorafenib


Renal cell carcinoma

It is a common type of kidney cancer found in adults. It is caused by obesity, smoking cigarettes, polycystic kidney disease, and some genetic condition. Symptoms include blood in urine, loss of appetite, weight loss, tiredness, and fever.

Hepatocellular carcinoma

It is also called malignant hepatoma, it is a common type of liver cancer. It usually occurs in people who are having a chronic liver disease such as cirrhosis, hepatitis B or C. Symptoms include weight loss, inflamed liver, loss of appetite, stomach pain, and jaundice

Thyroid cancer

Abnormal cell growth in the thyroid gland leads to the formation of tumor and cause cancer. Symptoms include a lump on your neck, change in your voice, pain in your neck and throat, inflamed lymph nodes in your neck, and difficulty in swallowing.

Mechanism of action of Sorafenib


Sorafenib is an anti-cancer medication, tyrosine kinase inhibitor. It produces its action by targeting several tyrosine kinase proteins present on surface receptors and intracellular structures of VEGF receptors, PDGF receptor, FGF receptor, cytokine receptor called as kit, IL 2 receptor, lymphocyte tyrosine kinase receptor, transmembrane tyrosine kinase receptor. In general, these receptors signal for angiogenesis and decrease apoptosis function. Sorafenib inhibits signals of angiogenesis and decreases the size of the tumor by starvation and increases apoptosis function.

Contraindications of Sorafenib


  • Do not take this medicine if you are allergic to Sorafenib
  • It is contraindicated to use this medicine in patients with squamous cell lung cancer along with carboplatin and paclitaxel

FAQs for Sorafenib


  • I have developed redness and pain in my palms and soles ever since I started taking the Sorafenib and my skin is also coming off. Is this dangerous? What should I do?

It looks like you have developed foot and hand skin reactions due to this medicine. Kindly consult with your doctor and apply cream or lotion to treat this issue.

  • Does Sorafenib interfere with blood sugar levels?

Yes, the use of this medicine decreases the blood glucose level and makes the patients faint. Kindly monitor your blood sugar level regularly.

  • When can I plan a pregnancy if I am taking a Sorafenib?

Avoid planning for pregnancy while you are receiving this medicine and also use an effective contraceptive for at least 1 month after taking the last medicine.

Driving or operating machinery


It is considered safe to drive while you are receiving this medicine it does not affect your ability to drive. Kindly consult with your doctor.

Breast Feeding


The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

Liver Disease


Therapy should be administered with caution in patients who are having hepatic impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.

Use of Medicine in Adult:


It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor

Use of Sorafenib in Elderly Patients


Sorafenib should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

Talk to your doctor if


  • You are not responding to the treatment
  • You have experienced any allergic reaction like rashes and itching
  • You have a receiving any concomitant medication and disease

Drug Interaction of Sorafenib

Drug-Drug Interaction


Dronedarone

It is contraindicated to use this medicine because the combination of this medicine increase the QTc interval

Carbamazepine

Use alternative drugs because the use of carbamazepine decreases the effect of sorafenib by increasing its metabolism.

Ketoconazole

Use alternative drugs because the use of ketoconazole increases the level of sorafenib by affecting its hepatic and intestinal enzyme metabolism.

Dichlorphenamide

Therapy should be administered with caution because the combination of this medicine may decrease the serum potassium

Fingolimod

Therapy should be administered with caution because the use of sorafenib increases the effect of fingolimod by immunosuppressive effect and it also increases the risk for developing infections.

Drug-Disease Interaction


Lung toxicity

Therapy should be administered with caution in patients who are with a history of interstitial pneumonia and pulmonary fibrosis because the use of these multikinase inhibitors may cause pulmonary toxicity.

Over Dose:


Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Storage and Disposal


  • Stored at 30°C in a refrigerator.
  • Protect from light and heat.
  • Keep away from children and pets. Otherwise, it becomes toxic to them.
  • Disposed of properly in a suitable bag.

Uses of Sorafenib


It is used in the treatment of the following conditions as renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid cancer

Prescribed for Follow Indication


The Sorafenib is prescribed in the following indications as

  • Unresectable hepatocellular carcinoma
  • Advanced renal cell carcinoma
  • Differentiated thyroid tumor – only when radioactive iodine treatment has failed

How to Sorafenib works


Sorafenib is an anti-cancer medication, tyrosine kinase inhibitor. It produces its action by inhibiting the function of tyrosine kinase protein present on receptors of vascular or platelet or lymphocyte etc. Thus, alters the function of receptors thereby inhibiting angiogenesis of abnormal cells and increasing apoptosis function thus proliferation of abnormal cells is inhibited.

Side effects of Sorafenib


  • Thrombocytopenia
  • Anemia
  • Rash
  • Diarrhea
  • Abdominal pain
  • Weight loss
  • Alopecia
  • Lymphopenia
  • Hypertension
  • Neuropathy
  • Dry skin

Precautions and general warning of Sorafenib

Alcohol


It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

pregnancy


The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

Kidney Problem


It is considered safe to use this medicine in patients who are having a renal impairment. Kindly consult with your doctor.

Use of Sorafenib in children:


Safety and efficacy were not established in children who are below 18 years old. Kindly consult with your doctor.

Other general warnings


  • The use of this medicine may cause osteonecrosis of the jaw
  • The use of this medicine may increase the risk of developing cardiac ischemia, hypertension, and hemorrhage
  • Hepatitis, QT prolongation, Congestive heart failure, and Gastrointestinal perforation were reported while you are receiving this medicine
  • Avoid pregnancy
  • The use of this medicine has a high incidence for developing skin toxicity, rash, and bleeding

General instructions


Sorafenib is used to treat renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid Cancer. It produces its action by inhibiting the function of tyrosine kinase protein present on receptors of vascular or platelet or lymphocyte etc. Thus, alters the function of receptors thereby inhibiting angiogenesis of abnormal cells and increasing apoptosis function thus proliferation of abnormal cells is inhibited.

Drug-Food Interaction


Sorafenib should be taken on an empty stomach one hour before the meal or 2 hours after the meal because the use of this medicine delays the absorption in presence of food.

Missed Dose


Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

Fast Tag


  • Sorafenib is an anti-cancer medication, a tyrosine kinase inhibitor
  • Sorafenib used to treat renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid cancer
  • Take this medicine 1 hour before or 2 hours after your meal
  • Closely monitor the patient kidney function and blood cell count while you are receiving this medicine
  • Kindly inform your doctor if you have experienced headache, stomach pain, and blood in your stool and urine while you are receiving this medicine.

AVAILABLE MEDICINE FOR Sorafenib

Sonora 200mg Tablet 200mg

Rs.0.00

Cadsonib Tablet 200mg

Rs.1734.84 Rs.1885.70

Sorafeb 200mg Tablet 200mg

Rs.1840.00 Rs.2000.00

Soranib 200mg Tablet 200mg

Rs.1820.81 Rs.2276.01

Adtrinib 200mg Tablet 200mg

Rs.1880.00 Rs.2350.00

Soratib 200mg Tablet 200mg

Rs.2162.00 Rs.2350.00


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