Abamune L Tablet

Brand Name Abamune L Tablet
Salt Composition Abacavir (600mg) + Lamivudine (300mg)
Strength 600mg + 300mg
Product Form Tablet
Storage Store at room temperature (10-30°C)
Category HIV
Country of Origin India
Manufacturer Cipla Ltd.
Manufacturer/Marketer AddressCipla Ltd, Cipla House, Peninsula Business Park, Ganpatrao, kadam Marag, Lower Parel, Mumbai-400013.India
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Abamune L Tablet, Abacavir 600mg, Lamivudine 300mg, Price, Uses, Side Effects - Drugcarts watermark
M.R.P : Rs.2996.04       Price : Rs.2247.03

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    Medical Description of Abamune L Tablet

    Abamune L tablet contains Abacavir 600mg and Lamivudine 300mg. Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV)-1 infection. Abamune L tablet is a nucleoside analogue. Abamune L tablet works by acting on reverse transcriptase which is required for HIV active particles multiplication process thus reduces viral load of HIV in your body. Abamune L tablet is used in combination with other antiviral HIV medications.


    Abamune L Tablet Uses

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet is used who are infected by HIV-1. Abamune L tablet is cautiously used in hepatic disorders and pregnant or lactating women.


    Abamune L Tablet Benefits

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet helps control HIV infection. Abamune L tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Abamune L tablet is a nucleoside reverse transcriptase inhibitor. Abamune L tablet is not a cure for HIV infection, it improves immunity that results in longevity of life; thus, precautions are necessary while sexual intercourse, surgery etc.


    Abamune L Tablet Indication

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet is indicated in the treatment of HIV infection that causes AIDS in humans. Abamune L tablet is used to boost the immunity of the affected hosts by reducing the viral load of the infected cells.


    Mechanism of action of Abamune L Tablet

    Abamune L tablet contains Abacavir 600mg and lamivudine 300mg. Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet is a selective inhibitor of HIV – 1. Abamune L tablet are metabolized to their active forms and these active forms incorporate themselves into DNA of HIV molecule thus prevents transcription of HIV molecule resulting in the formation of inactive virions.


    How Abamune L Tablet works

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet is a nucleoside reverse transcriptase inhibitor. The active component of Abamune L tablet incorporates with DNA of HIV molecular structure thus further process of multiplication is inhibited. This decreases the rate of infection spread and controls the multiplication of viral load.


    Abamune L Tablet Contraindication

    Absolute contraindications:

    • if you are allergic to Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet
    • if you have kidney impairment – if creatinine clearance <50ml/min
    • if you have hepatic impairment – like Child Purge disease
    • if you have HLA-B5701 allele that causes severe hypersensitivity to abacavir thus screening is advised.
    • if you are breastfeeding or pregnant
    • if <18 years of age

    Relative contraindication:

    • if you are diabetic
    • if you have anemia or neutropenia
    • if you have a bleeding disorder like haemophilia
    • if you have a lipid disorder like hyperlipidemia
    • if you have heart diseases like MI


    Abamune L Tablet Side Effects

    Common side effects that occur 1:10 patients: hypersensitivity (fever, cough, shortness of breath, abdominal pain, diarrhoea, and skin rash), alopecia, hyperlactataemia, arthralgia

    Rare side effects that occur 1:1,000 patients: pancreatitis, cardiomyopathy, convulsions, rhabdomyolysis, neutropenia, anemia, thrombocytopenia, raise in AST and ALT levelsVery rare side effects that occur 1:10,000 patients: erythema multiform, Stevens-Johnson syndrome, toxic epidermal necrolysis, lactic acidosis, pure red cell aplasia, paresthesia,


    FAQs for Abamune L Tablet

    Is Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet safe during pregnancy?

    This medication is not recommended in pregnancy unless pros outweigh the cons. Consult your physician.

    Can Abamune L tablet be taken while breastfeeding?

    There is no specific study to detail this. But in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding. Thus, consult your physician.

    Can Abamune L tablet be taken while alcohol consumption

    The interaction is unknown but this medication causes dizziness. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Abamune L tablet?

    This medication causes dizziness and instability thus caution is used while driving or operating machineries.

    Can Abamune L tablet be taken as a single dose?

    Abamune L tablet is a combination medicine thus in adults can be used as once a day or twice a day dose as prescribed by the physician


    Precautions and general warning of Abamune L Tablet

    Alcohol

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet generally causes lethargy thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet causes lathargy. For further queries, consult your physician.

    Pregnancy

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet is cautiously used during pregnancy as it may cause some side effects on the fetus. Thus, consult your physician.

    Breast Feeding

    The use of Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.

    Kidney Problem

    Inform your physician if you have hepatitis B or C or fatty liver or Childs Pugh disease. Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet may cause hepatomegaly with steatosis.

    Liver Disease

    If the renal creatine clearance is <50ml/min caution is required thus inform physician


    How to Take Abamune L Tablet

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet is taken orally with or without food.

    Abamune L tablet should be taken at a specific time

    Don’t chew or break the tablet.

    Swallow Abamune L tablet as a whole.

    After therapy has been initiated, do not take more or less of Abamune L than prescribed or stop taking it without your physicians’ approval. Skipping or changing Abamune L tablet dose without approval would increase the viral load making the infection more difficult to treat, or worsen side effects. For further queries consult your physician.


    Use of Abamune L Tablet in Adult

    The recommended dose is Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet once per day.


    Use of Abamune L Tablet in children

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet is not used in ages <18.


    Use of Abamune L Tablet in Elderly Patients

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Lactic acidosis
    • Changes in lipid and glucose metabolism
    • Accumulation or Redistribution of body fat or immune reconstitution syndrome.
    • Bone marrow disorders – anemia, eosinopenia
    • Heart diseases or disorders – MI
    • Any sign of infection – fever or lymph node enlargement
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.


    Talk to your doctor if

    If you have any allergy/ hypersensitivity

    If you have a liver problem

    If you have any kidney diseases

    If you have hypertension or any heart problem

    If you are pregnant or breastfeeding


    General instructions

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet is taken at a specific time regularly with food. If Abamune L tablet is taken without food the efficiency of medicine is reduced significantly, thus it is ill-advised.


    Drug Interaction of Abamune L Tablet

    Drug-Drug Interaction

    Risk of cytopenia increased– Ganciclovir

    serum level is Increased – fluconazole, flucytosine, amphotericin B, Aceclofenac

    serum level is Decreased - Hydrochlorothiazide , Isosorbide

    Efficacy is decreased by - methadone

    Metabolism is increased - phenytoin

    Drug-Food Interaction

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician.Abamune L tablet generally causes dizziness and instability thus it is advised not to be taken with alcohol.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and stroke. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use


    Over Dose

    Symptoms of overdose is not well documented thus in case of an overdose contact your doctor immediately.


    Missed Dose

    You can take the missed dosage if you notice within 12 hours if you take them once a day. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Always take with other antivirals and food Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Store them at <30°C

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately


    Fast Tag

    Abamune L (Abacavir (600mg) + Lamivudine (300mg)) tablet is a nucleoside reverse transcriptase inhibitor

    Abamune L tablet is used to control and treat HIV infection with other antivirals

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease, kidney disease.

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.