Abevmy 100mg Injection

Brand Name Abevmy 100mg Injection
Salt Composition Bevacizumab (100mg)
Strength 100mg
Product Form Injection
Pack 1 Injection in 1 Vial
Category Anti Cancer
Country of Origin India
Manufacturer Mylan Pharmaceuticals Private Limited
Manufacturer/Marketer AddressMylan Pharmaceuticals Private Limited , Commercial Operations , Prestige Tech Park,Platina-3, 7th to 12th floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103
-25%
Abevmy 100mg Injection,Bevacizumab,price,uses,side effects -Drugcarts watermark
M.R.P : Rs.13451.00       Price : Rs.10088.25

You Save : Rs.3,362.75    Inclusive of all taxes

- +

Availability : In Stock


    Medical Description of Abevmy 100mg Injection

    Abevmy contains its active substance called Bevacizumab. It is an antiangiogenic antineoplastic agent and vascular endothelial growth factor inhibitor. It is not recommended in paediatric. It is used in the treatment of colon and rectum cancer, lung cancer, breast cancer, brain tumor, Kidney cancer.


    Abevmy 100mg Injection Uses

    Used in the treatment of colorectal cancer, breast cancer, non-squamous non-small cell lung cancer, glioblastoma. It can be given with other chemotherapy agents like 5-fluorouracil. It is not used in children.


    Abevmy 100mg Injection Benefits

    It is an antiangiogenic used in the treatment of different cancers like cancer or tumor of brain, breast, uterus, colon, rectum and lungs. It is used only in adults.

    Colorectal Cancer

    Colon cancer is also known as bowel cancer, colorectal cancer, or rectal cancer. It is a type of cancer that develops from any part of the colon or rectum. The most common Signs and symptoms are blood in the stool, a change in bowel movements, weight loss, and fatigue.


    Abevmy 100mg Injection Indication

    • Metastatic colorectal cancer
    • Metastatic Non-squamous non-small cell lung cancer which is unresectable and locally advanced or recurrent
    • Metastatic renal cell carcinoma
    • Metastatic cervical cancer is persistent or recurrent
    • Metastatic breast cancer
    • Primary peritoneal cancer
    • Epithelial ovarian and fallopian tube cancer
    • Glioblastoma which is recurrent
    • Hepatocellular carcinoma


    Mechanism of action of Abevmy 100mg Injection

    Abevmy contains its active substance called Bevacizumab. Bevacizumab is an antineoplastic and an antiangiogenic agent that inhibits the function of vascular endothelial growth factor which is necessary for the supply of oxygen and nutrients to the abnormal cancerous cells. In other words, abnormal tumor cells send out VEGF into the blood that attached itself to endothelial surface VEGF thus forming new pathway for steady supply of nutrients and oxygen, the more oxygen the abnormal cell receives the better it grows and spread. Bevacizumab is a mAb that attaches itself to the circulating VEGF present in bloodstream thus inhibiting the process of angiogenesis, thus starves the abnormal cells, which in turn induces apoptosis and cell death.


    How Abevmy 100mg Injection works

    Abevmy contains its active substance called Bevacizumab. Bevacizumab is an antineoplastic and an antiangiogenic agent that inhibits the function of vascular endothelial growth factor which is necessary for the supply of oxygen and nutrients to the abnormal cancerous cells. In other words, abnormal tumor cells send out VEGF into the blood that attached itself to endothelial surface VEGF thus forming a new pathway for a steady supply of nutrients and oxygen, the more oxygen the abnormal cell receives the better it grows and spread. Bevacizumab is a mAb that attaches itself to the circulating VEGF present in the bloodstream thus inhibiting the process of angiogenesis, thus starves the abnormal cells, which in turn induces apoptosis and cell death.


    Abevmy 100mg Injection Contraindication

    • if you are allergic to Abevmy or its constituents
    • if you have a bleeding disorder
    • if you have heart disease
    • if you have a kidney disorder
    • if you are going to have surgery
    • if you are pregnant
    • if you are breastfeeding


    Abevmy 100mg Injection Side Effects

    Common side effects that occur 1:10 patients: hypertension, peripheral neuropathy, co-infection, easy bruising and bleeding, fatigue, weakness, diarrhoea, nausea, vomiting, abdominal pain, constipation, loss of appetite, weight loss, fever, watery eyes, change in voice, change in taste perception, runny nose, proteinuria, rash, itching of the skin, muscle and joint pain

    Uncommon side effects that occur 1:100 patients: thrombus formation (DVT/PE), intestinal perforation, intestinal fistula formation, heart failure, eczema and erythema of palm and soles, anaemia, increased thirst, difficulty micturition, mucosal inflammation of the intestine, full-body ache, lethargy.


    FAQs for Abevmy 100mg Injection

    • Is Abevmy safe during pregnancy?

    No, taking Abevmy during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    • Can Bevacizumab be taken while breastfeeding?

    No, in general, it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Bevacizumab can also pass via breastfeeding.

    • Does Bevacizumab cause fertility problems?

    Yes, Bevacizumab decreases male and female fertility, consult your physician.

    •  What type of cancer can Bevacizumab injection be used for?

    It is mainly approved in the treatment of colon or rectal cancer. It is also used in other types of cancer includes lung, kidney, ovarian, cervical cancer

    • Does a person taking Bevacizumab injection still need chemotherapy?

    Yes, chemotherapy is needed along with this medication to work better

    • How Bevacizumab injection works differently from chemotherapy?

    Usually, this chemotherapy targets the cancer cells but this injection that it also prevents the growth of blood vessels which is responsible for tumours.


    Precautions and general warning of Abevmy 100mg Injection

    Alcohol

    Alcohol intake may cause side effects thus caution is required. Kindly consult with your doctor.

    Driving or operating machinery

    Driving or operating heavy machinery may cause side effects thus caution is required. kindly consult with your doctor.

    Pregnancy

    It is unsafe to use during pregnancy it may cause embryo-fetal toxicity. Kindly consult with your doctor.

    Breast Feeding

    It is unsafe to use during breastfeeding. It may cause toxicity to the child. Kindly consult with your doctor.

    Kidney Problem

    It is safe to use for the patient with mild to moderate kidney problems.No dose adjustment required for severe kidney disease patients. Kindly consult with your doctor.

    Liver Disease

    It is safe to use in a patient with liver disease, dose adjustment is required. Kindly consult with your doctor.


    How to Take Abevmy 100mg Injection

    Abevmy is used only in the presence of the physician.

    It must be given intravenously as a slow infusion drip

    It is given in separate doses – the first dose is given in approximately 90mins and the following doses are given in 30 to 60mins if there is no adverse reaction

    It must be taken at the same time once a day as prescribed by your physician.

    After therapy has been initiated, do not take more or less of this drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing your dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Abevmy 100mg Injection in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.

    • In metastatic colorectal cancer the recommended dosage
    • as the first line of treatment is 5mg or 10mg per Kg given with IV 5-fluorouracil provided every 2 weeks
    • 5mg/kg when given with bolus IFL
    • 10mg/kg when given with FOLFOX4
    • as the second line of treatment is 5mg/kg given every 2 weeks or 7.5mg/kg every 3 weeks with IV 5-fluorouracil and irinotecanoxaliplatin-based chemotherapy
    • In metastatic non-squamous non-small cell lung cancer which is inoperable, either locally advanced or recurrent the recommended dosage is 15mg/kg given with carboplatin and paclitaxel every 3 weeks
    • In metastatic renal cell carcinoma, the recommended dosage is 10mg/kg given with interferon alpha2a every 2 weeks
    • In metastatic cervical cancer which is recurrent or persistent, the recommended dosage is 15mg/kg given with paclitaxel and cisplatin/topotecan every 3 weeks
    • In an ovarian or fallopian tube or peritoneal cancer, the recommended dosage is based on the type if it is
    • Platinum resistant – 10mg/kg given every 2 weeks with paclitaxel/ doxorubicin/ topotecan given weekly or 15mg/kg given every 3 weeks with topotecan
    • Platinum sensitive – 15mg/kg given every 3 weeks as monotherapy until the disease regress
    • In glioblastoma which is recurrent, the recommended dosage is 10mg/kg given every 2 weeks
    • In metastatic breast cancer which is HER-2 negative, the usage is revoked by FDA since 2011 but off lable 1.25mg in 0.05ml solution is given once a month
    • In metastatic hepatocellular carcinoma which is unresectable, the recommended dosage is 15mg/d with atezolizumab 1,200mg/kg is given every 3 weeks

    Dosage modification is required in the case of gastrointestinal perforation or fistula formation, necrotizing fasciitis, haemorrhage, arterial-venous thromboembolic events, hypertensive crisis, posterior reversible encephalopathy syndrome, nephrotic syndrome, congestive heart failure and severe infusion reaction.

    Cessation of dosage is required in the case of delayed wound healing, hemoptysis, uncontrolled hypertension, proteinuria >2gm/24 hrs


    Use of Abevmy 100mg Injection in children

    It is not recommended in children.


    Use of Abevmy 100mg Injection in Elderly Patients

    Abevmy has only been used in few patients 65 years or older. Dosage and usage are similar to adults.Kindly consult with your doctor.


    Other general warnings

    • Allergice reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Immunization with a live vaccine
    • Gastrointestinal perforation or fistula formation
    • Slow wound healing
    • Haemorrhage – minor or major/ internal or external
    • Arterial venous thrombotic events
    • Heart event – hypertension to congestive heart failure
    • Reversible posterior leukoencephalopathy syndrome
    • Renal toxicity – proteinuria
    • Infusion reaction
    • Co-infection – neutropenia


    Talk to your doctor if

    • If you have any allergy
    • If you have a liver problem
    • If you have a kidney problem
    • If you have a heart problem
    • If you have a bleeding problem
    • If you are pregnant or breastfeeding


    General instructions

    It can be given intravenously with 0.9% NaCl if compatible; if not compatible can use any dextrose containing solution. Do not shake the vial before use. Store the vials at 8ºC for 8 hrs. The first infusion takes 90mins if no reaction is observed, if followed by a second infusion that takes 60mins, the rest of the following infusion takes approximately 30 mins.


    Drug Interaction of Abevmy 100mg Injection

    Drug-Drug Interaction

    Palifermin + Bevacizumab

    Use alternative drug because the use of palifermin increase the toxicity of bevacizumab by other

    Daunorubicin + Bevacizumab

    Therapy should be administered with caution because the combination of this drug may increase the risk or developing cardiotoxicity

    Dichlorphenamide + Bevacizumab

    Therapy should be administered with caution because the combination of this drug decreases the serum potassium level

    Siponimod + Bevacizumab

    Therapy should be administered with caution because the combination of this drug increases the risk of immunosuppressive effect and also increase the risk for developing an infection

    Drug-Food Interaction

    Consuming grapefruit and grapefruit juice may alter the effect of bevacizumab in the blood level. Kindly avoid this while you are receiving this medicine. Kindly consult with your doctor

    Drug-Disease Interaction

    Bleeding:

    Therapy should be administered with caution because the use of bevacizumab will increase the risk of bleeding by impairing the mechanism of wound healing and increase the complication. So, it should be avoided 28 days before surgery

    Hypertension:

    Therapy should be administered with caution because the use of this drug itself will increase blood pressure. Discontinue the medication if you experience hypertensive crisis and encephalopathy

    Proteinuria:

    Therapy should be administered with caution in patients with renal dysfunction because the use of vascular endothelial growth factor receptors increases the severity of proteinuria 

    Thromboembolic disorders:

    Therapy should be administered with caution in patients who are having a history of venous thromboembolism because the use of this drug can cause venous and arterial thromboembolism.


    Over Dose

    In the case of Overdosage.Kindly consult with your doctor


    Missed Dose

    In case of the missed dose.Kindly consult with your doctor


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 8ºC


    Fast Tag

    Abevmy is an antiangiogenic drug

    It is used to control and treat several cancers that are metastatic and recurrent.

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease or renal diseases or cardiac disorders.