Abitra 250mg Tablet

Brand Name Abitra 250mg Tablet
Salt Composition Abiraterone Acetate (250mg)
Strength 250mg
Product Form Tablet
Pack 120 Tablet(s) in Bottle
Storage Store at room temperature (10-30°C)
Category Anti-Cancer
Country of Origin India
Manufacturer Torion Labs
Manufacturer/Marketer AddressTorion Labs, AAA 2nd Floor, Dooni House, Film Colony Choura Rasta Jaipur 302004.
-3%
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M.R.P : Rs.21900.00       Price : Rs.21243.00

You Save : Rs.657.00    Inclusive of all taxes

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120 Tablet(s) in Bottle

Availability : In Stock

  Online Payment Only



    Medical Description of Abitra 250mg Tablet

    Abitra 250mg Tablet contains its active substance called Abiraterone acetate. It is a CYP17 inhibitor. It is not recommended in paediatric and women. It is used in the treatment of metastasised prostate cancer. It is an anti-testosterone medication used with prednisolone. It is used in cases that have not responded to chemotherapy.


    Abitra 250mg Tablet Uses

    Abitra 250mg is a CYP17 inhibitor also called an adrenal inhibitor used in the treatment of prostate cancer that has metastasised in adults. It acts as an anti-testosterone medication. It is used in the treatment of prostate cancer who have been failed to be treated with chemotherapy. It is not used in children and women.


    Abitra 250mg Tablet Benefits

    It is an adrenal inhibitor used in the treatment of castration-resistant, pre-treated with chemotherapy and failed type of prostate cancer. It is used only in adult males. It is not recommended for women and children.

    Prostate Cancer : 

    Prostate Cancer is also called as prostatic carcinoma. It is a walnut-shaped gland in males which is caused by DNA changes of a normal prostate cell. Symptoms include difficulty in urinating, blood in urine and semen, bone pain, weight loss, and erectile dysfunction


    Abitra 250mg Tablet Indication

    It is an antineoplastic medication and inhibits the multiplication or proliferation of abnormal cells present in the prostate. It is used only in adult males. Abitra is recommended when prostate cancer is

    • Castration-resistant
    • Chemotherapy with docextal has failed
    • Metastasis to other organs

    It is used with prednisolone.


    Mechanism of action of Abitra 250mg Tablet

    Abitra 250mg contains abiraterone acetate is an antineoplastic and a CYP17 inhibitor. Abiraterone acetate is converted into abiraterone which is an androgen inhibitor. It inhibits the enzyme called as 17-alpha-hydroxylase also called CYP17 present in the testis, adrenal glands and prostate. In general, CYP 17, assists in the conversion process that results in the formation of progesterone and androstenedione. Abiraterone acetate can be used in treating androgen dependant prostate cancer. It reduces serum testosterone and progesterone levels. The visible decline in PSA levels is seen with the use of Abiraterone acetate in the treatment of chemo-resistant metastatic prostate cancer. In other words, It treats prostate cancer by inhibiting testosterone formation and decreases serum testosterone levels.


    How Abitra 250mg Tablet works

    Abitra 250mg contains abiraterone acetate is an antineoplastic and a CYP17 inhibitor. Abiraterone acetate is converted into abiraterone which is an androgen inhibitor. It inhibits the enzyme called as 17-alpha-hydroxylase also called CYP17 present in the testis, adrenal glands and prostate. In general, CYP 17, assists in the conversion process that results in the formation of progesterone and androstenedione. Abiraterone acetate can be used in treating androgen dependant prostate cancer. It reduces serum testosterone and progesterone levels. The visible decline in PSA levels is seen with the use of Abiraterone acetate in the treatment of chemo-resistant metastatic prostate cancer. In other words, It treats prostate cancer by inhibiting testosterone formation and decreases serum testosterone levels.


    Abitra 250mg Tablet Contraindication

    • if you are allergic to abiraterone acetate or its constituents
    • if you are pregnant
    • if you are breastfeeding
    • if you have heart disease
    • if you have a liver disorder
    • if you are diabetic
    • if you have adrenal disorders
    • if you have pituitary disorders


    Abitra 250mg Tablet Side Effects

    Very Common side effects that occur in more than 1:10 patients: co-infections, nausea, vomiting, loss of appetite, weight loss, eczema, fatigue, hypertension, bleeding disorders, diarrhoea, constipation, rash, thinning of hair, body ache, headache, hypophosphatemia, increase in serum amylase and lipase enzymes

    Common side effects that occur 1:10 patients: Hematuria, Pyrexia, Rash, Headache, Urinary frequency, Arrhythmia, Groin pain, Nocturia, Fractures, Chest pain or chest discomfort, Cardiac failure, Lymphopenia, Hypophosphatemia, Hyperglycemia, Increased ALT/AST, Hypokalemia, Joint swelling, Muscle discomfort, Dyspnea, Fatigue, Urinary tract infection, Hematuria,

    Uncommon side effects that occur 1:100 patients: Diarrhea, Pyrexia, Hypertriglyceridemia, Groin pain, Constipation, Edema, Hyponatremia, Hot flush, Headache, Insomnia, Increased total bilirubin


    FAQs for Abitra 250mg Tablet

    • Is Abitra 250mg safe during pregnancy?

    No, taking Abitra during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    • Can Abitra be taken while breastfeeding?

    No, in general, it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Abitra can also pass via breastfeeding.

    • Can Abitra be taken while alcohol consumption?

    The interaction is unknown but this medication causes side effects. Thus, consult your physician.

    • Can I take a drive or operate heavy machinery while on Abitra?

    This medication causes side effects thus caution is used while driving or operating machinery.

    • What is the best time to take Abitra?

    You should take Abitra on an empty stomach either 1 hr before food or 2 hrs after food intake.


    Precautions and general warning of Abitra 250mg Tablet

    Alcohol

    It generally causes side effects thus it is advised not to be taken with alcohol. Kindly consult your doctor.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution.

    Pregnancy

    It is highly unsafe and not recommended during pregnancy. Kindly consult your doctor

    Breast Feeding

    It is not safe during breastfeeding it may be toxic to the baby. Kindly consult your doctor.

    Kidney Problem

    No dose adjustment is required for mild to moderate kidney disease patients but for severe kidney disease patients dose adjustment with caution is required. Kindly consult your doctor before usage.

    Liver Disease

    Dose adjustment may be required with caution for patients with liver disease. Kindly consult your doctor before usage.


    How to Take Abitra 250mg Tablet

    • It Should be taken orally.
    • It must be taken at the same time once a day as prescribed by your physician.
    • It should be taken without food either 1 hr before food or 2 hrs after food intake
    •  It must be swallowed as a whole.
    • Don’t chew or crush the tablet.
    • It must be taken with prednisolone.
    • After therapy has been initiated, do not take more or less than the prescribed dose or stop taking it without your physicians’ approval. Skipping or changing the Abitra dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Abitra 250mg Tablet in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.

    It is always taken orally with prednisolone as per the doctor advice

    It is taken either 1 hr before food or 2 hrs after food intake.

    Dosage modification is required in the case of hepatic impairment

    Kindly consult your doctor before usage


    Use of Abitra 250mg Tablet in children

    It is not recommended in children. Consult your doctor


    Use of Abitra 250mg Tablet in Elderly Patients

    It has only been used in few patients 65 years or older. 

    It is always taken orally with prednisolone as per the doctor advice

    It is taken either 1 hr before food or 2 hrs after food intake.

    Dosage modification is required in the case of hepatic impairment

    Kindly consult your doctor before usage


    Other general warnings

    • Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Electrolyte imbalance – causes hypokalemia/ hypertension/ edema. monitor function before and during treatment
    • Adrenocortical insufficiency
    • Hepatotoxicity– monitor function before and during treatment
    • Increase risk of bone fracture
    • Renal toxicity – minimal to none
    • Pregnancy – causes embryo-fetal toxicity
    • Male infertility
    • Breastfeeding – causes side effects similar to adults
    • Alcohol intake or Driving or operating heavy machinery – Abitra causes side effects thus caution is required. consult your physician


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have an electrolyte problem

    If you have a heart problem

    If you have a bone problem

    If you are pregnant or breastfeeding


    General instructions

    It should be taken orally as prescribed dosage at the specific time regularly without food either 1 hr before food or 2 hrs after food intake to avoid adverse effects. This tablet is always taken with prednisolone.


    Drug Interaction of Abitra 250mg Tablet

    Drug-Drug Interaction

    Serum concentration is decreased by Dexamethasone and other steroids

    Serum concentration is increased by Carbamazepine, St. John's Wort, Omeprazole

    Drug-Food Interaction

    It should be taken either 1 hr before or 2 hrs after food, if doubts arise kindly refer to your physician.  Abiraterone acetate generally causes side effects thus it is advised not to be taken with alcohol, spicy foods, caffeinated beverages.

    Drug-Disease Interaction

    • Electrolyte disorders – used with caution in hypokalemia causing diseases. Consult a physician before use
    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
    • Blood disorders – used with caution in haemophilia or anaemia. Consult a physician before use
    • Adrenal disorder – used with caution in adrenocortical dysfunction. Consult a physician before use


    Over Dose

    Overdosage of abiraterone acetate has less literature kindly consult your doctor.


    Missed Dose

    You can take the missed dosage if you notice within 12 hours. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30ºC


    Fast Tag

    • Abitra is a CYP17 inhibitor
    • It is used to control and treat prostate cancer
    • Do not use this medication while pregnant and lactation period.
    • Don’t use this medication with liver disease or bone diseases or cardiac disorders.







Abitra 250mg Tablet

Brand Name Abitra 250mg Tablet
Salt Composition Abiraterone Acetate (250mg)
Strength 250mg
Category Anti-Cancer
Country of Origin India
-15%
image
M.R.P : Rs.21900.00       Price : Rs.18615.00

You Save : Rs.3,285.00    Inclusive of all taxes

- +

Availability : In Stock

  Online Payment Only



    Medical Description of Abitra 250mg Tablet

    Abitra 250mg Tablet contains Abiraterone Acetate 250mg used to treat prostate cancer in adult men along with prednisone that has spread to other parts of your body. It works by inhibiting the enzyme which is responsible for the production of male hormone (androgen) and stops the growth of cancer cells. It is used with other medicines like chemotherapy.


    Abitra 250mg Tablet Uses

    It is used in the treatment of the following conditions as Prostate cancer


    Abitra 250mg Tablet Benefits

    Prostate cancer

    It is cancer that occurs in a man’s prostate. Usually, it grows slowly and is confined to the prostate gland. Symptoms include difficulty in urinating, blood in urine, semen, bone pain, weight loss, and erectile dysfunction. This medicine helps to inhibit the multiplication of cancer cells.

    Metastatic castration-Resistant prostate cancer

    It is an advanced form of advanced prostate cancer. It is also found in other parts of the body and it can also spread lymph nodes, bones, the bladder rectum, liver, lungs, and brain. Symptoms include difficulty in urination, pain while urinating, weight loss, shortness of breath, and bone pain. This medicine helps to inhibit the multiplication of cancer cells.


    Abitra 250mg Tablet Indication

    The Abitra 250mg Tablet is prescribed in the following indications as prostate cancer. It is recommended when prostate cancer is

    • Castration-resistant
    • Chemotherapy with docextal has failed
    • Metastasis to other organs


    Mechanism of action of Abitra 250mg Tablet

    Abitra 250mg Tablet contains Abiraterone Acetate 250mg is an anti-cancer medication, an antiandrogen. It produces its action by inhibiting 17-alpha-hydroxylase also called CYP17 present in the testis, adrenal glands, and prostate. In general, CYP 17, assists in the conversion process of progesterone and androstenedione. Abiraterone acetate reduces serum testosterone and progesterone levels. The visible decline in (Prostate-specific antigen) PSA levels is seen with the use of this medicine in the treatment of chemo-resistant metastatic prostate cancer.


    How Abitra 250mg Tablet works

    Abitra 250mg Tablet contains Abiraterone Acetate 250mg is an anti-cancer medication, an antiandrogen. It produces its action by inhibiting 17-alpha-hydroxylase used in conversion processes that results in the formation of progesterone and androstenedione. It reduces serum levels of progesterone and testosterone levels by decreasing the size of prostate cancer. It treats prostate cancer by inhibiting testosterone formation and decreasing serum testosterone levels.


    Abitra 250mg Tablet Contraindication

    • Do not take this medicine if you are allergic to Abiraterone
    • It is not recommended to use in women and children


    Abitra 250mg Tablet Side Effects

    • Increased liver enzymes
    • Hypertriglyceridemia
    • Fatigue
    • Hypokalemia
    • Edema
    • Constipation
    • Insomnia
    • Confusion
    • Diarrhea
    • Hot flush
    • Urinary tract infection
    • Hypertension
    • Muscle discomfort


    FAQs for Abitra 250mg Tablet

    • Why do I need to take prednisone with the Abitra 250mg Tablet?

    Yes, you have to take prednisone along with this medicine because the combination of this medicine reduces the risk of getting high blood pressure, fluid retention, decreased potassium in your blood.

    • How to take an Abitra 250mg Tablet?

    Kindly take this medicine on an empty stomach with water. 1 hour before or after 2 hours after eating because the food may increase the level of Abitra in blood.

    • I am experiencing nausea and fatigue. Is this due to the Abitra 250mg Tablet?

    Yes, the common side effect of this medicine is nausea and fatigue so it is better to eat more frequent meals to decrease nausea and also avoid foods that are salty, spicy, fatty. Drink plenty of rest and do light exercise to keep yourself active


    Precautions and general warning of Abitra 250mg Tablet

    Alcohol

    It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered safe to drive while you are receiving this medicine it does not affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

    Kidney Problem

    It is considered safe to use this medicine in patients who are having a renal impairment. Kindly consult with your doctor.

    Liver Disease

    Therapy should be administered with caution in patients who are having hepatic impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.


    How to Take Abitra 250mg Tablet

    Abitra 250mg Tablet is to be taken on an empty stomach. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.


    Use of Abitra 250mg Tablet in Adult

    It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor


    Use of Abitra 250mg Tablet in children

    Safety and efficacy were not established. Kindly consult with your doctor.


    Use of Abitra 250mg Tablet in Elderly Patients

    Abitra 250mg Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • Therapy should be administered with caution in patients with a history of cardiovascular disease
    • Hypertension, hypokalemia, and fluid retention may occur due to increased mineralocorticoid due to CYP17 inhibition
    • Kindly monitor for QT prolongation in patients who develop hypokalemia
    • While taking the medicine along with prednisone you may have adrenocortical insufficiency
    • Kindly avoid pregnancy while you are receiving this medicine because it will cause fetal harm and loss of pregnancy


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease


    General instructions

    Abiraterone Acetate 250mg is used to treat prostate cancer. It produces its action by inhibiting 17-alpha-hydroxylase used in conversion processes that results in the formation of progesterone and androstenedione. It reduces serum levels of progesterone and testosterone levels by decreasing the size of prostate cancer. It treats prostate cancer by inhibiting testosterone formation and decreasing serum testosterone levels.


    Drug Interaction of Abitra 250mg Tablet

    Drug-Drug Interaction

    Ritonavir

    It is contraindicated to use this medicine because the use of abiraterone will increase the effect of ritonavir by decreasing its metabolism

    Apalutamide

    Use alternative drugs because the use of apalutamide will decrease the effect of abiraterone by affecting its hepatic and intestinal enzyme metabolism.

    Dichlorphenamide

    Therapy should be administered with caution because the combination of this medicine decreases the serum potassium level.

    Ceritinib

    Therapy should be administered with caution because the use of abiraterone increases the effect of ceritinib by P-glycoprotein efflux transporter.

    Drug-Food Interaction

    Food may increase the amount of medicine get absorbed by your body and it also increases the side effects such as high blood pressure, water retention, low blood potassium level.

    Drug-Disease Interaction

    Hepatic impairment

    Therapy should be administered with caution in patients with severe hepatic toxicity includes fulminant hepatitis, acute hepatic failure, and death.

    Cardiovascular diseases

    Therapy should be administered with caution in patients with increased blood pressure, hypokalemia, recent myocardial infarction, and ventricular arrhythmias because the use of this medicine may cause hypertension, hypokalemia, and fluid retention as there is an increase in mineralocorticoid level which results from CYP17 inhibition.


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 10-30°C room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Abiraterone Acetate 250mg is an anti-cancer medication, an antiandrogen
    • It is used to treat prostate cancer in adult men
    • Take this medicine on an empty stomach
    • Kindly use birth control to avoid pregnancy while you are receiving this medicine.
    • Monitor blood pressure, liver function, and potassium level in your blood while you are receiving this medicine