Actemra 80mg Injection

Brand Name Actemra 80mg Injection
Salt Composition

Tocilizumab (80mg)

Strength 80mg
Product Form Injection
Pack 1 Injection in 1 Vial
Storage Store below 30°C
Category

Arthritis

SubCategory

Rheumatoid arthritis

Country of Origin Switzerland
Manufacturer

Roche Products (India) Pvt Ltd

Manufacturer/Marketer Address Roche Products (India) Pvt Ltd, 146-B, 166 A, Unit No. 7, 8, 9 8th Floor, R City Office, R City Mall Lal Bahadur Shastri Marg Ghatkopar, Mumbai - 400 086.
Actemra 80mg Injection, Tocilizumab 80mg, price, uses, side effect - Drugcarts watermark
M.R.P : Rs.8112.00    

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1 Injection in 1 Vial

Availability : In Stock


    Medical Description of Actemra 80mg Injection

    Actemra injection contains Tocilizumab is in a class of medication called interleukin -6 receptor inhibitor which is meant for injectable use only. It is used along with other medications to treat rheumatoid arthritis, giant cell arteritis, interstitial lung diseases, cytokine release syndrome, and systemic juvenile idiopathic arthritis by inhibiting the activity of interleukin-6, a substance that causes inflammation in your body. And it is also used in the treatment of coronavirus disease in hospitalized adults and pediatric patients age above 2 years who are receiving systemic corticosteroids and require supplemental oxygen, and noninvasive, or invasive mechanical ventilation.


    Actemra 80mg Injection Uses

    • Rheumatoid arthritis
    • Giant cell arteritis
    • Interstitial lung disease
    • Cytokine release syndrome
    • Systemic juvenile idiopathic arthritis
    • Coronavirus disease


    Actemra 80mg Injection Benefits

    Tocilizumab is used in the treatment for the following conditions like

    Uses of Actemra injection in Rheumatoid arthritis:

    It is a chronic inflammatory disorder this will mainly affect the joints in your hands and feet. Here our body's immune system attacks its healthy tissue including joints. Symptoms include tender, warm and swollen joints, joint stiffness and fatigue, fever, and loss of appetite.

    Uses of Actemra injection in Giant cell arteritis:

    It is also known as Temporal arteritis. It is an inflammation in the lining of your blood vessels. The main cause of giant cell arteritis is not clear. Symptoms include severe head pain, scalp tenderness, jaw pain, fever, fatigue, weight loss, and vision loss.

    Uses of Actemra injection in Interstitial lung disease:

    It is also known as pulmonary fibrosis. It mainly occurs due to scarring and inflammation of the interstitium. This scarring makes the lung tissue stiff and makes it the person difficult to breathe. Symptoms include shortness of breath and coughing.

    Uses of Actemra injection in Cytokine release syndrome:

    It is an acute inflammatory response that can e triggered by many factors like infection and certain medications. It releases inflammatory cytokines when a large number of white blood cells are getting activated. Symptoms include fever, nausea, headache, irregular heartbeat, blood pressure, and breathing difficulty.

    Uses of Actemra injection in Systemic juvenile idiopathic arthritis:

    Systemic juvenile idiopathic arthritis is also known as juvenile rheumatoid arthritis. It is usually seen in children who are below the age of 16. It occurs when our body’s immune system attacks its tissues and cells. Symptoms include pain, swelling, stiffness, and swollen lymph nodes.

    Uses of Actemra injection in Coronavirus disease:

    It is a highly infectious disease that is caused by a strain of viruses called coronavirus. Symptoms include fever, cough, loss of smell or taste, difficulty in breathing, nasal congestion, and diarrhea.


    Actemra 80mg Injection Indication

    It is used along with other medications to treat rheumatoid arthritis, giant cell arteritis, interstitial lung diseases, cytokine release syndrome, and systemic juvenile idiopathic arthritis by inhibiting the activity of interleukin-6, a substance that causes inflammation in your body. And it is also used in the treatment of coronavirus disease in hospitalized adults and pediatric patients age above 2 years who are receiving systemic corticosteroids and require supplemental oxygen, and noninvasive, or invasive mechanical ventilation.


    Mechanism of action of Actemra 80mg Injection

    It is an interleukin-6 receptor inhibitor that produces its action by binding with both the soluble and membrane-bound interleukin-6 receptors and it also inhibits the interleukin-6 mediated signaling through these receptors; Interleukin-6 is produced by many varieties of cell types includes synovial, and endothelial cells which leads to local production of interleukin-6 in joints and get affected by inflammatory processes such as rheumatoid arthritis.


    How Actemra 80mg Injection works

    It is an interleukin-6 receptor inhibitor that produces its action by binding with both the soluble and membrane-bound interleukin-6 receptors and it also inhibits the interleukin-6 mediated signaling through these receptors; Interleukin-6 is produced by many varieties of cell types includes synovial, and endothelial cells which leads to local production of interleukin-6 in joints and get affected by inflammatory processes such as rheumatoid arthritis.


    Actemra 80mg Injection Contraindication

    If you’re allergic to the composition of the medicines


    Actemra 80mg Injection Side Effects

    • Constipation
    • Upper respiratory tract infection
    • Nasopharyngitis
    • Hypertension
    • Dizziness
    • Mouth ulceration
    • Total bilirubin increased
    • Pneumonia
    • Septic shock
    • Hypokalemia
    • Insomnia
    • Hypoglycemia


    FAQs for Actemra 80mg Injection

    Is Actemra injection recommended for all Covid-19 patients? If not, why?

    No, this injection is not recommended for all Covid-19 patients because the use of these medicines itself has its potential health hazards which can lead to persistent serious infection.

    Who should be treated with Actemra injection?

    This medicine can be given to patients who are suffering from moderate to severe coronavirus infections who have a persistent reduction in their oxygen levels.

    What are all the side effects of Actemra injection?

    The side effect includes anaphylaxis, transaminitis, leukopenia, and neutropenia. If you have experienced any serious side effects immediately consult with your doctor.


    Precautions and general warning of Actemra 80mg Injection

    Alcohol

    It is not clear whether consuming alcohol may affect the effectiveness of the drug. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered unsafe during driving and it may affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    It is considered unsafe during pregnancy it may cause harmful effects to the fetus. Kindly consult with your doctor.

    Breast Feeding

    It is considered safe during breastfeeding it does not excrete via breast milk. Kindly consult with your doctor.

    Kidney Problem

    Use caution to the patient who is having a renal impairment. Kindly consult with your doctor. Closely monitor the patient renal function.

    Liver Disease

    Use caution to the patient who is having a hepatic impairment. Kindly consult with your doctor.  Closely monitor the patient hepatic functions.


    How to Take Actemra 80mg Injection

    This injection comes in a liquid solution as an intravenous, subcutaneous, and intramuscular injection. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.


    Other general warnings

    The use of this drug may cause increased lipid parameters neutropenia, increased level of liver enzymes, and decreased platelets.

    Therapy should be administered with caution in patients with GI perforation

    The use of this drug may increase the chances of developing the infections


    Talk to your doctor if

    If you’re allergic to the composition of the medicines

    If you’re using any concomitant medications

    If you’re not responding to the corresponding treatment


    Drug Interaction of Actemra 80mg Injection

    Drug-Drug Interaction

    Abatacept + Tocilizumab

    The use of this drug is contraindicated because the combination of this drug may cause unspecified interaction mechanisms.

    Anthrax vaccine + Tocilizumab

    The use of this drug is contraindicated because the use of tocilizumab decreases the effect of the anthrax vaccine by pharmacodynamic antagonism. The use of this drug increases the risk of infection.

    Rabies vaccine + Tocilizumab

    The use of this drug is contraindicated because the use of tocilizumab decreases the effect of the rabies vaccine by pharmacodynamic antagonism. The use of immunosuppressants may interfere with the development of immunity.

    Adalimumab + Tocilizumab

    Use alternative drugs because the combination of this drug may increase the immunosuppressive effects and also increase the risk of infections.

    Etanercept + Tocilizumab

    Use alternative drug because the combination of this drug either increase the effect of the other by pharmacodynamic synergism and also increase the risk of serious infections.

    Oxaliplatin + Tocilizumab

    The use of oxaliplatin with immunosuppressants may increase the risk of serious infection.

    Drug-Food Interaction

    No information is available kindly consult with your doctor.

    Drug-Disease Interaction

    GI perforation:

    Therapy should be administered with caution in patients with an increased risk of gastrointestinal perforation.  Patients who are with new onset of abdominal symptoms should be evaluated for early identification of gastrointestinal perforation.

    Hepatic disorder:

    Tocilizumab has not been studied in a patient with severe hepatic impairment and the use of this drug has been associated with an increased risk of liver enzyme elevation. So it is recommended in patients with hepatic impairment. Frequently monitor the patient's liver function tests.

    Infections:

    Serious bacterial, mycobacterial, invasive fungal, viral and other opportunistic infections have been reported in patients who are all receiving Tocilizumab. Before initiating the treatment it is recommended to avoid the use of this drug in patients with an active and serious infection.

    Renal disease:

    Patients with moderate and severe renal impairment had greater tocilizumab in blood levels. No dose adjustment of Tocilizumab is necessary for patients with mild renal impairment.


    Over Dose

    Consuming more quantity than the prescribed dose may cause an overdose. Kindly use the medicine as per you’re doctor advice


    Missed Dose

    If you missed the dose take the medicine as soon as you remember. If it is time for a subsequent dose skip the missed dose and continue with a daily dose


    Storage and Disposal

    Store the drugs in a closed container at room temperature, and keep the medicines away from heat, moisture, and direct daylight

    Do not keep reaching out to children’s

    Do not keep outdated medicine

    Ask your doctor or pharmacist the way to eliminate the medicine that’s not in use

    Store below 30C


    Fast Tag

    Tocilizumab injection is an interleukin-6 receptor inhibitor

    The drug is employed along with other medications to treat rheumatoid arthritis, giant cell arteritis, interstitial lung diseases, cytokine release syndrome, and systemic juvenile idiopathic arthritis, and coronavirus disease.

    This injection comes in a liquid solution as an intravenous, subcutaneous, and intramuscular injection.

    Do not use this medicine if you're allergic to the composition of the medicine