Brand Name Amigraf 1.0 Capsule
Salt Composition Tacrolimus (1.0mg)
Strength 1.0mg
Product Form Capsule
Pack 10 Capsule(s) in Strip
Storage Store at room temperature (10-30°C)
Category Immunosuppressant
Country of Origin India
Manufacturer Biokindle Lifesciences Pvt Ltd
Manufacturer/Marketer AddressBiokindle Lifesciences Pvt Ltd,A/412, Siddhi Vinayak Towers, Off S G Highway, Makarba, Ahmedabad - 380051 , Gujarat, INDIA
-20%
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    Medical Description of Amigraf 1.0 Capsule

    Amigraf 1.0 capsule contains Tacrolimus 1.0 an Immunosuppressant used to prevent organ rejection in patients who have undergone kidney, heart, and liver transplants. It produces its action by reducing the activity of our immune system so that it will not attack the transplanted organs.


    Amigraf 1.0 Capsule Uses

    It is used to prevent organ rejection in the kidney, heart, and liver


    Amigraf 1.0 Capsule Benefits

    Organ rejection:

    It occurs when the immune system attacks the organ donated and started to destroy the transplanted organs. It is caused by antibodies that act against the organs and it begins within minutes to hours as soon as organ transplantation.


    Amigraf 1.0 Capsule Indication

    The Amigraf 1.0 capsule is prescribed for the following indications to prevent organ  rejection


    Mechanism of action of Amigraf 1.0 Capsule

    Amigraf 1.0 capsule contains Tacrolimus 1.0 is an Immunosuppressant that produces its action by decreasing your body's immune response following an organ transplant like liver, kidney, and heart. The use of this medicine helps your body to accept the new organ.


    How Amigraf 1.0 Capsule works

    Amigraf 1.0 capsule contains Tacrolimus 1.0 is an Immunosuppressant that produces its action by decreasing your body's immune response following an organ transplant like liver, kidney, and heart. The use of this medicine helps your body to accept the new organ.


    Amigraf 1.0 Capsule Contraindication

    Do not take this medicine if you are allergic to Tacrolimus


    Amigraf 1.0 Capsule Side Effects

    • Tremor
    • Hypertension
    • Increased creatinine
    • Infection
    • Diarrhea
    • Constipation
    • Urinary tract infection
    • Abdominal pain
    • Diabetes mellitus
    • Dizziness
    • Chest pain
    • Skin rash


    FAQs for Amigraf 1.0 Capsule

    • What should I be aware of before I start taking the Amigraf 1.0 capsule?

    This medicine decreases the immune system so it increases the risk of infection. Kindly consult with your doctor before initiating the medicine.

    • Which vaccines should not be taken while taking Amigraf 1.0 capsule?

    You should avoid taking any live vaccines while you are receiving this medicine. Vaccines include measles, mumps, rubella, BCG, yellow fever, chickenpox, and typhoid. 

    • Does Amigraf 1.0 capsule have an abuse potential?

    No, the use of this medicine does not have abuse potential, it does not come under a controlled substances

     


    Precautions and general warning of Amigraf 1.0 Capsule

    Alcohol

    It is considered unsafe to consume alcohol while taking this medication. Kindly consult with your doctor

    Driving or operating machinery

    It is considered unsafe to drive while you are using this medicine. Kindly consult with the doctor

    Pregnancy

    It is considered unsafe during pregnancy it may produce harmful effects on the fetus. Kindly consult with your doctor.

    Breast Feeding

    It is considered unsafe to use this medicine during breastfeeding it may excrete via breast milk. Kindly consult with your doctor.

    Kidney Problem

    This medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

    Liver Disease

    This medicine should be used with caution in patients with severe liver impairment. The use of this medicine required dose modification. Kindly consult with your doctor.


    How to Take Amigraf 1.0 Capsule

    The capsule is taken orally on an empty stomach. You should not chew, cut or crush the capsule. Take this medicine as per the dose and duration advised by your doctor. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

     


    Use of Amigraf 1.0 Capsule in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Amigraf 1.0 Capsule in children

    Amigraf 1.0 capsule is considered safe to use this medicine in children. Kindly consult with your doctor.


    Use of Amigraf 1.0 Capsule in Elderly Patients

    Amigraf 1.0 capsule should be used with caution in patients in an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • The use of this medicine may cause a hypersensitivity reaction and it also increases the risk of infection and lymphoma
    • The patients who are receiving immunosuppressants are at increased risk of developing infections
    • The use of this medicine may cause hypertension, mild-severe hyperkalemia, myocardial hypertrophy, QT prolongation, gastrointestinal perforation, and posterior reversible encephalopathy


    Talk to your doctor if

    • You have a history of gastrointestinal disease
    • You are not responding to the treatment
    • You have experienced any allergic reactions like rashes and itching
    • You are suffering from anemia
    • You have watery diarrhea, stomach pain, and fever

     


    General instructions

    Tacrolimus 1.0 is an Immunosuppressant used to prevent organ rejection in patients who have undergone kidney, heart, and liver transplants. It produces its action by reducing the activity of our immune system so that it will not attack the transplanted organs. Closely monitor the blood pressure while you are receiving this medicine. Do not stop this medicine without consulting with your doctor.


    Drug Interaction of Amigraf 1.0 Capsule

    Drug-Drug Interaction

    Anthrax vaccine + Tacrolimus

    Tacrolimus decreases the effect of the anthrax vaccine by pharmacodynamic antagonism. Immunosuppressants increase the risk of infection in combination with live vaccines

    Adalimumab + Tacrolimus

    The combination of this drug increases the effect of immunosuppressive effect and also increases the risk of infection. Use alternative drug

    Amikacin + Tacrolimus

    Combination of this drug increase nephrotoxicity and ototoxicity. Use alternative drug

    Bosutinib + Tacrolimus

    Tacrolimus increases the effect of bosutinib by P-glycoprotein efflux transporter. Use alternative drug

    Drug-Food Interaction

    The use of grapefruit can increase the effect of Tacrolimus and increase the side effect on the kidney, liver, and nervous systems. Consult with your doctor if you have the following symptoms such as fever, rash, nausea, vomiting, dark urine, and jaundice.

    Drug-Disease Interaction

    Diabetes Mellitus:

    Tacrolimus induces post-transplant insulin-dependent diabetes mellitus. Therapy with tacrolimus should be administered with caution in a patient who is having pre-transplant diabetes mellitus.

    Hepatic dysfunction:

    Tacrolimus metabolised in liver. The patient who is having moderate and severe hepatic impairment may alter the metabolic activity of tacrolimus and increase the tacrolimus concentration in the blood. Therapy with tacrolimus should be administered with caution in a patient with hepatic impairment.

    Renal dysfunction:

    Therapy with tacrolimus should be administered with caution in a patient with renal impairment because oliguria and hematuria were reported.

     


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose on this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 10-30°C room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.

     


    Fast Tag

    • Amigraf 1.0 capsule contains Tacrolimus 1.0 an Immunosuppressant used to prevent graft rejection in patients who have undergone kidney, heart, and liver transplants.
    • It produces its action by reducing the activity of our immune system so that it will not attack the transplanted organs
    • It may take 3-4 months for the medication to work
    • Kindly monitor your kidney and liver function while you are receiving this medicine
    • Without consulting with a doctor do not take this medicine
    • Inform your doctor if you have experienced bruising, bleeding, sore throat, mouth ulcers, fever and illness