Arbitus 250mg Tablet

Brand Name Arbitus 250mg Tablet
Salt Composition

Abiraterone Acetate (250mg)

Strength 250mg
Product Form Tablet
Storage Store below 30°C
Category

Anti-Cancer

SubCategory

Prostate Cancer

Country of Origin India
Manufacturer

Dr. Reddy's Laboratories Ltd.

Manufacturer/Marketer Address Dr. Reddy's Laboratories Ltd,7-1-27, Ameerpet, Hyderabad, Andhra Pradesh, 500 016 India
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Arbitus 250mg Tablet, Abiraterone Acetate 250mg Tablet, Price, Uses, Side Effects – Drugcarts watermark
M.R.P : Rs.39500.00       Price : Rs.33575.00

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    Medical Description of Arbitus 250mg Tablet

    Arbitus 250mg Tablet contains Abiraterone Acetate 250mg used to treat prostate cancer in adult men along with prednisone that has spread to other parts of your body. It works by inhibiting the enzyme which is responsible for the production of male hormone (androgen) and stops the growth of cancer cells. It is used with other medicines like chemotherapy.


    Arbitus 250mg Tablet Uses

    It is used in the treatment of the following conditions as Prostate cancer


    Arbitus 250mg Tablet Benefits

    Prostate cancer

    It is cancer that occurs in a man’s prostate. Usually, it grows slowly and is confined to the prostate gland. Symptoms include difficulty in urinating, blood in urine, semen, bone pain, weight loss, and erectile dysfunction. This medicine helps to inhibit the multiplication of cancer cells.

    Metastatic castration-Resistant prostate cancer

    It is an advanced form of advanced prostate cancer. It is also found in other parts of the body and it can also spread lymph nodes, bones, the bladder rectum, liver, lungs, and brain. Symptoms include difficulty in urination, pain while urinating, weight loss, shortness of breath, and bone pain. This medicine helps to inhibit the multiplication of cancer cells.


    Arbitus 250mg Tablet Indication

    The Arbitus 250mg Tablet is prescribed in the following indications as prostate cancer. It is recommended when prostate cancer is

    • Castration-resistant
    • Chemotherapy with docextal has failed
    • Metastasis to other organs


    Mechanism of action of Arbitus 250mg Tablet

    Arbitus 250mg Tablet contains Abiraterone Acetate 250mg is an anti-cancer medication, an antiandrogen. It produces its action by inhibiting 17-alpha-hydroxylase also called CYP17 present in the testis, adrenal glands, and prostate. In general, CYP 17, assists in the conversion process of progesterone and androstenedione. Abiraterone acetate reduces serum testosterone and progesterone levels. The visible decline in (Prostate-specific antigen) PSA levels is seen with the use of this medicine in the treatment of chemo-resistant metastatic prostate cancer.


    How Arbitus 250mg Tablet works

    Arbitus 250mg Tablet contains Abiraterone Acetate 250mg is an anti-cancer medication, an antiandrogen. It produces its action by inhibiting 17-alpha-hydroxylase used in conversion processes that results in the formation of progesterone and androstenedione. It reduces serum levels of progesterone and testosterone levels by decreasing the size of prostate cancer. It treats prostate cancer by inhibiting testosterone formation and decreasing serum testosterone levels.


    Arbitus 250mg Tablet Contraindication

    • Do not take this medicine if you are allergic to Abiraterone
    • It is not recommended to use in women and children


    Arbitus 250mg Tablet Side Effects

    • Increased liver enzymes
    • Hypertriglyceridemia
    • Fatigue
    • Hypokalemia
    • Edema
    • Constipation
    • Insomnia
    • Confusion
    • Diarrhea
    • Hot flush
    • Urinary tract infection
    • Hypertension
    • Muscle discomfort


    FAQs for Arbitus 250mg Tablet

    • Why do I need to take prednisone with the Arbitus 250mg Tablet?

    Yes, you have to take prednisone along with this medicine because the combination of this medicine reduces the risk of getting high blood pressure, fluid retention, decreased potassium in your blood.

    • How to take an Arbitus 250mg Tablet?

    Kindly take this medicine on an empty stomach with water. 1 hour before or after 2 hours after eating because the food may increase the level of Arbitus in blood.

    • I am experiencing nausea and fatigue. Is this due to the Arbitus 250mg Tablet?

    Yes, the common side effect of this medicine is nausea and fatigue so it is better to eat more frequent meals to decrease nausea and also avoid foods that are salty, spicy, fatty. Drink plenty of rest and do light exercise to keep yourself active


    Precautions and general warning of Arbitus 250mg Tablet

    Alcohol

    It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered safe to drive while you are receiving this medicine it does not affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

    Kidney Problem

    It is considered safe to use this medicine in patients who are having a renal impairment. Kindly consult with your doctor.

    Liver Disease

    Therapy should be administered with caution in patients who are having hepatic impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.


    How to Take Arbitus 250mg Tablet

    Arbitus 250mg Tablet is to be taken on an empty stomach. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.


    Use of Arbitus 250mg Tablet in Adult

    It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor


    Use of Arbitus 250mg Tablet in children

    Safety and efficacy were not established. Kindly consult with your doctor.


    Use of Arbitus 250mg Tablet in Elderly Patients

    Arbitus 250mg Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • Therapy should be administered with caution in patients with a history of cardiovascular disease
    • Hypertension, hypokalemia, and fluid retention may occur due to increased mineralocorticoid due to CYP17 inhibition
    • Kindly monitor for QT prolongation in patients who develop hypokalemia
    • While taking the medicine along with prednisone you may have adrenocortical insufficiency
    • Kindly avoid pregnancy while you are receiving this medicine because it will cause fetal harm and loss of pregnancy


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease


    General instructions

    Abiraterone Acetate 250mg is used to treat prostate cancer. It produces its action by inhibiting 17-alpha-hydroxylase used in conversion processes that results in the formation of progesterone and androstenedione. It reduces serum levels of progesterone and testosterone levels by decreasing the size of prostate cancer. It treats prostate cancer by inhibiting testosterone formation and decreasing serum testosterone levels.


    Drug Interaction of Arbitus 250mg Tablet

    Drug-Drug Interaction

    Ritonavir

    It is contraindicated to use this medicine because the use of abiraterone will increase the effect of ritonavir by decreasing its metabolism

    Apalutamide

    Use alternative drugs because the use of apalutamide will decrease the effect of abiraterone by affecting its hepatic and intestinal enzyme metabolism.

    Dichlorphenamide

    Therapy should be administered with caution because the combination of this medicine decreases the serum potassium level.

    Ceritinib

    Therapy should be administered with caution because the use of abiraterone increases the effect of ceritinib by P-glycoprotein efflux transporter.

    Drug-Food Interaction

    Food may increase the amount of medicine get absorbed by your body and it also increases the side effects such as high blood pressure, water retention, low blood potassium level.

    Drug-Disease Interaction

    Hepatic impairment

    Therapy should be administered with caution in patients with severe hepatic toxicity includes fulminant hepatitis, acute hepatic failure, and death.

    Cardiovascular diseases

    Therapy should be administered with caution in patients with increased blood pressure, hypokalemia, recent myocardial infarction, and ventricular arrhythmias because the use of this medicine may cause hypertension, hypokalemia, and fluid retention as there is an increase in mineralocorticoid level which results from CYP17 inhibition.


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 10-30°C room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Abiraterone Acetate 250mg is an anti-cancer medication, an antiandrogen
    • It is used to treat prostate cancer in adult men
    • Take this medicine on an empty stomach
    • Kindly use birth control to avoid pregnancy while you are receiving this medicine.
    • Monitor blood pressure, liver function, and potassium level in your blood while you are receiving this medicine


    References