Atubri 500mg Tablet

Brand Name Atubri 500mg Tablet
Salt Composition

Capecitabine (500mg)

Strength 500mg
Product Form Tablet
Pack 10 Tablet(s) in Strip
Storage Store below 30°C
Category

Anti-Cancer

SubCategory

Breast Cancer

Country of Origin India
Manufacturer

Pfizer Ltd (India)

Manufacturer/Marketer Address Pfizer Ltd (India), The Capital, 1802 / 1901, Plot No. C-70, G Block, Bandra Kurla Complex, Bandra (E), Mumbai – 400 051.
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Atubri 500mg Tablet, Capecitabine 500mg Tablet, Price, Uses, Side effects –Drugcarts watermark
M.R.P : Rs.1730.77       Price : Rs.1384.62

You Save : Rs.346.15    Inclusive of all taxes

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10 Tablet(s) in Strip

Availability : In Stock

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    Medical Description of Atubri 500mg Tablet

    Atubri 500mg Tablet contains Capecitabine 500mg used to treat Colorectal cancer and Breast cancer by inhibiting the growth of cancer cells. This medication is recommended only for adults. It is used alone or with other combination medicine as chemotherapy.


    Atubri 500mg Tablet Uses

    It is used in the treatment of the following conditions as Colorectal cancer and Breast cancer


    Atubri 500mg Tablet Benefits

    Breast cancer

    It is a type of cancer that forms in the breast cells. It is common among women. Symptoms include breast lump, change in breast size, redness, pitting of the skin, color change, and peeling surrounding the breast skin or nipple. This medicine helps to inhibit the multiplication of cancer cells.

    Colorectal cancer

    It is also called colon cancer. It is a type of cancer that starts from the large intestine and it usually affects older adults. It occurs when there is a change in the DNA of the normal cells. Symptoms include a change in bowel movement, rectal bleeding, fatigue, and weight loss. This medicine helps to inhibit the multiplication of cancer cells.


    Atubri 500mg Tablet Indication

    The Atubri 500mg Tablet is prescribed in the following indications as

    • Metastatic colon cancer
    • Colorectal cancer
    • Breast cancer that is resistant to paclitaxel or anthracycline.


    Mechanism of action of Atubri 500mg Tablet

    Atubri 500mg Tablet contains Capecitabine 500mg is an anti-cancer medication, an antimetabolite. It produces its action by converting to 5-fluorouracil which is then converted to 5-fluoro-2-deoxyuridine monophosphate and 5-fluorouridine triphosphate. 5-fluoro-2-deoxyuridine monophosphate binds to thymidylate which is necessary for thymidine triphosphate a substrate for DNA molecule thus inhibiting cell division. The nuclear transcriptional enzyme incorporates into 5-fluorouridine triphosphate and converts into uridine triphosphate which acts as a substrate for RNA molecules thus inhibiting protein synthesis.


    How Atubri 500mg Tablet works

    Atubri 500mg Tablet contains Capecitabine 500mg is an anti-cancer medication, an antimetabolite. It produces its action by inhibiting the progression of abnormal cells by inhibiting the protein synthesis process that results in the modification of DNA and RNA strands. Atubri active substance contains capecitabine which is converted to 5-fluoro-2-deoxyuridine monophosphate and 5-fluorouridine triphosphate that incorporates into DNA and RNA strand thus inhibits the protein synthesis process that results in multiplication and spread of cancer.


    Atubri 500mg Tablet Contraindication

    • Do not take this medicine if you are allergic to Capecitabine
    • It is contraindicated to use this medicine in patients who are a history of severe renal impairment.


    Atubri 500mg Tablet Side Effects

    • Diarrhea
    • Anemia
    • Edema
    • Fatigue
    • Fever
    • Headache
    • Pain
    • Alopecia
    • Constipation
    • Stomatitis
    • Dyspnea
    • Eye irritation
    • Dizziness
    • Dry mouth
    • Back pain
    • Taste disturbances


    FAQs for Atubri 500mg Tablet

    • What kind of drug is a Atubri 500mg Tablet?

    Atubri tablet is not a cytostatic medicine, it gets converted into anti-cancer medicine once it gets absorbed by your body

    • Does the Atubri 500mg Tablet make you tired?

    Yes, the use of this medicine makes you feel tired and weak and it is a common side effect. So kindly avoid driving while you are receiving this medicine

    • Can I take warfarin along with a Atubri 500mg Tablet?

    No, you should not use this combination because it may change the rate of clot formation and cause bleeding which leads to cell death.


    Precautions and general warning of Atubri 500mg Tablet

    Alcohol

    It is considered unsafe to consume alcohol while you are receiving this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

    Kidney Problem

    The medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

    Liver Disease

    The medicine should be used with caution in patients with hepatic impairment. The use of this medicine required dose modification. Kindly consult with your doctor.


    How to Take Atubri 500mg Tablet

    Atubri 500mg Tablet is taken orally with food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.


    Use of Atubri 500mg Tablet in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Atubri 500mg Tablet in children

    Safety and efficacy were not established in children. Kindly consult with your doctor.


    Use of Atubri 500mg Tablet in Elderly Patients

    Atubri 500mg Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • The use of this medicine may cause blooding, severe diarrhea
    • Cardiotoxicity includes myocardial infarction, ischemia, angina, cardiac arrest, cardiac failure, sudden death, and cardiomyopathy
    • The use of this medicine may cause fetal death and embryofetal toxicity
    • Therapy should be administered with caution in geriatric patients because it may increase the risk of developing side effects
    • Hyperbilirubinemia, Severe mucocutaneous reactions, stevens-johnson syndrome, and toxic epidermal necrolysis was reported while you are receiving this medicine


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease
    • You develop shortness of breath


    General instructions

    Capecitabine 500mg is used to treat Colorectal cancer and Breast cancer. It produces its action by inhibiting the progression of abnormal cells by inhibiting the protein synthesis process that results in the modification of DNA and RNA strands. Atubri 500mg Tablet active substance contains capecitabine which is converted to 5-fluoro-2-deoxyuridine monophosphate and 5-fluorouridine triphosphate that incorporates into DNA and RNA strand thus inhibits the protein synthesis process that results in multiplication and spread of cancer.


    Drug Interaction of Atubri 500mg Tablet

    Drug-Drug Interaction

    Cedazuridine

    Use alternative drugs because the use of cedazuridine will increase the effect of capecitabine by decreasing its metabolism.

    Warfarin

    Use alternative drug because the use of capecitabine increases the effect of warfarin by unspecified interaction mechanism

    Aluminum hydroxide

    Therapy should be administered with caution because the use of aluminum hydroxide increases the effect of capecitabine by enhancing GI absorption

    Fingolimod

    Therapy should be administered with caution because the use of capecitabine increases the effect of fingolimod by immunosuppressive effects and it also increases the risk of developing an infection

    Diclofenac

    Therapy should be administered with caution because the use of capecitabine will increase the effect of diclofenac by affecting its hepatic enzyme metabolism.

    Drug-Food Interaction

    Folic acid-containing products may increase the effect of capecitabine and you may develop some side effects such as anemia, bleeding problems, infection, and nerve damage. Kindly consult with your doctor if you have experienced any severe nausea and vomiting, diarrhea, pale skin, fatigue, dizziness, fainting, blood in stools, fever, chills, body ache, and mouth ulcer.

    Drug-Disease Interaction

    Myelosuppression

    Therapy should not be administered in patients whose neutrophil count is less than 1,500/mm3. The use of this medicine may cause myelosuppression, bone marrow failure, and severe immunosuppression which leads to developing septic shock and sepsis

    Infections

    The use of this medicine is contraindicated in patients who are having the infectious disease because of their cytotoxic effect their induce myelosuppression.

    Coronary artery disease

    Therapy should be administered with caution in patients with a history of coronary artery disease because the use of capecitabine may cause cardiotoxicity includes myocardial infarction, ischemia, angina, cardiac failure, sudden death, ECG changes, and cardiomyopathy.

    Renal dysfunction

    Therapy is contraindicated to use this medicine in patients who are having a history of severe renal impairment

    Hepatic dysfunction

    Therapy should be administered with caution because the use of this medicine may cause liver metastases


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 30°C room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Atubri 500mg Tablet contains Capecitabine 500mg used to treat Colorectal cancer and Breast cancer by inhibiting the growth of cancer cells. This medication is recommended only for adults. It is used alone or with other combination medicine as chemotherapy.
    • It should be taken 30 minutes after your meal
    • Kindly avoid taking this medicine while you are pregnant
    • Avoid consuming alcohol while you are receiving this medicine because it may increase the risk of developing serious side effects.


    References