Azofit 50mg Tablet

Azofit 50mg Tablet contains Azathioprine 50mg an Immunosuppressant used to prevent organ rejection in patients who have undergone kidney, heart, and liver transplants and it is also used in the treatment of rheumatoid arthritis. It produces its action by reducing the activity of our immune system so that it will not attack the transplanted organs

It is used to prevent organ rejection in the kidney, heart, and liver and Rheumatoid arthritis

Organ rejection:

It occurs when the immune system attacks the organ donated and started to destroy the transplanted organs. It is caused by antibodies that act against the organ and it begins within minutes to hours as soon as organ transplantation.

Rheumatoid arthritis

It is a chronic inflammatory disorder this will mainly affect joints in the hands and feet. Here our body's immune system attacks its healthy tissue including joints. Symptoms include tender, warm and swollen joints, joint stiffness and fatigue, fever, and loss of appetite.

The Azofit 50mg Tablet is prescribed for the following indications to prevent organ rejection and rheumatoid arthritis

Azofit 50mg Tablet contains Azathioprine 50mg an Immunosuppressant that produces its action by reducing the action of our body’s defense system and it also prevents the rejection of the transplanted organ. It also inhibits the action of certain chemical messengers which are responsible for inflammation, swelling, and redness associated with joint diseases.

Azofit 50mg Tablet contains Azathioprine 50mg an Immunosuppressant that produces its action by reducing the action of our body’s defense system and it also prevents the rejection of the transplanted organ. It also inhibits the action of certain chemical messengers which are responsible for inflammation, swelling, and redness associated with joint diseases.

• Do not take this medicine if you are allergic to Azathioprine
• It is contraindicated to use this medicine in patients with rheumatoid arthritis who are previously treated with alkylating agents

• Infection
• Abdominal pain
• Alopecia
• Diarrhea
• Bone marrow suppression
• Fever
• Skin cancer

• How long doesAzofit 50mg Tablet take to start working?

Usually, it takes 3-12 weeks to start working and it depends upon the severity of the patient. Do not withdraw the drug without consulting with your doctor

• What happens if I forget to take theAzofit 50mg Tablet?

If you missed the dose take it as soon as you remember do not take the tablet between the meals. If it is time for the next dose skip the missed dose and continue with a regular dose

• CanAzofit 50mg Tablets cause cancer?

Yes, the use of this tablet may increase the chance of developing skin cancer, lymphoma and sarcomas, and cervical cancer. Kindly consult with your doctor if you have noticed any changes in your body.

Alcohol

It is not clear whether it is safe to consume alcohol while you are receiving this medicine. Kindly consult with your doctor.

Driving or operating machinery

It is not clear whether it is safe to drive while you are receiving this medicine. Kindly consult with your doctor.

Pregnancy

It is considered unsafe during pregnancy it may produce harmful effects on the fetus. Kindly consult with your doctor.

Breast Feeding

It is considered unsafe during pregnancy it may produce harmful effects on the fetus. Kindly consult with your doctor.

Kidney Problem

This medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

Liver Disease

This medicine should be used with caution in patients with severe liver impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

The tablet is taken orally with food. You should not chew, cut or crush the tablet. Take this medicine as per the dose and duration advised by your doctor. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.

It is considered unsafe to use this medicine in children who are below 12 years old. Kindly consult with your doctor

Azofit 50mg Tablets should be used with caution in patients in an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

• Long-term use may increase the risk of neoplasia
• The use of this medicine increases the risk of infection and hepatotoxicity
• Severe leukopenia, thrombocytopenia, anemia, severe bone marrow suppression may occur
• Patients who are receiving immunosuppressants are at higher risk for bacterial, viral, fungal, protozoal, and opportunistic infection
• Hepatosplenic T-cell lymphoma was reported

• You have a history of gastrointestinal disease
• You are not responding to the treatment
• You have experienced any allergic reactions like rashes and itching
• You are suffering from anemia
• You have watery diarrhea, stomach pain, and fever

Azathioprine 50mg is an Immunosuppressant used to prevent organ rejection in patients who have undergone kidney, heart, and liver transplants and it is also used in the treatment of rheumatoid arthritis. It produces its action by reducing the activity of our immune system so that it will not attack the transplanted organs

Drug-Drug Interaction

Anthrax vaccine

Azathioprine increases the effect of the anthrax vaccine by pharmacodynamic antagonism. Immunosuppressants increase the risk of infection in combination with live vaccines

Rabies vaccine

Azathioprine decreases the effect of the rabies vaccine by pharmacodynamic antagonism. Immunosuppressants interfere in the development of immunity.

 Allopurinol

The use of this drug is contraindicated because the use of allopurinol increases the effect of azathioprine by decreasing its metabolism. A combination of these drugs may increase the risk of bone marrow toxicity.

Anakinra

Use alternative drug because the combination of these drugs increases the effect of immunosuppressant and increase the risk of infections.

Infliximab

Use alternative drug because the combination of these drugs increases the effect of immunosuppressant and increase the risk of infections.

Altretamine

Altretamine increases the effect of azathioprine through immunosuppressive effects. Use with Therapy should be administered with caution because the combination of this drug may increase the risk of serious infections

Drug-Food Interaction

The use of grapefruit can increase the effect of immunosuppressants and increase the side effect on the kidney, liver, and nervous systems. Consult with your doctor if you have the following symptoms such as fever, rash, nausea, vomiting, dark urine, and jaundice.

Drug-Disease Interaction

Hypertension

The use of immunosuppressants is contraindicated in patients who are having rheumatoid arthritis and psoriasis with uncontrolled hypertension.

Renal dysfunction:

The use of immunosuppressants is contraindicated in patients who are having rheumatoid arthritis and psoriasis with renal impairment. Immunosuppressant causes a reversible reduction in renal blood flow and glomerular filtration rate which leads to an increase in serum creatinine level. Closely monitor the patient's renal function

Hepatic dysfunction:

The use of immunosuppressant has contraindicated the patients who are having rheumatoid arthritis and psoriasis with hepatic dysfunction because immunosuppressant is metabolized in the liver and eliminated through bile and feces. The use of this drug may alter the hepatic and bilirubin functions. Closely monitor the patient hepatic functions

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose on this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 10-30°C room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

• Azofit 50mg Tablet contains Azathioprine 50mg an Immunosuppressant used to prevent organ rejection in patients who have undergone kidney, heart, and liver transplants and it is also used in the treatment of rheumatoid arthritis.
• It produces its action by reducing the activity of our immune system so that it will not attack the transplanted organs
• Kindly monitor your kidney and liver function while you are receiving this medicine
• Without consulting with a doctor do not take this medicine
• Inform your doctor if you have experienced bruising, bleeding, sore throat, mouth ulcers, fever and illness

• Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 30 November 2021]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016324s034s035lbl.pdf>
• Stewart, M., 2021. Azathioprine (Imuran). [online] Patient.info. Available at: <o/medicine/azathioprine-azapress-imuran> [Accessed 30 November 2021]. https://patient.inf
• Drugs, H., 2021. Azathioprine: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 30 November 2021]. https://medlineplus.gov/druginfo/meds/a682167.html>
• Medicines.org.uk. 2021. Azathioprine 50 mg Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 30 November 2021]. https://www.medicines.org.uk/emc/product/3301/smpc#PHARMACOKINETIC_PROPS>