Bevnexxa 400mg Injection

Brand Name Bevnexxa 400mg Injection
Salt Composition Bevacizumab (400mg)
Strength 400mg
Product Form Injection
Pack 1 x 16ml in 1 vial
Category Anti-Cancer
Country of Origin India
Manufacturer Celon Laboratories Ltd
Manufacturer/Marketer AddressCelon Laboratories Ltd, Plot No. 264, Patrika Nagar, HITEC City, Madhapur, Telangana 500081
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M.R.P : Rs.39000.00       Price : Rs.31200.00

You Save : Rs.7,800.00    Inclusive of all taxes

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1 x 16ml in 1 vial

Availability : In Stock

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    Medical Description of Bevnexxa 400mg Injection

    Bevnexxa 400mg Injection contains Bevacizumab 400mg used to treat various types of cancer of colon, lung, kidney, brain, ovarian, and cervix. It works by inhibiting the protein and stopping the formation of blood vessels which brings oxygen and nutrients to the cancer cells. It is used alone or with other combinations.


    Bevnexxa 400mg Injection Uses

    It is used in the treatment of the following conditions as Renal cell carcinoma, colorectal cancer, non-small cell lung cancer, cervical cancer, ovarian cancer, fallopian tube cancer, peritoneal cancer, breast cancer, hepatic carcinoma, and glioblastoma multiforme


    Bevnexxa 400mg Injection Benefits

    Ovarian cancer

    It is a type of cancer that occurs in an ovary a female reproductive system that produces women’s eggs and female hormones. The exact is not clear but if you have a history of ovarian cancer in your family. Symptoms include abdominal bloating, weight loss, discomfort in the pelvic area, fatigue, back pain, constipation, and frequent urination. This medicine helps to inhibit the multiplication of cancer cells.

    Renal cell carcinoma

    It is a common type of kidney cancer found in adults. It is caused by obesity, smoking cigarettes, polycystic kidney disease, and some genetic condition. Symptoms include blood in urine, loss of appetite, weight loss, tiredness, and fever.

    Non-small cancer lung cancer

    It is a type of lung cancer. It grows and spreads slowly when compared with small cell lung cancer. Smoking is considered a major risk factor for non-small cancer lung cancer. Symptoms include chronic cough, shortness of breath, chest pain, bone pain, and headache.

    Colorectal cancer

    It is also called colon cancer. It is a type of cancer that starts from the large intestine and it usually affects older adults. It occurs when there is a change in the DNA of the normal cells. Symptoms include a change in bowel movement, rectal bleeding, fatigue, and weight loss. This medicine helps to inhibit the multiplication of cancer cells.

    Cervical cancer

    It is a type of cancer that occurs in cervix cells. The major cause of this cancer is human papillomavirus, a sexually transmitted infection. It usually occurs when there is a change in the cell DNA. Symptoms include vaginal bleeding after intercourse, bloody or blood vaginal discharge, and pelvic pain

    Fallopian tube cancer

    It is a type of cancer that affects the tube which carries the egg from the ovaries to the uterus. Symptoms include abdominal pain, abnormal menstruation, constipation, fatigue, frequent urination, painful intercourse, and back pain.

    Peritoneal cancer

    It is a rare type of cancer that usually affects the epithelial cells that line inside the abdomen wall. It usually occurs when there is a change in the cell DNA. Symptoms include bowel changes, loss of appetite, vaginal discharge, weight loss, inflamed abdomen, pain, vaginal discharge, and shortness of breath

    Glioblastoma multiforme

    It is an aggressive type of cancer that occurs in the brain and spinal cord. It affects mostly older adults. Symptoms include headache, nausea or vomiting, memory loss, confusion, difficulty in balance, urinary intolerance, blurred vision, speech difficulties, seizures, and irritability

    Metastatic breast cancer

    It is a type of cancer that forms in the breast cells. It is common among women. Symptoms include breast lump, change in breast size, redness, pitting of the skin, color change, and peeling surrounding the breast skin or nipple. This medicine helps to inhibit the multiplication of cancer cells.

    Hepatocellular carcinoma

    It is also called malignant hepatoma, it is a common type of liver cancer. It usually occurs in people who are having a chronic liver disease such as cirrhosis, hepatitis B or C. Symptoms include weight loss, inflamed liver, loss of appetite, stomach pain, and jaundice


    Bevnexxa 400mg Injection Indication

    • The Bevnexxa injection is prescribed in the following indications as
    • Metastatic colorectal cancer
    • Metastatic Non-squamous non-small cell lung cancer which is unresectable and locally advanced or recurrent
    • Metastatic renal cell carcinoma
    • Metastatic cervical cancer is persistent or recurrent
    • Metastatic breast cancer
    • Primary peritoneal cancer
    • Epithelial ovarian and fallopian tube cancer
    • Recurrent glioblastoma
    • Hepatocellular carcinoma


    Mechanism of action of Bevnexxa 400mg Injection

    Bevnexxa 400mg Injection contains Bevacizumab 400mg is an anti-cancer medication, a vascular endothelial growth factor (VEGF, which supplies oxygen and nutrients to the abnormal cancerous cells). It is a monoclonal antibody that attaches itself to the circulating VEGF which is present in the bloodstream and inhibits the process of angiogenesis, thus starves the abnormal cells, which in turn induces cell death.


    How Bevnexxa 400mg Injection works

    Bevnexxa 400mg Injection contains Bevacizumab 400mg is an anti-cancer medication, a vascular endothelial growth factor(VEGF, which supplies oxygen and nutrients to the abnormal cancerous cells). It is a monoclonal antibody that attaches itself to the circulating VEGF which is present in the bloodstream and inhibits the process of angiogenesis, thus starves the abnormal cells, which in turn induces cell death.


    Bevnexxa 400mg Injection Contraindication

    • Do not take this medicine if you are allergic to Bevacizumab
    • It is contraindicated to use this medicine in patients with a bleeding disorder
    • It is not recommended to use this medicine for at least 28 days after a surgical procedure

     


    Bevnexxa 400mg Injection Side Effects

    • Diarrhea
    • Fatigue
    • Nausea
    • Hypertension
    • Epistaxis
    • Stomatitis
    • Muscle weakness
    • Hypertension
    • Thrombocytopenia
    • Loss of appetite
    • Back pain
    • Dizziness


    FAQs for Bevnexxa 400mg Injection

    • Is Bevnexxa 400mg Injection safe?

    Yes, the use of this medicine is considered safe if you have taken the medicine as per the dose and duration advised by the doctor.

    • Can I stop using the Bevnexxa 400mg Injection immediately or do I have to slowly wean off the use?

    You should not withdraw the medicine immediately, you should taper the dose to avoid rebound effects.           

    • How to treat constipation during the treatment?

    To treat constipation drink plenty of water a day and keep you active, add fiber to your diet. If you do not have a bowel movement for more than 3 days kindly consult with your doctor.


    Precautions and general warning of Bevnexxa 400mg Injection

    Alcohol

    It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

    Kidney Problem

    It is considered safe to use this medicine in patients who are with renal impairment. Kindly consult with your doctor.

    Liver Disease

    It is considered safe to use this medicine in patients who are with hepatic impairment. Kindly consult with your doctor.


    How to Take Bevnexxa 400mg Injection

    Bevnexxa 400mg Injection comes in a liquid solution as an intravenous. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.

     


    Use of Bevnexxa 400mg Injection in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Bevnexxa 400mg Injection in children

    It is considered unsafe to use this medicine in children who are below 18 years old. Kindly consult with your doctor.


    Use of Bevnexxa 400mg Injection in Elderly Patients

    Bevnexxa 400mg Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • The use of this medicine may cause hemorrhage, arterial thromboembolic events includes cerebral infarction, transient ischemic attacks, myocardial infarction, angina
    • The use of this medicine increases the risk of developing venous thromboembolic events, hypertension, and heart failure
    • Posterior reversible encephalopathy syndrome, proteinuria, and ovarian failure were reported
    • The infusion-related reaction can occur
    • The use of this medicine impairs the wound healing, cause GI perforation, and fistula formation


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease
    • You develop shortness of breath


    General instructions

    Bevacizumab 400mg is used to treat various types of cancer of the colon, lung, kidney, brain, ovarian, and cervix. It is a monoclonal antibody that attaches itself to the circulating VEGF which is present in the bloodstream and inhibits the process of angiogenesis, thus starves the abnormal cells, which in turn induces cell death.


    Drug Interaction of Bevnexxa 400mg Injection

    Drug-Drug Interaction

    Sunitinib

    It is contraindicated to use this medicine in combination because the use of this may cause microangiopathic hemolytic anemia

    Daunorubicin

    Use alternative drugs because the combination of this medicine may increase the risk of developing cardiotoxicity

    Dichlorphenamide

    Therapy should be administered with caution because the combination of this medicine because decreases the serum potassium

    Cholera vaccine

    Therapy should be administered with caution because the use of bevacizumab decreases the effect of cholera vaccine by immunosuppressive effect and it also increases the risk for developing an infection

    Drug-Food Interaction

    No data is available. Kindly consult with your doctor

    Drug-Disease Interaction

    Fistula formation

    Therapy should be administered with caution because the use of this medicine may cause tracheoesophageal, bronchopleural, biliary, vaginal, renal, and bladder sites.

    GI perforation

    Kindly avoid using this medicine in patients with ovarian cancer because there are clinical symptoms of bowel obstruction

    Bleeding

    Therapy should be administered with caution in patients who are at increased risk for bleeding because the use of this medicine impairs the wound healing process and increase wound-healing complications.

    Posterior reversible encephalopathy syndrome (PRES)

    While using vascular endothelial growth factor receptor PRES, a neurological disorder has been reported. This includes headache, seizures, lethargy, confusion, blindness, and other neurological disturbances

    Renal dysfunction

    Therapy should be administered with caution in a patient with renal impairment because the use of this medicine increases the incidence and severity of proteinuria


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 2-8°C in a refrigerator.
    • Do not freeze
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Bevacizumab 400mg is an anti-cancer medication, a vascular endothelial growth factor
    • It is used to treat Renal cell carcinoma, colorectal cancer, non-small cell lung cancer, cervical cancer, ovarian cancer, fallopian tube cancer, peritoneal cancer, breast cancer, hepatic carcinoma, and glioblastoma multiforme
    • Therapy should be administered with caution if you have scheduled for surgery because this medicine interfere with the wound healing
    • Kindly inform your doctor if you are diabetic because the use of this medicine increases your blood glucose level
    • Do not withdraw the medicine without consulting with a doctor
    • Kindly consult with your doctor if you have experienced shortness of breath, chest pain, loss of appetite, and dark urine while you are receiving this medicine