Biocure 2mg Injection

Brand Name Biocure 2mg Injection
Salt Composition Bortezomib (2mg)
Strength 2mg
Product Form Injection
Category Anti Cancer
Country of Origin India
Manufacturer Emcure Pharmaceuticals Ltd
Manufacturer/Marketer AddressEmcure Pharmaceuticals Ltd, 255/2, Hinjawadi, Pune - 411057, India.
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Biocure 2mg Injection, Bortezomib 2mg, price, uses, side Effects - Drugcarts watermark
M.R.P : Rs.15852.40       Price : Rs.14267.16

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    Medical Description of Biocure 2mg Injection

    Biocure 2mg Injection contains Bortezomib 2mg it is an antineoplastic agent and proteasome inhibitor. This medication is not recommended in paediatric. Biocure 2mg Injection is used in the treatment of mantle cell lymphoma and multiple myeloma.


    Biocure 2mg Injection Uses

    Biocure 2mg Injection is used in the treatment of bone marrow cancer and cancer that affects the immune system. It is not used in children.


    Biocure 2mg Injection Benefits

    Biocure 2mg Injection is used in the treatment of mantle cell lymphoma and multiple myeloma. It is not recommended in children.


    Biocure 2mg Injection Indication

    Biocure 2mg Injection is indicated in the treatment of:

    • Mantle cell lymphoma
    • Multiple myeloma


    Mechanism of action of Biocure 2mg Injection

    Bortezomib is an antineoplastic and an antiangiogenic agent. Bortezomib is a proteasome inhibitor that targets the ubiquitin-proteasome pathway.  Bortezomib assisted proteasome inhibits alters regulatory protein like NF-kB activation which is required for signalling required for cell growth, survival, and metastasis of abnormal cells. Thus, inhibiting the action of proteasome results in the ceasing of the cell cycle that causes the proliferation of abnormal cells and induces apoptosis.


    How Biocure 2mg Injection works

    Bortezomib is an antineoplastic agent that inhibits the function of regulatory proteins like NF-kB present in the ubiquitin-proteasome pathway. Thus, the proliferation of abnormal cells is inhibited and apoptosis is induced which results in the slow progression of tumor and controls multiple myeloma and mantle cell lymphoma.


    Biocure 2mg Injection Contraindication

    Absolute contraindication:

    • if you are allergic to Biocure 2mg (Bortezomib 2mg) Injection or its constituents
    • if you are pregnant
    • if you are breastfeeding
    • if you are less than 18 years of age

    Relative contraindication:

    • if you have a lung disorder like acute diffuse infiltrative pulmonary disease
    • if you have heart disease
    • if you have a blood disorder
    • if you had herpes zoster infection
    • if you had hepatitis B or C infection
    • if you have a nervous disorder
    • if you have renal disorders


    Biocure 2mg Injection Side Effects

    Common side effects that occur 1:10 patients: Asthenia, Nausea, Diarrhea, Anorexia, Constipation, Thrombocytopenia, Peripheral neuropathy, Pyrexia, Vomiting, Anemia, Arthralgia, Headache, Insomnia, Limb pain, Dizziness, Dyspnea, Edema, Neutropenia, Paresthesia, Rash, Cough, Dehydration, URI, Rigors

    Uncommon side effects that occur 1:100 patients: Atrioventricular block complete, cardiac tamponade, Ischemic colitis, hepatitis, acute pancreatitis, Encephalopathy, dysautonomia, progressive multifocal leukoencephalopathy, acute diffuse infiltrative pulmonary disease, PRES, herpes meningoencephalitis, DIC, Acute diffuse infiltrative pulmonary disease, epidermal necrolysis, Sweet’s syndrome, Optic neuropathy, deafness bilateral, blindness, and ophthalmic herpes


    FAQs for Biocure 2mg Injection

    Is Biocure 2mg (Bortezomib 2mg) Injection safe during pregnancy?

    No, taking Biocure 2mg Injection during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    Can Biocure 2mg Injection be taken while breastfeeding?

    No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Biocure 2mg Injection can also pass via breastfeeding.

    Can Biocure 2mg Injection be taken while alcohol consumption?

    Biocure 2mg Injection is unknown but this medication causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Biocure 2mg Injection?

    Biocure 2mg Injection causes side effects thus caution is used while driving or operating machineries.

    Does Biocure 2mg Injection cause fertility problems?

    Yes, Biocure 2mg Injection decreases male and female fertility, consult your physician.


    Precautions and general warning of Biocure 2mg Injection

    Alcohol

    Intake of alcohol with Biocure 2mg Injection causes side effects thus caution is required. Consult your physician.

    Driving or operating machinery

    Driving or operating heavy machinery with Biocure 2mg Injection causes side effects thus caution is required. Consult your physician

    Pregnancy

    Using Bortezomib during pregnancy may cause embryo-fetal toxicity. Consult your physician.

    Breast Feeding

    Using Bortezomib during Breastfeeding may cause side effects similar to adults. Consult your physician.

    Kidney Problem

    Using Bortezomib may lead to mild proteinuria. Consult your physician.

    Liver Disease

    Using Bortezomib may cause hepatitis/jaundice. Consult your physician.


    How to Take Biocure 2mg Injection

    This injection is used only in the presence of a physician.

    This injection can be given intravenously or as a subcutaneous injection into the thigh or abdomen

    This injection should not be given intrathecally.

    This injection must be taken on schedule as prescribed by your physician.

    After therapy has been initiated, do not take more or less of Biocure drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing Biocure dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Biocure 2mg Injection in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.


    Use of Biocure 2mg Injection in children

    This injection is not recommended in children.


    Use of Biocure 2mg Injection in Elderly Patients

    This injection has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Peripheral neuropathy
    • Heart event – hypotension, congestive heart failure, prolonged QT syndrome
    • Pulmonary toxicity – ARDS, acute diffuse infiltrative pulmonary disease
    • Reversible posterior leukoencephalopathy syndrome
    • Gastrointestinal toxicity – perforation
    • Co-infection – neutropenia/ thrombocytopenia
    • Tumor lysis syndrome
    • Hepatotoxicity – hepatitis/jaundice
    • Renal toxicity – mild proteinuria
    • Pregnancy – causes embryo-fetal toxicity
    • Breastfeeding – causes side effects similar to adults
    • Alcohol intake or Driving or operating heavy machinery – Biocure 2mg Injection causes side effects thus caution is required. consult your physician


    Talk to your doctor if

    • If you have any allergy
    • If you have a liver problem
    • If you have a kidney problem
    • If you are pregnant or breastfeeding


    General instructions

    Biocure 2mg Injection is can be given intravenously with 0.9% NaCl. Do not shake the vial before use. Add 3.5ml for 1mg/ml concentration and give them as IV infusion. Add 1.4ml for 2mg/ml concentration and give them as SC injection. Store the vials at room temperature.


    Drug Interaction of Biocure 2mg Injection

    Drug-Drug Interaction

    Serum concentration is increased by Arsenic trioxide, Erythromycin

    Serum concentration is decreased by Dexamethasone, Levothyroxine, Mifepristone, St. John's Wort

    Severity of adverse effects is increased by Allopurinol, Fludrocortisone, Interferon alfa, Methotrexate

    Drug-Food Interaction

    Avoid taking grapes, grape juice and flavonoids like green vegetables, fruits, and green tea while taking this injection. Also, avoid vitamin C. This injection can be taken with any type of food, if doubts arise kindly refer to your physician. It generally causes side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use


    Over Dose

    In the case of Overdosage with this injection. Contact your physician.


    Missed Dose

    Consult your physician immediately.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at room temperature


    Fast Tag

    Biocure 2mg Injection is an antineoplastic medication

    Bortezomib is a proteasome inhibitor

    This injection is used to control and treat multiple myeloma and mantle cell lymphoma.

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease or renal diseases or cardiac disorders.