Bleomycin Sulphate 15IU Injection

Brand Name Bleomycin Sulphate 15IU Injection
Salt Composition

Bleomycin (15IU)

Strength 15IU
Product Form Injection
Pack 1 x 1ml in 1 vial
Storage Store in a refrigerator (2 - 8°C). Do not freeze
Category

Anti-Cancer

SubCategory

Ovarian Cancer

Country of Origin India
Manufacturer

Dabur India Ltd

Manufacturer/Marketer Address Dabur India Ltd, No. 115/18, Y Block, Main Rd, Anna Nagar, Chennai, Tamil Nadu 600040
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M.R.P : Rs.654.76    

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1 x 1ml in 1 vial

Availability : In Stock

  Online Payment Only

  Non Returnable Read More



    Medical Description of Bleomycin Sulphate 15IU Injection

    Bleomycin Sulphate 15IU Injection contains Bleomycin 15IU used to treat squamous cell carcinoma of head and neck, cervix and external genitalia, Hodgkin and non-Hodgkin lymphoma, testicular carcinoma, pleural sclerosing. It works by inhibiting the growth and multiplication of abnormal cells. It is used as a palliative treatment in the case of malignant neoplasm of the trachea, bronchi, and lungs. It is used as an orphan drug in the case of pancreatic cancer.


    Bleomycin Sulphate 15IU Injection Uses

    It is used in the treatment of the following conditions squamous cell carcinoma, Hodgkin diseases, non-Hodgkin lymphoma, testicular carcinoma and pleural sclerosing.


    Bleomycin Sulphate 15IU Injection Benefits

    Squamous cell carcinoma

    It is a skin cancer that usually develops in the squamous cells. It occurs when the flat, thin squamous cells in your skin develop changes in their DNA. Symptoms include rough, scaly patchy inside your mouth, scaly crust, red nodule, new sore.

    Carcinoma of head and neck

    It is also called throat cancer. Alcohol and Smoking are considered major risk factors for head and neck cancer. Symptoms include swelling in the jaw, lump, trouble in speaking and breathing, pain in ears, headache, nose bleeding, and pain in the upper teeth. This medicine helps to inhibit the multiplication of cancer cells.

    Testicular cancer

    It is also called a malignant neoplasm of the testis. Cancer usually occurs in the testicles when compared with another type of cancer it is rare. Symptoms include testicle enlargement, abdomen and groin pain, enlargement of breast and back pain

    Hodgkin’s lymphoma

    It is also known as Hodgkin’s disease, cancer in part of your immune system called the lymphatic system. It occurs when there is a change in the DNA of white blood cells called B lymphocytes. Symptoms include fever, night sweats, weight loss, severe itching, increased sensitivity and swelling of lymph nodes.

     Non-Hodgkins leukemia

    It is also known as Non-Hodgkin’s disease, cancer in part of your immune system called the lymphatic system. It occurs when there is a change in the DNA of white blood cells called B lymphocytes. Symptoms include fever, night sweats, weight loss, severe itching, increased sensitivity and swelling of lymph nodes.

    Pleural sclerosing

    It is a build of excess amount of fluid between the layers of the pleura. It usually occurs when you have heart failure, pulmonary embolism, cirrhosis, tuberculosis, pneumonia, cancer, kidney and inflammatory disease. Symptoms include chest pain, dry cough, dyspnea, orthopnea.


    Bleomycin Sulphate 15IU Injection Indication

    The Bleomycin Sulphate 15IU Injection is prescribed in the following indications as

    1. Squamous cell carcinoma
      • Head and neck
      • Cervix
      • External genitalia
    2. Lymph node lymphoma
      • Hodgkin’s lymphoma
      • Non-Hodgkin’s lymphoma
    3. Testicular cancer
      • Embryonal cell carcinoma
      • Choriocarcinoma
      • Teratocarcinoma
    4. Pulmonary association
      • Pleural sclerosing
      • Pleural effusion
    5. It is used as an orphan drug in the case of intracranial germ cell tumor, penile cancer, ovarian cancer, vulvar carcinoma and kaposi sarcoma.


    Mechanism of action of Bleomycin Sulphate 15IU Injection

    Bleomycin Sulphate 15IU Injection contains Bleomycin 15IU is an anti-cancer medication and antibiotics. It produces its action by inhibiting DNA and RNA replication by arresting the G2 and M phase of the cell cycle. Bleomycin may also cause breaks in double bonds in DNA strands. Thus, causes the formation of an impaired DNA sequence containing abnormal cells where apoptosis occurs and results in cell death.


    How Bleomycin Sulphate 15IU Injection works

    Bleomycin Sulphate 15IU Injection contains Bleomycin 15IU is an anti-cancer medication and antibiotics. It produces its action by inhibiting the function of the cell cycle by arresting them at the G2 and M phase of DNA and RNA replication. It causes impairment in DNA breaking resulting in impaired cells thus inducing apoptosis of these abnormal cancer cells.


    Bleomycin Sulphate 15IU Injection Contraindication

    • Do not take this medicine if you are allergic to Bleomycin.
    • It is contraindicated to use this medicine along with brentuximab because of pulmonary toxicity.


    Bleomycin Sulphate 15IU Injection Side Effects

    • Weight loss
    • Hair loss
    • Confusion
    • Urticaria
    • Hyperpigmentation
    • Pulmonary fibrosis
    • Interstitial pneumonitis
    • Nausea
    • Myocardial infarction


    FAQs for Bleomycin Sulphate 15IU Injection

    • Is Bleomycin Sulphate 15IU Injection safe?

    Yes, the use of this medicine is considered safe if you have taken the medicine as per the dose and duration advised by the doctor.

    • Does Bleomycin Sulphate 15IU Injection cause hair loss?

    Yes, one of the common side effects of this medicine is hair loss. This will get treated once you stop the treatment.

    • How does Bleomycin Sulphate 15IU Injection cause pulmonary fibrosis?

    Yes, the use of this medicine may cause pulmonary fibrosis. It is caused by a lack of an enzyme that metabolizes the medicine in the lungs.


    Precautions and general warning of Bleomycin Sulphate 15IU Injection

    Alcohol

    It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor.

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor.

    Kidney Problem

    Therapy should be administered with caution in patients who are having a renal impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.

    Liver Disease

    It is considered safe to use this medicine in patients who are with liver impairment. Kindly consult with your doctor.


    How to Take Bleomycin Sulphate 15IU Injection

    Bleomycin Sulphate 15IU Injection comes in a powder for injection form. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.


    Use of Bleomycin Sulphate 15IU Injection in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Bleomycin Sulphate 15IU Injection in children

    It is not recommended in children. Kindly consult with your doctor.


    Use of Bleomycin Sulphate 15IU Injection in Elderly Patients

    Bleomycin Sulphate 15IU Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • The use of this medicine may cause severe idiosyncratic reactions including hypotension, confusion, fever, chills and wheezing.
    • Therapy should be administered with caution in patients with renal impairment
    • Hepatic toxicity was reported while you are receiving this medicine.
    • The use of this medicine increases the risk of developing pulmonary toxicity and fibrosis.
    • Kindly avoid this medicine if you are pregnant because it may cause fetal harm.


    Talk to your doctor if

    • You are not responding to the treatment.
    • You have experienced any allergic reaction like rashes and itching.
    • You have a receiving any concomitant medication and disease.
    • You develop shortness of breath.


    General instructions

    Bleomycin 15IU is used to treat squamous cell carcinoma of the head and neck, cervix and external genitalia, Hodgkin and non-Hodgkin lymphoma, testicular carcinoma, pleural sclerosing. It produces its action by inhibiting the function of the cell cycle by arresting them at the G2 and M phase of DNA and RNA replication. It causes impairment in DNA breaking resulting in impaired cells thus inducing apoptosis of these abnormal cancer cells.


    Drug Interaction of Bleomycin Sulphate 15IU Injection

    Drug-Drug Interaction

    Palifermin

    Use alternative drugs because the use of palifermin increases the toxicity of the bleomycin by increasing the severity and duration of oral mucositis.

    Cholera vaccine

    Therapy should be administered with caution because the use of bleomycin decreases the effect of cholera vaccine by immunosuppressive effect and it also increases the risk for infection.

    Ethotoin

    Therapy should be administered with caution because the use of bleomycin decreases the effects of ethotoin by increasing its metabolism.

    Tenofovir DF

    Therapy should be administered with caution because the use of bleomycin increases the effect of tenofovir DF by decreasing its renal clearance.

    Olaparib

    Therapy should be administered with caution because the combination of this medicine increases the pharmacodynamic synergism.

    Drug-Food Interaction

    No data available kindly consult with your doctor.

    Drug-Disease Interaction

    Pulmonary infiltrates

    Therapy should be administered with caution in patients who are with pulmonary impairment because 10% of patients develop pulmonary pneumonitis and 1% of patients develop pulmonary fibrosis and death during this treatment. Kindly inform your doctor if you have experience dyspnea, cough, congestion.

    Renal dysfunction

    Therapy should be administered with caution in patients with renal impairment because the patients who are with moderate renal function reduce the elimination of the drug by 20%.


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 2-8°C in the refrigerator.
    • Do not freeze.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Bleomycin 15IU is an anti-cancer medication, an antibiotics.
    • It is used to treat squamous cell carcinoma, Hodgkin diseases, non-Hodgkin lymphoma, testicular carcinoma, and pleural sclerosing.   
    • Do not withdraw the medicine without consulting with a doctor.
    • Kindly avoid pregnancy while you are receiving this medicine.
    • Kindly monitor the patient blood cell, liver function, and kidney function while you are receiving this medicine.
    • Inform your doctor if you have developed a cough, shortness of breath, and craking sound while you are breathing.