Bosutris 400mg Tablet

Brand Name Bosutris 400mg Tablet
Salt Composition Bosutinib (400mg)
Strength 400mg
Product Form Tablet
Pack 30 Tablet(s) in Bottle
Storage Store at room temperature (10-30°C)
Category Anti Cancer
Country of Origin India
Manufacturer Mylan Pharmaceuticals Private Limited
Manufacturer/Marketer AddressMylan Pharmaceuticals Private Limited , Commercial Operations , Prestige Tech Park,Platina-3, 7th to 12th floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103
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M.R.P : Rs.8900.00       Price : Rs.6942.00

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Availability : In Stock


    Medical Description of Bosutris 400mg Tablet

    Bosutris 400mg Tablet contains Bosutinib 400mg it’s a tyrosine kinase inhibitor. It inhibits metastasis, angiogenesis and oncogenesis of abnormal cancer cells. Bosutris 400mg Tablet is used in the treatment of renal cancer. This medication is recommended only for adults.


    Bosutris 400mg Tablet Uses

    Bosutris 400mg Tablet is used in the treatment of chronic myelogenous leukemia. This tablet is not used in children less than 18yrs of age.


    Bosutris 400mg Tablet Benefits

    Bosutris 400mg Tablet is used in the treatment of chronic myelogenous leukemia. This tablet is recommended only in adults above the age 18.


    Bosutris 400mg Tablet Indication

    Bosutris 400mg Tablet is a tyrosine kinase inhibitor. It is an antineoplastic and antiangiogenic medication. This tablet inhibits the multiplication or proliferation of abnormal cells by inhibiting endothelial growth factors. It must be used only in adults. This medication is recommended in the treatment of chronic myelogenous leukemia with Philadelphia chromosome +ve at chronic phase or blast phase.


    Mechanism of action of Bosutris 400mg Tablet

    Bosutinib is an antineoplastic and an antiangiogenic agent. It is a tyrosine kinase inhibitor. It targets several tyrosine kinase proteins of the Bcr-Abl and SRc family which is required for angiogenesis and increases apoptosis function. It inhibits signals of angiogenesis and decreases the size of tumor by starvation and increases apoptosis function.


    How Bosutris 400mg Tablet works

    Bosutinib inhibits tyrosine kinase protein required for angiogenesis and proliferation of abnormal cells. This results in the shrinking of tumor cells and cell death thus controls and treats various cancers.


    Bosutris 400mg Tablet Contraindication

    • if you are allergic to Bosutris 400mg (Bosutinib 400mg) Tablet or its constituents
    • if you have a blood disorder
    • if you have a kidney disorder
    • if you have a liver disorder
    • if you are pregnant
    • if you are breastfeeding


    Bosutris 400mg Tablet Side Effects

    Common side effects that occur 1:10 patients: decrease in platelet/neutrophils/hemoglobin levels, abnormal liver enzymes, Diarrhea, Nausea, Abdominal pain, Rash, Vomiting, Fatigue, Pyrexia, Cough, Headache, edema, Neutropenia, Arthralgia

    Uncommon side effects that occur 1:100 patients: Febrile neutropenia, Pericardial effusion, Tinnitus, Gastritis, Chest pain, Pain, Hepatotoxicity, Abnormal hepatic function, Drug hypersensitivity, Pneumoniae, influenza, bronchitis, pleural effusion, QT prolonged, Increased blood CPK/creatinine, renal failure, Hyperkalemia, Dehydration

    Rare side effects that occur 1:1,000 patients: increased lipase, Pericarditis, Acute pancreatitis, GI hemorrhage, Liver injury, Anaphylactic shock, Acute pulmonary edema, Respiratory failure, Pulmonary hypertension, Erythema multiforme, Exfoliative rash, Drug eruption, Hypertension, Steven's Johnson Syndrome, Thrombotic microangiopathy, Cardiac failure, endocrine disorder


    FAQs for Bosutris 400mg Tablet

    Is Bosutris 400mg (Bosutinib 400mg) Tablet safe during pregnancy?

    No, taking Bosutris 400mg Tablet during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    Can Bosutris 400mg Tablet be taken while breastfeeding?

    No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Bosutris 400mg Tablet can also pass via breastfeeding.

    Can Bosutris 400mg Tablet be taken while alcohol consumption?

    The interaction is unknown but Bosutris 400mg Tablet causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Bosutris 400mg Tablet?

    Bosutris 400mg Tablet causes side effects thus caution is used while driving or operating machineries.


    Precautions and general warning of Bosutris 400mg Tablet

    Alcohol

    Intake of alcohol with Bosutris 400mg Tablet causes side effects thus caution is required. Consult your physician.

    Driving or operating machinery

    Driving or operating heavy machinery with Bosutris 400mg Tablet causes side effects thus caution is required. Consult your physician.

    Pregnancy

    Using Bosutinib during pregnancy may cause embryo-fetal toxicity. Consult your physician

    Breast Feeding

    Using Bosutinib during Breastfeeding may cause side effects similar to adults. Consult your physician

    Kidney Problem

    Using Bosutinib may lead to proteinuria. During this therapy monitor kidney function before and during treatment. Consult your physician.

    Liver Disease

    During Bosutinib therapy monitor liver function before and during treatment. Consult your physician.


    How to Take Bosutris 400mg Tablet

    This tablet is taken orally. It must be taken at the same time once a day as prescribed by your physician. It should be taken with food don’t drink grape juice or eat grapes. It must be swallowed as a whole.

    Don’t chew or crush this tablet.

    After therapy has been initiated, do not take more or less of this drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing your dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Bosutris 400mg Tablet in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.


    Use of Bosutris 400mg Tablet in children

    This tablet is not recommended in children.


    Use of Bosutris 400mg Tablet in Elderly Patients

    This tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Gastrointestinal toxicity – perforation
    • Myelosuppression
    • Hepatotoxicity– monitor function before and during treatment
    • Fluid retention - pericardial effusion, pleural effusion, pulmonary edema, and/or peripheral edema
    • Cardiotoxicity - Cardiac failure and left ventricular dysfunction
    • Renal toxicity – proteinuria. Monitor function before and during treatment.
    • Pregnancy – causes embryo-fetal toxicity
    • Breastfeeding – causes side effects similar to adults
    • Alcohol intake or Driving or operating heavy machinery – Bosutris 400mg Tablet causes side effects thus caution is required. consult your physician


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have a renal problem

    If you are pregnant or breastfeeding


    General instructions

    Bosutris 400mg Tablet is taken orally as prescribed dosage at a specific time regularly with food to avoid adverse effects. Do not take grape juice or eat grapes with this medication. Do not take medications that alter the PH of the stomach like PPI, H2 blockers and if you are taking them, it is best to take them either 1 hr before or 2 hrs after intake of food.


    Drug Interaction of Bosutris 400mg Tablet

    Drug-Drug Interaction

    Metabolism is increased by Calcitriol, St. John's Wort and Vit E

    Serum level is increased by Folic acid

    Metabolism is decreased by Ginkgo biloba, Niacin

    Drug-Food Interaction

    Do not take grapes and grape juice while taking this medication. To avoid diarrhea, take small sips of sugar-free drinks or take small amounts of meals or take spicy food with this medication. It should be taken either with food, if doubts arise kindly refer to your physician. It generally causes side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution while taking this medication.

    Drug-Disease Interaction

    • Lung disorders – used with caution in interstitial lung disease. Consult a physician before use
    • Electrolyte disorders – used with caution in electrolyte imbalance. Consult a physician before use
    • Bone disorders – used with caution in hypocalcemia and hypopotassemia. Consult a physician before use
    • Cardiac disorders – used with caution in hypotension or hypertension and heart failure. Consult a physician before use
    • Hematological disorders – used with caution in bleeding disorders like thrombosis. Consult a physician before use
    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory depression. Consult a physician before use


    Over Dose

    Overdosage of this tablet has less literature thus Contact your physician.


    Missed Dose

    You can take the missed dosage if you notice within 12 hours. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30°C


    Fast Tag

    Bosutris 400mg Tablet is an antiangiogenic antineoplastic

    Bosutinib is a tyrosine kinase inhibitor

    This tablet is used to control and treat CML

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease or kidney disease.