Cabotib 20 Tablet

Brand Name Cabotib 20 Tablet
Salt Composition

Cabozantinib (20mg)

Strength 20mg
Product Form Tablet
Pack 30 Tablet(s) in Bottle
Category

Anti-Cancer

SubCategory

Thyroid Cancer

Country of Origin India
Manufacturer

Glenmark Pharmaceuticals Ltd

Manufacturer/Marketer Address Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
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Cabotib 20 Tablet, Cabozantinib 20 Tablet, Price, Uses, Side Effects – Drugcarts watermark
M.R.P : Rs.4900.00       Price : Rs.3920.00

You Save : Rs.980.00    Inclusive of all taxes

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30 Tablet(s) in Bottle

Availability : In Stock

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    Medical Description of Cabotib 20 Tablet

    Cabotib 20 Tablet contains Carbozantinib 20 used to treat renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid cancer by killing the cancer cells. It is not recommended for children.


    Cabotib 20 Tablet Uses

    It is used in the treatment of the following conditions as Medullary thyroid cancer, Renal cell carcinoma, and Hepatocellular carcinoma


    Cabotib 20 Tablet Benefits

    Renal cell carcinoma

    It is a common type of kidney cancer found in adults. It is caused by obesity, smoking cigarettes, polycystic kidney disease, and some genetic condition. Symptoms include blood in urine, loss of appetite, weight loss, tiredness, and fever.

    Hepatocellular carcinoma

    It is also called malignant hepatoma, it is a common type of liver cancer. It usually occurs in people who are having a chronic liver disease such as cirrhosis, hepatitis B or C. Symptoms include weight loss, inflamed liver, loss of appetite, stomach pain, and jaundice

    Thyroid cancer

    Abnormal cell growth in the thyroid gland leads to the formation of tumor and cause cancer. Symptoms include a lump on your neck, change in your voice, pain in your neck and throat, inflamed lymph nodes in your neck, and difficulty in swallowing.


    Cabotib 20 Tablet Indication

    The Cabotib 20 Tablet is prescribed in the following indications as

    • Metastatic medullary thyroid cancer
    • Advanced renal cell carcinoma
    • Hepatocellular carcinoma


    Mechanism of action of Cabotib 20 Tablet

    Cabotib 20 Tablet contains Cabozantinib 20 is an anti-cancer medicationTyrosine kinase inhibitor. It produces its action by targeting several tyrosine kinase proteins which are present on surface receptors and intracellular structures of VEGF receptors, cytokine receptors called kit, RET, MET, and TIE2, etc. In general, these receptors signal angiogenesis and decrease apoptosis function. Cabozantinib inhibits signals of angiogenesis and decreases the size of the tumor by starvation and increases apoptosis function.

     


    How Cabotib 20 Tablet works

    Cabotib 20 Tablet contains Cabozantinib 20 is an anti-cancer medicationTyrosine kinase inhibitor. It produces its action by inhibiting tyrosine kinase protein present in epithelial growth factor receptors which are present in the intracellular and extracellular surface. Thus, the signaling process for angiogenesis and proliferation of abnormal cells is inhibited. This results in the shrinking of tumor cells and cell death thus controlling and treating various cancers.


    Cabotib 20 Tablet Contraindication

    • Do not take this medicine if you are allergic to Cabozantinib
    • It is contraindicated to use this medicine in a patient who is having an active infection


    Cabotib 20 Tablet Side Effects

    • Diarrhea
    • Loss of appetite
    • Weight loss
    • Infection
    • Edema
    • Fever
    • Constipation
    • Weakness
    • Hypertension
    • Skin discolouration
    • Dry skin


    FAQs for Cabotib 20 Tablet

    • Does Cabotib 20 Tablet cause hair loss?

    Yes, one of the common side effects of this medicine is hair loss. Kindly consult with your doctor if your symptoms even persist after withdrawal of the medicines.

    • Can I stop using Cabotib 20 Tablet immediately or do I have to slowly wean off the use?

    You should not withdraw the medicine immediately, you should taper the dose to avoid rebound effects.

    • What blood tests are required before administration of Cabotib 20 Tablet?

    Before initiating the treatment with this medicine you may be asked to have blood tests, liver function tests.


    Precautions and general warning of Cabotib 20 Tablet

    Alcohol

    No data available kindly consult with your doctor

    Driving or operating machinery

    No data available kindly consult with your doctor

    Pregnancy

    No data available kindly consult with your doctor

    Breast Feeding

    No data available kindly consult with your doctor

    Kidney Problem

    No data available kindly consult with your doctor

    Liver Disease

    No data available kindly consult with your doctor


    How to Take Cabotib 20 Tablet

    Cabotib 20 Tablet is taken orally with or without food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.


    Use of Cabotib 20 Tablet in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Cabotib 20 Tablet in children

    It is considered unsafe to use this medicine in children who are below 18 years old. Kindly consult with your doctor.


    Use of Cabotib 20 Tablet in Elderly Patients

    Cabotib 20 Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • The use of this medicine may cause GI perforation, fistulas, serious hemorrhage, and thromboembolic events
    • If you are planning for surgery kindly discontinue the medicine 28 days prior because the use of cabozantinib may impair the wound healing process
    • Proteinuria may occur while you are receiving this medicine
    • Use of this medicine along with nivolumab may cause primary or secondary adrenal insufficiency
    • Kindly avoid this medicine if you are pregnant because it may cause fetal harm
    • The use of this medicine may cause reversible posterior leukoencephalopathy syndrome
    • Therapy should be administered with caution in patients who are having a history of liver impairment and diarrhea.


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease
    • You develop shortness of breath


    General instructions

    Cabozantinib 20 is used to treat renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid Cancer. It produces its action by inhibiting tyrosine kinase protein present in epithelial growth factor receptors which are present in the intracellular and extracellular surface. Thus, the signaling process for angiogenesis and proliferation of abnormal cells is inhibited. This results in the shrinking of tumor cells and cell death thus controlling and treating various cancers.


    Drug Interaction of Cabotib 20 Tablet

    Drug-Drug Interaction

    Armodafinil

    Use alternative drugs because the use of armodafinil will decrease the effect of cabozantinib by affecting its hepatic and intestinal enzyme metabolism.

    Dichlorphenamide

    Therapy should be administered with caution because the combination of this medicine decreases the level of serum potassium

    Palifermin

    Use alternative drugs because the use of palifermin increases the toxicity of the other by increasing the severity and duration of oral mucositis

    Drug-Food Interaction

    Food may interfere with this medicine so it is better to take this medicine on an empty stomach, one hour before or 2 hours after your meal. Do not consume grapefruit unless it is advised by the doctor because it may increase the blood levels of cabozantinib.

    Drug-Disease Interaction

    Hemorrhagic events

    Therapy should be administered with caution in patients with severe hemorrhage because the use of this medicine itself may cause fatal hemorrhagic events.

    GI perforation

    Therapy should be administered with caution in patients who are having a history of diverticulitis. Kindly discontinue the treatment if you have experienced fistula

    Hepatic impairment

    Kindly adjust the dose in patients who are with mild to moderate hepatic impairment because increased exposure is observed in patients with mild to moderate liver dysfunction

    Reversible posterior leukoencephalopathy syndrome

    Therapy should be administered with caution because the use of cabozantinib causes reversible posterior leukoencephalopathy syndrome. Closely monitor the patients

    Thromboembolism

    Therapy should be administered with caution in patients with thromboembolism because arterial and venous thromboembolic events have been reported while you are using cabozantinib


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 30°C at room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Cabozantinib is an anti-cancer medication, a Tyrosine kinase inhibitor
    • It is used to treat renal cell carcinoma (kidney cancer), Hepatocellular carcinoma (hepatic cancer), and Thyroid cancer
    • It may cause a serious bleeding problem
    • The use of this  medicine may cause diarrhea so to avoid this drink plenty of fluids