Cefine Plus Tablet

Brand Name Cefine Plus Tablet
Salt Composition Cefixime (200mg) + Ofloxacin (200mg)
Strength 200mg + 200mg
Product Form Tablet
Pack 10 Tablet(s) in Strip
Storage Store at room temperature (10-30°C)
Category Antibiotic
Country of Origin India
Manufacturer Finecure Pharmaceuticals
Manufacturer/Marketer AddressFinecure Pharmaceuticals,612-615 , Anand Mangal III, Near Parimal Crossing, Ambawadi - Ahmedabad-380006, Gujarat, 380006 India
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Availability : In Stock

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    Medical Description of Cefine Plus Tablet

    Cefine Plus Tablet contains Cefixime 200mg and Ofloxacin 200mg used to treat conditions like Bacterial infections, Urinary Tract Infection, Pneumonia, Ear infection, Tonsillitis/Pharyngitis, typhoid fever, and Skin and structure infection. Cefixime 200mg is an antibiotic used to treat infections and it mainly targets the ear, eyes, nose, throat, lungs, skin, gastrointestinal tract, and urinary tract bacterial infection. Ofloxacin 200mg is a fluoroquinolone antibiotic used to treat bacterial infection by preventing the bacteria from reproduction and repairing themselves. The combination of this medicine helps to fight against microbes and also prevents the growth of bacteria. This medicine is not used for common flu and cold symptoms that occur due to viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial infections. Swallow the whole tablet at once. Don’t break, chew, or crush the tablet


    Cefine Plus Tablet Uses

    It is used in the treatment of the following conditions as Bacterial infections, Urinary Tract Infection, Pneumonia, Ear infection, Tonsillitis/Pharyngitis, and Skin and structure infection


    Cefine Plus Tablet Benefits

    Bacterial infections

    Bacterial infection occurs when bacteria enter your body and start multiplying which may cause tissue damage and make you sick. Mostly it is caused by Staphylococcus and Streptococcus organisms. The bacterial diseases are cholera, bacterial meningitis, tetanus, gonorrhea, pneumonia, and syphilis. Symptoms include fever, chills, and sweats, inflamed lymph nodes, headache, diarrhea, abdominal pain

    Urinary tract infection

    It is a type of infection that affects the urethra, kidneys, and bladder. It is caused by Escherichia coli (E.coli). Symptoms include abdominal pain, frequent urination, dysuria, blood in urine, foul-smell while urinating

    Acute bronchitis

    It is a viral infection that causes inflammation in the bronchial tubes. It is mostly caused by rhinovirus, adenovirus, influenza A and B, and parainfluenza virus. Symptoms include cough, fatigue, breathing difficulty, fever and chills, and chest discomfort.

    Lower respiratory tract infections

    Infection in the lungs especially in the lower airways Common infections are Bronchiolitis and Pneumonia which are caused by Streptococcus pneumonia. Symptoms include runny nose, dry cough, sore throat, low-grade fever, and headache.

    Skin infection

    It is usually caused by bacteria, fungi, viruses, and parasites. Common skin infection includes cellulitis, impetigo. Symptoms include red skin, blisters, swelling, pain, red spots, and tenderness

    Tonsillitis/Pharyngitis

    Infection of the swelling and soreness in the throat and tonsils is called pharyngitis and tonsillitis. The infection that affects both throat and tonsil is called pharyngotonsillitis. It is caused by bacteria.

    Otitis media

    It is also called as ear infections. While comparing with adults children are more prone to this infection. It is caused by Streptococcus pneumonia. Symptoms include ear pain, difficulty in sleeping, loss of balance, headache, loss of appetite and drainage of fluid from the ear.

    Pneumonia

    It is a lung infection that causes inflammation in the alveoli. It is usually caused by Streptococcus pneumonia. Symptoms include chest pain, fatigue, fever, sweating, nausea, vomiting, diarrhea, breathing difficulty, cough, and confusion

    Typhoid fever

    It is also called as enteric fever. Typhoid fever is a bacterial infection caused by Salmonella typhi bacteria. This infection spreads through contaminated food and water. Symptoms include fever, headache, muscle aches, sweating, dry cough, loss of appetite, diarrhea, rash, weight loss and fatigue.


    Cefine Plus Tablet Indication

    Cefine Plus Tablet is prescribed in the following indications as Bacterial infections, Urinary Tract Infection, Pneumonia, Ear infection, Tonsillitis/Pharyngitis, typhoid fever, and Skin and structure infection.


    Mechanism of action of Cefine Plus Tablet

    Cefine Plus Tablet contains Cefixime 200mg and Ofloxacin 200mg it is a combination of two medicines. Cefixime 200mg is a third-generation cephalosporin antibiotic that produces its action by preventing bacterial cell wall synthesis which is essential for the growth of bacteria and it also prevents the spreading of infections. Ofloxacin 200mg is a fluoroquinolone antibiotic that produces its action by preventing the multiplication of bacteria and helps to repair themselves


    How Cefine Plus Tablet works

    Cefine Plus Tablet contains Cefixime 200mg and Ofloxacin 200mg it is a combination of two medicines. Cefixime 200mg is a third-generation cephalosporin antibiotic that produces its action by preventing bacterial cell wall synthesis which is essential for the growth of bacteria and it also prevents the spreading of infections. Ofloxacin 200mg is a fluoroquinolone antibiotic that produces its action by preventing the multiplication of bacteria and helps to repair themselves


    Cefine Plus Tablet Contraindication

    • Do not take this medicine if you are allergic to Cefixime and Ofloxacin
    • Kindly avoid using this medicine while you are receiving Lidocaine and calcium-containing products
    • Kindly avoid this medicine if you are having hepatic and renal impairment, Seizures
    • The use of this medicine may increase the risk of developing tendinitis and tendon rupture in all ages
    • It is contraindicated to use this medicine in patients who are having prolonged QT intervals and family history of red blood cell disorder
    • It should be the first drug of choice for children because of its higher risk of adverse events


    Cefine Plus Tablet Side Effects

    • Diarrhea
    • Stomach pain
    • Dark or clay-colored stools
    • Dizziness
    • Heartburn
    • Indigestion
    • Joint pain
    • Confusion
    • Fever
    • Difficulty or painful urination
    • Abdominal pain
    • Swelling
    • Change in taste
    • Flatulence
    • Anxiety
    • Loss of appetite
    • Photosensitivity


    FAQs for Cefine Plus Tablet

    • What is the treatment option if Urinary tract infection and how to prevent it?

    Take your medicines as per the dose and duration prescribed by your doctor and this will help you to get a cure for your infection. Change your hygiene habits water your private parts before and after urinating. Drink plenty of water this will help you to remove the bacteria from your body.

    • What is the time duration for Cefine Plus Tablet to react on the body?

    It starts its action starts within 1 to 3 hours after administration. But continue to complete the course of taking this medicine even you feel better also.

    • Can we take the full course of this medicine, if you feel better?

    Yes. Finish the complete course of antibiotics even if you feel better. Otherwise, it will lead to Antibiotic resistance (the bacteria may be resistant to antibiotics). After taking of complete course not feel better, ask your doctor and then make a better life.


    Precautions and general warning of Cefine Plus Tablet

    Alcohol

    Consuming alcohol is considered unsafe while you are receiving this treatment. Kindly consult with your doctor.

    Driving or operating machinery

    No, the Cefine Plus Tablet is not safe to drive after administration. This combination tablet causes disturbance in alertness, may lead to dizziness, sleepiness, and alters the ability to drive. Kindly consult with your doctor before taking any medication.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may excrete via breastmilk. Kindly consult with your doctor

    Kidney Problem

    Cefine Plus Tablet should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

    Liver Disease

    Cefine Plus Tablet should be used with caution in patients with severe liver impairment. The use of this medicine required dose modification. Kindly consult with your doctor.


    How to Take Cefine Plus Tablet

    Cefine Plus Tablet is taken orally with or without food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.


    Use of Cefine Plus Tablet in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Cefine Plus Tablet in children

    Cefine Plus Tablet is not prescribed in children who are below 18 years old. Kindly consult with your doctor.


    Use of Cefine Plus Tablet in Elderly Patients

    Cefine Plus Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • Therapy should be administered with caution if you have a history of penicillin allergy and gastrointestinal disease
    • Long-term use may cause bacterial or fungal overgrowth
    • The use of this medicine may cause Immune-mediated hemolytic anemia, kindly discontinue the treatment if you have anemia
    • The use of this medicine may cause a renal failure like tubulointerstitial nephritis
    • It produces limited effect against anaerobes
    • Higher risk for developing superinfection
    • Kindly avoid excessive exposure to the sun because it has a photosensitivity effect


    Talk to your doctor if

    • You have a history of gastrointestinal disease
    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You are suffering from anemia
    • You have watery diarrhea, stomach pain, and fever
    • You have experienced suicidal thoughts, irregular heartbeats,  and low potassium levels


    General instructions

    Cefixime 200mg and Ofloxacin 200mg used to treat conditions like Bacterial infections, Urinary Tract Infection, Pneumonia, Ear infection, Tonsillitis/Pharyngitis, typhoid fever, and Skin and structure infection. Cefixime 200mg is an antibiotic used to treat infections and it mainly targets the ear, eyes, nose, throat, lungs, skin, gastrointestinal tract, and urinary tract bacterial infection.  Ofloxacin 200mg is a fluoroquinolone antibiotic used to treat bacterial infection by preventing the bacteria reproduction and repairing themselves


    Drug Interaction of Cefine Plus Tablet

    Drug-Drug Interaction

    BCG vaccine live

    The use of this drug is contraindicated because the use of medicine decreases the effect of the BCG vaccine live by pharmacodynamic antagonism

    Cholera vaccine

    Use alternative drugs, because the use of the cholera vaccine with antibiotics may activate the vaccine strain. So, avoid receiving this combination of medicines before 14 days of vaccination

    Estradiol

    Therapy should be administered with caution because the use of cefixime will decrease the effect of estradiol by altering the intestinal flora and it also lowers the risk of contraceptive failure

    Warfarin

    Therapy should be administered with caution because the combination of this drug may decrease the vitamin K producing intestinal flora and increase the INR level after a few days

    Furosemide

    The use of cefixime increase the toxicity of furosemide by pharmacodynamic synergism and it also increases the risk of developing nephrotoxicity

    Aspirin

    The use of cefixime will increase the effect of aspirin by acidic drug competition for renal tubular clearance.

    Quinidine

    It is an antiarrhythmic drug used in cardiac diseases. This medicine alters the action of quinidine.

    Escitalopram

    It is an antidepressant, selective serotonin reuptake inhibitor used to treat seizures. This medicine alters the action of escitalopram.

    Nifedipine, aspirin and antidiabetic drugs

    This medicine alters the action of Nifedipine, aspirin, and antidiabetic drugs, which leads to worsening the patient's health conditions.

    Drug-Food Interaction

    The food may increase the effect of the drug in your body so it is advised to take this medicine with food to increase the absorption

    Drug-Disease Interaction

    Colitis

    This medicine kills the good helpful bacteria in your stomach or intestine and causes diarrhea. This drug should be used caution in patients with gastrointestinal disease, especially colitis (swelling of the colon inner lining). It leads to worsening the patient’s health condition.

    Kidney disease

    This medicine is filtered by the kidneys and passes through the urine. Then it leads to the risk of kidney damage. It should be used with caution in a patient with kidney disease. Inform your doctor and then take. Based on the patient's condition, dose adjustment is needed.

    Seizures

    Using this medicine is needs caution in patients with seizures or fits. Inform the doctor, then will do dose adjustment if necessary to take this medicine with seizure medications.

    QT Prolongation

    This medicine is used caution in patients with heart diseases or electrolyte disturbances. It causes chest pain or discomfort, heart palpitations, etc. if necessary, then dose adjustment or replacement is needed.

    Central nervous system disorder

    Using this medicine is needs caution in patients with seizures, other central nervous system abnormalities, or fits. It causes hallucinations, anxiety, confusion, and restlessness, etc. Inform the doctor, then will do dose adjustment or replacement is needed.

    Tendinitis and Tendon rupture

    This medicine causes tendinitis and tendon rupture, which mainly affects your shoulder, hands, ankles, or other joint parts of your body. It should be a risk in patients of more than 60 years of age or undergone a transplant of kidney, heart, or lung. If necessary, then needs dose adjustment or replacement.

    Lab interactions

    This medicine gives a false positive test for Coombs test and Urine ketones test.


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 10-30°C room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    Cefine Plus Tablet contains Cefixime 200mg and Ofloxacin 200mg used to treat conditions like Bacterial infections, Urinary Tract Infection, Pneumonia, Ear infection, Tonsillitis/Pharyngitis, typhoid fever, and Skin and structure infection.

    Cefixime 200mg is a third-generation cephalosporin antibiotic used to treat bacterial infections. Mainly bacterial infection targets the ear, eyes, nose, throat, lungs, skin, gastrointestinal tract, and urinary tract. Also used to treat typhoid fever in children and adults.

    Ofloxacin 200mg is a fluoroquinolone antibiotic used to treat bacterial infection by preventing the bacteria from reproduction and repairing themselves. This medicine is not used for common flu and cold symptoms. And not treat viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial infections.

    This medicine is not administered to children under 18 years of age. Consult your doctor and then consume.

    This medicine is contraindicated to allergy, tendinitis or tendon rupture, and myasthenia gravis.