Celgem 200mg Injection

Brand Name Celgem 200mg Injection
Salt Composition Gemcitabine (200mg)
Strength 200mg
Product Form Injection
Pack 1 Injection in 1 Vial
Category Anti Cancer
Country of Origin India
Manufacturer Alkem Laboratories Limited
Manufacturer/Marketer AddressAlkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Celgem 200mg  Injection, Gemcitabine 200mg, price, uses, side effects - Drugcarts watermark
M.R.P : Rs.1069.33    

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Availability : In Stock


    Medical Description of Celgem 200mg Injection

    Celgem 200mg Injection contains Gemcitabine 200mg it’s a nucleoside metabolic inhibitor. It has antineoplastic activity. It is used in the treatment of pancreas, lung, breast and ovarian cancer. It is used as an orphan drug in the case of bladder and gallbladder cancer. This medication is recommended only for adults.


    Celgem 200mg Injection Uses

    Celgem 200mg Injection is used in the treatment of pancreatic cancer, non-small cell lung cancer, breast cancer and ovarian cancer. It is not used in children.


    Celgem 200mg Injection Benefits

    Celgem 200mg Injection is used in the treatment of pancreatic cancer, non-small cell lung cancer, breast cancer and ovarian cancer. It is used as a monotherapy or in combination with chemotherapy medications. It is recommended only in adults.


    Celgem 200mg Injection Indication

    Celgem 200mg Injection is used in the treatment of:

    • Pancreatic adenocarcinoma which is locally advanced or metastatic or unresectable
    • Non-small cell lung cancer which is unresectable, locally advanced or metastatic
    • Metastatic breast cancer after failure of prior anthracycline-containing adjuvant chemotherapy
    • Ovarian cancer which is advanced or recurrent

    It is used as an orphan drug in the treatment of Transitional cell carcinoma, cholangiocarcinoma, cutaneous T cell lymphoma, Hodgkin’s lymphoma, mesothelioma, and head and neck carcinoma


    Mechanism of action of Celgem 200mg Injection

    Gemcitabine is an antineoplastic and an antimetabolite. It is a pyrimidine analogue. It is phosphorylated to Gemcitabine monophosphate which is converted to Gemcitabine diphosphate and Gemcitabine triphosphate. Gemcitabine triphosphate incorporates into DNA thus inhibits DNA chain elongation and causes masked DNA chain termination, DNA fragmentation and apoptosis of abnormal cancer cells. Thus Gemcitabine inhibits proliferation and induces apoptosis of abnormal cancer cells.


    How Celgem 200mg Injection works

    Celgem 200mg Injection that phosphorylates into gemcitabine triphosphate an active metabolite that incorporates into DNA molecule thus terminates elongation and causes fragmentation of DNA. It inhibits proliferation and induces apoptosis of abnormal cancer cells.


    Celgem 200mg Injection Contraindication

    Absolute contraindication:

    • if you are allergic to Celgem 200mg (Gemcitabine 200mg) Injection or its constituents
    • if you are pregnant
    • if you are breastfeeding
    • if you are less than 18 years of age

    Relative contraindication:

    • if you have a blood disorder
    • if you have renal disorder
    • if you have lung disease
    • if you have a liver disorder


    Celgem 200mg Injection Side Effects

    Common side effects that occur 1:10 patients: Anemia, Elev LFTs, Neutropenia, Leukopenia, Pain, Proteinuria, Fever, Hematuria, Rash

    Uncommon side effects that occur 1:100 patients: Thrombocytopenia, Dyspnea, Constipation, Diarrhea, Flu-like syndrome, Hemorrhage, BUN increased, Infection, Alopecia, Edema, Elev bilirubin

    Rare side effects that occur 1:1,000 patients: Paresthesia, Creatinine increased, Inj site reactions, Bronchospasm, CHF, MI, arrhythmias, supraventricular arrhythmias, Peripheral vasculitis, gangrene, capillary leak syndrome, Cellulitis, desquamation and bullous skin eruptions, Hepatic failure, Interstitial pneumonitis, pulmonary fibrosis, pulmonary edema, ARDS, Pulmonary eosinophilia, Thrombotic microangiopathy


    FAQs for Celgem 200mg Injection

    Is Celgem 200mg (Gemcitabine 200mg) Injection safe during pregnancy?

    No, taking Celgem 200mg Injection during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    Can Celgem 200mg Injection be taken while breastfeeding?

    No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Celgem 200mg Injection can also pass via breastfeeding.

    Can Celgem 200mg Injection be taken while alcohol consumption?

    The interaction is unknown but Celgem 200mg Injection causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Celgem 200mg Injection?

    Celgem 200mg Injection causes side effects thus caution is used while driving or operating machineries.


    Precautions and general warning of Celgem 200mg Injection

    Alcohol

    Intake of alcohol with Celgem 200mg Injection causes side effects thus caution is required. consult your physician

    Driving or operating machinery

    Driving or operating heavy machinery with Celgem 200mg Injection causes side effects thus caution is required. consult your physician

    Pregnancy

    Using Gemcitabine during pregnancy may cause embryo-fetal toxicity. Consult your physician

    Breast Feeding

    Using Gemcitabine during  Breast feeding may cause side effects similar to adults. Consult your physician

    Kidney Problem

    Using Gemcitabine may lead to renal failure/ hemolytic uremic syndrome. Consult your physician

    Liver Disease

    During Gemcitabine therapy monitor liver function before and during treatment.Consult your physician


    How to Take Celgem 200mg Injection

    Celgem 200mg Injection is taken intravenously; It must be taken at the same time once a day as prescribed by your physician; It is taken with NaCl

    After therapy has been initiated, do not take more or less of this drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing your dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Celgem 200mg Injection in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.


    Use of Celgem 200mg Injection in children

    This injection is not recommended in children.


    Use of Celgem 200mg Injection in Elderly Patients

    This injection has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Immunization with live vaccines
    • Hemotoxicity - myelosuppression
    • Bleeding disorder – easy bruising and bleeding
    • Pulmonary toxicity
    • Cardiotoxicity – MI
    • Renal toxicity – renal failure/ hemolytic uremic syndrome
    • Hepatotoxicity– monitor function before and during treatment
    • Posterior reversible encephalopathy syndrome
    • Pregnancy – causes embryo-fetal toxicity
    • Breast feeding – causes side effects similar to adults
    • Alcohol intake or Driving or operating heavy machinery – Celgem 200mg Injection causes side effects thus caution is required. consult your physician


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have a heart problem

    If you have a renal problem

    If you are pregnant or breastfeeding


    General instructions

    Celgem 200mg Injection is taken orally as prescribed dosage at a specific time regularly with or without food.


    Drug Interaction of Celgem 200mg Injection

    Drug-Drug Interaction

    IV Incompatibilities - acyclovir, amphotericin B, cefoperazone, cefotaxime, furosemide, ganciclovir, imipenem/cilastatin, irinotecan, methotrexate, methylprednisolone sodium succinate, mitomycin, piperacillin, piperacillin/tazobactam, prochlorperazine

    Severity of adverse effects is increased by Allopurinol, Steroids, Erythropoietin, Interferon alfa

    Serum levels are increased by Aceclofenac, Acetaminophen, Cetirizine

    Serum levels are decreased by Methazolamide, Hydrochlorothiazide

    Drug-Food Interaction

    This injection can be taken with any type of food, if doubts arise kindly refer to your physician. It generally causes side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
    • Blood disorders – used with caution in thrombocytopenia and anemia. Consult a physician before use.


    Over Dose

    In the case of Overdosage with this injection. Contact your physician.


    Missed Dose

    You can take the missed dosage if you notice within 12 hours. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30°C


    Fast Tag

    Celgem 200mg Injection is an antineoplastic medication

    Gemcitabine is an antimetabolic inhibitor

    This injection is used to control and treat pancreatic cancer, lung cancer, breast cancer and ovarian cancer

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease or kidney diseases or.