Combactin 12mg Tablet
Brand Name | Combactin 12mg Tablet |
Salt Composition |
Ivermetctin (12mg) |
Strength | 12mg |
Product Form | Tablet |
Pack | 10 Tablet(s) in Strip |
Storage | Store below 30°C |
Category |
Antiparasitic |
SubCategory |
anti-parasitic |
Country of Origin | India |
Manufacturer |
Oaknet Healthcare Pvt Ltd |
Manufacturer/Marketer Address | Oaknet Healthcare Pvt Ltd, Art Guild House,Experience Center, Phoenix Marketcity, L.B.S. Road, Kamani, West Nav Pada, Kurla West, Mumbai, Maharashtra 400070. |
You Save : Rs.35.00 Inclusive of all taxes
- Strongyloidiasis is an intestinal parasite
- Onchocerciasis causing river blindness
- Scabies
- It is used as an orphan drug in the cases of head lice, Blepharitis, filariasis and Gnathostomiasis
- It is used as an off label drug in the case of SARS-COV-2 mild and moderate cases.
- if you are allergic to Combactin (Ivermectin (12mg)) tablet or its constituents
- if you are immunocompromised
- if you are pregnant
- if you are breastfeeding
- Abdominal pain
- Asthenia
- Hypotension
- Mild EKG changes
- Peripheral & facial edema
- Transient tachycardia
- Dizziness
- Headache
- Hyperthermia
- Insomnia
- Somnolence
- Vertigo
- Pruritus
- Rash
- Urticaria
- Diarrhea
- Nausea
- Vomiting
- Eosinophilia
- Leukopenia
- ALT/AST increased
- Limbitis
- Myalgia
- Tremor
- Blurred vision
- Mild conjunctivitis
- Punctate opacity
- Mazzotti reaction (with onchocerciasis)
- Edema
- Fever
- Lymphadenopathy
- Ocular damage
- Pruritus rash
- Conjunctival hemorrhage (with onchocerciasis), Hepatitis
- Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
- Ocular disorder
- Neurological disorder
- Hepatotoxic
- Pregnancy – causes embryo-fetal toxicity
- Breast feeding – causes side effects similar to adults
- Alcohol intake or Driving or operating heavy machinery may cause side effects thus caution is required. consult your physician
- If you have any allergy
- If you have a neurological problem
- If you have a heart problem
- If you are pregnant or breastfeeding
- Lung disorders – used with caution in interstitial lung disease. Consult a physician before use
- Electrolyte disorders – used with caution in electrolyte imbalance. Consult a physician before use
- Bone disorders – used with caution in hypocalcemia. Consult a physician before use
- Cardiac disorders – used with caution in bradycardia and QT prolongation. Consult a physician before use
- Hematological disorders – used with caution in bleeding disorders like thrombosis. Consult a physician before use
- Liver disorders – used with caution in severe liver diseases. Consult a physician before use
- Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
Medical Description of Combactin 12mg Tablet
Combactin 12mg Tablet contains Ivermectin 12mg its an Anthelminthic (antiparasitic ) medication. This tablet is used to treat strongyloidiasis, onchocerciasis and scabies and is used as an orphan drug in the cases of head lice, Blepharitis, filariasis and Gnathostomiasis. This tablet is safely used in children above 15 kgs of weight. Recently It is used as an orphan drug in the treatment of SARS-COV-2 mild and moderate infection.
Combactin 12mg Tablet Uses
Used in the treatment of several parasitic infections in adults and children above 15 kgs
Combactin 12mg Tablet Benefits
It's an Anthelminthic (antiparasitic) medication used in the treatment of strongyloidiasis, onchocerciasis and scabies in adults and not recommended in children less than 15 kgs caution in geriatrics due to its toxicity.
Combactin 12mg Tablet Indication
Mechanism of action of Combactin 12mg Tablet
Combactin 12mg (Ivermectin 12mg) tablet binds with glutamate-gated chloride ion channels present in muscles and nerve cells of microfilaria that causes an increased influx of chloride ions resulting in paralysis of parasites and death of the parasite. Combactin 12mg tablet acts as a GABA agonist thus interrupts CNS neurosynaptic transmission.
How Combactin 12mg Tablet works
This tablet is an Anthelminthic (antiparasitic ) medication, increases the influx of chloride ions that causes paralysis and death of parasites by binding to glutamate-gated chloride ion channels.
Combactin 12mg Tablet Contraindication
Combactin 12mg Tablet Side Effects
FAQs for Combactin 12mg Tablet
Is Combactin 12mg (Ivermectin 12mg) tablet safe during pregnancy?
No, taking Combactin 12mg tablet during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant
Can Combactin 12mg tablet be taken while breastfeeding?
No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Combactin 12mg can also pass via breastfeeding.
Can Combactin 12mg tablet be taken while alcohol consumption?
The interaction is unknown but Combactin 12mg tablet causes neurologic side effects. Thus, consult your physician.
Can I take a drive or operate heavy machineries while on Combactin 12mg tablet?
Combactin 12mg tablet causes neurologic side effects thus caution is used while driving or operating machineries.
Precautions and general warning of Combactin 12mg Tablet
Alcohol
Alcohol intake may cause side effects thus caution is required. consult your physician
Driving or operating machinery
Driving or operating heavy machinery causes side effects thus caution is required. consult your physician
Pregnancy
Pregnancy – causes embryo-fetal toxicity
Breast Feeding
Breastfeeding – causes side effects similar to adults
Kidney Problem
Consult your physician.
Liver Disease
Hepatotoxic
How to Take Combactin 12mg Tablet
This tablet is taken orally best on an empty stomach at least 1 hr before food.
Do not cut, break or crush the tablet
Use of Combactin 12mg Tablet in Adult
If you are pregnant or breastfeeding inform your physician as they are not advisable.
Use of Combactin 12mg Tablet in children
This tablet is not recommended to use in children with weight less than 14 kgs.
Use of Combactin 12mg Tablet in Elderly Patients
This tablet has only been used in few patients 60 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage. Use with caution due to toxicity.
Other general warnings
Talk to your doctor if
General instructions
This tablet is given orally on an empty stomach 1 hr before food.
Drug Interaction of Combactin 12mg Tablet
Drug-Drug Interaction
Severity of myopathy, rhabdomyolysis, and myoglobinuria is increased by Niacin, Amphotericin B
metabolism is increased by St. John's Wort
metabolism is decreased by Amiodarone.
Serum concentration is increased by Beclomethasone, Caffeine
Drug-Food Interaction
It can be taken with any type of food, if doubts arise kindly refer to your physician. It generally causes side effects thus it is advised not to be taken with alcohol. Combactin 12mg tablet is preferred to drive or operate heavy machinery with caution while using this medication.
Drug-Disease Interaction
Over Dose
In the case of Overdosage with tablet Contact your physician.
Missed Dose
Consult your physician immediately
Storage and Disposal
Keep the medication out of children’s reach
Keep the medication away from pets
Once expired dispose immediately
Store at room temperature
Fast Tag
Combactin 12mg (Ivermectin 12mg) tablet is an Anthelminthic (antiparasitic) medication
Do not use this medication while pregnant and lactation period.