Decarb 200 Injection

Brand Name Decarb 200 Injection
Salt Composition

Dacarbazine (200mg)

Strength 200mg
Product Form Powder For Injection
Pack 1 Powder for Injection in 1 vial
Category

Anti-Cancer

SubCategory

Skin Cancer

Country of Origin India
Manufacturer

Cipla Ltd

Manufacturer/Marketer Address Cipla Ltd,Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013.
-20%
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Availability : In Stock

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    Medical Description of Decarb 200 Injection

    Decarb 200 Injection contains Dacarbazine 200 used to treat Hodgkin lymphoma, and metastatic malignant melanoma. It works by inhibiting the growth and multiplication of cancer cells by damaging the DNA and RNA of cancer cells.


    Decarb 200 Injection Uses

    It is used in the treatment of the following conditions as Hodgkin lymphoma, and metastatic malignant melanoma


    Decarb 200 Injection Benefits

    Hodgkin’s lymphoma

    It is also known as Hodgkin’s disease, cancer in part of your immune system called the lymphatic system. It occurs when there is a change in the DNA of white blood cells called B lymphocytes. Symptoms include fever, night sweats, weight loss, severe itching, increased sensitivity, and swelling of lymph nodes.

    Metastatic malignant melanoma

    It is also called skin cancer. It starts in the melanocytes, that produce melanin (responsible for skin color). It usually occurs when cancer spreads to other parts of the body. Symptoms include a change in an existing mole, development of new pigmentation.


    Decarb 200 Injection Indication

    The Decarb 200 Injection is prescribed in the following indications as Hodgkin lymphoma, and metastatic malignant melanoma


    Mechanism of action of Decarb 200 Injection

    Decarb 200 Injection contains Dacarbazine 200 is an anti-cancer medication, an alkylating agent produces its action by causing intra- and inter-strand crosslinks between DNA bases causing a break in DNA strand thus apoptosis is induced resulting in cell death of abnormal DNA containing cancer cells.


    How Decarb 200 Injection works

    Decarb 200 Injection contains Dacarbazine 200 is an anti-cancer medication, an alkylating agent produces its action by causing fragmentation in the DNA base pair which leads to inhibition of further synthesis and transcription of DNA. Thus it inhibits proliferation and induces apoptosis (cell death) of these abnormal cancer cells.


    Decarb 200 Injection Contraindication

    • Do not take this medicine if you are allergic to Dacarbazine
    • It is contraindicated to use this medicine in patients who are breastfeeding, severe anemia and thrombocytopenia


    Decarb 200 Injection Side Effects

    • Injection site pain
    • Nausea and vomiting
    • Leukopenia
    • Thrombocytopenia
    • Hair loss
    • Photosensitivity
    • Metallic taste
    • Seizure
    • Myelosuppression
    • Hepatic necrosis
    • Hepatic vein thrombosis


    FAQs for Decarb 200 Injection

    • Is Decarb 200 Injection safe?

    Yes, the use of this medicine is considered safe if you have taken the medicine as per the dose and duration advised by the doctor.

    • I am experiencing nausea and fatigue. Is this due to Decarb 200 Injection?

    Yes, the common side effect of this medicine is nausea and fatigue so it is better to eat more frequent meals to decrease nausea and also avoid foods that are salty, spicy, fatty. Drink plenty of rest and do light exercise to keep yourself active

    • Does Decarb 200 Injection cause hair loss?

    Yes, one of the common side effects of this medicine is hair loss. This will get treated once you stop the treatment


    Precautions and general warning of Decarb 200 Injection

    Alcohol

    The patients should be very cautious when consuming alcohol while they are receiving this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive because the use of this medicine will increase the risk for developing dizziness, nausea, and vomiting. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

    Kidney Problem

    Therapy should be administered with caution in patients who are having a renal impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.

    Liver Disease

    Therapy should be administered with caution in patients who are having hepatic impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.

     


    How to Take Decarb 200 Injection

    Decarb 200 Injection comes in a liquid solution as an intravenous. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.


    Use of Decarb 200 Injection in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Decarb 200 Injection in children

    It is considered safe to use this medicine in children. Kindly consult with your doctor.


    Use of Decarb 200 Injection in Elderly Patients

    Decarb 200 Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

     


    Other general warnings

    • The use of this medicine may cause bone marrow depression and hepatic necrosis
    • It may cause severe pain and burn on the injection site
    • Therapy should be administered with caution because in patients with hepatic and renal impairment


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease
    • You develop shortness of breath


    General instructions

    Dacarbazine 200 is used to treat Hodgkin lymphoma and metastatic malignant melanoma. It produces its action by causing fragmentation in the DNA base pair which leads to inhibition of further synthesis and transcription of DNA. Thus it inhibits proliferation and induces apoptosis (cell death) of these abnormal cancer cells.


    Drug Interaction of Decarb 200 Injection

    Drug-Drug Interaction

    Tofacitinib

    Use alternative drug because the combination of this medicine either increase the toxicity of the other by immunosuppressive effect and it also increases the risk for developing an infection.

    Carbamazepine

    Therapy should be administered with caution because the use of carbamazepine decreases the effect of dacarbazine by affecting its hepatic enzyme metabolism.

    Cisplatin

    Therapy should be administered with caution because the combination of this medicine either increases the toxicity of the other by pharmacodynamic synergism

    Drug-Food Interaction

    The use of caffeine may increase the blood level of dacarbazine and it also increases the risk for developing side effect that affects your bone marrow. Kindly consult with your doctor if you have experience paleness, fatigue, dizziness, fainting, bleeding, fever, chills, sore throat, body aches, and fever.

    Drug-Disease Interaction

    Infections

    The use of this medicine is contraindicated in patients who are having the infectious disease because of their cytotoxic effect their induce myelosuppression.

    Hepatic impairment

    Therapy should be administered with caution in patients with hepatic impairment and it should not be used in patients with moderate to severe hepatic impairment

    Renal impairment

    Therapy should be used in patients whose creatinine clearance value is less than 40ml/min

    Myelosuppression

    Therapy should not be administered in patients whose neutrophil count is less than 1,500/mm3. The use of this medicine may cause myelosuppression, bone marrow failure, and severe immunosuppression which leads to developing septic shock and sepsis


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 2-8°C in the refrigerator.
    • Do not freeze
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Dacarbazine 200 is an anti-cancer medication, an alkylating agent
    • It is used to treat Hodgkin lymphoma and metastatic malignant
    • Do not withdraw the medicine without consulting with a doctor
    • Kindly consult with your doctor if you have experienced shortness of breath, chest pain, loss of appetite, and dark urine while you are receiving this medicine