Danavir R Tablet
Brand Name | Danavir R Tablet |
Salt Composition |
Darunavir (800mg) + Ritonavir (100mg) |
Strength | 800mg + 100mg |
Product Form | Tablet |
Pack | 30 Tablet(s) in Bottle |
Storage | Store below 30°C |
Category |
HIV |
SubCategory |
HIV |
Country of Origin | India |
Manufacturer |
Hetero Drugs Limited |
Manufacturer/Marketer Address | Hetero Drugs Limited,Hetero House, H. No. 8-3-166/7/1, Erragadda, Hyderabad, Andhra Pradesh, 500018 India |
You Save : Rs.1,430.60 Inclusive of all taxes
- if you are allergic to darunavir or ritonavir- toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome
- if you have severe liver problems like hepatitis B or C
- if you have any bleeding disorders like haemophilia
- if you are diabetic
- if you have lipid disorder like hyperlipidaemia
- if you have heart diseases
- if you are pregnant – this medication lowers the risk of passing HIV infection to the baby
- Is Darunavir 600mg+Ritonavir 100mg ) safe during pregnancy?
- CanDarunavir 600mg+Ritonavir 100mg be taken while breast feeding?
- Can I take Darunavir 600mg+Ritonavir 100mg with alcohol?
- Drug interactions
- Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis. In mild cases, additional medications are prescribed to control the spread of infection. DiscontinueDarunavir 600mg+Ritonavir 100mg, if a severe reaction develops.
- Pancreatitis – discontinue treatment
- Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
- New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
- Accumulation or Redistribution of body fat or immune reconstitution syndrome.
- Known case of sulfonamide allergy.
- Hemophilia may develop increased bleeding events.
- Immune Reconstitution Syndrome
- Any sign of infection – fever or lymph node enlargement
- Avoid in case of patients below 3 years of age
- Darunavir 600mg+Ritonavir 100mg is taken with ritonavir orally as prescribed dosage at specific time regularly with food.
Medical Description of Danavir R Tablet
Danavir R contains two drugs namely darunavir 600mg and ritonavir 100mg. Darunavir 600mg+Ritonavir 100mg is an antiretroviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection in adults. Darunavir 600mg+Ritonavir 100mg
acts as a protease inhibitorthat interferes with the reproductive cycle of HIV thus reduces the viral load of HIV in your body. Ritonavir50mg is a potent CYP3A inhibitor that increases plasma drug concentrations of other protease inhibitors. The drug is used in combination with other antiretrovirals to control and treat HIV-1 infection.
Danavir R Tablet Uses
Darunavir 600mg+Ritonavir 100mg is used to treat adults and children above 3 years of age or if weight is more than 15Kg who are infected by HIV-1. Darunavir 600mg+Ritonavir 100mg is a protease inhibitor that interferes with the multiplication of HIV particles.
Danavir R Tablet Benefits
Darunavir 600mg+Ritonavir 100mg decreases the amount of HIV in your body , thus your immunityworks better by reducing your chance of getting HIV complications like co-infections and other cancers.Darunavir 600mg+Ritonavir 100mg is a protease inhibitor that interfers with the reproduction cycle of HIV.Darunavir 600mg+Ritonavir 100mg is not a cure for HIV infection, it improves immunity that results in longevity of life.
Danavir R Tablet Indication
Darunavir 600mg+Ritonavir 100mg is indicated in case of HIV-1 infection that causes AIDS in humans.Darunavir 600mg+Ritonavir 100mg is used with together to boost immunity of the affected hosts. Darunavir 600mg+Ritonavir 100mg is indicated in ages above 3 years or above 15kgs of body weight.
Mechanism of action of Danavir R Tablet
Darunavir 600mg+Ritonavir 100mg is HIV-1 protease inhibitor. Protease inhibitors are used as a part of highly active antiretroviral therapy (HAART) in HIV infected patients. Darunavir 600mg+Ritonavir 100mg prevents HIV replication by binding to this specific enzyme thus selectively inhibits the cleavage of HIV-1 encoded Gag-Pol polyproteinsprecursors of HIV-1 protease in cells affected by the virus, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection.
How Danavir R Tablet works
Darunavir 600mg+Ritonavir 100mg is HIV-1 protease inhibitor. Darunavir 600mg+Ritonavir 100mg binds to different sites on the enzyme namely the active site and the surface of one of the flexible flaps in the protease dimer. Darunavir 600mg+Ritonavir 100mg prevents HIV replication by binding to this specific enzyme thus selectively inhibits the cleavage of HIV-1 encoded Gag-Pol polyproteins in cells affected by the virus, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection.
Danavir R Tablet Contraindication
Absolute contraindicationsofDarunavir 600mg+Ritonavir 100mg :
Relative contraindicationof Darunavir 600mg+Ritonavir 100mg tab:
if you have kidney disease
Danavir R Tablet Side Effects
Common side effects that occur 1:10 patients: diarrhoea, vomiting, nausea, abdominal pain or distension, dyspepsia, flatulence, flushing, headache, tiredness, dizziness, fatigue, swelling of the face or lymph glands, increase of eosinophils, drowsiness, numbness, tingling or pain in hands or feet, loss of strength,itching, rash, difficulty falling asleep.
Uncommon side effects that occur 1:100 patients: chest pain, rapid heart rate, decrease in skin sensitivity, pins and needles, loss of memory, problems with balance, difficulty breathing, cough, nosebleed, heartburn, retching, dry mouth, constipation, belching, kidney stones, frequent or excessive passage of urine, urticaria, severe swelling of the skin around lips or eyes, eczema, excessive sweating, hair loss, acne, scaly skin, colouration of nails, muscle pain, muscle cramps or weakness, osteoporosis, high blood pressure, flushing, red or dry eyes, fever, swelling of lower limbs due to fluids, malaise, irritability, erectile dysfunction, decrease in sexual drive, enlargement of breasts, sleeping problems.
Rare side effects that occur 1:1000 patients: a reaction called DRESS [severe rash, accompanied by fever, , effects on liver, kidney or lung], severe or life-threatening skin reaction including blisters like Stevens Johnson syndrome, toxic epidermal necrolysis, anaphylaxis heart attack, slow heart beating, visual disturbance, chills, altered mood, fainting, epileptic fits, changes or loss of taste, mouth sores, vomiting blood, skin lesions, dry skin, stiffness of muscles or joints, joint pain with or without inflammation, changes in blood chemistry, changes in urine chemistry
FAQs for Danavir R Tablet
Yes, taking Darunavir 600mg+Ritonavir 100mg during pregnancy is safe and this significantly reduces the rate of the viral load transmitted to the fetus.
Consult your physician
What is the most common side effect ofDarunavir 600mg+Ritonavir 100mg )?
Diarrhea is the most common side effect caused byDarunavir 600mg+Ritonavir 100mg
and this can be treated by taking plenty of fluids.
Darunavir 600mg+Ritonavir 100mg is not advised to be taken with alcohol. For queries talk to your physician
Can I drive or operate heavy machinery while onDarunavir 600mg+Ritonavir 100mg?
It is not advisable to drive or operate heavy machinery while onDarunavir 600mg+Ritonavir 100mg.For queries talk to your physician
Precautions and general warning of Danavir R Tablet
Alcohol
Darunavir 600mg+Ritonavir 100mg generally causes blurry vision, fainting, and movement disorders thus it is advised not to be taken with alcohol.For further queries, consult your physician.
Driving or operating machinery
It is preferred to drive or operate heavy machinery with caution asDarunavir 600mg+Ritonavir 100mg causes fainting spells and movement disorders. For further queries, consult your physician.
Pregnancy
The use of Darunavir 600mg+Ritonavir 100mg is well tolerated during pregnancy. In addition, it decreases the rate of HIV transmission to the fetus and decreases mortality rate.
Breast Feeding
Consult your doctor
Kidney Problem
Monitor renal function. For further queries, consult your physician.
Liver Disease
In patients with hepatitis B or C or marked transaminase elevation caution is recommended as Darunavir 600mg+Ritonavir 100mg may cause hepatotoxicity and lead to death. Thus, monitor liver function before and during therapy.
Other general warnings
Talk to your doctor if
If you have any allergy
If you have a liver problem
If you have hypertension or any heart problem
If you have any bleeding problem
If you are pregnant or breastfeeding
General instructions
Drug Interaction of Danavir R Tablet
Drug-Drug Interaction
Amiodarone
Alfuzosin
Midazolam
Colchicine
Cisapride
Ergot alkaloids
Lovastatin
Lurasidone
Rifampicin
Lopinavir
Lovastatin
Lomitapide
Ritonavir
Ranolazine
Sildenafil
Domperidone
Quinidine
Voriconazole
Over Dose
Contact your doctor immediately.
Missed Dose
You can take the missed dosage of Darunavir 600mg+Ritonavir 100mg if you notice within 6 hours. Always Darunavir 600mg+Ritonavir 100mg with food. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.
Storage and Disposal
Keep the medication out of children’s reach
Keep the medication away from pets
Once expired dispose immediately
Store at 25?C
Fast Tag
Darunavir 600mg+Ritonavir 100mg) contains two drugs namely darunavir 600mg and ritonavir 100mg. Darunavir 600mg+Ritonavir 100mg is an antiretroviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection in adults. Darunavir 600mg+Ritonavir 100mg acts as a protease inhibitorthat interferes with the reproductive cycle of HIV thus reduces the viral load of HIV in your body. Ritonavir50mg is a potent CYP3A inhibitor that increases plasma drug concentrations of other protease inhibitors. The drug is used in combination with other antiretrovirals to control and treat HIV-1 infection.