Daunotec 20mg Injection contains Daunorubicin 20mg used to treat blood cancer. It works by inhibiting the growth and multiplication of cancer cells by suppressing the enzyme which is involved in the DNA multiplication of cancer cells. It is used alone or with other medication as chemotherapy

It is used in the treatment of the following conditions as Acute Non-lymphocytic leukemia, and Acute Lymphocytic leukemia.

Acute Lymphoblastic Leukemia

It is a type of blood and bone marrow cancer that affects white blood cells in your body. It occurs when a cell in bone marrow develops changes in DNA. Symptoms include frequent infection, pale skin, shortness of breath, fatigue, bleeding from gums, nosebleeds, and bone pain.

Acute Non-lymphocytic leukemia

It is also called acute myelogenous leukemia. This cancer occurs in the bone marrow and causes an increase in white blood cells. It occurs due to genetic changes in the stem cells which are produced by the bone marrow. Symptoms include easy bleeding, fever, weight loss, loss of appetite, night sweats, fatigue, and bone pain.

The Daunotec 20mg Injection is prescribed in the following indications as Acute Non-lymphocytic leukemia, and Acute Lymphocytic leukemia.

Daunotec 20mg Injection contains Daunorubicin 20mg is an anti-cancer medication, an anthracycline produces its action by inhibiting DNA and RNA replication by acting on DNA topoisomerase 2 that intercalates DNA base pairs. Thus, causes the formation of an impaired DNA sequence containing abnormal cells where apoptosis occurs and results in cell death.

Daunotec 20mg Injection contains Daunorubicin 20mg is an anti-cancer medication, an anthracycline produces its action by inhibiting the function of DNA topoisomerase 2 enzymes. This causes impairment in DNA intercalation inducing apoptosis of these abnormal cancer cells.

• Do not take this medicine if you are allergic to Daunorubicin
• It is contraindicated to use this medicine in patients who are with active infection
• Kindly avoid in patients with a history of myelosuppression from other drug treatments

• Urine discoloration
• Hair loss
• Injection site pain
• Hyperuricemia
• GI ulceration
• Diarrhea
• Cardiomyopathy
• Increased bilirubin
• Rash
• Myelosuppression

• I am experiencing nausea and fatigue. Is this due to Daunotec 20mg Injection?

Yes, the common side effect of this medicine is nausea and fatigue so it is better to eat more frequent meals to decrease nausea and also avoid foods that are salty, spicy, fatty. Drink plenty of rest and do light exercise to keep yourself active

• Does Daunotec 20mg Injection cause hair loss?

Yes, one of the common side effects of this medicine is hair loss. This will get treated once you stop the treatment.

• I have noticed some changes in my skin after taking the Daunotec 20mg Injection? What should I do?

Use sunscreen whenever you step outdoors and use moisturizer to get relief from the rash, dry and itchy skin. Your skin will return to normal once your treatment is stopped.

Alcohol

It is not clear whether it is safe to consume alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

Driving or operating machinery

It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

Pregnancy

The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

Breast Feeding

The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

Kidney Problem

Therapy should be administered with caution in patients with renal impairment. Kindly adjust the dose if it is necessary. Kindly consult with your doctor.

Liver Disease

Therapy should be administered with caution in patients with hepatic impairment. Kindly adjust the dose if it is necessary. Kindly consult with your doctor.

Daunotec 20mg Injection comes in a liquid solution as an intravenous. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.

It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.

It is considered safe to use this medicine in children. Kindly consult with your doctor.

Daunotec 20mg Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

• Kindly avoid pregnancy while you are receiving this medicine
• Children are more sensitive to cardiotoxic effects when compared with adults
• The use of this medicine increases the risk of developing severe cardiotoxicity and myelosuppression
• Secondary leukemia was reported
• Therapy should be administered with caution in patients with hepatic and renal impairment

• You are not responding to the treatment
• You have experienced any allergic reaction like rashes and itching
• You have a receiving any concomitant medication and disease

Daunorubicin 20mg is used to treat Acute Non-lymphocytic leukemia and Acute Lymphocytic leukemia. It produces its action by inhibiting the function of the DNA topoisomerase 2 enzymes. This causes impairment in DNA intercalation inducing apoptosis of these abnormal cancer cells.

Drug-Drug Interaction

Tofacitinib

Use alternative drug because the combination of this drug either increases the toxicity of the other by immunosuppressive effects and it also increases the risk for developing an infection

Amiodarone

Therapy should be administered with caution because the use of amiodarone will increase the effect of doxorubicin by P-glycoprotein efflux transporter

Hydroxyurea

The combination of this medicine may increase the risk of developing myelosuppression

Apalutamide

Therapy should be administered with caution because the use of apalutamide will decrease the effect of daunorubicin by increasing elimination.

Drug-Food Interaction

No data available kindly consult with your doctor

Drug-Disease Interaction

Infections

The use of this medicine may cause severe infections to include urinary tract infections, pneumonia, sepsis, herpes encephalitis, and mycobacterial infection which lead to retroperitoneal hemorrhage.

Cardiomyopathy

The use of this medicine is contraindicated to use this medicine in patients with severe myocardial insufficiency and recent myocardial infarction because the use of this medicine may cause myocardial damage including acute left ventricular failure

Hepatic dysfunction

Therapy should be administered with caution in patients with mild to moderate hepatic impairment because the doxorubicin is metabolized by the liver. It is contraindicated to use this medicine in severe hepatic impairment patients

Myelosuppression

Therapy should be administered with extreme caution in patients with bone marrow suppression because the use of this medicine induces dose-related myelosuppression

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 30°C at room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

• Daunorubicin 20mg is an anti-cancer medication, an anthracycline
• It is used to treat Acute Non-lymphocytic leukemia and Acute Lymphocytic leukemia.
• Do not withdraw the medicine without consulting with a doctor
• Kindly avoid pregnancy while you are receiving this medicine
• Kindly consult with your doctor if you have experienced shortness of breath, chest pain, loss of appetite, and dark urine while you are receiving this medicine

Daunotec 20mg Injection contains Temsirolimus 20mg used to treat kidney cancer by inhibiting the growth of abnormal proteins that multiplication of cancer cells. This medicine is not recommended for children.

It is used in the treatment of the following conditions as Renal cell carcinoma

Renal cell carcinoma

It is a common type of kidney cancer found in adults. It is caused by obesity, smoking cigarettes, polycystic kidney disease, and some genetic condition. Symptoms include blood in urine, loss of appetite, weight loss, tiredness, and fever.

The Daunotec 20mg Injection is prescribed in the following indications as renal cell carcinoma. It is also used as an orphan drug in the case of breast cancer, lymphoma, rheumatoid arthritis, and multiple myeloma

Daunotec 20mg Injection contains Temsirolimus 20mg is an anti-cancer medication, a mammalian target of rapamycin kinase inhibitor. It produces its action by inhibiting rapamycin. Rapamycin is a serine-threonine kinase. Temsirolimus binds to an intracellular protein that inhibits rapamycin. It reduces protein kinase activity and eukaryotic elongation factor and stops hypoxia-inducible factor and decreases VEGF expression. Inhibition of Rapamycin reduces cell proliferation, angiogenesis, and glucose uptake. Thus it inhibits signals of angiogenesis and decreases the size of the tumor by starvation and increases apoptosis function.

Daunotec 20mg Injection contains Temsirolimus 20mg is an anti-cancer medication, a mammalian target of rapamycin kinase inhibitor. It produces its action by binding to rapamycin that decreases the function of protein kinase and elongation factor and inhibits hypoxia factor and VEGF thus inhibiting cell proliferation and angiogenesis. This results in the shrinking of tumor cells and cell death thus controlling and treating various cancers

• Do not take this medicine if you are allergic to Temsirolimus
• It is contraindicated to use this medicine whose bilirubin level is more than the upper limit of normal

• Anemia
• Increased blood sugar level
• Increased cholesterol level
• Increased serum creatinine
• Increased alkaline phosphatase
• Rash
• Decreased platelet count
• Pain
• Diarrhea
• Cough
• Constipation
• Weight loss
• Chest pain
• Dry skin
• Insomnia
• Chills
• Depression

• Is Daunotec 20mg Injection safe?

Yes, the use of this medicine is considered safe if you have taken the medicine as per the dose and duration advised by the doctor.

• Can I stop using the Daunotec 20mg  Injection immediately or do I have to slowly wean off the use?

You should not withdraw the medicine immediately, you should taper the dose to avoid rebound effects.           

• How to treat constipation during the treatment?

To treat constipation drink plenty of water a day and keep you active, add fiber to your diet. If you do not have a bowel movement for more than 3 days kindly consult with your doctor.

Alcohol

It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

Driving or operating machinery

It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

Pregnancy

The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

Breast Feeding

The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

Kidney Problem

It is considered safe to use this medicine in patients who are with renal impairment. Kindly consult with your doctor.

Liver Disease

Therapy should be administered with caution in patients with hepatic impairment. Adjust the dose whenever it is necessary.

Daunotec 20mg Injection comes in a liquid solution as an intravenous. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.

It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.

It is considered unsafe to use this medicine in children who are below 18 years old. Kindly consult with your doctor.

Daunotec 20mg Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

• The use of this medicine increases the risk of developing hypersensitivity reaction, hyperglycemia, hyperlipidemia, and intracerebral hemorrhage
• Interstitial lung disease was suspected
• Infection may result from immunosuppression
• The use of this medicine may cause bowel perforation and renal failure
• Therapy should be administered with caution in the perioperative period due to an abnormal wound healing
• Elderly patients may develop diarrhea, edema, and pneumonia
• The use of this medicine decreases the effect of live vaccinations
• Kindly avoid grapefruit juice while you are receiving this medicine
• Angioedema and proteinuria was reported
• Kindly avoid pregnancy while you are in treatment

• You are not responding to the treatment
• You have experienced any allergic reaction like rashes and itching
• You have a receiving any concomitant medication and disease
• You develop shortness of breath

Temsirolimus 20mg is used to treat kidney cancer. It produces its action by binding to rapamycin that decreases the function of protein kinase and elongation factor and inhibits hypoxia factor and VEGF thus inhibiting cell proliferation and angiogenesis. This results in the shrinking of tumor cells and cell death thus controlling and treating various cancers

Drug-Drug Interaction

BCG vaccine live

It is contraindicated to use this medicine because the use of immunosuppressants increase the risk for infection with live vaccines

Apalutamide

Use alternative drugs because the use of apalutamide will decrease the effect of temsirolimus by affecting its hepatic and intestinal enzyme metabolism.

Pregabalin

Use alternative drugs because the combination of this medicine increases the toxicity of the other

Bosutinib

Therapy should be administered with caution because the use of bosutinib increases the effect of temsirolimus by P-glycoprotein efflux transporter

Dichlorphenamide

Therapy should be administered with caution because the combination of this medicine decreases the serum potassium

Drug-Food Interaction

Kindly avoid consuming grapefruit and grapefruit juice while you are receiving this medicine because the use of grapefruit increases the level of temsirolimus in your body and causes serious side effects.

Drug-Disease Interaction

Renal diseases

Therapy should be administered with caution in patients with renal impairment because the use of this medicine may cause acute renal failure and increase the serum creatinine and proteinuria level.

GI perforation

Therapy should be administered with caution in patients who increased the risk for gastrointestinal perforation because the use of this medicine cause bowel perforation

Liver diseases

Therapy should be administered with caution in patients with mild hepatic impairment. And dose reduction or adjustment should depend upon the AST and bilirubin level

Lung dysfunctions

Closely monitor the patients for the occurrence of respiratory symptoms because the use of temsirolimus may lead to interstitial lung diseases

Infections

Therapy should be administered with caution in patients with an infection because the use of this medicine decreases the resistance to host and increase the bacterial, fungal, viral, and protozoal infection, and reactivate the viral infection

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 30°C at room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

• Temsirolimus 20mg is an anti-cancer medication, a mammalian target of rapamycin kinase inhibitor
• It is used to treat kidney cancer
• Therapy should be administered with caution if you have scheduled for surgery because this medicine interfere with the wound healing
• Kindly inform your doctor if you are diabetic because the use of this medicine increases your blood glucose level
• Do not withdraw the medicine without consulting with a doctor
• Kindly consult with your doctor if you have experienced shortness of breath, chest pain, loss of appetite, and dark urine while you are receiving this medicine