Drug Interaction of Defrab-D Capsule
The use of this medicine is contraindicated because the combination of the anti-ulcer drug with erlotinib may alter the upper stomach Ph and decrease its metabolism of medicine.
The use of rabeprazole decreases the effect of atazanavir by increasing the gastric Ph. Use alternative drugs also reduce the concentration of drug
Therapy should be administered with caution because the use of rabeprazole increases the effect of methotrexate by decreasing its renal clearance. At a higher dose, it increases the risk of developing toxicity.
Therapy should be administered with caution because the use of fluvoxamine will increase the effect of rabeprazole by affecting the liver enzymes.
Ketoconazole is an antifungal drug used to treat fungal infections. This medication requires an acidic environment in the intestine to be absorbed. This medicine with rabeprazole affects the absorption of the drug in the intestine.
Antacids containing aluminum and magnesium are used for indigestion. This medicine alters the action of antacids. It is better to give this medicine at least 1 hour before or 2 hours after taking antacids. Kindly consult with your doctor
By using this medicine with food should be maintained time gap at least 1 hour before the meals for better effectiveness of the medicine. By using this medicine with spicy, fatty foods, alcohol, caffeinated drinks, or beverages such as coffee, tea, cola, etc, should be avoided for better effectiveness of the medicine.
It should be used with caution in patients with gastrointestinal perforations (intestinal problems such as internal bleeding, an obstruction, or perforation of the stomach, and intestine, etc) that lead to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.
It should be used with caution in patients with pheochromocytoma (adrenal gland tumor, leads to developing high blood pressure, sweating, fast heartbeat, etc), which leads to worsening the patient's health conditions. Kindly consult with your doctor
This combinational capsule should be used with caution in patients with liver impairment, or liver diseases. Then it leads to a risk of a liver problem or liver damage. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.
By using the medicine for a very long period of this time leads the osteoporosis (Bone fracture). To avoid osteoporosis calcium and other vitamin D supplement are given to minimize calcium and vitamin deficiency. Kindly consult with your doctor.
Vitamin B12 deficiency
By using the medicine for a very long period of this time leads the Vitamin B12 deficiency. Vitamin B12 supplements are given with rabeprazole to minimize this vitamin deficiency. Kindly consult with your doctor
By long-term use of this medicine leads to developing hypomagnesemia (low magnesium levels), which leads to developing dizziness, shivering, muscle pain, irregular heartbeat, seizures, or fits. Kindly consult with your doctor. Based on the patient clinical conditions, dose adjustment or replacement is needed.
For the patients with a heart problem, caution should be taken before taking the medicine otherwise leads to heart-related problems such as heart failure, etc which leads to the patient's conditions most worsening. Kindly consult with your doctor before prescribing the medicine based on the health or clinical conditions, dose adjustment or replacement is necessary.