Dgrab L 75mg/20mg Capsule SR

Dgrab L 75mg/20mg Capsule SR contains Rabeprazole 20mg and Levosulpiride 75mg used to treat conditions like Gastro-oesophageal reflux disease (GERD) and Irritable bowel syndrome. Rabeprazole is a proton pump inhibitor that helps to get relief from acid-related indigestion and heartburn in the stomach. It produces its action by decreasing the secretion of acid in the parietal cells of the stomach by producing a chemical messenger called acetylcholine. This combination softens the stools and decreases the acid secretion from the stomach. Take the medicine on an empty stomach, preferably in the morning. Kindly avoid consuming spicy, fatty, and caffeinated drinks such as tea, coffee, and soft drinks. Don’t break, chew, or crush the capsule.

It is used in the treatment of the following conditions as Gastro-oesophageal reflux disease (GERD) and Irritable bowel syndrome.

Gastroesophageal reflux disease (GERD)

GERD occurs due to stomach acid frequently flowing backward direction from the stomach to the oesophagus, leading to developing heartburn, and acid indigestion. Primarily it can manage lifestyle changes, and use OTC (Over the counter) medicines. This medicine is used to treat this backflow acid secretion in the stomach.

Irritable bowel syndrome

An intestinal disorder leads to develop persistent stomach pain, flatulence, diarrhoea, or constipation, which is treated by this medicine.

Dgrab L 75mg/20mg Capsule SR is prescribed in the following indications as Gastro-oesophageal reflux disease (GERD) and Irritable bowel syndrome.

Dgrab L 75mg/20mg Capsule SR contains Rabeprazole and Levosulpiride is a combination of two medicines. Rabeprazole is a proton pump inhibitor. It produces its action by inhibiting the H+/K+ ATP pumps which are released by parietal cells in the stomach for gastric acid secretion. By blocking these pumps reduce the acid secretion in the stomach and helps to get relief from the acidity. Levosulpiride is a prokinetic drug that increases the production of chemical messengers called acetylcholine which is much more needed for the increased movement of the stomach and intestine to prevent acid reflux. (flow of the acid to the food pipe).

Dgrab L 75mg/20mg Capsule SR contains Rabeprazole and Levosulpiride a combination of two medicines. Rabeprazole is a proton pump inhibitor. It produces its action by inhibiting the H+/K+ ATP pumps which are released by parietal cells in the stomach for gastric acid secretion. By blocking these pumps reduce the acid secretion in the stomach and helps to get relief from the acidity. Levosulpiride is a prokinetic drug that increases the production of chemical messengers called acetylcholine which is much more needed for the increased movement of the stomach and intestine to prevent acid reflux. (flow of the acid to the food pipe).

• Do not take this medicine if you are allergic to rabeprazole and levosulpiride.  And other proton pump inhibitors (pantoprazole)
• Long term use may cause Cutaneous lupus erythematosus and systemic lupus erythematosus
• Kindly avoid this drug if you have any hepatic impairment and interstitial nephritis
• It is contraindicated to use this medicine if you have diarrhoea because of Clostridium difficile bacterial infection
• It is contraindicated to use this medicine for patients who are having a history of epilepsy and mental disorders

• Headache
• Abdominal pain
• Flatulence
• Diarrhoea
• Hypomagnesemia
• Hyponatremia
• Dizziness
• Constipation
• Pharyngitis
• Abnormal taste
• Chest pain

• Is there anything else I need to know before taking the Dgrab L 75mg/20mg Capsule SR?

The levosulpride present in the medicine increases the prolactin level in the blood which results in painful menstruation in females and milk discharge from the nipple. Kindly consult with your doctor

• Is it safe to take the Dgrab L 75mg/20mg Capsule SR for longer durations?

No, you should not take this medicine for a longer duration unless if it is prescribed by the doctor

• How long do I need to use Dgrab L 75mg/20mg Capsule SR to see improvement in my conditions?

Usually, it takes 1 to 2 days to see improvement. But it may differ according to your health conditions

Alcohol

Consuming alcohol while receiving this medication is considered unsafe because the use of this medicine may cause acidity which worsens the condition of patients. Kindly consult with your doctor.

Driving or operating machinery

No, Dgrab L 75mg/20mg Capsule SR is not safe to drive after administration. The combination of this capsule may cause dizziness and sleepiness which alters the ability to drive. Kindly consult with your doctor.

Pregnancy

No, the use of this medicine is considered unsafe during pregnancy because it may produce a harmful effect on the developing fetus. Kindly consult with your doctor.

Breast Feeding

No, information is available regarding the use of this capsule while breastfeeding. Kindly consult with your doctor.

Kidney Problem

It is considered unsafe to use this medicine for patients who are having a renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

Liver Disease

The capsule should be used with caution in patients with severe liver impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

It should be taken on an empty stomach, at least one hour before the meal as prescribed by the doctor. Take this medicine at a regular interval of time. It is better, try to finish your dinner as earlier as possible at least 2 – 3 hours before going to the bed, which leads to the reduction of acid secretion in the stomach.

Take the correct dose and duration of medicine as prescribed by the doctor. Swallow the whole capsule at once. Take the capsule has fully or wholly, don’t break, cut, chew, or crush the capsule.

It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor.

Dgrab L 75mg/20mg Capsule SR is not prescribed in children who are below 18 years old. Kindly consult with your doctor.

Dgrab L 75mg/20mg Capsule SR should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

• The use of proton pump inhibitors may increase the risk of developing salmonella and campylobacter infection
• Monitor your INR and prothrombin time when you are receiving this medicine along with warfarin
• Long-term use may cause Vitamin B12 deficiency

• You have experienced pain in your joints, skin rashes, indigestion, and stomach pain
• You have a family history of stomach cancer
• You are responding to the treatment

Dgrab L 75mg/20mg Capsule SR consists of Rabeprazole + Levosulpiride is used in the treatment of the following conditions as Gastro-oesophageal reflux disease (GERD), and Irritable bowel syndrome.

Rabeprazole is an anti-ulcer agent used to relieve acid-related indigestion and heartburn in the stomach. Levosulpiride is a prokinetic that helps in the movement of food from the stomach to the intestine by producing a chemical messenger (acetylcholine). This combination softens the stools and decreases the acid secretion from the stomach.

Drug-Drug Interaction

Erlotinib

The use of this medicine is contraindicated because the combination of the anti-ulcer drug with erlotinib may alter the upper stomach Ph and decrease its metabolism of medicine.

Atazanavir

The use of rabeprazole decreases the effect of atazanavir by increasing the gastric Ph. Use alternative drugs also reduce the concentration of drug

Methotrexate

Therapy should be administered with caution because the use of rabeprazole increases the effect of methotrexate by decreasing its renal clearance. At a higher dose, it increases the risk of developing toxicity.

Fluvoxamine

Therapy should be administered with caution because the use of fluvoxamine will increase the effect of rabeprazole by affecting the liver enzymes.

Ketoconazole

Ketoconazole is an antifungal drug used to treat fungal infections. This medication requires an acidic environment in the intestine to be absorbed. This medicine with rabeprazole affects the absorption of the drug in the intestine.

Antacids

Antacids containing aluminium and magnesium are used for indigestion. This medicine alters the action of antacids. It is better to give this medicine at least 1 hour before or 2 hours after taking antacids. Kindly consult with your doctor

Drug-Food Interaction

By using this medicine with food should be maintained time gap at least 1 hour before the meals for better effectiveness of the medicine. By using this medicine with spicy, fatty foods, alcohol, caffeinated drinks, or beverages such as coffee, tea, cola, etc, should be avoided for better effectiveness of the medicine.

Drug-Disease Interaction

Gastrointestinal perforation

It should be used with caution in patients with gastrointestinal perforations (intestinal problems such as internal bleeding, an obstruction, or perforation of the stomach, and intestine, etc) that lead to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

Pheochromocytoma

It should be used with caution in patients with pheochromocytoma (adrenal gland tumor, leads to developing high blood pressure, sweating, fast heartbeat, etc), which leads to worsening the patient's health conditions. Kindly consult with your doctor

Liver diseases

This combinational capsule should be used with caution in patients with liver impairment, or liver diseases. Then it leads to a risk of a liver problem or liver damage. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

Bone fractures

By using the medicine for a very long period of this time leads the osteoporosis (Bone fracture). To avoid osteoporosis calcium and other vitamin D supplement are given to minimize calcium and vitamin deficiency. Kindly consult with your doctor.

Vitamin B12 deficiency                               

By using the medicine for a very long period of this time leads the Vitamin B12 deficiency. Vitamin B12 supplements are given with rabeprazole to minimize this vitamin deficiency. Kindly consult with your doctor

Hypomagnesemia

By long-term use of this medicine leads to developing hypomagnesemia (low magnesium levels), which leads to developing dizziness, shivering, muscle pain, irregular heartbeat, seizures, or fits. Kindly consult with your doctor. Based on the patient clinical conditions, dose adjustment or replacement is needed.

Heart problems

For the patients with a heart problem, caution should be taken before taking the medicine otherwise leads to heart-related problems such as heart failure, etc which leads to the patient's conditions most worsening. Kindly consult with your doctor before prescribing the medicine based on the health or clinical conditions, dose adjustment or replacement is necessary.

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 10-30°C room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

Dgrab L 75mg/20mg Capsule SR contains Rabeprazole 20mg + Levosulpiride 75mg used in the treatment of GERD, intestinal ulcers, Irritable bowel syndrome.

Rabeprazole is a proton pump inhibitor, the anti-ulcer agent used to relieve acid-related indigestion, and heartburn in the stomach. Levosulpiride is a prokinetic that helps in the movement of food from the stomach to the intestine by producing a chemical messenger (acetylcholine).

Likewise, it is better, try to finish your dinner as earlier as possible at least 2 – 3 hours before going to the bed, which leads to the reduction of acid secretion in the stomach.