Docetax 80mg Injection

Brand Name Docetax 80mg Injection
Salt Composition Docetaxel (80mg)
Strength 80mg
Product Form Injection
Category Anti Cancer
Country of Origin India
Manufacturer Cipla Ltd.
Manufacturer/Marketer AddressCipla Ltd, Cipla House, Peninsula Business Park, Ganpatrao, kadam Marag, Lower Parel, Mumbai-400013.India
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M.R.P : Rs.5000.00       Price : Rs.3750.00

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    Medical Description of Docetax 80mg Injection

    Docetax contains its active substance called Docetaxel. It is an antineoplastic agent and antimicrotubular. It is not recommended in paediatric. Docetax is used in the treatment of breast cancer, non-small cell lung cancer, gastric cancer, head and neck cancer, prostate cancer.


    Docetax 80mg Injection Uses

    Docetax is used in the adult to treat breast cancer, non-small cell lung cancer, gastric cancer, head and neck cancer, prostate cancer.


    Docetax 80mg Injection Benefits

    It is used in the treatment of hormone-based cancers like breast cancer, prostate cancer, gastric cancer, lung cancer, head and neck cancer. Docetaxel is used only in adults.

    Prostate Cancer :

    Prostate Cancer is also called prostatic carcinoma. It is a walnut-shaped gland in males which is caused by DNA changes of a normal prostate cell. Symptoms include difficulty in urinating, blood in urine and semen, bone pain, weight loss, and erectile dysfunction

    Gastric Cancer : 

     It is also called stomach cancer. This abnormal growth of cells can occur in any region of your stomach. The condition worsens gastric cancer includes gastroesophageal reflux disease, obesity, smoking and family history of stomach cancer. Symptoms include bloating, heartburn, indigestion, nausea, stomach pain, vomiting and weight loss

    Lung Cancer :

    It usually occurs when cells in the lungs start growing uncontrollably. The major cause of lung cancer is smoking but it can occur to people who are non-smokers also because they had long-term exposure to secondhand smoke. Symptoms include chest pain, blood while coughing, shortness of breath, bone pain, headache, weight loss and hoarseness

    Head and Neck Cancer :

    It is also called as throat cancer. The most common neck and head cancer is squamous cell carcinoma. This cancer develops in the mouth, throat, nose, salivary gland. It is caused by using alcohol and tobacco. Symptoms include Sore throat, dentures, difficulty in breathing, ear pain, sinus infection


    Docetax 80mg Injection Indication

    It is indicated in adults in the treatment of 

    • Breast cancer which is locally advanced or metastatic and failure to respond to chemotherapy
    • Non-small cell lung cancer which is locally advanced or metastatic and failure to respond to platinum-based chemotherapy
    • Advanced gastric adenocarcinoma
    • Advanced adenocarcinoma of the gastroesophageal junction
    • Head and neck cancer which is locally advanced squamous cell carcinoma
    • Metastatic Prostate cancer which is hormone based


    Mechanism of action of Docetax 80mg Injection

    Docetaxel is an antineoplastic and anti microtubular medication that inhibits the multiplication or proliferation of abnormal cells by inhibiting blood supply and nutrients.It binds to tubulin and causes dismemberment of microtubules thus interferes with mitosis of cell cycle resulting in metaphase of cell cycle thus induce apoptosis of abnormal cancer cells. This results in the growth of cancer cells.


    How Docetax 80mg Injection works

    Docetaxel is an antineoplastic and anti microtubular medication that inhibits the multiplication or proliferation of abnormal cells by inhibiting blood supply and nutrients. It binds to tubulin and causes dismemberment of microtubules thus interferes with mitosis of cell cycle resulting in metaphase of cell cycle thus induce apoptosis of abnormal cancer cells. This results in the growth of cancer cells.


    Docetax 80mg Injection Contraindication

    • if you are allergic to Docetaxal or its constituents
    • if you have neutropenia
    • if you have a neurological disorder
    • if you are pregnant
    • if you are breastfeeding


    Docetax 80mg Injection Side Effects

    Common side effects that occur 1:10 patients: Alopecia, Anemia, Leukopenia, Neutropenia, Asthenia

    Uncommon side effects that occur 1:100 patients: Fever, Infections, Fluid retention, Hypersensitivity, Skin reactions, Diarrhea, Nausea, Vomiting, Sensory neuropathy, Myalgia, Nail changes

    Rare side effects that occur 1:1,000 patients: Arthralgia, Thrombocytopenia, Atrial fibrillation, DVT, ECG abnormalities, thrombophlebitis, pulmonary embolism, syncope, tachycardia, myocardial infarction; ventricular arrhythmia including ventricular tachycardia, Cutaneous lupus erythematosus, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, Enterocolitis, duodenal ulcer, esophagitis, gastrointestinal haemorrhage, GI perforation, intestinal obstruction, ileus, Ototoxicity, DIC, tumor lysis syndrome, Hepatitis, Electrolyte imbalance, seizures, Conjunctivitis, cystoid macular edema, pulmonary edema, acute respiratory distress syndrome/pneumonitis, interstitial lung disease, interstitial pneumonia, respiratory failure, and pulmonary fibrosis, Renal insufficiency and renal failure, secondary malignancies


    FAQs for Docetax 80mg Injection

    • Is Docetax safe during pregnancy?

    No, taking Docetax during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    • Can Docetax be taken while breastfeeding?

    No, in general, it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Docetax can also pass via breastfeeding.

    • Does Docetaxel injection cause weight gain?

    Yes, the use of docetaxel injection cause weight gain and this may occur due to the retention of fluid in your body. Kindly consult with the doctor if you have noticed any edema in your feet

    • How long do I have to take Docetaxel injection?

     The duration of this injection may get vary according to The type of cancer you are suffering from. Usually, it is taken once every three weeks.

    • What type of drug is Docetaxel injection?

    It comes under anticancer medication called taxoids which produce its action by inhibiting the growth of cancer cells


    Precautions and general warning of Docetax 80mg Injection

    Alcohol

    Alcohol intake may cause side effects thus caution is required. Kindly consult with your doctor.

    Driving or operating machinery

    Driving or operating heavy machinery may cause side effects thus caution is required. Kindly consult with your doctor.

    Pregnancy

    It is unsafe to use during pregnancy it may cause embryo-fetal toxicity. Kindly consult with your doctor

    Breast Feeding

    It is unsafe to use during breastfeeding. It may cause the toxicity to child. Kindly consult with your doctor.

    Kidney Problem

    It is safe to use for the patient with mild to moderate kidney problems.No dose adjustment required for severe kidney disease patients. Kindly consult with your doctor.

    Liver Disease

    Dose adjustment is required for the patient with liver disease. Kindly consult with your doctor.


    How to Take Docetax 80mg Injection

    Docetax is used only in the presence of a physician.

    It must be given intravenously as a slow infusion drip

    It is compatible is NS and D5W

    Docetaxel is a cytotoxic drug thus it should be disposed of safely

    It must be diluted twice before administration

    Dilution must be done with repeated inversion technique and infused within 1 hr as a slow infusion

    Administer antihistamine, H2 agonist and dexamethasone 30mins before Docetaxal administration

    Store multiuse vials at 8C and bring them down to room temperature before use.

    After therapy has been initiated, do not take more or less of this drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing your dosage without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Docetax 80mg Injection in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.

    The recommended dosage in the case of breast cancer as monotherapy is 60-100mg/m2 IV over 1 hr every 3 weeks

    The recommended dosage in the case of breast cancer as combination therapy is 75mg/m2 IV over 1 hr after administration of doxorubicin and cyclophosphamide given every 3 weeks for 6 cycles

    The recommended dosage in the case of non-small cell lung cancer is 75mg/m2 IV over 1 hr every 3 weeks

    The recommended dosage in the case of gastric cancer is 75mg/m2 IV over 1 hr followed by cisplatin 75mg/m2 over 3 hr infusion followed by 5FU 750mg/m2/d given as 24hrs infusion for 5 days. Treatment is repeated every 3 weeks

    The recommended dosage in the case of head and neck cancer is 75mg/m2 IV over 1 hr followed by cisplatin 75mg/m2 over 3 hr infusion followed by 5FU 750mg/m2/d given as 24hrs infusion for 5 days. Treatment is repeated every 3 weeks for 4 cycles

    The recommended dosage in the case of prostate cancer is 75mg/m2 IV over 1 hr every 3 weeks given with prednisone 5mg taken orally twice a day

    Dosage modification is required in the case of diarrhoea, neutropenia, peripheral neuropathy, renal or hepatic impairment


    Use of Docetax 80mg Injection in children

    It is not recommended in children.


    Use of Docetax 80mg Injection in Elderly Patients

    Docetaxel has been used in few patients 65 years or older.

    Dosage and usage are similar to adults.

    Kindly consult with your doctor


    Other general warnings

    • Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Hepatic impairment
    • Bone marrow suppression – Neutropenia, pancytopenia, thrombocytopenia
    • Fluid retention – edema, pleural effusion
    • GI toxicity – nausea, vomiting, diarrhea, GI hemorhage, perforation, ileus, enterocolitis
    • Pulmonary toxicity - Interstitial pneumonia/pneumonitis, interstitial lung disease and acute respiratory distress syndrome
    • Peripheral neuropathy
    • Cystoid macular edema
    • Tumor lysis syndrome
    • Immunization with live vaccine
    • Secondary malignancy – acute myeloid leukemia, myelodysplastic syndrome, non-hodgkins lymphoma


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have kidney problem

    If you have lung problem

    If you are pregnant or breastfeeding


    General instructions

    Docetaxel is can be given intravenously. Administer antiemetics, antihistamine and steroids before 30mins to Docetaxel IV. Avoid drinking grape juice or eat grape fruit.


    Drug Interaction of Docetax 80mg Injection

    Drug-Drug Interaction

    Apalutamide + Docetaxel 
    Use alternative drugs because the use of apalutamide will decrease the effect of docetaxel by affecting the patient hepatic or intestinal enzymes.

    Deferiprone + Docetaxel
    Use alternative drugs because the combination of this drug either increases the toxicity of the other by pharmacodynamic synergism.

    Erdafitnib + Docetaxel
     Use alternative drug because the use of erdafitnib increase the effect of docetaxel by P-glycoprotein efflux

    Belatacept + Docetaxel
    Therapy should be administered with caution because the combination of this drug increase the immunosuppressive effect which increases the risk of developing an infection

    Ethotoin + Docetaxel
    Therapy should be administered with caution because the use of docetaxel decreases the level of ethotoin by inhibiting the GI absorption

    Drug-Food Interaction

    Do not consume grapefruit or grapefruit juice while you are receiving docetaxel because the use of this increase the blood level of docetaxel and increase the risk of adverse events such as nausea, vomiting, diarrhoea, mouth sores, fluid retention, nerve and muscle pain. 

    Drug-Disease Interaction

    Edema 
    Therapy should be administered with caution because the use of docetaxel cause peripheral edema, generalized edema, pleural effusion, dyspnea, cardiac tamponade, and abdominal distension

    Eye disorders:
    The use of docetaxel is contraindicated because it may cause cystoids macular edema. So, before initiating the treatment do an ophthalmologic test.

    Hepatic dysfunctions:
    Therapy should be administered with caution in patients with hepatic impairment because the use of docetaxel shows a decrease in the total body clearance and an increase in the serum concentration of docetaxel.


    Over Dose

    Kindly consult with your doctor


    Missed Dose

    Kindly consult with your doctor


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 2-8ºC


    Fast Tag

    Docetax is an antineoplastic drug

    It is an antimicrotubular inhibitor

    It contains its active substance Docetaxel

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease.