Brand Name Doloplus 50mg/325mg Tablet
Salt Composition

Diclofenac (50mg) + Paracetamol (325mg)

Strength 50mg + 325mg
Product Form Tablet DT
Pack 10 Tablet(s) in Strip
Storage Store below 30°C
Category

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

SubCategory

Analgesic and Antipyretic

Country of Origin India
Manufacturer

Mankind Pharma Ltd

Manufacturer/Marketer Address Mankind Pharma Ltd, Unit-III, Blocck B & C, Village Kunja, Rampur Ghat Road, Opp. Dental College, Sirmaur, Himachal Pradesh - 173025
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M.R.P : Rs.10.00       Price : Rs.9.20

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10 Tablet(s) in Strip

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    Medical Description of Doloplus 50mg/325mg Tablet

    Doloplus 50mg/325mg Tablet contains Diclofenac (50mg) and Paracetamol (325mg) is a pain-relieving medicine used to treat pain, inflammation, and swelling which are associated with arthritis, ankylosing spondylitis, and it is also used to treat headaches, toothaches, menstrual pain. The combination of this medicine produces its action by inhibiting the release of chemical substances which cause pain and inflammation in your body.


    Doloplus 50mg/325mg Tablet Uses

    It is used in the treatment of the pain.


    Doloplus 50mg/325mg Tablet Benefits

    Pain relief

    The use of this tablet helps to relieve moderate to severe pain in conditions like menstrual cramps, headaches, joints, muscles, rheumatoid arthritis, and osteoarthritis by inhibiting the chemical messengers in the brain.


    Doloplus 50mg/325mg Tablet Indication

    The Doloplus 50mg/325mg Tablet is prescribed in the following indications as a pain reliever.


    Mechanism of action of Doloplus 50mg/325mg Tablet

    Doloplus 50mg/325mg Tablet contains Diclofenac (50mg) and Paracetamol (325mg). Diclofenac is an analgesic and anti-inflammatory medication. It produces its action by inhibiting the cyclooxygenase (COX-1) and (COX-2). Thus it inhibits the synthesis of prostaglandins which is responsible for pain and inflammation. It also inhibits the aggregation and activation of neutrophil and chemotaxis, decreases the proinflammatory cytokine level, and alter the activity of lymphocyte.

    Paracetamol is an analgesic and antipyretic. It produces its action by acting on the hypothalamus to produce antipyresis. It also works peripherally to block the pain impulse generation and it also inhibits the synthesis of prostaglandin synthesis in the central nervous system.


    How Doloplus 50mg/325mg Tablet works

    Doloplus 50mg/325mg Tablet contains Diclofenac (50mg) and Paracetamol (325mg). Diclofenac is an analgesic and anti-inflammatory medication. It produces its action by inhibiting the release of chemical messengers which is responsible for pain and inflammation

    Paracetamol  is an analgesic and antipyretic. It produces its action by the release of chemical messengers which is responsible for pain and fever


    Doloplus 50mg/325mg Tablet Contraindication

    • Do not take this medicine if you are allergic to Diclofenac and Paracetamol
    • It is contraindicated to use this medicine in patients with a history of asthma, urticaria, coronary artery bypass graft surgery.
    • It is contraindicated to use this medicine in patients with severe active liver disease.


    Doloplus 50mg/325mg Tablet Side Effects

    • Edema
    • Headache
    • Dizziness
    • Abdominal pain
    • Constipation
    • Diarrhea
    • Flatulence
    • Heartburn
    • GI ulcers
    • Abnormal renal function
    • Elevated liver enzymes
    • Hepatotoxicity
    • Live failure
    • Pneumonitis
    • Nephrotoxicity


    FAQs for Doloplus 50mg/325mg Tablet

    • Can Doloplus 50mg/325mg Tablet damage your kidneys?

    Long-term use of this medicine may cause renal damage such as protein or blood in urine and painful urination. Kindly monitor the patient's kidney function.

    • Is the Doloplus 50mg/325mg Tablet a good painkiller?

    Yes, the use of this tablet is considered an effective treatment to relieve pain and inflammation.

    • Does the Doloplus 50mg/325mg Tablet make you drowsy?

    Yes, the use of this tablet makes you feel drowsy, fatigue and drowsiness but it is considered a common effect.


    Precautions and general warning of Doloplus 50mg/325mg Tablet

    Alcohol

    It is considered unsafe to consume alcohol while taking this medication. Kindly consult with your doctor.

    Driving or operating machinery

    It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    It is considered unsafe during pregnancy it may produce harmful effects on the fetus. Kindly consult with your doctor.

    Breast Feeding

    It is considered safe during breastfeeding it does not excrete via breast milk. Kindly consult with your doctor.

    Kidney Problem

    The tablet should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

    Liver Disease

    The tablet should be used with caution in patients with severe liver impairment. The use of this medicine required dose modification. Kindly consult with your doctor.


    How to Take Doloplus 50mg/325mg Tablet

    The Tablet is taken orally with food. You should not chew, cut or crush the tablet. Dissolve it in a glass of water. Take this medicine as per the dose and duration advised by your doctor. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.


    Use of Doloplus 50mg/325mg Tablet in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Doloplus 50mg/325mg Tablet in children

    Doloplus 50mg/325mg Tablet is considered unsafe in children who are below 12 years old. Kindly consult with your doctor.


    Use of Doloplus 50mg/325mg Tablet in Elderly Patients

    Doloplus 50mg/325mg Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • Nonsteroidal anti-inflammatory drugs may increase the risk of developing cardiovascular thrombotic events, myocardial infarction, and stroke
    • The use of this medicine also increase the risk of developing serious GI adverse events including bleeding, ulceration, and gastric perforation
    • Therapy should be administered with caution in patients with bronchospasm, cardiac diseases, hepatic porphyria, hypertension, fluid retention, severe renal impairment, smoking, and systemic lupus erythematosus
    • The use of this medicine decrease platelet aggregation and may prolong the bleeding time
    • Therapy should be administered with caution in patients with blood dyscrasias, and bone marrow depression
    • The use of this medicine may increase the risk of hyperkalemia and aseptic meningitis
    • Therapy should be administered with caution in patients with severe hepatic impairment, renal impairment, chronic malnutrition, and G6PD deficiency.
    • The use of this medicine increase the risk of developing hepatotoxicity, and serious skin reactions


    Talk to your doctor if

    • You have a history of gastrointestinal disease
    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You are suffering from anemia
    • You have watery diarrhea, stomach pain, and fever


    General instructions

    Diclofenac (50mg) and Paracetamol (325mg) is a pain-relieving medicine used to treat pain, inflammation, and swelling which are associated with arthritis, ankylosing spondylitis, and it is also used to treat headaches, toothaches, menstrual pain. The combination of this medicine produces its action by inhibiting the release of chemical substances which cause pain and inflammation in your body.


    Drug Interaction of Doloplus 50mg/325mg Tablet

    Drug-Drug Interaction

    Apixaban + Diclofenac

    The use of this drug is contraindicated because the combination of this drug increases the effect of anticoagulation

    Captopril + Diclofenac

    Use alternative drug because the use of the non-steroidal anti-inflammatory drug may decrease the effectiveness of the antihypertensive drug and the combination of these drugs also decrease the renal functions

    Aliskiren + Diclofenac

    Therapy should be administered with caution because the use of diclofenac will decrease the effect of aliskiren by other

    Asenapine + Diclofenac

    Therapy should be administered with caution because the use of diclofenac decreases the effect of asenapine by pharmacodynamic synergism

    Apalutamide + Acetaminophen

    Therapy should be administered with caution because the use of apalutamide will decrease the effect of acetaminophen by increasing its elimination.

    Eltrombopog + Acetaminophen

    Therapy should be administered with caution because the use of eltrombopag increases the levels of acetaminophen by decreasing its metabolism.

    Isoniazid + Acetaminophen

    Isoniazid will increase the effect of acetaminophen by affecting its hepatic enzyme metabolism. Therapy should be administered with caution.

    Colestipol + Acetaminophen

    Colestipol decreases the effect of acetaminophen by inhibiting GI absorption. Use alternative drugs.

    Drug-Food Interaction

    Alcohol

    The use of alcohol should be avoided in patients who are taking this medicine because it may increase the risk of bleeding in the stomach which includes tarry, bloody stools, or coughing up blood while vomiting.  Do not withdraw the medication without consulting with the doctor

    Drug-Disease Interaction

    Asthma

    Therapy should be administered with caution in patients who are having asthma because the use of the non-steroidal anti-inflammatory drug (NSAIDs) to an asthma patient may cause nasal polyposis, pansinusitis, eosinophilia, and rhinitis. Before initiating the therapy ask the patients whether they are allergic to salicylate salts.

    Heart failure

    Therapy should be administered with caution in patients with heart failure because the use of NSAIDs may cause fluid retention and edema

    Hepatotoxicity

    Therapy should be administered with caution in a patient with liver diseases because the use of NSAIDs may increase the serum transaminases, LDH, and alkaline phosphatase. And in rare cases, it may cause hepatotoxicity including liver cirrhosis, jaundice, and hepatic failure

    Hypertension

    Therapy should be administered with caution in patients with hypertension because the use of NSAIDs may increase blood pressure and cardiovascular events. During this course of treatment monitor the patient blood pressure

    Renal toxicities

    Therapy should be administered with caution in a patient with renal diseases because the use of NSAIDs may increase the serum creatinine, BUN, tubular necrosis, glomerulus, renal papillary necrosis, nephrotic syndrome, and cause renal failure.

    Liver diseases + Acetaminophen

    Therapy should be administered with caution in patients with hepatic insufficiency because severe liver injury including acute liver failure resulting in liver transplant and death has been reported in patients using acetaminophen. Patients with hepatic impairment may increase the risk of toxicity due to increased metabolic pathway activity. During acetaminophen-containing treatment, patients should avoid consuming alcohol.

    Alcoholism + Acetaminophen

    Therapy should be administered with caution in patients who are consuming alcohol because severe liver injury including acute liver failure resulting in liver transplant and death has been reported in patients using acetaminophen. During acetaminophen-containing treatment, patients should avoid consuming alcohol. The patient should immediately seek the hospital if they experience signs and symptoms of liver injury such as fever, rash, anorexia, nausea, vomiting, fatigue, dark urine, and jaundice.


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 10-30°C room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Doloplus 50mg/325mg Tablet contains Diclofenac (50mg) and Paracetamol (325mg) is a pain-relieving medicine used to treat pain
    • It produces its action by inhibiting the release of chemical substances which cause pain and inflammation in your body.
    • Kindly inform your doctor if you have a history of heart disease or stroke
    • The tablet is taken orally by mouth with food
    • Monitor the patient's kidney functions, liver function, and levels of blood components
    • Avoid consuming alcohol because it may cause excessive drowsiness and stomach problems