Duovir Tablet

Brand Name Duovir Tablet
Salt Composition Lamivudine (150mg) + Zidovudine (300mg)
Strength 150mg + 300mg
Product Form Tablet
Pack 60 Tablet(s) in Bottle
Storage Store at room temperature (10-30°C)
Category HIV
Country of Origin India
Manufacturer Cipla Ltd.
Manufacturer/Marketer AddressCipla Ltd, Cipla House, Peninsula Business Park, Ganpatrao, kadam Marag, Lower Parel, Mumbai-400013.India
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Duovir Tablet, Lamivudine 150mg, Zidovudine 300mg, Price, Uses, Side Effects - Drugcarts watermark
M.R.P : Rs.1293.54       Price : Rs.1034.83

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    Medical Description of Duovir Tablet

    Duovir tablet contains Zidovudine 300mg and Lamivudine 150mg. Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Duovir tablet is a nucleoside reverse transcriptase inhibitor. Duovir tablet works by reducing the viral load of HIV in your body. Duovir tablet improves your immune system and reduces the risk of conditions associated with HIV infection. Duovir tablet is used in combination with other antivirals for efficiency. It is used in children above 14 kgs of weight and in adults.


    Duovir Tablet Uses

    Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet is used to treat adults and children above 14kgs weight who are infected by HIV-1. Duovir tablet can be taken in combination with other anti-HIV medicines. Your doctor will discuss which combination of medicines is best for you.


    Duovir Tablet Benefits

    Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet is used with other anti-HIV medication to help control HIV infection. Duovir tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. It is a nucleoside reverse transcriptase inhibitor. It is not a cure for HIV infection, it improves immunity that results in longevity of life. It is not recommended for use in children less than 14Kgs of due to the increased risk of serious side effects.


    Duovir Tablet Indication

    Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. Duovir tablet can be used with other antiviral medications to boost the immunity of the affected hosts. Duovir tablet is indicated in ages above 14Kgs of body weight.


    Mechanism of action of Duovir Tablet

    Duovir tablet contains Zidovudine 300mg and Lamivudine 150mg. Zidovudine present in is HIV-1 nucleoside reverse transcriptase inhibitor. Zidovudine is phosphorylated to its active forms Zidovudine triphosphate that incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Lamivudine is HIV-1 nucleoside reverse transcriptase inhibitor. Lamivudine is phosphorylated to its active forms lamivudine triphosphate that incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.


    How Duovir Tablet works

    Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Duovir tablet inhibits the action of HIV-1 reverse transcriptase enzyme by incorporating themselves into the nucleotide sequence thus inhibits the action of the reverse transcriptase of HIV-1, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection and improves immunity.


    Duovir Tablet Contraindication

    Absolute contraindication:

    • if you are allergic to Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet or its components
    • if you are pregnant
    • if you are lactating

    Relative contraindication:

    • if you have a liver disorder like hepatitis B or C or Child-Pugh disease
    • if you have blood disorders like anemia/ neutropenia
    • if you have renal diseases where creatinine clearance rate <50ml/min


    Duovir Tablet Side Effects

    Common side effects that occur 1:10 patients: Headache, insomnia, Cough, nausea, vomiting, abdominal pain or cramps, diarrhoea, Rash, alopecia, Arthralgia, Fatigue, malaise, fever.

    Uncommon side effects that occur 1:100 patients: Neutropenia and anaemia, thrombocytopenia, pancytopenia, raise in AST, ALT levels, Dyspnoea

    Rare side effects that occur 1:1000 patients: Pancreatitis, elevations in serum amylase, Hepatitis, Angioedema, Rhabdomyolysis, Anxiety and depression, Cardiomyopathy, Oral mucosa pigmentation, hepatomegaly with steatosis, Gynaecomastia

    Very rare side effects that occur 1:10,000 patients: Peripheral neuropathy, Pure red cell aplasia, Lactic acidosis, loss of mental acuity, convulsions


    FAQs for Duovir Tablet

    Is Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet safe during pregnancy?

    No, taking Duovir tablet during pregnancy is not recommended. Consult your physician.

    Can Duovir tablet be taken while breastfeeding?

    No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.

    Can Duovir tablet be taken while alcohol consumption?

    The interaction is unknown but this medication causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Duovir tablet?

    This medication causes side effects thus caution is used while driving or operating machineries.

    Can Duovir tablet be used in pediatric HIV treatment?

    No, Duovir tablet at this dosage must be given from weight above 14Kgs only.


    Precautions and general warning of Duovir Tablet

    Alcohol

    Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Duovir tablet causes side effects. For further queries, consult your physician.

    Pregnancy

    The use of Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet is not recommended during pregnancy. Consult your physician.

    Breast Feeding

    The use of Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effect in newborn.

    Kidney Problem

    Renal filtration impairment – monitor function. For further queries, consult your physician.

    Liver Disease

    Liver disorders and diseases like hepatitis B or C, hepatomegaly with steatosis

    Monitor liver function before and during therapy, especially in patients with other


    How to Take Duovir Tablet

    Duovir (Lamivudine (150mg) + Zidovudine (300mg)) tablet is taken orally with or without food.

    Duovir tablet must be taken at the same time once or twice a day as prescribed by your physician.

    Duovir tablets can be taken with other antivirals.

    After therapy has been initiated, do not take more or less Duovir medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing Duovir tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.


    Use of Duovir Tablet in Adult

    If you are pregnant consult your physician

    If you are breastfeeding consult your physician

    The recommended dosage in an adult above 30 Kgs of weight for Duovir tablet is one tablet taken orally twice per day

    Duovir tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken with or without food on a regular time basis.


    Use of Duovir Tablet in children

    Duovir tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken with or without food on a regular time basis.


    Use of Duovir Tablet in Elderly Patients

    Duovir tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Bone marrow suppression – anemia/ neutropenia
    • Pancreatitis - New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
    • Lactic acidosis – hyperlactatemia/ respiratory symptoms/ neurologic symptoms
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • Accumulation or Redistribution of body fat
    • immune reconstitution syndrome.
    • Any sign of infection – fever or lymph node enlargement


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have a kidney problem

    If you are pregnant or breastfeeding


    General instructions

    Duovir tablets can be taken with other antivirals orally as prescribed dosage at a specific time regularly.


    Drug Interaction of Duovir Tablet

    Drug-Drug Interaction

    side effects are increased by Acyclovir, Beclomethasone, Hydroxyurea, Tretinoin, Amphotericin B

    serum concentration is decreased by St. John's Wort, Cholesterol, Acetazolamide, Potassium citrate

    serum concentration is increased by Caffeine, Methadone, Omeprazole, Aceclofenac, Acetaminophen

    Drug-Food Interaction

    Duovir tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. It is best to avoid caffeine. Duovir tablet generally causes side effects thus it is advised not to be taken with alcohol.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
    • Blood disorders – used with caution in hemophilia or anemia. Consult a physician before use.
    • Pancreases disorders – used with caution in pancreatitis. Consult a physician before use


    Over Dose

    Contact your doctor, pharmacist, or nurse immediately.


    Missed Dose

    If you take once a day dosage, then the missed dosage if you notice within 12 hours. If it is more than 12 hours, then skip the dosage and take the next doses as usual. If you take twice a day dosage, then the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30°C


    Fast Tag

    Duovir tablet is a nucleoside reverse transcriptase inhibitor.

    Duovir tablet is used to control and treat HIV infection with other antivirals

    Do not use this medication while pregnancy or lactation period.

    Don’t use this medication with liver disease, kidney disease, and blood disorders.

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.