Egsure 1mg Tablet contains Anastrozole it’s an aromatase inhibitor. It shrinks and stops the progression of abnormal cancer cells. Egsure 1mg Tablet is used in the treatment of breast cancer in postmenopausal women. This medication can be used to treat breast cancer in males when treated with tamoxifen.

Anastrozole acts on breast cells that are stimulated by estrogen receptors causing cancer. Egsure 1mg Tablet is used in the treatment of breast cancer specially in postmenopausal women. This tablet is not used in children.

Egsure 1mg Tablet is used in the treatment of breast cancer that has expressive estrogen receptors. It is recommended only in adults.

Egsure 1mg Tablet is an aromatase inhibitor and antineoplastic medication. It inhibits the multiplication or proliferation of abnormal breast cells by inhibiting the estrogen receptors. This tablet is used in the treatment of breast cancer in post-menopausal women which is metastatic who have positive or negative estrogen receptor.

Egsure 1mg (Anastrozole) is an antineoplastic and an aromatase inhibitor. In postmenopausal women, estrogen is derived from an aromatase enzyme that converts adrenal androgens to estrone and estradiol. Anastrozole is a non-steroidal aromatase inhibitor that reduces serum estrogen and its derivatives levels thus signalling processes for the proliferation of abnormal cells is inhibited. Anastrozole shrinks the abnormal cells and minimises metastasis thus treats and controls cancers or tumors.

Anastrozole is an antineoplastic, antiangiogenic and aromatase inhibitor. It inhibits estrogen receptors thus the signalling process for angiogenesis and proliferation of abnormal cells is inhibited. It minimises the growth of abnormal cancer cells and terminates metastasis of tumors or cancers.

Absolute contraindication:

• if you are allergic to Egsure 1mg (Anastrozole 1mg) Tablet or its constituents
• if you are pregnant
• if you are breastfeeding

Relative contraindication:

• if you have an endocrine disorder
• if you have a heart disorder
• if you have a bone disorder
• if you have cholesterol disorder

Common side effects that occur 1:10 patients: Hot flashes, Vasodilation, Fatigue, Mood disturbances, Nausea and vomiting, Weakness, Arthritis, Pain, Arthralgia, Pharyngitis, Depression, Hypertension, Bone pain, cough, Osteoporosis, Rash

Uncommon side effects that occur 1:100 patients: Back pain, Fracture, Headache, Insomnia, Peripheral edema, Dyspnea, Abdominal pain, Infection, Lymphedema, Diarrhea, Constipation, Breast pain, Dizziness, Urinary tract infection, Chest pain, Dyspepsia, Paresthesia, Anxiety, Cataracts, Sinusitis, Vulvovaginitis, Xerostomia,

Rare side effects that occur 1:1,000 patients: Breast neoplasm, Bronchitis, Cyst, Diaphoresis, Vaginal bleeding, Ischemic cardiovascular disease, Vaginal hemorrhage, Vaginitis, Leukorrhea, Deep vein thrombosis, Endometrial cancer, Ischemic cerebrovascular event, Weight gain, Lethargy, hepatitis, anaphylaxis, hypercalcemia

Is Egsure 1mg (Anastrozole 1mg) Tablet safe during pregnancy?

No, taking Egsure 1mg Tablet during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

Can Egsure 1mg Tablet be taken while breastfeeding?

No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Egsure 1mg Tablet can also pass via breastfeeding.

Can Egsure 1mg Tablet be taken while alcohol consumption?

The interaction is unknown but Egsure 1mg Tablet causes side effects. Thus, consult your physician.

Can I take a drive or operate heavy machineries while on Egsure 1mg Tablet?

Egsure 1mg Tablet causes side effects thus caution is used while driving or operating machineries.

Does Egsure 1mg Tablet cause weight gain or hair loss?

Yes, Egsure 1mg Tablet causes weight gain and hair loss.

Alcohol

Intake of alcohol with Egsure 1mg Tablet causes side effects thus caution is required. Consult your physician.

Driving or operating machinery

Driving or operating heavy machinery with Egsure 1mg Tablet causes side effects thus caution is required. Consult your physician.

Pregnancy

Using Anastrozole during pregnancy may cause embryo-fetal toxicity. Consult your physician.

Breast Feeding

Using Anastrozole during Breastfeeding may cause side effects similar to adults. Consult your physician.

Kidney Problem

Using Anastrozole may lead to renal failure. This therapy monitor kidney functions before and during treatment. Consult your physician.

Liver Disease

During Anastrozole therapy monitor liver function before and during treatment. Consult your physician.

This tablet is taken orally.

This tablet must be taken at the same time once a day as prescribed by your physician.

This tablet should be taken with or without food

This tablet must be swallowed as a whole.

Don’t chew or crush this tablet.

After therapy has been initiated, do not take more or less of Egsure drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing Egsure dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.

If you are pregnant or breastfeeding inform your physician as they are not advisable.

This tablet is not recommended in children.

This tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.

• Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
• Hepatotoxicity– monitor function before and during treatment
• Renal toxicity – renal failure. Monitor function before and during treatment.
• Cardiotoxicity – MI
• Bone mineral disorder
• Pregnancy – causes embryo-fetal toxicity
• Breastfeeding – causes side effects similar to adults
• Alcohol intake or Driving or operating heavy machinery – Egsure 1mg Tablet causes side effects thus caution is required. consult your physician

If you have any allergy

If you have a liver problem

If you have a heart problem

If you are pregnant or breastfeeding

This tablet is taken orally as a prescribed dosage at a specific time regularly with or without food to avoid adverse effects.

Drug-Drug Interaction

Severity of cardiotoxicity is caused by Arsenic trioxide, Bleomycin, Methotrexate

Severity of Thrombosis is caused by Erythropoietin

Serum concentration increased by Mifepristone, Tamoxifen that causes an increase in adverse effects

Drug-Food Interaction

This tablet should be taken with or without food, there is no restriction to food intake, if doubts arise kindly refer to your physician. To avoid diarrhea, take small sips of sugar-free drinks or take small amounts of a meal or take spicy food with the tablet. This tablet generally causes side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution.

Drug-Disease Interaction

• Electrolyte disorders – used with caution in electrolyte imbalance. Consult a physician before use
• Liver disorders – used with caution in severe liver diseases. Consult a physician before use
• Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
• Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
• Respiratory disorders – used with caution in respiratory distress and interstitial lung disorder. Consult a physician before use
• Endocrine disorder – used with caution in hypo and hyperthyroidism. Consult a physician before use.

Overdosage of this tablet has less literature thus Contact your physician.

You can take the missed dosage if you notice within 12 hours. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.

Keep the medication out of children’s reach

Keep the medication away from pets

Once expired dispose immediately

Store at 30°C

Egsure 1mg Tablet is an antiangiogenic antineoplastic medication

Anastrozole is an aromatase inhibitor

This tablet is used to control and treat breast cancer

Do not use this medication while pregnant and lactation period.

Don’t use this medication with liver disease or kidney disease or cardiac disorders.

• Drugs.com. Anastrozole. [Accessed 03 Apr. 2019] (online) Available from: https://www.drugs.com/pregnancy/anastrozole.html
• Anastrozole: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 18 August 2017]. Available from: https://medlineplus.gov/druginfo/meds/a696018.html
• DailyMed - ANASTROZOLE - anastrozole tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 18 August 2017]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a96e22b2-eca3-4438-b959-dc5381085d31
• Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 18 August 2017]. Available from: https://www.tga.gov.au/prescribing-medicines-pregnancy-database

Egsure 1mg Tablet contains Anastrozole 1mg used to treat early-stage breast cancer in postmenopausal women and it is also used as a first-line treatment of advanced breast cancer that has spread to other parts of your body. It works by decreasing the amount of female hormone in the body and stops the growth of cancer cells that required estrogen to grow.

It is used in the treatment of the following conditions as Breast cancer

Breast cancer

It is a type of cancer that forms in the breast cells. It is common among women. Symptoms include breast lump, change in breast size, redness, pitting of the skin, color change, and peeling surrounding the breast skin or nipple. This medicine helps to inhibit the multiplication of cancer cells.

The Egsure 1mg Tablet is prescribed in the following indications as breast cancer in postmenopausal women which is metastatic who has positive or negative estrogen receptors.

Egsure 1mg Tablet contains Anastrozole 1mg is an anti-cancer medication, an aromatase inhibitor. In postmenopausal women, estrogen is derived from an aromatase enzyme that converts adrenal androgens to estrone and estradiol. Anastrozole 1mg is a non-steroidal aromatase inhibitor that reduces serum estrogen and its derivatives levels thus signaling process for the proliferation of abnormal cells is inhibited. Thus it shrinks the abnormal cells and minimizes metastasis thus treating and controlling cancers or tumors.

Egsure 1mg Tablet contains Anastrozole 1mg is an anti-cancer medication, an aromatase inhibitor. It produces its action by inhibiting estrogen receptors thus the signaling process for angiogenesis and proliferation of abnormal cells is inhibited. It minimizes the growth of abnormal cancer cells and terminates metastasis of tumors or cancers.

• Do not take this medicine if you are allergic to Anastrozole
• It is not recommended to use in children
• It is contraindicated to use this medicine during pregnancy

• Hot flashes
• Pain
• Depression
• Hypertension
• Vasodilation
• Mood disturbances
• Abdominal pain
• Diarrhea
• Constipation
• ‘Chest pain

• When can I plan a pregnancy if I am using the Egsure 1mg Tablet?

Avoid planning for pregnancy while you are receiving this medicine and also use an effective contraceptive for at least 3 months after taking the last medicine.

• Does the Egsure 1mg Tablet cause hair loss?

Yes, one of the common side effects of this medicine is hair loss. Kindly consult with your doctor if your symptoms even persist after withdrawal of the medicines.

• How to treat constipation during the treatment?

To treat constipation drink plenty of water a day and keep you active, add fiber to your diet. If you do not have a bowel movement for more than 3 days kindly consult with your doctor.

Alcohol

It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

Driving or operating machinery

It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive, decrease alertness, and make you feel sleepy and drowsy. Kindly consult with your doctor.

Pregnancy

The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

Breast Feeding

The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

Kidney Problem

Therapy should be administered with caution in patients who are having a renal impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.

Liver Disease

Therapy should be administered with caution in patients who are having hepatic impairment. Adjust the dose as per the requirement. Kindly consult with your doctor.

Egsure 1mg Tablet can be taken with or without food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor

It is not recommended to use this medicine in children. Kindly consult with your doctor.

Egsure 1mg Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

• The use of this medicine increases the incidence of developing ischemic cardiovascular events in women with a history of ischemic heart diseases.
• The use of this medicine decreases the lumbar spine and total hip bone mineral density and it also increases the risk for developing fractures and osteoporosis,
• Increased serum cholesterol was reported while you are using this medicine

• You are not responding to the treatment
• You have experienced any allergic reaction like rashes and itching
• You have a receiving any concomitant medication and disease

Anastrozole 1mg is used to treat early-stage breast cancer. It produces its action by inhibiting estrogen receptors thus the signaling process for angiogenesis and proliferation of abnormal cells is inhibited. It minimizes the growth of abnormal cancer cells and terminates metastasis of tumors or cancers.

Drug-Drug Interaction

Estradiol

It is contraindicated to use this medicine because the use of estradiol decreases the effect of anastrozole by pharmacodynamic antagonism.

Tamoxifen

It is contraindicated to use this medicine because the use of tamoxifen decreases the effect of anastrozole by unspecified interaction mechanism.

Palifermin

Use alternative drug because the use of palifermin increase the toxicity of the anastrozole by increasing the severity and duration of oral mucositis

Cholera vaccine

Therapy should be administered with caution because the use of anastrozole decreases the effect of the cholera vaccine by immunosuppressive effects and it also increases the risk of developing an infection

Drug-Food Interaction

No data is available kindly consult with your doctor.

Drug-Disease Interaction

Cardiovascular events

Therapy should be administered with caution in women with a history of ischemic heart diseases because they have a higher incidence of ischemic cardiovascular events while using this medicine

Hepatic dysfunction

Therapy should be administered with caution in patients with severe hepatic impairment because the use of this medicine metabolized in the liver and cause hepatic cirrhosis

Osteoporosis

Therapy should be administered with caution in patients with osteoporosis because the use of this medicine decreases the lumbar spine and bone mineral density.

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 30°C at room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

• Anastrozole 1mg is an anti-cancer medication, an aromatase inhibitor
• It is used to treat breast cancer in postmenopausal women
• Kindly avoid pregnancy while you are taking this medicine
• Kindly check your vitamin D and bone mineral density if needed

• Drugs.com. Anastrozole. [Accessed 03 Apr. 2019] (online) Available from: https://www.drugs.com/pregnancy/anastrozole.html
• Anastrozole: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 18 August 2017]. Available from: https://medlineplus.gov/druginfo/meds/a696018.html
• DailyMed - ANASTROZOLE - anastrozole tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 18 August 2017]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a96e22b2-eca3-4438-b959-dc5381085d31
• Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 18 August 2017]. Available from: https://www.tga.gov.au/prescribing-medicines-pregnancy-database