Egybort 2mg Injection

Brand Name Egybort 2mg Injection
Salt Composition Bortezomib (2mg)
Strength 2mg
Product Form Injection
Pack 1 Injection in 1 Vial
Storage Store at room temperature (10-30°C)
Category Anti-Cancer
Country of Origin India
Manufacturer United Biotech Pvt Limited
Manufacturer/Marketer AddressUnited Biotech Pvt Limited,FC/B-1 (Extn.), Mohan Co-operative Industrial Estate, Mathura Rd, Badarpur, New Delhi, Delhi 110044
-16%
Egybort 2mg Injection, Bortezomib 2mg, price, uses, side Effects - Drugcarts watermark
M.R.P : Rs.11982.15       Price : Rs.10065.01

You Save : Rs.1,917.14    Inclusive of all taxes

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1 Injection in 1 Vial

Availability : In Stock


    Medical Description of Egybort 2mg Injection

    Egybort 2mg Injection contains Bortezomib 2mg it is an antineoplastic agent and proteasome inhibitor. This medication is not recommended in paediatric. Egybort 2mg Injection is used in the treatment of mantle cell lymphoma and multiple myeloma.


    Egybort 2mg Injection Uses

    Egybort 2mg Injection is used in the treatment of bone marrow cancer and cancer that affects the immune system. It is not used in children.


    Egybort 2mg Injection Benefits

    Egybort 2mg Injection is used in the treatment of mantle cell lymphoma and multiple myeloma. It is not recommended in children.


    Egybort 2mg Injection Indication

    Egybort 2mg Injection is indicated in the treatment of:

    • Mantle cell lymphoma
    • Multiple myeloma


    Mechanism of action of Egybort 2mg Injection

    Bortezomib is an antineoplastic and an antiangiogenic agent. Bortezomib is a proteasome inhibitor that targets the ubiquitin-proteasome pathway.  Bortezomib assisted proteasome inhibits alters regulatory protein like NF-kB activation which is required for signalling required for cell growth, survival, and metastasis of abnormal cells. Thus, inhibiting the action of proteasome results in the ceasing of the cell cycle that causes the proliferation of abnormal cells and induces apoptosis.


    How Egybort 2mg Injection works

    Bortezomib is an antineoplastic agent that inhibits the function of regulatory proteins like NF-kB present in the ubiquitin-proteasome pathway. Thus, the proliferation of abnormal cells is inhibited and apoptosis is induced which results in the slow progression of tumor and controls multiple myeloma and mantle cell lymphoma.


    Egybort 2mg Injection Contraindication

    Absolute contraindication:

    • if you are allergic to Egybort 2mg (Bortezomib 2mg) Injection or its constituents
    • if you are pregnant
    • if you are breastfeeding
    • if you are less than 18 years of age

    Relative contraindication:

    • if you have a lung disorder like acute diffuse infiltrative pulmonary disease
    • if you have heart disease
    • if you have a blood disorder
    • if you had herpes zoster infection
    • if you had hepatitis B or C infection
    • if you have a nervous disorder
    • if you have renal disorders


    Egybort 2mg Injection Side Effects

    Common side effects that occur 1:10 patients: Asthenia, Nausea, Diarrhea, Anorexia, Constipation, Thrombocytopenia, Peripheral neuropathy, Pyrexia, Vomiting, Anemia, Arthralgia, Headache, Insomnia, Limb pain, Dizziness, Dyspnea, Edema, Neutropenia, Paresthesia, Rash, Cough, Dehydration, URI, Rigors

    Uncommon side effects that occur 1:100 patients: Atrioventricular block complete, cardiac tamponade, Ischemic colitis, hepatitis, acute pancreatitis, Encephalopathy, dysautonomia, progressive multifocal leukoencephalopathy, acute diffuse infiltrative pulmonary disease, PRES, herpes meningoencephalitis, DIC, Acute diffuse infiltrative pulmonary disease, epidermal necrolysis, Sweet’s syndrome, Optic neuropathy, deafness bilateral, blindness, and ophthalmic herpes


    FAQs for Egybort 2mg Injection

    Is Egybort 2mg (Bortezomib 2mg) Injection safe during pregnancy?

    No, taking Egybort 2mg Injection during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    Can Egybort 2mg Injection be taken while breastfeeding?

    No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Egybort 2mg Injection can also pass via breastfeeding.

    Can Egybort 2mg Injection be taken while alcohol consumption?

    Egybort 2mg Injection is unknown but this medication causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Egybort 2mg Injection?

    Egybort 2mg Injection causes side effects thus caution is used while driving or operating machineries.

    Does Egybort 2mg Injection cause fertility problems?

    Yes, Egybort 2mg Injection decreases male and female fertility, consult your physician.


    Precautions and general warning of Egybort 2mg Injection

    Alcohol

    Intake of alcohol with Egybort 2mg Injection causes side effects thus caution is required. Consult your physician.

    Driving or operating machinery

    Driving or operating heavy machinery with Egybort 2mg Injection causes side effects thus caution is required. Consult your physician

    Pregnancy

    Using Bortezomib during pregnancy may cause embryo-fetal toxicity. Consult your physician.

    Breast Feeding

    Using Bortezomib during Breastfeeding may cause side effects similar to adults. Consult your physician.

    Kidney Problem

    Using Bortezomib may lead to mild proteinuria. Consult your physician.

    Liver Disease

    Using Bortezomib may cause hepatitis/jaundice. Consult your physician.


    How to Take Egybort 2mg Injection

    This injection is used only in the presence of a physician.

    This injection can be given intravenously or as a subcutaneous injection into the thigh or abdomen

    This injection should not be given intrathecally.

    This injection must be taken on schedule as prescribed by your physician.

    After therapy has been initiated, do not take more or less of Egybort drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing Egybort dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Egybort 2mg Injection in Adult

    This injection is not recommended in children.


    Use of Egybort 2mg Injection in children

    This injection is not recommended in children.


    Use of Egybort 2mg Injection in Elderly Patients

    This injection has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Peripheral neuropathy
    • Heart event – hypotension, congestive heart failure, prolonged QT syndrome
    • Pulmonary toxicity – ARDS, acute diffuse infiltrative pulmonary disease
    • Reversible posterior leukoencephalopathy syndrome
    • Gastrointestinal toxicity – perforation
    • Co-infection – neutropenia/ thrombocytopenia
    • Tumor lysis syndrome
    • Hepatotoxicity – hepatitis/jaundice
    • Renal toxicity – mild proteinuria
    • Pregnancy – causes embryo-fetal toxicity
    • Breastfeeding – causes side effects similar to adults
    • Alcohol intake or Driving or operating heavy machinery – Egybort 2mg Injection causes side effects thus caution is required. consult your physician


    Talk to your doctor if

    • If you have any allergy
    • If you have a liver problem
    • If you have a kidney problem
    • If you are pregnant or breastfeeding


    General instructions

    Egybort 2mg Injection is can be given intravenously with 0.9% NaCl. Do not shake the vial before use. Add 3.5ml for 1mg/ml concentration and give them as IV infusion. Add 1.4ml for 2mg/ml concentration and give them as SC injection. Store the vials at room temperature.


    Drug Interaction of Egybort 2mg Injection

    Drug-Drug Interaction

    Serum concentration is increased by Arsenic trioxide, Erythromycin

    Serum concentration is decreased by Dexamethasone, Levothyroxine, Mifepristone, St. John's Wort

    Severity of adverse effects is increased by Allopurinol, Fludrocortisone, Interferon alfa, Methotrexate

    Drug-Food Interaction

    Avoid taking grapes, grape juice and flavonoids like green vegetables, fruits, and green tea while taking this injection. Also, avoid vitamin C. This injection can be taken with any type of food, if doubts arise kindly refer to your physician. It generally causes side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use


    Over Dose

    In the case of Overdosage with this injection. Contact your physician.


    Missed Dose

    Consult your physician immediately.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at room temperature


    Fast Tag

    Egybort 2mg Injection is an antineoplastic medication

    Bortezomib is a proteasome inhibitor

    This injection is used to control and treat multiple myeloma and mantle cell lymphoma.

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease or renal diseases or cardiac disorders.







Egybort 2mg Injection

Brand Name Egybort 2mg Injection
Salt Composition Bortezomib (2mg)
Strength 2mg
Category Anti-Cancer
Country of Origin India
-20%
image
M.R.P : Rs.11982.15       Price : Rs.9585.72

You Save : Rs.2,396.43    Inclusive of all taxes

- +

Availability : In Stock


    Medical Description of Egybort 2mg Injection

    Egybort 2mg Injection contains Bortezomib 2mg used to treat Mantle cell lymphoma, and Multiple myeloma. It works by inhibiting the growth and multiplication by increasing the number of proteins in the cancer cells. It is not recommended in pediatrics.


    Egybort 2mg Injection Uses

    It is used in the treatment of the following conditions as Mantle cell lymphoma, and Multiple myeloma.  


    Egybort 2mg Injection Benefits

    Multiple myeloma

    It is also called Kahler’s disease. It is a type of cancer that occurs in a plasma cell. In this condition, cancer gets accumulated in the bone marrow and affects healthy blood cells. Symptoms include constipation, loss of appetite, fatigue, bone pain, weight loss, frequent infections, excessive thirst, and numbness in your legs.

    Mantle cell lymphoma

    It is a type of non-Hodgkin's lymphoma cancer. It usually affects a part of your immune system called the lymphatic system. It occurs when there is a change in the DNA of white blood cells called B lymphocytes. Symptoms include night sweats, belly pain, enlarged tonsils, fatigue, pain in the lower back, fever, weight loss, and loss of appetite. 


    Egybort 2mg Injection Indication

    The Egybort injection is prescribed in the following indications as Mantle cell lymphoma, and Multiple myeloma.  


    Mechanism of action of Egybort 2mg Injection

    Egybort 2mg Injection contains Bortezomib 2mg is an anti-cancer medication, Proteasome inhibitors. It produces its action by targeting the ubiquitin-proteasome pathway. This alters regulatory protein like NF-kB activation which is required for signaling and cell growth, survival, and metastasis of abnormal cells. Thus, inhibiting the action of proteasome results in the ceasing of the cell cycle that causes proliferation of abnormal cells and induces apoptosis.


    How Egybort 2mg Injection works

    Egybort 2mg Injection contains Bortezomib 2mg is an anti-cancer medication, Proteasome inhibitors. It produces its action by inhibiting the breakdown of protein in cells which results in an increase in the number of proteins in the cancer cells and leads to cell death.


    Egybort 2mg Injection Contraindication

    Do not take this medicine if you are allergic to Bortezomib


    Egybort 2mg Injection Side Effects

    • Asthenia
    • Nausea
    • Diarrhea
    • Constipation
    • Peripheral neuropathy
    • Insomnia
    • Limb pain
    • Dizziness
    • Rash
    • Cough
    • Dehydration
    • Back pain
    • Blurred vision
    • Abdominal pain


    FAQs for Egybort 2mg Injection

    • Can Egybort 2mg Injection affect my lungs?

    Yes, the use of this medicine can affect your lungs. Kindly consult with your doctor if you have experienced shortness of breath, confusion, dry cough, dizziness, and extreme fatigue.

    • I am experiencing nausea and fatigue. Is this due to Egybort 2mg Injection?

    Yes, the common side effect of this medicine is nausea and fatigue so it is better to eat more frequent meals to decrease nausea and also avoid foods that are salty, spicy, fatty. Drink plenty of rest and do light exercise to keep yourself active

    • How to treat constipation during the treatment?

    To treat constipation drink plenty of water a day and keep you active, add fiber to your diet. If you do not have a bowel movement for more than 3 days kindly consult with your doctor.


    Precautions and general warning of Egybort 2mg Injection

    Alcohol

    It is unsafe to consume alcohol while you are receiving this medicine, Kindly consult with your doctor.

    Driving or operating machinery

    It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

    Kidney Problem

    Therapy should be administered with caution in patients with renal impairment. Kindly adjust the dose if it is necessary. Kindly consult with your doctor.

    Liver Disease

    Therapy should be administered with caution in patients with hepatic impairment. Kindly adjust the dose if it is necessary. Kindly consult with your doctor.


    How to Take Egybort 2mg Injection

    Egybort 2mg Injection comes in a liquid solution as an intravenous. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.


    Use of Egybort 2mg Injection in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Egybort 2mg Injection in children

    Safety and efficacy were not established. Kindly consult with your doctor.


    Use of Egybort 2mg Injection in Elderly Patients

    Egybort 2mg Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • Therapy should be administered with caution in patients with hepatic impairment
    • The use of this medicine associated with thrombocytopenia and neutropenia
    • Nausea, diarrhea, constipation, and vomiting may occur while you are receiving this medicine so use antiemetic and antidiarrheal medication
    • Kindly avoid pregnancy during this therapy because it may cause embryo-fetal harm
    • Acute respiratory distress syndrome such as pneumonitis, interstitial pneumonia, and lung infiltration has occurred
    • Posterior reversible encephalopathy syndrome and hypotension was reported


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease
    • You develop shortness of breath


    General instructions

    Bortezomib 2mg is used to treat mantle cell lymphoma and Multiple myeloma. It produces its action by inhibiting the breakdown of protein in cells which results in an increase in the number of proteins in the cancer cells and leads to cell death.


    Drug Interaction of Egybort 2mg Injection

    Drug-Drug Interaction

    Eliglustat

    It is contraindicated to use this medicine because the use of bortezomib increases the effect of eliglustat by affecting its hepatic and intestinal enzyme metabolism

    Mefloquine

    Use alternative drugs because the use of mefloquine increases the toxicity of bortezomib by QTc interval

    Benazepril

    Therapy should be administered with caution because the combination of this medicine either increases the effect of the other by pharmacodynamic synergism and it also increases the risk of developing hypotension

    Clopidogrel

    Therapy should be administered with caution because the use of bortezomib decreases the effect of clopidogrel by decreasing its metabolism

    Dichlorphenamide

    Therapy should be administered with caution because the combination of this medicine decreases the serum potassium

    Drug-Food Interaction

    Consuming green tea interferes with the antitumor effect of bortezomib. Kindly avoid green tea while you are receiving this medicine.

    Drug-Disease Interaction

    Cardiac toxicity

    The use of this medicine may cause acute development of congestive heart failure and decrease left ventricular ejection fraction.

    Diabetes

    Therapy should be administered with caution because the use of this medicine may cause hypoglycemia and hyperglycemia

    Hepatotoxicity

    Therapy should be administered with caution in patients with hepatic impairment because the use of this medicine may cause acute liver failure, hepatitis and also increase liver enzymes and hyperbilirubinemia.

    Pulmonary toxicity

    Therapy should be administered with caution in patients with cardiopulmonary pathologies because it may cause acute respiratory distress syndrome and acute diffuse infiltrative pulmonary diseases.


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 30°C at room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Bortezomib 2mg is an anti-cancer medication, a Proteasome inhibitors
    • It is used to treat mantle cell lymphoma and Multiple myeloma
    • Do not withdraw the medicine without consulting with a doctor
    • Use non-hormonal methods of contraception to avoid pregnancy because the use of this medicine may cause fetal harm
    • Kindly consult with your doctor if you have experienced shortness of breath, chest pain, loss of appetite, and dark urine while you are receiving this medicine