Emduo 40 Tablet

Brand Name Emduo 40 Tablet
Salt Composition

Lamivudine (150mg) + Stavudine (40mg)

Strength 150mg + 40mg
Product Form Tablet
Pack 10 Tablet(s) in Strip
Storage Store below 30°C
Category

HIV

SubCategory

HIV

Country of Origin India
Manufacturer

Emcure Pharmaceuticals Ltd

Manufacturer/Marketer Address Emcure Pharmaceuticals Ltd./Add:255/2, Hinjawadi, Pune - 411057, India
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M.R.P : Rs.122.30       Price : Rs.95.39

You Save : Rs.26.91    Inclusive of all taxes

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10 Tablet(s) in Strip

Availability : In Stock


    Medical Description of Emduo 40 Tablet

    Emduo 40 Tablet contains Lamivudine 150mg and stavudine 40mg. Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Emduo 40 tablet is a nucleoside reverse transcriptase inhibitor. Emduo 40 tablet works by reducing the viral load of HIV in your body. It improves your immune system and reduces the risk of conditions associated with HIV infection.


    Emduo 40 Tablet Uses

    Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is used to treat adults and children above 12 years of age who are infected by HIV-1. Emduo 40 tablet can be taken in combination with other anti-HIV medicines. Your doctor will discuss which combination of medicines is best for you.


    Emduo 40 Tablet Benefits

    Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is used with other anti-HIV medicines to help control HIV infection. Emduo 40 tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Emduo 40 tablet is nucleoside reverse transcriptase inhibitor. It is not a cure for HIV infection, it improves immunity that results in longevity of life. It is not recommended for use in children less than 12 years of age due to the increased risk of serious side effects.


    Emduo 40 Tablet Indication

    Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. Emduo 40 tablet is used with other antiviral medications to boost the immunity of the affected hosts. Emduo 40 tablet is indicated in ages above 12 years of age.


    Mechanism of action of Emduo 40 Tablet

    Emduo 40 tablet contains Lamivudine 150mg and Stavudine 40mg. Lamivudine present in Emduo 40 tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Lamivudine is phosphorylated to its active forms lamivudine triphosphate that is incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Stavudine is a nucleoside reverse transcriptase inhibitor that is phosphorylated into stavudine -5- triphosphate. Stavudine-5-triphosphate battle with deoxythymidine triphosphate and incorporate themselves into the DNA of HIV molecular structure. After they incorporate within the DNA of HIV molecule the further process such as transcription, reverse transcriptase enzyme is inhibited. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.


    How Emduo 40 Tablet works

    Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Emduo 40 tablet inhibits the action of HIV-1 reverse transcriptase enzyme by incorporating themselves into the nucleotide sequence thus inhibits the action of the reverse transcriptase of HIV-1, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection and improves immunity.


    Emduo 40 Tablet Contraindication

    Absolute contraindication:

    • if you are allergic to Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet and its contents
    • if you are pregnant
    • if you are breastfeeding

    Relative contraindication:

    • if you have a liver disorder like hepatitis B or C or Child-Pugh disease
    • if you have neurologic disorders
    • if you have pancreatitis
    • if you have renal diseases
    • if you are diabetic


    Emduo 40 Tablet Side Effects

    Common side effects that occur 1:10 patients: Headache, Cough, nausea, vomiting, abdominal pain or cramps, diarrhoea, Rash, alopecia, Arthralgia, Myalgia, Fatigue, malaise, fever, Back pain. Neutropenia, Thrombocytopenia, increase in AST, ALT bilirubin levels.

    Uncommon side effects that occur 1:100 patients: anaemia, Insomnia, Anxiety, Depression, Pancreatitis, Peripheral neuropathy

    Rare side effects that occur 1:1000 patients: Pure red cell aplasia, Lactic acidosis, Pancreatitis, elevations in serum amylase, Hepatitis, Angioedema, Rhabdomyolysis, cardiomyopathy, convulsions, lipodystrophy, lactic acidosis

    Very rare side effects that occur 1:10,000 patients: erythema multiform, Stevens–Johnson syndrome, toxic epidermal necrolysis, hepatic failure


    FAQs for Emduo 40 Tablet

    Is Emduo40 (Lamivudine (150mg) + Stavudine (40mg)) tablet safe during pregnancy?

    No, taking Emduo 40 tablet during is not recommended unless the pros outweigh the cons. Consult your physician.

    Can Emduo 40 tablet be taken while breastfeeding?

    No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.

    Can Emduo 40 tablet be taken while alcohol consumption?

    The interaction is unknown but this medication causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Emduo 40 tablet?

    This medication causes side effects thus caution is used while driving or operating machineries.

    Is Emduo 40 tablet habit forming?

    No, Emduo 40 tablet is not habit-forming.


    Precautions and general warning of Emduo 40 Tablet

    Alcohol

    Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, Consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet causes side effects. For further queries, consult your physician.

    Pregnancy

    The use of Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is not recommended during pregnancy unless the pros outweigh the cons.

    Breast Feeding

    The use of Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.

    Kidney Problem

    Renal filtration impairment – monitor function.

    Liver Disease

    Liver disorders and diseases like hepatitis B or C, Child-Pugh disease

    Monitor liver function before and during therapy


    How to Take Emduo 40 Tablet

    Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is taken orally without food.

    Emduo 40 tablet must be taken at the same time every day as prescribed by your physician.

    Emduo 40 tablet can be taken with other antivirals.

    After therapy has been initiated, do not take more or less of Emduo 40 medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing Emduo 40 tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.


    Use of Emduo 40 Tablet in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.

    The recommended dosage for Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is one tablet taken twice per day

    Emduo 40 tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake


    Use of Emduo 40 Tablet in children

    The recommended dosage is one tablet of Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet taken twice a day on empty stomach.

    Emduo 40 tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake

    Caution is used in cases where the creatine clearance rate is <50ml/min


    Use of Emduo 40 Tablet in Elderly Patients

    Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Pancreatitis
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
    • Accumulation or Redistribution of body fat or
    • immune reconstitution syndrome.
    • Any sign of infection – fever or lymph node enlargement

      If you have any allergy

      If you have a liver problem

      If you have a kidney problem

      If you are pregnant or breastfeeding


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have a kidney problem

    If you are pregnant or breastfeeding


    General instructions

    Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is taken with other antivirals orally as prescribed dosage at a specific time regularly.


    Drug Interaction of Emduo 40 Tablet

    Drug-Drug Interaction

    Serum concentration decreased by Acetazolamide, Potassium citrate

    Serum concentration increased by Aceclofenac, Acetaminophen, Alprazolam

    severity of adverse effects is increased by Acyclovir, Amphotericin B, Baclofen

    Drug-Food Interaction

    Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Emduo 40 tablet generally causes side effects thus it is advised not to be taken with alcohol.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
    • Pancreases disorders – used with caution in pancreatitis. Consult a physician before use


    Over Dose

    Contact your doctor, pharmacist or nurse immediately.


    Missed Dose

    If you take twice a day dosage, then the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Always take with other antivirals Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30°C


    Fast Tag

    Emduo 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is a nucleoside reverse transcriptase inhibitor.

    Emduo 40 tablet is used to control and treat HIV infection with other antivirals

    Do not use this medication while pregnant or lactation period.

    Don’t use this medication with liver disease and kidney diseases.

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.