Emsulfan 60mg Injection

Brand Name Emsulfan 60mg Injection
Salt Composition

Busulfan (60mg)

Strength 60mg
Product Form Injection
Pack 1 Injection in 1 Vial
Category

Anti-Cancer

SubCategory

Blood Cancer

Country of Origin India
Manufacturer

Emcure Pharmaceuticals Ltd

Manufacturer/Marketer Address Emcure Pharmaceuticals Ltd./Add:255/2, Hinjawadi, Pune - 411057, India
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M.R.P : Rs.5500.00       Price : Rs.4400.00

You Save : Rs.1,100.00    Inclusive of all taxes

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1 Injection in 1 Vial

Availability : In Stock

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    Medical Description of Emsulfan 60mg Injection

    Emsulfan 60mg Injection contains Busulfan 60mg used in the treatment of chronic myeloid leukemia and It is used with other anti-cancer medication during Hematopoietic stem cell transplantation. It is used alone or in combination with other medications.


    Emsulfan 60mg Injection Uses

    It is used in the treatment of the following conditions as chronic myeloid leukemia

     


    Emsulfan 60mg Injection Benefits

    Chronic myeloid leukemia

    It is an uncommon type of bone marrow cancer and it increases the number of white blood cells in the blood. It is caused by changes in the stem cells produced by the bone marrow. Symptoms include bone pain, bleeding, loss of appetite, night sweats, fatigue, and weight loss.

    Hematopoietic Stem Cell Transplantation

    It is an intravenous infusion of hematopoietic stem cells for the production of blood cells in patients whose immune system is weakened or damaged.


    Emsulfan 60mg Injection Indication

    The Emsulfan 60mg Injection is prescribed in the following indications as

    • chronic myelogenous leukemia like myeloid, myelocytic, and granulocytic type
    • As an orphan drug in the treatment of brain malignancy, stem cell transplantation, and CML Ph type.


    Mechanism of action of Emsulfan 60mg Injection

    Emsulfan 60mg Injection contains Busulfan 60mg is an anti-cancer medication, alkylating agent. It produces its action by interfering with DNA replication and transcription of RNA. It cause inter and intra cross-links between DNA strands and affects myeloid cells more than lymphoid cells due to its immunosuppressive activity. Thus, inhibits proliferation and induces apoptosis of abnormal cancer cells. It is not used as a cure for leukemia or lymphoma


    How Emsulfan 60mg Injection works

    Emsulfan 60mg Injection contains Busulfan 60mg is an anti-cancer medication, alkylating agent. It produces its action by damaging the DNA and RNA of the cancer cells. This induces apoptosis and inhibits the proliferation of abnormal cancer cells.


    Emsulfan 60mg Injection Contraindication

    • Do not take this medicine if you are allergic to Busulfan
    • It is contraindicated to use this medicine in patients who are without a diagnosis of chronic myelogenous leukemia


    Emsulfan 60mg Injection Side Effects

    • Neutropenia
    • Thrombocytopenia
    • Nausea
    • Anorexia
    • Diarrhea
    • Fever
    • Insomnia
    • Headache
    • Anemia
    • Pain
    • Hypocalcemia
    • Hyperkalemia


    FAQs for Emsulfan 60mg Injection

    • Does Emsulfan 60mg Injection cause hair loss and Constipation?

    No, the use of this medicine does not cause hair loss and constipation

    • What if I don’t get better after using the Emsulfan 60mg Injection?

    Kindly consult with your doctor even you didn’t feel well after completing the full course of treatment.

    • What lab tests are important before starting the Emsulfan 60mg Injection?

    Your doctor will advise you to take blood pressure, thyroid function, kidney function, liver, and pancreatic function tests, complete blood count, urine test


    Precautions and general warning of Emsulfan 60mg Injection

    Alcohol

    It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is not clear that the use of this medicine will affect the ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor

    Kidney Problem

    It is considered safe to use this medicine in patients who are having a renal impairment. Kindly consult with your doctor.

    Liver Disease

    Limited information is available regarding the use of this medicine in patients who are having a history of hepatic impairment. Kindly consult with your doctor.


    How to Take Emsulfan 60mg Injection

    Emsulfan 60mg Injection comes in a liquid for intravenous use only. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.


    Use of Emsulfan 60mg Injection in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Emsulfan 60mg Injection in children

    Safety and efficacy were not established in children who are below 18 years old. Kindly consult with your doctor.


    Use of Emsulfan 60mg Injection in Elderly Patients

    Emsulfan 60mg Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    Other general warnings

    • The use of this medicine may cause bone marrow depression, ovarian failure, seizure, and secondary malignancies were reported
    • Cardiac tamponade was reported in children who are with thalassemia in combination with cyclophosphamide
    • The use of this medicine may increase the risk of developing hepatic veno-occlusive diseases
    • Bronchopulmonary dysplasia with pulmonary fibrosis was reported
    • Therapy should be administered with caution in patients who are having a history of seizures, head trauma


    Talk to your doctor if

    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a receiving any concomitant medication and disease


    General instructions

    Busulfan 60mg is used in the treatment of chronic myeloid leukemia. It produces its action by damaging the DNA and RNA of the cancer cells. This induces apoptosis and inhibits the proliferation of abnormal cancer cells.


    Drug Interaction of Emsulfan 60mg Injection

    Drug-Drug Interaction

    Tofacitinib

    Use alternative drug because the combination of this medicine either increases the toxicity of the other by immunosuppressive effect and it also increases the risk for developing an infection

    Abametapir

    Use alternative drugs because the use of abametapir will increase the effect of busulfan by affecting the hepatic and intestinal enzyme metabolism.

    Acetaminophen

    Therapy should be administered with caution because the use of acetaminophen increases the effect of busulfan by decreasing its metabolism.

    Deferasirox

    Therapy should be administered with caution because the use of deferasirox increases the toxicity of busulfan by unspecified interaction mechanisms.

    Phenytoin

    Therapy should be administered with caution because the use of phenytoin decreases the effect of busulfan by increasing its hepatic clearance.

    Drug-Food Interaction

    No data available kindly consult with your doctor

    Drug-Disease Interaction

    Infections

    The use of this medicine is contraindicated in patients who are having the infectious disease because of their cytotoxic effect their induce myelosuppression.

    Bone marrow suppression

    Therapy should be administered with caution in patients with a bone marrow reserve who is depressed because the use of this medicine suppresses the bone marrow function.

    Cardiac tamponade

    Therapy should be administered with caution in patients with thalassemia because Cardiac tamponade was reported in children who are with thalassemia in combination with cyclophosphamide


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 2-8°C room temperature.
    • Do not freeze
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Emsulfan 60mg Injection is an antineoplastic agent used in the treatment of chronic myeloid leukemia and It is used with other anti-cancer medications during Hematopoietic stem cell transplantation.
    • Do not self-administer by your own
    • Closely monitor the patient kidney function and blood cell count while you are receiving this medicine
    • Kindly inform your doctor if you have experienced headache, stomach pain, and blood in your stool and urine while you are receiving this medicine