Enfeira 500mg Injection

Brand Name Enfeira 500mg Injection
Salt Composition Rituximab (500mg)
Strength 500mg
Product Form Injection
Pack 50 ml in 1 vial
Storage Store at room temperature (10-30°C)
Category Anti-Cancer
Country of Origin India
Manufacturer Zydus Cadila
Manufacturer/Marketer AddressZydus Cadila,Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
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Enfeira 500mg Injection, Rituximab 500mg Injection, Price, Uses, Side effects – Drugcarts watermark
M.R.P : Rs.40502.00       Price : Rs.32401.60

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50 ml in 1 vial

Availability : In Stock

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    Medical Description of Enfeira 500mg Injection

    Enfeira 500mg Injection contains Rituximab 500mg used to treat Non-Hodgkin lymphoma, Rheumatoid arthritis, Chronic lymphocytic leukemia, Granulomatosis with polyangiitis, Pemphigus Vulgaris, and Microscopic polyangiitis. It is used alone or with other combinations.


    Enfeira 500mg Injection Uses

    It is used in the treatment of the following conditions as Non-Hodgkin lymphoma, Rheumatoid arthritis, Chronic lymphocytic leukemia, Granulomatosis with polyangiitis, Pemphigus Vulgaris, and Microscopic polyangiitis


    Enfeira 500mg Injection Benefits

    Rheumatoid arthritis

    It is a chronic inflammatory disease that affects many joints. It usually occurs when your body's immune system attacks healthy tissue in your joints. Symptoms include tender, inflamed joints, fatigue, fever, and loss of appetite.  

    Non-Hodgkins leukemia

    It is also known as Non-Hodgkin’s disease, cancer in part of your immune system called the lymphatic system. It occurs when there is a change in the DNA of white blood cells called B lymphocytes. Symptoms include fever, night sweats, weight loss, severe itching, increased sensitivity, and swelling of lymph nodes.

    Chronic lymphatic leukemia

    It is a type of blood and bone marrow cancer. The exact cause is unknown but it is assumed that some changes happen in the DNA of blood-producing cells. It progresses more slowly when compared with other leukemia. Symptoms include inflamed lymph nodes, fever, night sweats, weight loss, enlarged spleen, fatigue, and frequent infections.

    Granulomatosis with polyangiitis

    It is also called Wegener’s granulomatosis which causes inflammation of the blood vessels in your nose, sinuses, throat, lungs, and kidneys. Symptoms include cough, shortness of breath, fever, fatigue, joint pain, blood in urine, weight loss, skin sores, eye redness, blurred vision, and hearing problem.

    Microscopic polyangiitis

    It is an uncommon condition that causes inflammation of the blood vessel in your kidneys, lung, nerves, skin, and joints. Symptoms include dark-colored urine, weight loss, fever, fatigue, muscle, and joint pain.

    Pemphigus Vulgaris

    It is an autoimmune disease that blisters and sores in the mouth and genitals. It usually occurs when your body produces antibodies that damage your skin cells. Symptoms include blisters, itching, and redness.


    Enfeira 500mg Injection Indication

    The Enfeira 500mg Injection is prescribed in the following indications as

    • Non-Hodgkin lymphoma who has relapsed or follicular type with CD20 positive and B cell-based
    • Chronic lymphocytic leukemia
    • Rheumatoid arthritis
    • Wegener granulomatosis
    • Microscopic polyangiitis
    • Pemphigus Vulgaris

    It is used as an orphan drug in the case of idiopathic thrombocytopenic purpura and Rasmussen encephalitis


    Mechanism of action of Enfeira 500mg Injection

    Enfeira 500mg Injection contains Rituximab 500mg is an anti-cancer medication, a monoclonal CD20 antibody. It produces its action by binding with CD20 antigen which is located on premature and mature B cells lymphocytes. CD20 regulates initiation and differentiation of cell cycle thus promoting B cell lysis initiated by complement dependant cytotoxicity, and antibody-mediated cell-mediated cytotoxicity thus cell death occurs.


    How Enfeira 500mg Injection works

    Enfeira 500mg Injection contains Rituximab 500mg is an anti-cancer medication, a monoclonal CD20 antibody. It produces its action by binding to the receptor of CD20 surface antigen present on B cell lymphocytes. Enfeira 500mg Injection promotes abnormal B cell lysis thus apoptosis is triggered to control and treat B cell dependant types of cancers and related conditions.

     


    Enfeira 500mg Injection Contraindication

    • Do not take this medicine if you are allergic to Rituximab
    • It is contraindicated to use this medicine in a patient who is having an active infection and with severe immunocompromise.

     


    Enfeira 500mg Injection Side Effects

    • Abdominal pain
    • Cough
    • Infection
    • Night sweats
    • Diarrhea
    • Insomnia
    • Peripheral edema
    • Fatigue
    • Hypertension
    • Hair loss
    • Flushing
    • Anemia
    • Conjunctivitis


    FAQs for Enfeira 500mg Injection

    • Does Enfeira 500mg Injection cause hair loss?

    Yes, one of the common side effects of this medicine is hair loss. Kindly consult with your doctor if your symptoms even persist after withdrawal of the medicines.

    • Can I stop using Enfeira 500mg Injection immediately or do I have to slowly wean off the use?

    You should not withdraw the medicine immediately, you should taper the dose to avoid rebound effects.

    • What blood tests are required before administration of Enfeira 500mg Injection?

    Before initiating the treatment with Enfeira 500mg Injection you may be asked to have blood tests, liver function tests.


    Precautions and general warning of Enfeira 500mg Injection

    Alcohol

    Patients should be cautious while consuming alcohol along with this medicine. Kindly consult with your doctor.

    Driving or operating machinery

    It is not clear that the use of this medicine will affect the ability to drive. Kindly consult with your doctor.

    Pregnancy

    The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor

    Breast Feeding

    The use of this medicine is considered safe during breastfeeding because it does not produce any harmful effects. Kindly consult with your doctor

    Kidney Problem

    It is considered safe to use this medicine in patients who are having a renal impairment. Kindly consult with your doctor.

    Liver Disease

    Limited information is available regarding the use of this medicine in patients who are having a history of hepatic impairment. Kindly consult with your doctor.


    How to Take Enfeira 500mg Injection

    Enfeira 500mg Injection comes in a liquid solution as an intravenous infusion. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.


    Use of Enfeira 500mg Injection in Adult

    It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.


    Use of Enfeira 500mg Injection in children

    It is considered unsafe to use this medicine in children who are below 2 years old. Kindly consult with your doctor.


    Talk to your doctor if

    Enfeira 500mg Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.


    General instructions

    • The severe infusion-related reaction may occur while you are receiving this medicine
    • The use of this medicine may increase the risk of developing fatal mucocutaneous reactions, fatal hepatitis B virus reactivation, progressive multifocal leukoencephalopathy, and tumor lysis syndrome
    • After completion of the therapy, serious bacterial, fungal, and reactivation of viral infection can occur
    • Cardiac side effects like ventricular fibrillation, myocardial infarction, cardiogenic shock may occur
    • Hypogammaglobulinemia was observed in a pediatric patient
    • Abdominal pain, bowel obstruction, and perforation were reported


    Drug Interaction of Enfeira 500mg Injection

    Drug-Drug Interaction

    Baricitinib

    Use alternative drug because the combination of this medicine either increase the toxicity of the other by immunosuppressive effect and it also increases the risk for developing infections

    Mechlorethamine

    Therapy should be administered with caution because the combination of the medicine either increase the toxicity of the other by pharmacodynamic synergism and also increase the risk for developing immunosuppression and myelosuppression

    Amphotericin B

    Therapy should be administered with caution because the combination of this medicine may increase the risk of developing nephrotoxicity and ototoxicity

    Drug-Food Interaction

    No data is available kindly consult with your doctor.

    Drug-Disease Interaction

    Cardiac dysfunction

    Therapy should be administered with caution in patients with a history of arrhythmias, coronary artery, and ischemic heart diseases because the use of this medicine may cause cardiotoxicity

    Hepatitis B

    The drugs which have CD20-directed cytolytic antibodies may cause hepatitis B virus reactivation

    Tumor lysis syndrome

    After taking the first infusion of rituximab in patients who are with Non-Hodgkin lymphoma may cause acute renal failure, hyperkalemia, hypocalcemia, hyperuricemia, and hyperphosphatemia

    Infections

    The use of this medicine is contraindicated in patients who are having the infectious disease because of their cytotoxic effect their induce myelosuppression.

    Bone marrow suppression

    Therapy should be administered with caution in patients with a bone marrow reserve who is depressed because the use of this medicine suppresses the bone marrow function.

    Renal impairment

    Therapy should be administered with caution because the use of rituximab in patients with Non-Hodgkin’s lymphoma may cause fatal renal toxicity


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 2-8°C in a refrigerator.
    • Do not freeze
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    • Rituximab 500mg is an anti-cancer medication, a monoclonal CD20 antibody
    • It is to treat Non-Hodgkin lymphoma, Rheumatoid arthritis, Chronic lymphocytic leukemia, Granulomatosis with polyangiitis, Pemphigus Vulgaris, and Microscopic polyangiitis
    • Do not self administer
    • Kindly avoid taking this medicine while you are pregnant
    • Avoid consuming alcohol while you are receiving this medicine because it may increase the risk of developing serious side effects.