Epitaz 10mg Injection
Brand Name | Epitaz 10mg Injection |
Salt Composition |
Epirubicin (10mg) |
Strength | 10mg |
Product Form | Injection |
Pack | 1 Injection in 1 Vial |
Storage | Store in a refrigerator (2 - 8°C). Do not freeze |
Category |
Anti-Cancer |
SubCategory |
Breast Cancer |
Country of Origin | India |
Manufacturer |
Intas Pharmaceuticals Ltd |
Manufacturer/Marketer Address | Intas Pharmaceuticals Ltd,Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India. |
You Save : Rs.90.82 Inclusive of all taxes
- Do not take this medicine if you are allergic to Epirubicin
- It is contraindicated to use this medicine in patients with cardiomyopathy or heart failure, with recent myocardial infarction, and severe myocardial insufficiency
- Kindly avoid taking this medicine if you have a drug that induces myelosuppression and severe hepatic impairment
- Hair loss
- Vomiting
- Anemia
- Mucositis
- Thrombocytopenia
- Hot flashes
- Diarrhea
- Rash
- Skin changes
- Hyperpigmentation
- Fatigue
- I am experiencing nausea and fatigue. Is this due to Epitaz 10mg Injection?
- Does Epitaz 10mg Injection cause hair loss?
- I have noticed some changes in my skin after taking the Epitaz 10mg Injection? What should I do?
- Kindly adjust the dose in patients with impaired hepatic function
- The use of this medicine may cause secondary acute myelogenous leukemia
- Thrombophlebitis and thromboembolic including pulmonary embolism were reported
- The use of this medicine along with living vaccine in patients with immunocompromised by the chemotherapeutic agent may result in serious infections
- After initiating the treatment lysis syndrome may occur
- Kindly avoid this medicine if you are pregnant because it may cause fetal harm
- You are not responding to the treatment
- You have experienced any allergic reaction like rashes and itching
- You have a receiving any concomitant medication and disease
- Stored at 2-8°C in the refrigerator.
- Do not freeze
- Protect from light and heat.
- Keep away from children and pets. Otherwise, it becomes toxic to them.
- Disposed of properly in a suitable bag.
- Epirubicin 10mg is an anti-cancer medication, an anthracycline
- It is used to treat adjuvant treatment for breast cancer
- Do not withdraw the medicine without consulting with a doctor
- Kindly consult with your doctor if you have experienced shortness of breath, chest pain, loss of appetite, and dark urine while you are receiving this medicine
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 478-79.
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from: https://cdscoonline.gov.in/CDSCO/Drugs https://cdscoonline.gov.in/CDSCO/Drugs
- DailyMed - Epirubicin hydrochloride injection, solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 16 May 2017]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7ec5ec1-fb05-4c78-b821-9aea638cf144
- Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 16 May 2017]. Available from: https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname
Medical Description of Epitaz 10mg Injection
Epitaz 10mg Injection contains Epirubicin 10mg used to treat adjuvant treatment for breast cancer. It is used as an orphan drug in the treatment of soft tissue sarcoma. It works by inhibiting the growth and multiplication of cancer cells by suppressing the enzyme which is involved in the DNA multiplication of cancer cells. This medicine is recommended for adults only.
Epitaz 10mg Injection Uses
It is used in the treatment of the following conditions as breast cancer.
Epitaz 10mg Injection Benefits
Primary breast cancer
It is a type of cancer that forms in the breast cells. It is common among women. Symptoms include breast lump, change in breast size, redness, pitting of the skin, color change, and peeling surrounding the breast skin or nipple. This medicine helps to inhibit the multiplication of cancer cells.
Epitaz 10mg Injection Indication
The Epitaz 10mg Injection is prescribed in the following indications as Breast cancer as an adjuvant.
Mechanism of action of Epitaz 10mg Injection
Epitaz 10mg Injection contains Epirubicin 10mg is an anti-cancer medication, an anthracycline produces its action by inhibiting DNA and RNA replication by acting on DNA topoisomerase 2 that intercalates DNA base pairs. Thus, causes the formation of an impaired DNA sequence containing abnormal cells where apoptosis occurs and results in cell death.
How Epitaz 10mg Injection works
Epitaz 10mg Injection contains Epirubicin 10mg is an anti-cancer medication, an anthracycline produces its action by inhibiting the function of DNA topoisomerase 2 enzymes. Epitaz 10mg Injection, causes impairment in DNA intercalation inducing apoptosis of these abnormal cancer cells. Thus, Epitaz 10mg Injection treats breast cancer and other cancers.
Epitaz 10mg Injection Contraindication
Epitaz 10mg Injection Side Effects
FAQs for Epitaz 10mg Injection
Yes, the common side effect of this medicine is nausea and fatigue so it is better to eat more frequent meals to decrease nausea and also avoid foods that are salty, spicy, fatty. Drink plenty of rest and do light exercise to keep yourself active
Yes, one of the common side effects of this medicine is hair loss. This will get treated once you stop the treatment.
Use sunscreen whenever you step outdoors and use moisturizer to get relief from the rash, dry and itchy skin. Your skin will return to normal once your treatment is stopped.
Precautions and general warning of Epitaz 10mg Injection
Alcohol
It is considered unsafe to consume alcohol while you are receiving this medicine. Kindly consult with your doctor.
Driving or operating machinery
It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.
Pregnancy
The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor
Breast Feeding
The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor
Kidney Problem
It is considered safe to use this medicine in patients who are with renal impairment. Kindly consult with your doctor.
Liver Disease
Therapy should be administered with caution in patients with hepatic impairment. Kindly adjust the dose if it is necessary. Kindly consult with your doctor.
How to Take Epitaz 10mg Injection
Epitaz 10mg Injection comes in a liquid solution as an intravenous. It is injected by a health care professional in doctor clinics, hospitals. Use the injection as prescribed by your doctor. Do not discontinue the medicine when you feel better kindly consult together with your doctor.
Use of Epitaz 10mg Injection in Adult
It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.
Use of Epitaz 10mg Injection in children
It is considered unsafe to use this medicine in children who are below 18 years old. Kindly consult with your doctor.
Use of Epitaz 10mg Injection in Elderly Patients
Epitaz 10mg Injection should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.
Other general warnings
Talk to your doctor if
General instructions
Epirubicin 10mg is used to treat adjuvant treatment for breast cancer. It produces its action by inhibiting the function of the DNA topoisomerase 2 enzymes. Epitaz 10mg Injection causes impairment in DNA intercalation inducing apoptosis of these abnormal cancer cells.
Drug Interaction of Epitaz 10mg Injection
Drug-Drug Interaction
Deferiprone
Use alternative drug because the combination of this medicine either increases the toxicity of the other by pharmacodynamic synergism
Cimetidine
Therapy should be administered with caution because the use of cimetidine increases the effect of epirubicin by decreasing its metabolism
Hydroxyurea
The combination of this medicine may increase the risk of developing myelosuppression
Olaparib
Therapy should be administered with caution because the combination of this medicine increases the pharmacodynamic synergism
Trastuzumab
The combination of this medicine either increases the toxicity of the other by immunosuppressive effect and also increase the risk for developing an infection
Drug-Food Interaction
Consuming alcohol may increase the risk of affecting your liver. Kindly consult with your doctor if you have experienced fever, chills, joint pain, swelling, bleeding, rash, itching, loss of appetite, fatigue, nausea, abdominal pain, dark-colored urine, and yellow-colored skin or eyes.
Drug-Disease Interaction
Liver diseases
The patients who are with severe hepatic impairment should not be treated with epirubicin because the route of elimination is a hepatobiliary system and serum total bilirubin and AST level should be increased during or after the treatment so kindly reduce the dose in these patients
Neutropenia
The patients who are having a baseline neutrophil count is less than 1500 cells/mm3 because dose-dependent reversible leucopenia and neutropenia were observed
Infections
The use of this medicine may cause severe infections to include urinary tract infections, pneumonia, sepsis, herpes encephalitis, and mycobacterial infection which lead to retroperitoneal hemorrhage.
Over Dose
Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.
Missed Dose
Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).
Storage and Disposal
Fast Tag
References