Imatinib 400mg Tablet

Brand Name Imatinib 400mg Tablet
Salt Composition Imatinib 400mg
Strength 400mg
Product Form Tablet
Pack 10 Tablet(s) in Strip
Storage Store at room temperature (10-30°C)
Category Anti-Cancer
Country of Origin India
Manufacturer Sun Pharmaceutical Industries Ltd
Manufacturer/Marketer Addresssun pharmaceutical industries ltd/90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
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M.R.P : Rs.2500.00    

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10 Tablet(s) in Strip

Availability : In Stock


    Medical Description of Imatinib 400mg Tablet

    Imatinib 400mg Tablet contains Imatinib 400mg it’s an antineoplastic and tyrosine kinase inhibitor. Imatinib 400mg Tablet is used in the treatment of cancers and tumors. It inhibits proliferation and causes apoptosis of abnormal cells. This medication is recommended for ages above 2 years of age.


    Imatinib 400mg Tablet Uses

    Imatinib 400mg Tablet is used in the treatment of chronic myeloid leukemia, Philadelphia positive acute lymphoblastic leukemia, myeloproliferative disease, chronic eosinophilic leukemia, Gastrointestinal stromal tumors, Dermaofibrosarcoma protuberans.


    Imatinib 400mg Tablet Benefits

    Imatinib 400mg Tablet is used in the treatment of several types of hemotological leukemia that cause abnormal cell growth like Chronic myeloid leukemia, Philadelphia positive acute lymphoblastic leukemia, myeloproliferative disease, chronic eosinophilic leukemia, and in Gastrointestinal stromal tumors, Dermatofibrosarcoma protuberans where there is abnormal structural cellular proliferation. It can be used in children and adults.


    Imatinib 400mg Tablet Indication

    Imatinib is used in the treatment of the following conditions

    • Chronic myeloid leukemia – it is a type of leukemia that causes abnormal myeloid cell growth. Imatinib 400mg Tablet used in children and adults
    • Philadelphia positive acute lymphoblastic leukemia – it is a type of leukemia that causes abnormal lymphoblast cell growth. Imatinib 400mg Tablet used in children and adults
    • Myelodysplastic or myeloproliferative disease - it is a type of leukemia that causes abnormal blood cell growth. Imatinib 400mg Tablet used only in adults
    • Hypereosinophilic syndrome or chronic eosinophilic leukemia – it is a type of leukemia that causes abnormal eosinophil cell growth. Imatinib 400mg Tablet used only in adults
    • Aggressive systemic mastocytosis without c-kit mutation
    • Gastrointestinal stromal tumors – uncontrolled intestinal cell growth. Imatinib 400mg Tablet used only in adults
    • Dermatofibrosarcoma protuberans – uncontrolled tissue growth below the skin. Imatinib 400mg Tablet used only in adults


    Mechanism of action of Imatinib 400mg Tablet

    Imatinib is an antineoplastic and tyrosine kinase inhibitor that induces apoptosis and inhibits the proliferation of abnormal cells. Imatinib inhibits bcr-abr tyrosine kinase expressed on positive cell lines of chronic myeloid leukemia (CML )and acute lymphoblastic lukemia (ALL) thereby inhibiting proliferation and induce apoptosis of abnormal cells. Imatinib also inhibits tyrosine kinase receptors present on platelets derived growth factor (PDGF) and stem cell growth factor called as c-kit of myeloproliferative diseases (MD), chronic eosinophilic leukemia (CEL), aggressive systemic mastocytosis (ASM), gastrointestinal stromal tumors (GIST) and dermatofibrosarcoma protuberans (DFP).


    How Imatinib 400mg Tablet works

    Imatinib inhibits the bcr-abr tyrosine kinase expressed on CML and ALL. Thus, the tablet is used in these types of leukemia in children and adults. It also inhibits tyrosine kinase receptors present on PDGF and SCGF called c-kit expressed on MD, CEL, ASM, GIST and DFP. Thus, it is used in these types of disorders and leukemias in adults only.


    Imatinib 400mg Tablet Contraindication

    • if you are allergic to Imatinib 400mg (imatinib 400mg) Tablet or its constituents
    • if you have lung disorders
    • if you have a liver disorder
    • if you have heart disease
    • if you have a thyroid disorder
    • if you have kidney disease
    • if you are pregnant
    • if you are breastfeeding


    Imatinib 400mg Tablet Side Effects

    Common side effects that occur 1:10 patients: Rapid weight gain, severe fluid retention, Signs of infection (fever, severe chills, sore throat or mouth ulcers), decreased WBC, Unexpected bleeding or bruising

    Uncommon and rare side effects that occur 1:100 patients: Chest pain, irregular heart rhythm, Cough, having difficulty breathing or painful breathing, Feeling light-headed, dizzy or fainting, nausea, loss of appetite, dark-coloured urine, yellow skin or eyes, Rash, red skin with blisters on the lips, eyes, skin or mouth, peeling skin, fever, raised red or purple skin patches, itching, burning sensation, pustular eruption, Severe abdominal pain, blood in your vomit, stools or urine, black stools,  decreased urine output, feeling thirsty, diarrhoea, vomiting, abdominal pain, paralysis of limbs or face, difficulty speaking, sudden loss of consciousness, anemia, Eye pain, cold toes and fingers, cellulitis, Difficulty hearing, Muscle weakness and spasms, hypokalemia, Bruising, shortness of breath, irregular heartbeat, hypercalcimia, hypophosphatemia, thrombotic microangiopathy


    FAQs for Imatinib 400mg Tablet

    Is Imatinib 400mg (imatinib 400mg) Tablet safe during pregnancy?

    No, taking Imatinib 400mg Tablet during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    Can Imatinib 400mg Tablet be taken while breastfeeding?

    No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Imatinib 400mg Tablet can also pass via breastfeeding.

    Can Imatinib 400mg Tablet be taken while alcohol consumption?

    The interaction is unknown but this medication causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Imatinib 400mg Tablet?

    This medication causes side effects thus caution is used while driving or operating machineries.

    What type of food can I take while on Imatinib 400mg Tablet?

    Except grape juice all type of food and drinks are acceptable with Imatinib 400mg Tablet


    Precautions and general warning of Imatinib 400mg Tablet

    Alcohol

    Imatinib 400mg Tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as that tablet causes side effects. For further queries, consult your physician.

    Pregnancy

    The use of Imatinib 400mg Tablet is not recommended during pregnancy as it causes fetal toxicity in the newborn.

    Breast Feeding

    The use of this tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.

    Kidney Problem

    Renal filtration impairment and fluid retention that causes generalised or localised edema

    Monitor renal function before and during treatment.

    Liver Disease

    Causes jaundice and raise in other liver enzymes that result in acute liver failure

    Monitor liver function before and during therapy


    How to Take Imatinib 400mg Tablet

    This tablet is taken orally.

    This tablet must be taken at the same time once a day as prescribed by your physician.

    This tablet can be taken with food.

    This tablet must be swallowed as a whole.

    Don’t chew or crush this tablet.

    If you can’t swallow, take 200ml of water in a glass and place the tablet into the water and wait for 20mins until the tablet dissolves completely, once dissolved drink the fluid. Make sure that you have taken the required dosage without spillage or wastage.

    After therapy has been initiated, do not take more or less of this drug than prescribed or stop taking it without your physicians’ approval. Missing or changing dosage without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Imatinib 400mg Tablet in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.


    Use of Imatinib 400mg Tablet in children

    This tablet is not recommended in children less than 2 years of age.


    Use of Imatinib 400mg Tablet in Elderly Patients

    This tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Gastrointestinal perforation
    • Hemorhage – spontaneous bleeding from internal organs and systems.
    • Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Hypothyroidism
    • Embryo-fetal toxicity in pregnant women
    • Growth retardation in children and adolescence
    • Tumor lysis syndrome
    • Decrease fertility
    • Carcinogenic and mutagenic – causes lesions and tumors in other systems


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have a kidney problem

    If you have a heart problem

    If you have a blood disorder

    If you are pregnant or breastfeeding


    General instructions

    This tablet is taken orally as a prescribed dosage at a specific time regularly with food to avoid adverse effects.


    Drug Interaction of Imatinib 400mg Tablet

    Drug-Drug Interaction

    ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, and voriconazole, alfentanil, cyclosporine, diergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus or tacrolimus, calcium channel blockers, HMG-CoA reductase inhibitors, acetaminophen, warfarin

    Drug-Food Interaction

    This tablet should not be taken with grape juice. It can be safely taken with any type of food, if doubts arise kindly refer to your physician. It generally causes neurological side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution.


    Over Dose

    In pediatric overdosage occurs when tablet dosage is more than 400mg/d

    In adults, overdosage occurs when tablet dosage is more than 1,200mg/d

    Adverse effects are mild to moderate thus monitoring is required. Contact your physician.


    Missed Dose

    You can take the missed dosage if you notice within 12 hours. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30°C


    Fast Tag

    Imatinib 400mg Tablet is a tyrosine kinase inhibitor.

    This tablet is used to control and treat several leukemia in children and adults

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease or renal diseases or hematological conditions.