Imbruvica 140mg Capsule
Brand Name | Imbruvica 140mg Capsule | |
Salt Composition |
Ibrutinib (140mg) |
Ibrutinib (140mg) |
Strength | 140mg | |
Product Form | Capsule | |
Pack | 120 Capsule(s) in 1 Bottle | |
Storage | Store below 30°C | |
Category |
Anti-Cancer |
|
SubCategory |
Blood Cancer |
|
Country of Origin | India | |
Manufacturer |
Johnson & Johnson Pvt Ltd |
|
Manufacturer/Marketer Address | Johnson & Johnson Pvt Ltd, 501 Arena Space Behind Majas Bus Depot Off Jogeshwari Vikhroli Link Road Jogeshwari (E) Mumbai 400 060. |
You Save : Rs.65,600.00 Inclusive of all taxes
- Chronic lymphocytic leukemia or small lymphocytic lymphoma with 17p deletion
- Mantle cell lymphoma
- Waldenstrom macroglobulinemia
- Marginal zone lymphoma who has taken antiCD20 therapy before
- Graft vs host disease who has failed previous treatment
- Increased serum creatinine
- Diarrhea
- Hemorrhage
- Fatigue
- Peripheral edema
- Urinary tract infection
- Nausea
- Constipation
- Abdominal pain
- Loss of appetite
- Cough
- When can I plan a pregnancy if I am taking an Imbruvica 140mg Capsule?
- When should I call my doctor right away?
- I am experiencing nausea and fatigue. Is this due to the Imbruvica 140mg Capsule?
- Therapy should be administered with caution in patients with cardiac arrhythmias, and hemorrhage
- Tumor lysis syndrome, hypertension, and other malignancies were reported
- Infection and renal failure may occur
- You are not responding to the treatment
- You have experienced any allergic reaction like rashes and itching
- You have a receiving any concomitant medication and disease
- Stored at 10-30°C room temperature.
- Protect from light and heat.
- Keep away from children and pets. Otherwise, it becomes toxic to them.
- Disposed of properly in a suitable bag.
- Ibrutinib 140mg is an antineoplastic, a tyrosine kinase inhibitor
- It is used to treat chronic lymphocytic lymphoma, mantle cell lymphoma, Waldenstrom macroglobulinemia, marginal zone lymphoma, and graft vs host disease
- The use of this medicine may cause a bleeding problem
- Do not take this medicine if you are pregnant because the use of this medicine may cause fetal harm
- Kindly inform your doctor if you have experienced headache, stomach pain, and blood in your stool and urine while you are receiving this medicine.
- Take this medicine 1 hour before or 2 hours after your meal
Medical Description of Imbruvica 140mg Capsule
Imbruvica 140mg Capsule contains Ibrutinib 140mg used to treat chronic lymphocytic lymphoma, mantle cell lymphoma, Waldenstrom macroglobulinemia, marginal zone lymphoma, and graft vs host disease. It works by inhibiting the abnormal protein that helps the cancer cells to get multiply. This medicine is not recommended in children.
Imbruvica 140mg Capsule Uses
It is used in the treatment of the following conditions as chronic lymphocytic lymphoma, mantle cell lymphoma, Waldenstrom macroglobulinemia, marginal zone lymphoma, and graft vs host disease.
Imbruvica 140mg Capsule Benefits
Chronic lymphatic leukemia
It is a type of blood and bone marrow cancer. The exact cause is unknown but it is assumed that some changes happen in the DNA of blood-producing cells. It progresses more slowly when compared with other leukemia. Symptoms include inflamed lymph nodes, fever, night sweats, weight loss, enlarged spleen, fatigue, and frequent infections.
Mantle cell lymphoma
It is a type of non-Hodgkin's lymphoma cancer. It usually affects a part of your immune system called the lymphatic system. It occurs when there is a change in the DNA of white blood cells called B lymphocytes. Symptoms include night sweats, belly pain, enlarged tonsils, fatigue, pain in the lower back, fever, weight loss, and loss of appetite.
Marginal zone lymphoma
It is a type of cancer that begins in the lymphatic system, a network of tissue that removes waste and toxins from the body. It is a group of slow-growing ones. It occurs when there is a change in the DNA of white blood cells called B lymphocytes. Symptoms include fever, night sweats, weight loss, skin rash, chest pain, indigestion, fatigue, abdominal pain, and nausea.
Waldenstrom macroglobulinemia
It is a rare type of cancer that starts in white blood cells. In this condition, your bone marrow produces more amount of abnormal cells that crowd out the healthy blood cells. Symptoms include bleeding, fatigue, weight loss, fever, headache, blurred vision, and confusion.
Graft vs host disease
Usually, this occurs after an allogenic transplant. In this condition donated bone marrow sees the recipient body as foreign particles and started to attack the body. Symptoms include skin rash, yellow discoloration of the skin, diarrhea, abdominal pain, dry eyes, and difficulty in swallowing.
Imbruvica 140mg Capsule Indication
The Imbruvica 140mg Capsule is prescribed in the following indications as
Mechanism of action of Imbruvica 140mg Capsule
Imbruvica 140mg Capsule contains Ibrutinib 140mg is an antineoplastic, tyrosine kinase inhibitor. It produces its action by acting on Bruton’s tyrosine which is present on the B cell antigen receptor and cytokine receptor pathway. The formation of a covalent bond between Ibrutinib 140mg and surface antigen causes the signaling process to be inhibited. Ibrutinib 140mg inhibits tyrosine kinase present in receptors thus signaling process required for angiogenesis and proliferation of abnormal cells is inhibited. Thus it shrinks the abnormal cells and minimizes metastasis thus treating and controlling cancers.
How Imbruvica 140mg Capsule works
Imbruvica 140mg Capsule contains Ibrutinib 140mg is an antineoplastic, tyrosine kinase inhibitor. It produces its action by inhibiting Bruton’s tyrosine present on B cell antigen receptor thus the signaling process for angiogenesis and proliferation of abnormal cells is inhibited. Imbruvica 140mg Capsule minimizes the growth of abnormal cancer cells and terminates metastasis of tumors or cancers.
Imbruvica 140mg Capsule Contraindication
Do not take this medicine if you are allergic to Ibrutinib
Imbruvica 140mg Capsule Side Effects
FAQs for Imbruvica 140mg Capsule
Avoid planning for pregnancy while you are receiving this medicine and also use an effective contraceptive for at least 1 month after taking the last medicine.
If you have experienced muscle cramping, muscle weakness, confusion, vision loss, blindness, seizures, headaches, shortness of breath, swelling of your feet, high blood pressure, tiredness, fainting, tightness in the chest.
Yes, the common side effect of this medicine is nausea and fatigue so it is better to eat more frequent meals to decrease nausea and also avoid foods that are salty, spicy, fatty. Drink plenty of rest and do light exercise to keep yourself active
Precautions and general warning of Imbruvica 140mg Capsule
Alcohol
It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.
Driving or operating machinery
It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.
Pregnancy
The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor
Breast Feeding
The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor
Kidney Problem
The medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.
Liver Disease
The medicine should be used with caution in patients with hepatic impairment. The use of this medicine required dose modification. Kindly consult with your doctor.
How to Take Imbruvica 140mg Capsule
Imbruvica 140mg Capsule is taken orally with or without food. You should not chew, cut or crush the capsule. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.
Use of Imbruvica 140mg Capsule in Adult
It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor
Use of Imbruvica 140mg Capsule in children
Safety and efficacy were not established in children who are below 18 years old. Kindly consult with your doctor.
Use of Imbruvica 140mg Capsule in Elderly Patients
Imbruvica 140mg Capsule should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.
Other general warnings
Talk to your doctor if
General instructions
Ibrutinib 140mg is used to treat chronic lymphocytic lymphoma, mantle cell lymphoma, Waldenstrom macroglobulinemia, marginal zone lymphoma, and graft vs host disease. It produces its action by inhibiting Bruton’s tyrosine present on B cell antigen receptor thus the signaling process for angiogenesis and proliferation of abnormal cells is inhibited. Imbruvica 140mg Capsule minimizes the growth of abnormal cancer cells and terminates metastasis of tumors or cancers.
Drug Interaction of Imbruvica 140mg Capsule
Drug-Drug Interaction
Cholera vaccine
It is contraindicated to use this medicine because the use of ibrutinib decreases the effect of the cholera vaccine by pharmacodynamic antagonism.
Deferiprone
Use alternative drug because the combination of this medicine either increases the toxicity of the other by pharmacodynamic synergism
Alteplase
Therapy should be administered with caution because the use of ibrutinib will increase the effect of alteplase by anticoagulation
Dabigatran
Therapy should be administered with caution because the use of ibrutinib will increase the effect of dabigatran by P-glycoprotein efflux transporter.
Drug-Food Interaction
Kindly avoid consuming grapefruit or grapefruit juice while you are receiving this medicine because grapefruit juice increases the blood level of ibrutinib which increases the risk for developing irregular heart rhythm. If you have experienced dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation immediately consult with your doctor.
Drug-Disease Interaction
Atrial fibrillation
Therapy should be administered with caution in patients with atrial fibrillation because the use of this medicine increases the risk in patients with cardiac factors, hypertension, and acute infections.
Bleeding
Therapy should be administered with caution because the use of this medicine may cause hemorrhage and should be monitored for signs of bleeding
Hepatic impairment
The use of this medicine is not recommended in patients who are with moderate to severe hepatic impairment
Infections
Therapy should be administered with caution because the fatal and non-fatal infection may cause progressive multifocal leukoencephalopathy and pneumocystis jirovecii pneumonia have been reported.
Lung toxicity
Therapy should be administered with caution in patients who are with a history of interstitial pneumonia and pulmonary fibrosis because the use of these multikinase inhibitors may cause pulmonary toxicity.
Over Dose
Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.
Missed Dose
Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).
Storage and Disposal
Fast Tag
Imbruvica 140mg Capsule
Brand Name | Imbruvica 140mg Capsule |
Salt Composition | |
Strength | 140mg |
Category |
Anti-Cancer |
SubCategory |
Blood Cancer |
Country of Origin | India |
You Save : Rs.87,200.00 Inclusive of all taxes
- Chronic lymphocytic leukemia or small lymphocytic lymphoma with 17p deletion
- Mantle cell lymphoma
- Waldenstrom macroglobulinemia
- Marginal zone lymphoma who has taken antiCD20 therapy before
- Graft vs host disease who has failed previous treatment
- Increased serum creatinine
- Diarrhea
- Hemorrhage
- Fatigue
- Peripheral edema
- Urinary tract infection
- Nausea
- Constipation
- Abdominal pain
- Loss of appetite
- Cough
- When can I plan a pregnancy if I am taking an Imbruvica 140mg Capsule?
- When should I call my doctor right away?
- I am experiencing nausea and fatigue. Is this due to the Imbruvica 140mg Capsule?
- Therapy should be administered with caution in patients with cardiac arrhythmias, and hemorrhage
- Tumor lysis syndrome, hypertension, and other malignancies were reported
- Infection and renal failure may occur
- You are not responding to the treatment
- You have experienced any allergic reaction like rashes and itching
- You have a receiving any concomitant medication and disease
- Stored at 10-30°C room temperature.
- Protect from light and heat.
- Keep away from children and pets. Otherwise, it becomes toxic to them.
- Disposed of properly in a suitable bag.
- Ibrutinib 140mg is an antineoplastic, a tyrosine kinase inhibitor
- It is used to treat chronic lymphocytic lymphoma, mantle cell lymphoma, Waldenstrom macroglobulinemia, marginal zone lymphoma, and graft vs host disease
- The use of this medicine may cause a bleeding problem
- Do not take this medicine if you are pregnant because the use of this medicine may cause fetal harm
- Kindly inform your doctor if you have experienced headache, stomach pain, and blood in your stool and urine while you are receiving this medicine.
- Take this medicine 1 hour before or 2 hours after your meal
Medical Description of Imbruvica 140mg Capsule
Imbruvica 140mg Capsule contains Ibrutinib 140mg used to treat chronic lymphocytic lymphoma, mantle cell lymphoma, Waldenstrom macroglobulinemia, marginal zone lymphoma, and graft vs host disease. It works by inhibiting the abnormal protein that helps the cancer cells to get multiply. This medicine is not recommended in children.
Imbruvica 140mg Capsule Uses
It is used in the treatment of the following conditions as chronic lymphocytic lymphoma, mantle cell lymphoma, Waldenstrom macroglobulinemia, marginal zone lymphoma, and graft vs host disease.
Imbruvica 140mg Capsule Benefits
Chronic lymphatic leukemia
It is a type of blood and bone marrow cancer. The exact cause is unknown but it is assumed that some changes happen in the DNA of blood-producing cells. It progresses more slowly when compared with other leukemia. Symptoms include inflamed lymph nodes, fever, night sweats, weight loss, enlarged spleen, fatigue, and frequent infections.
Mantle cell lymphoma
It is a type of non-Hodgkin's lymphoma cancer. It usually affects a part of your immune system called the lymphatic system. It occurs when there is a change in the DNA of white blood cells called B lymphocytes. Symptoms include night sweats, belly pain, enlarged tonsils, fatigue, pain in the lower back, fever, weight loss, and loss of appetite.
Marginal zone lymphoma
It is a type of cancer that begins in the lymphatic system, a network of tissue that removes waste and toxins from the body. It is a group of slow-growing ones. It occurs when there is a change in the DNA of white blood cells called B lymphocytes. Symptoms include fever, night sweats, weight loss, skin rash, chest pain, indigestion, fatigue, abdominal pain, and nausea.
Waldenstrom macroglobulinemia
It is a rare type of cancer that starts in white blood cells. In this condition, your bone marrow produces more amount of abnormal cells that crowd out the healthy blood cells. Symptoms include bleeding, fatigue, weight loss, fever, headache, blurred vision, and confusion.
Graft vs host disease
Usually, this occurs after an allogenic transplant. In this condition donated bone marrow sees the recipient body as foreign particles and started to attack the body. Symptoms include skin rash, yellow discoloration of the skin, diarrhea, abdominal pain, dry eyes, and difficulty in swallowing.
Imbruvica 140mg Capsule Indication
The Imbruvica 140mg Capsule is prescribed in the following indications as
Mechanism of action of Imbruvica 140mg Capsule
Imbruvica 140mg Capsule contains Ibrutinib 140mg is an antineoplastic, tyrosine kinase inhibitor. It produces its action by acting on Bruton’s tyrosine which is present on the B cell antigen receptor and cytokine receptor pathway. The formation of a covalent bond between Ibrutinib 140mg and surface antigen causes the signaling process to be inhibited. Ibrutinib 140mg inhibits tyrosine kinase present in receptors thus signaling process required for angiogenesis and proliferation of abnormal cells is inhibited. Thus it shrinks the abnormal cells and minimizes metastasis thus treating and controlling cancers.
How Imbruvica 140mg Capsule works
Imbruvica 140mg Capsule contains Ibrutinib 140mg is an antineoplastic, tyrosine kinase inhibitor. It produces its action by inhibiting Bruton’s tyrosine present on B cell antigen receptor thus the signaling process for angiogenesis and proliferation of abnormal cells is inhibited. Imbruvica 140mg Capsule minimizes the growth of abnormal cancer cells and terminates metastasis of tumors or cancers.
Imbruvica 140mg Capsule Contraindication
Do not take this medicine if you are allergic to Ibrutinib
Imbruvica 140mg Capsule Side Effects
FAQs for Imbruvica 140mg Capsule
Avoid planning for pregnancy while you are receiving this medicine and also use an effective contraceptive for at least 1 month after taking the last medicine.
If you have experienced muscle cramping, muscle weakness, confusion, vision loss, blindness, seizures, headaches, shortness of breath, swelling of your feet, high blood pressure, tiredness, fainting, tightness in the chest.
Yes, the common side effect of this medicine is nausea and fatigue so it is better to eat more frequent meals to decrease nausea and also avoid foods that are salty, spicy, fatty. Drink plenty of rest and do light exercise to keep yourself active
Precautions and general warning of Imbruvica 140mg Capsule
Alcohol
It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.
Driving or operating machinery
It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.
Pregnancy
The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor
Breast Feeding
The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor
Kidney Problem
The medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.
Liver Disease
The medicine should be used with caution in patients with hepatic impairment. The use of this medicine required dose modification. Kindly consult with your doctor.
How to Take Imbruvica 140mg Capsule
Imbruvica 140mg Capsule is taken orally with or without food. You should not chew, cut or crush the capsule. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.
Use of Imbruvica 140mg Capsule in Adult
It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor
Use of Imbruvica 140mg Capsule in children
Safety and efficacy were not established in children who are below 18 years old. Kindly consult with your doctor.
Use of Imbruvica 140mg Capsule in Elderly Patients
Imbruvica 140mg Capsule should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.
Other general warnings
Talk to your doctor if
General instructions
Ibrutinib 140mg is used to treat chronic lymphocytic lymphoma, mantle cell lymphoma, Waldenstrom macroglobulinemia, marginal zone lymphoma, and graft vs host disease. It produces its action by inhibiting Bruton’s tyrosine present on B cell antigen receptor thus the signaling process for angiogenesis and proliferation of abnormal cells is inhibited. Imbruvica 140mg Capsule minimizes the growth of abnormal cancer cells and terminates metastasis of tumors or cancers.
Drug Interaction of Imbruvica 140mg Capsule
Drug-Drug Interaction
Cholera vaccine
It is contraindicated to use this medicine because the use of ibrutinib decreases the effect of the cholera vaccine by pharmacodynamic antagonism.
Deferiprone
Use alternative drug because the combination of this medicine either increases the toxicity of the other by pharmacodynamic synergism
Alteplase
Therapy should be administered with caution because the use of ibrutinib will increase the effect of alteplase by anticoagulation
Dabigatran
Therapy should be administered with caution because the use of ibrutinib will increase the effect of dabigatran by P-glycoprotein efflux transporter.
Drug-Food Interaction
Kindly avoid consuming grapefruit or grapefruit juice while you are receiving this medicine because grapefruit juice increases the blood level of ibrutinib which increases the risk for developing irregular heart rhythm. If you have experienced dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation immediately consult with your doctor.
Drug-Disease Interaction
Atrial fibrillation
Therapy should be administered with caution in patients with atrial fibrillation because the use of this medicine increases the risk in patients with cardiac factors, hypertension, and acute infections.
Bleeding
Therapy should be administered with caution because the use of this medicine may cause hemorrhage and should be monitored for signs of bleeding
Hepatic impairment
The use of this medicine is not recommended in patients who are with moderate to severe hepatic impairment
Infections
Therapy should be administered with caution because the fatal and non-fatal infection may cause progressive multifocal leukoencephalopathy and pneumocystis jirovecii pneumonia have been reported.
Lung toxicity
Therapy should be administered with caution in patients who are with a history of interstitial pneumonia and pulmonary fibrosis because the use of these multikinase inhibitors may cause pulmonary toxicity.
Over Dose
Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.
Missed Dose
Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).
Storage and Disposal
Fast Tag