Instgra 50mg Tablet - 30 Tablets Pack

Brand Name Instgra 50mg Tablet - 30 Tablets Pack
Salt Composition Dolutegravir (50mg)
Strength 50mg
Product Form Tablet
Storage Store at room temperature (10-30°C)
Category HIV
Country of Origin India
Manufacturer Emcure Pharmaceuticals Ltd
Manufacturer/Marketer AddressEmcure Pharmaceuticals Ltd, 255/2, Hinjawadi, Pune - 411057, India.
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Instgra 50mg Tablet, Dolutegravir 50mg, Price, Uses, Side Effects - Drugcarts watermark
M.R.P : Rs.3563.00       Price : Rs.2672.25

You Save : Rs.890.75    Inclusive of all taxes

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Availability : In Stock


    Medical Description of Instgra 50mg Tablet - 30 Tablets Pack

    Instgra tablet contains Dolutegravir 50mg. Instgra tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV)-1 infection. This medicine is an integrase strand transfer inhibitor. This tablet is used only on people above 40kgs or in children above age 12. This tablet is always used in combination with other antiretroviral medications. This medicine doesn’t cure HIV infection it only reduces the rate of viral load multiplication thus helps manage the illness.


    Instgra 50mg Tablet - 30 Tablets Pack Uses

    Instgra tablet is an antiviral belonging to the family of integrase strand transfer inhibitors which is used to treat HIV – 1 infection in children above 12 years of age and adults. This tablet is always used in combination with other antiviral medications. While using Dolutegravir sometimes causes resistance thus caution is required and follow up blood works are required to support the continued use of this medication.


    Instgra 50mg Tablet - 30 Tablets Pack Benefits

    Instgra tablet is used with other anti-HIV medicines to help control HIV infection & helps to decrease the amount of HIV in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. This medicine is not a cure for HIV infection, it improves immunity that results in longevity of life; thus, precautions are necessary while sexual intercourse, surgery etc.


    Instgra 50mg Tablet - 30 Tablets Pack Indication

    Instgra (Dolutegravir (50mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. This tablet is used with other antiviral medications to boost the immunity of the affected hosts by reducing the viral load of the infected cells. It is indicated in patients above the age of 12 or if the patient weighs >40kgs


    Mechanism of action of Instgra 50mg Tablet - 30 Tablets Pack

    Instgra (Dolutegravir (50mg)) tablet is an integrase strand transfer inhibitor that binds to the integrase active site of HIV particles and blocks the strand transfer of retroviral DNA integration which is necessary for HIV replication process.


    How Instgra 50mg Tablet - 30 Tablets Pack works

    Dolutegravir in the Instgra tablet is an integrase strand transfer inhibitor. Dolutegravir binds to the active site of integrase present in HIV active particle. This process blocks the transfer of DNA thus the replication process of HIV -1 is stopped. This causes an increase in immunity. Caution is used in case of resistance to dolutegravir.


    Instgra 50mg Tablet - 30 Tablets Pack Contraindication

    Absolute contraindications:

    • if you are allergic to Instgra (Dolutegravir (50mg)) tablet
    • if you are pregnant
    • if you are breastfeeding
    • if you have kidney disease
    • if you have liver disease

    Relative contraindication:

    • if you are diabetic
    • if you have bleeding disorder like haemophilia
    • if you have heart diseases


    Instgra 50mg Tablet - 30 Tablets Pack Side Effects

    Very common side effect that occur more than 1:10 patients: headache, diarrhoea, nausea

    Common side effects that occur 1:10 patients: rash, pruritus, vomiting, abdominal pain, flatulence, insomnia, abnormal dreams, depression dizziness, tiredness, changes in LFT and increased creatine kinase

    Uncommon side effects that occur 1:100 patients: hepatitis, suicidal thoughts and behaviours, joint and muscle pain

    Rare side effects that occur 1:1000 patients: osteonecrosis


    FAQs for Instgra 50mg Tablet - 30 Tablets Pack

    Is Instgra (Dolutegravir (50mg)) tablet safe during pregnancy?

    No, this drug has shown evidence of neural tube defects in fetus. Thus, consult your physician.

    Can Instgra tablet be taken while breast feeding?

    There is no specific study to detail this. But in general HIV virions can pass via breastfeeding thus it is suspected that antiretrovirals can also pass via breastfeeding. Thus, consult your physician.

    Can Instgra tablet be taken while alcohol consumption?

    The interaction is unknown. Thus, consult your physician.

    Can I take Instgra tablet as monotherapy?

    No, Instgra tablet should be used with other antiretrovirals for treatment

    Can I take Instgra tablet while driving or operating heavy machinery?

    Though there are no direct studies it is best to remember that Instgra tablet causes side effects that may affect your work progress. Thus, consult your physician


    Precautions and general warning of Instgra 50mg Tablet - 30 Tablets Pack

    Alcohol

    Instgra tablet generally causes fatigue thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Instgra tablet causes fatigue. For further queries, consult your physician.

    Pregnancy

    The use of Instgra tablet causes fetal toxicity and malformation in the uterine, thus caution is used.

    Breast Feeding

    Instgra  tablet crosses the placenta and breast milk thus it is not advised to breastfeed while on this drug. For queries consult your physician

    Kidney Problem

    Consult your physician

    Liver Disease

    Instgra  tablet causes abnormal liver function values like the elevation of GGT thus close monitoring is advised and after 2 months of treatment monitoring with blood work for signs of jaundice is advised every 2 weeks and after 3 months of treatment monthly blood work is advised.


    How to Take Instgra 50mg Tablet - 30 Tablets Pack

    Instgra tablet should not be taken alone and must be combined with other antiretrovirals.

    Instgra tablet is taken orally with food.

    Swallow Instgra tablet as a whole.

    Don’t crush, break or chew the Instgra tablet.

    After therapy has been initiated, do not take more or less of Instgra than prescribed or stop taking it without your physicians’ approval. Skipping or changing Instgra (Dolutegravir (50mg)) tablet dose without approval would increase the viral load making the infection more difficult to treat, or worsen side effects. For further queries consult your physician.


    Use of Instgra 50mg Tablet - 30 Tablets Pack in Adult

    The recommended dosage of Instgra (Dolutegravir (50mg)) tablet is one tablet taken orally in combination with other antiretroviral medications.


    Use of Instgra 50mg Tablet - 30 Tablets Pack in children

    Instgra  tablet can be used in children only above 40kgs


    Use of Instgra 50mg Tablet - 30 Tablets Pack in Elderly Patients

    Instgra  tablet has only been used in few patients 60 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Increase in glucose levels
    • Increase in lipid levels
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • Accumulation or Redistribution of body fat or immune reconstitution syndrome.


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have a kidney problem

    If you have any bleeding problem

    If you are pregnant or breastfeeding


    General instructions

    Instgra tablet is taken with other antiretrovirals orally as prescribed dosage at a specific time regularly with food. If Instgra tablet is taken separately or without food, the efficiency of the drug is reduced significantly, thus it is ill-advised.


    Drug Interaction of Instgra 50mg Tablet - 30 Tablets Pack

    Drug-Drug Interaction

    Metabolism increased by Carbamazepine, Oxcarbazepine, Phenytoin, Phenobarbital

    Metabolism decreased by Ketoconazole, Fluconazole, Itraconazole

    Serum concentration increased by Bisoprolol, Clarithromycin

    St. John's wort

    Decreased absorption caused by Magnesium/ aluminium-containing antacid

    Drug-Food Interaction

    Instgra tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Instgra tablet generally causes fatigue thus it is advised not to be taken with alcohol.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
    • Blood disorders – used with caution in anemia and thrombocytopenia. Consult physician before use


    Over Dose

    There are no clear studies thus contact your doctor immediately.


    Missed Dose

    You can take the missed dosage if you notice within 8 hours. Always take with other antiretrovirals and food. If it is more than 8 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 30°C


    Fast Tag

    Instgra (Dolutegravir (50mg)) tablet is an integrase strand transfer inhibitor

    Instgra tablet is used to control and treat HIV infection with at least two other antiretrovirals.

    Instgra tablet is not advised during the pregnancy and lactation period

    Don’t use this medication with liver disease or kidney disease

    This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.