Instgra 50mg Tablet - 30 Tablets Pack

Brand Name Instgra 50mg Tablet - 30 Tablets Pack
Salt Composition

Dolutegravir (50mg)

Strength 50mg
Product Form Tablet
Pack 30 Tablet(s) in 1 Bottle
Storage Store below 30°C
Category

HIV

SubCategory

HIV

Country of Origin India
Manufacturer

Emcure Pharmaceuticals Ltd

Manufacturer/Marketer Address Emcure Pharmaceuticals Ltd, 255/2, Hinjawadi, Pune - 411057, India.
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Instgra 50mg Tablet, Dolutegravir 50mg,Price,Uses,Side Effects - Drugcarts watermark
M.R.P : Rs.3563.00       Price : Rs.2992.92

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30 Tablet(s) in 1 Bottle

Availability : In Stock

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    Medical Description of Instgra 50mg Tablet - 30 Tablets Pack

    Instgra 50mg Tablet contains an active substance called dolutegravir. Dolutegravir is an antiretroviral medicine used in the treatment of Human Immunodeficiency Virus (HIV)-1 infection. Dolutegravir is an integrase strand transfer inhibitor. Dolutegravir is used only on people above 40kgs or in children above age 12. It is always used in combination with other antiretroviral medications. Dolutegravir doesn’t cure HIV infection it only reduces the rate of viral load multiplication thus helps manage the illness.


    Instgra 50mg Tablet - 30 Tablets Pack Uses

    Instgra 50mg Tablet is an antiretroviral belonging to the family of integrase strand transfer inhibitor which is used to treat HIV – 1 infection in children above 12 years of age and adults. Dolutegravir is always used in combination with other antiretroviral medications. While using Dolutegravir sometimes causes resistance thus caution is required and follow up blood works are required to support continuous use of this medication.


    Instgra 50mg Tablet - 30 Tablets Pack Benefits

    Instgra 50mg Tablet is used with other anti-HIV medication to help control HIV infection. Dolutegravir helps to decrease the amount of HIV in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Dolutegravir is not a cure for HIV infection, it improves immunity that results in longevity of life; thus, precautions are necessary while sexual intercourse, surgery etc.


    Instgra 50mg Tablet - 30 Tablets Pack Indication

    Instgra 50mg Tablet contains Dolutegravir. Dolutegravir is indicated in case of HIV-1 infection that causes AIDS in humans. Dolutegravir is used with other antiretroviral medications to boost immunity of the affected hosts by reducing the viral load of the infected cells. It is indicated in patients above the age of 12 or if patient weighs >40kgs


    Mechanism of action of Instgra 50mg Tablet - 30 Tablets Pack

    Instgra 50mg Tablet contains Dolutegravir. Dolutegravir is an integrase strand transfer inhibitor that binds to integrase active site of HIV particle and blocks the strand transfer of retroviral DNA integration which is necessary for HIV replication process.


    How Instgra 50mg Tablet - 30 Tablets Pack works

    Instgra 50mg Tablet contains Dolutegravir. Dolutegravir is an integrase strand transfer inhibitor. Dolutegravir binds to the active site of integrase present in HIV active particle. This process blocks the transfer of DNA thus the replication process of HIV -1 is stopped. This causes an increase in immunity. Caution is used in case of resistance to dolutegravir.


    Instgra 50mg Tablet - 30 Tablets Pack Contraindication

    • if you are allergic to Dolutegravir
    • if you are pregnant
    • if you are breastfeeding
    • if you have kidney disease
    • if you have liver disease
    • if you are diabetic
    • if you have bleeding disorder like haemophilia
    • if you have heart diseases


    Instgra 50mg Tablet - 30 Tablets Pack Side Effects

    Very common side effect that occur more than 1:10 patients: headache, diarrhoea, nausea

    Common side effects that occur 1:10 patients: rash, pruritus, vomiting, abdominal pain, flatulence, insomnia, abnormal dreams, depression dizziness, tiredness, changes in LFT and increased creatine kinase

    Uncommon side effects that occur 1:100 patients: hepatitis, suicidal thoughts and behaviours, joint and muscle pain

    Rare side effects that occur 1:1000 patients: osteonecrosis


    FAQs for Instgra 50mg Tablet - 30 Tablets Pack

    • Is Instgra 50mg Tablet safe during pregnancy?

    No, this drug has shown evidence of neural tube defects in fetus. Thus, consult your physician.

    • Can Instgra 50mg Tablet be taken while breast feeding?

    There is no specific study to detail this. But in general HIV virions can pass via breastfeeding thus it is suspected that antiretrovirals can also pass via breastfeeding. Thus, consult your physician.

    • Can Instgra 50mg Tablet be taken while alcohol consumption?

    The interaction is unknown. Thus, consult your physician.

    • Can I take Instgra 50mg Tablet alone?

    No, Instgra 50mg Tablet should be used with other antiretrovirals for treatment

    • Can I take Instgra 50mg Tablet while driving or operating heavy machinery?

    Though there are no direct studies it is best to remember that Dolutegravir causes side effects that may affect your work progress. Thus, consult your physician


    Precautions and general warning of Instgra 50mg Tablet - 30 Tablets Pack

    Alcohol

    Instgra 50mg Tablet generally causes fatigue thus it is advised not to be taken with alcohol. For further queries, consult your physician.

    Driving or operating machinery

    It is preferred to drive or operate heavy machinery with caution as Instgra 50mg Tablet causes fatigue. For further queries, consult your physician.

    Pregnancy

    The use of Instgra 50mg Tablet causes fetal toxicity and malformation in uterine, thus caution is used.

    Breast Feeding

    Instgra 50mg Tablet crosses placenta and breast milk thus it is not advised to breastfeed while on this drug. For queries consult your physician

    Liver Disease

    Instgra 50mg Tablet causes abnormal liver function values like elevation of GGT thus close monitoring is advised and after 2 months of treatment monitoring with blood work for signs of jaundice is advised every 2 weeks and after 3 months of treatment monthly blood work is advised.


    How to Take Instgra 50mg Tablet - 30 Tablets Pack

    • Instgra 50mg Tablet should not be taken alone and must be combined with other antiretrovirals.
    • Instgra 50mg Tablet is taken orally with food.
    • Swallow Instgra 50mg Tablet as whole.
    • Don’t crush, break or chew Instgra 50mg Tablet.
    • After therapy has been initiated, do not take more or less of this drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing your dose without approval would increase the viral load making the infection more difficult to treat, or worsen side effects. For further queries consult your physician.


    Use of Instgra 50mg Tablet - 30 Tablets Pack in Adult

    Instgra 50mg Tablet can be used in children only above 40kgs. The recommended dose is 50mg in combination with other antiretroviral medications.


    Use of Instgra 50mg Tablet - 30 Tablets Pack in children

    Instgra 50mg Tablet can be used in children only above 40kgs


    Use of Instgra 50mg Tablet - 30 Tablets Pack in Elderly Patients

    Instgra 50mg Tablet has only been used in few patients 60 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Increase in glucose levels
    • Increase in lipid levels
    • Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
    • Accumulation or Redistribution of body fat or immune reconstitution syndrome


    Talk to your doctor if

    • If you have any allergy
    • If you have a liver problem
    • If you have a kidney problem
    • If you have any bleeding problem
    • If you are pregnant or breastfeeding


    General instructions

    Instgra 50mg Tablet is taken with other antiretrovirals orally as prescribed dosage at specific time regularly with food. If Instgra 50mg Tablet is taken separately or without food the efficiency of drug is reduced significantly, thus it is ill advised.


    Drug Interaction of Instgra 50mg Tablet - 30 Tablets Pack

    Drug-Drug Interaction

    • Fampridine
    • Carbamazepine, Oxcarbazepine
    • Phenytoin, Phenobarbital
    • Ketoconazole, Fluconazole, Itraconazole, Posaconazole, Voriconazole
    • Calcium supplements, iron supplements or multivitamins
    • St. John's wort
    • Magnesium/ aluminium-containing antacid

    Drug-Food Interaction

    Instgra 50mg Tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Instgra 50mg Tablet generally causes fatigue thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution.

    Drug-Disease Interaction

    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
    • Blood disorders – used with caution in anemia and thrombocytopenia. Consult physician before use


    Over Dose

    There are no clear studies thus contact your doctor immediately.


    Missed Dose

    You can take the missed dosage if you notice within 8 hours. Always take with other antiretrovirals and food. If it is more than 8 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.


    Storage and Disposal

    • Keep the medication out of children’s reach
    • Keep the medication away from pets
    • Once expired dispose immediately
    • Store at 30?C


    Fast Tag

    • Dolutegravir is an integrase strand transfer inhibitor
    • It is used to control and treat HIV infection with at least two other antiretrovirals.
    • Instgra 50mg Tablet is not advised during pregnancy and lactation period
    • Instgra 50mg Tablet is used in adolescence, adults, and geriatrics
    • Don’t use this medication with liver disease or kidney disease
    • This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.