Karplat 450mg Infusion

Brand Name Karplat 450mg Infusion
Salt Composition Carboplatin 450mg
Strength 450mg
Product Form Infusion
Storage Store at room temperature (10-30°C)
Category Anti-Cancer
Country of Origin India
Manufacturer Cadila Pharmaceuticals
Manufacturer/Marketer AddressCadila Pharmaceuticals,,Cadila Corporate Campus, Sarkhej Dholka road, Bhat, India
M.R.P : Rs.1952.53       Price : Rs.1562.02

You Save : Rs.390.51    Inclusive of all taxes

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Availability : In Stock

    Medical Description of Karplat 450mg Infusion

    Karplat 450mg Infusion contains Carboplatin 450mg it’s an antineoplastic medication and alkylating agent. It is a platinum analogue. It is used in the treatment of ovarian cancer. It is used as an orphan drug in the advanced stages of cervical cancer, endometrial cancer, esophageal cancer, head and neck cancer, melanoma, non-small cell lung cancer, sarcoma, small cell lung cancer, testicular cancer, and thymoma. It is also used as an orphan drug in metastatic breast cancer and neuroendocrine carcinoma of the skin.

    Karplat 450mg Infusion Uses

    Karplat 450mg Infusion is used in the treatment of advanced ovarian cancer. It is not used in neonates. It is also used as an orphan drug in several cancers and leukemia.

    Karplat 450mg Infusion Benefits

    Karplat 450mg Infusion used in the treatment of ovarian cancer in adults and children above age 2

    Karplat 450mg Infusion Indication

    Carboplatin is used as an orphan drug in the case of

    • Advanced Cervical Cancer
    • Advanced Endometrial Cancer
    • Advanced Esophageal Cancers
    • Malignant Pleural Mesothelioma
    • Metastatic Breast Cancer
    • Neuroendocrine Carcinoma of the Skin
    • Refractory Hodgkin Lymphoma
    • Retinoblastoma
    • Advanced Head and Neck Cancer
    • Advanced Melanoma
    • Advanced Non Small Cell Lung Cancer
    • Advanced Ovarian Carcinoma
    • Advanced Testicular cancer
    • Advanced Thymoma
    • Advanced thymic carcinoma
    • Advanced Sarcoma
    • Advanced Bladder cancer
    • Advanced Small cell lung cancer
    • Refractory Non-Hodgkin's lymphoma

    Mechanism of action of Karplat 450mg Infusion

    Carboplatin is an alkylating medication. It causes intra- and inter-strand crosslinks between DNA bases causing break in DNA strand thus apoptosis is induced resulting in cell death of abnormal DNA containing cancer cells.

    How Karplat 450mg Infusion works

    Carboplatin is an antineoplastic and alkylating medication. It causes DNA base pairs to break inducing apoptosis of these abnormal cancer cells.

    Karplat 450mg Infusion Contraindication

    Absolute contraindication:

    • if you are allergic to Karplat 450mg (Carboplatin 450mg) Infusion or its constituents
    • if you are pregnant
    • if you are breastfeeding

    Relative contraindication:

    • if you are vaccinating
    • if you have a kidney disorder
    • if you have a neurological disorder
    • if you have a lung disorder
    • if you have a heart disorder
    • if you have a liver disorder
    • if you are a smoking/tobacco user

    Karplat 450mg Infusion Side Effects

      Common side effects that occur 1:10 patients: Peripheral neuropathy, Anemia, Nausea, Fatigue, Diarrhea, Vomiting, Abdominal pain, Constipation, Thrombocytopenia, Fever, Anorexia, Leukopenia, Dyspnea, Cough

    Uncommon side effects that occur 1:100 patients:Edema, Neutropenia, Pharyngolaryngeal dysesthesia, Anaphylactic-like reaction, Pulmonary fibrosis,hypokalemia

    Rare side effects that occur 1:1,000 patients: Pulmonary fibrosis, Posterior leukoencephalopathy syndrome, Loss of deep tendon reflexes, dysarthria, Lhermitte’s sign, cranial nerve palsies, fasciculations, convulsion, RPLS, Deafness, Laryngospasm, colitis, metabolic acidosis, ileus, intestinal obstruction, pancreatitis; veno-occlusive disease of liver, perisinusoidal fibrosis, Hemolytic uremic syndrome, Acute tubular necrosis, acute interstitial nephritis, acute renal failure, Pulmonary fibrosis, interstitial lung diseases, Rhabdomyolysis, Septic shock

    FAQs for Karplat 450mg Infusion

     Is Karplat 450mg (Carboplatin 450mg) Infusion safe during pregnancy?

    No, taking Karplat 450mg Infusion during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    Can Karplat 450mg Infusion be taken while breastfeeding?

    No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Karplat 450mg Infusion can also pass via breastfeeding.

    Can Karplat 450mg Infusion be taken while alcohol consumption?

    The interaction is unknown but Karplat 450mg Infusion causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Karplat 450mg Infusion?

    Karplat 450mg Infusion causes side effects thus caution is used while driving or operating machineries.

    Can you smoke or use tobacco while using Karplat 450mg Infusion?

    No, smoking and tobacco use causes interaction with Karplat 450mg Infusion thus should be avoided.

    Precautions and general warning of Karplat 450mg Infusion


    Intake of alcohol with Karplat 450mg Infusion causes side effects thus caution is required. consult your physician

    Driving or operating machinery

    Driving or operating heavy machinery with Karplat 450mg Infusion causes side effects thus caution is required. consult your physician


    Using Carboplatin during pregnancy may cause embryo-fetal toxicity. Consult your physician

    Breast Feeding

    Using Carboplatin during Breastfeeding may cause side effects similar to adults. Consult your physician

    Kidney Problem

    Consult your physician

    Liver Disease

    Consult your physician

    How to Take Karplat 450mg Infusion

    This Infusion is used only in the presence of physician; Do not shake medicine containing vial while diluting or infusing; It is compatible with D5W; Do not use NS or chloride containing solutions; It is infused into 250-500ml of D5W and administered as slow infusion; Refrigerate unopened or opened 8?C

    After therapy has been initiated, do not take more or less of this drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing your dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.

    Use of Karplat 450mg Infusion in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.

    Use of Karplat 450mg Infusion in children

    This Infusion is not recommended in children less than 2 years of age. If used to be done so only with caution.

    Use of Karplat 450mg Infusion in Elderly Patients

    This Infusion has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.

    Other general warnings

    • Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Renal toxicity – impaired renal clearance
    • Neurotoxicity – causes tremors
    • Avoid cold food/air for next 4 days
    • Pulmonary toxicity – pulmonary fibrosis
    • Gastrointestinal effects -
    • Cardiotoxic – MI/CHF/AF/bradycardia/prolonged QT syndrome
    • Electrolyte imbalance – hypokalemia
    • Reversible posterior leukoencephalopathy syndrome
    • Rhabdomyolysis
    • Hepatotoxic – impaired liver enzymes
    • Pregnancy – causes embryo-fetal toxicity
    • Breast feeding – causes side effects similar to adults
    • Alcohol intake or Driving or operating heavy machinery – Karplat 450mg Infusion causes side effects thus caution is required. consult your physician

    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have a kidney problem

    If you have a neurological problem

    If you are pregnant or breastfeeding

    General instructions

    This Infusion is was given intravenously in the presence of a physician. It must be kept at 8°C. Do not store after a single-use.

    Drug Interaction of Karplat 450mg Infusion

    Drug-Drug Interaction

    Severity of adverse effects is increased by Allopurinol, Beclomethasone

    Severity of adverse effects is increased by Carboplatin combined with Arsenic trioxide, Doxorubicin

    Severity of nephrotoxicity is increased byAceclofenac, Acyclovir, Etoposide, Mefenamic acid

    Severity of ototoxicity and nephrotoxicity is increased by Capreomycin, Dihydrostreptomycin, Gentamicin

    Severity of bleeding is increased by Abciximab, Antithrombin Alfa

    Drug-Food Interaction

    This medication can be taken with any type of food, if doubts arise kindly refer to your physician. It generally causes side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution. Do not smoke while taking this medication. Do not use tobacco while taking this medication.

    Drug-Disease Interaction

    • Cardiac disorders – used with caution in QTc prolongation. Consult a physician before use
    • Hematological disorders – used with caution in bleeding disorders like thrombosis. Consult a physician before use
    • Bone disorders – used with caution in osteonecrosis. Consult a physician before use.
    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress and interstitial lung disorder. Consult a physician before use

    Over Dose

    In the case of Overdosage with this Infusion Contact your physician.

    Missed Dose

    Consult your physician immediately.

    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 8°C

    Fast Tag

    Karplat 450mg Infusion is an antineoplastic drug

    Carboplatin is an alkylating agent

    This Infusion is used to control and treat ovarian cancer

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease or renal diseases