Kemocarb 450mg Injection

Brand Name Kemocarb 450mg Injection
Salt Composition Carboplatin (450mg)
Strength 450mg
Product Form Injection
Pack 1 Injection in 1 Vial
Storage Store at room temperature (10-30°C)
Category Anti Cancer
Country of Origin India
Manufacturer Fresenius Kabi India Pvt Ltd
Manufacturer/Marketer AddressFresenius Kabi India Pvt Ltd, Fifth Floor, A-wing, Ashoka Plaza, Pune-Nagar Road, Survey No. 32/2 Vadgaon Sheri, Viman Nagar, Pune, Maharashtra 411014
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M.R.P : Rs.2466.00       Price : Rs.1849.50

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    Precautions and general warning of Kemocarb 450mg Injection








Kemocarb 450mg Injection

Brand Name Kemocarb 450mg Injection
Salt Composition Carboplatin 450mg
Strength 450mg
Category Anti Cancer
Country of Origin India
-20%
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M.R.P : Rs.2466.00       Price : Rs.1972.80

You Save : Rs.493.20    Inclusive of all taxes

- +

Availability : In Stock


    Medical Description of Kemocarb 450mg Injection

    Kemocarb 450mg Injection contains Carboplatin 450mg it’s an antineoplastic medication and alkylating agent. It is a platinum analogue. It is used in the treatment of ovarian cancer. It is used as an orphan drug in the advanced stages of cervical cancer, endometrial cancer, esophageal cancer, head and neck cancer, melanoma, non-small cell lung cancer, sarcoma, small cell lung cancer, testicular cancer, and thymoma. It is also used as an orphan drug in metastatic breast cancer and neuroendocrine carcinoma of the skin.


    Kemocarb 450mg Injection Uses

    Kemocarb 450mg Injection contains Carboplatin 450mg it’s an antineoplastic medication and alkylating agent. It is a platinum analogue. It is used in the treatment of ovarian cancer. It is used as an orphan drug in the advanced stages of cervical cancer, endometrial cancer, esophageal cancer, head and neck cancer, melanoma, non-small cell lung cancer, sarcoma, small cell lung cancer, testicular cancer, and thymoma. It is also used as an orphan drug in metastatic breast cancer and neuroendocrine carcinoma of the skin.


    Kemocarb 450mg Injection Benefits

    Kemocarb 450mg Injection used in the treatment of ovarian cancer in adults and children above age 2


    Kemocarb 450mg Injection Indication

    Carboplatin is used as an orphan drug in the case of

    • Advanced Cervical Cancer
    • Advanced Endometrial Cancer
    • Advanced Esophageal Cancers
    • Malignant Pleural Mesothelioma
    • Metastatic Breast Cancer
    • Neuroendocrine Carcinoma of the Skin
    • Refractory Hodgkin Lymphoma
    • Retinoblastoma
    • Advanced Head and Neck Cancer
    • Advanced Melanoma
    • Advanced Non Small Cell Lung Cancer
    • Advanced Ovarian Carcinoma
    • Advanced Testicular cancer
    • Advanced Thymoma
    • Advanced thymic carcinoma
    • Advanced Sarcoma
    • Advanced Bladder cancer
    • Advanced Small cell lung cancer
    • Refractory Non-Hodgkin's lymphoma


    Mechanism of action of Kemocarb 450mg Injection

    Carboplatin is an alkylating medication. It causes intra- and inter-strand crosslinks between DNA bases causing break in DNA strand thus apoptosis is induced resulting in cell death of abnormal DNA containing cancer cells.


    How Kemocarb 450mg Injection works

    Carboplatin is an antineoplastic and alkylating medication. It causes DNA base pairs to break inducing apoptosis of these abnormal cancer cells.


    Kemocarb 450mg Injection Contraindication

    Absolute contraindication:

    • if you are allergic to Kemocarb 450mg (Carboplatin 450mg) Injection or its constituents
    • if you are pregnant
    • if you are breastfeeding

    Relative contraindication:

    • if you are vaccinating
    • if you have a kidney disorder
    • if you have a neurological disorder
    • if you have a lung disorder
    • if you have a heart disorder
    • if you have a liver disorder
    • if you are a smoking/tobacco user


    Kemocarb 450mg Injection Side Effects

     Common side effects that occur 1:10 patients: Peripheral neuropathy, Anemia, Nausea, Fatigue, Diarrhea, Vomiting, Abdominal pain, Constipation, Thrombocytopenia, Fever, Anorexia, Leukopenia, Dyspnea, Cough

    Uncommon side effects that occur 1:100 patients:Edema, Neutropenia, Pharyngolaryngeal dysesthesia, Anaphylactic-like reaction, Pulmonary fibrosis,hypokalemia

    Rare side effects that occur 1:1,000 patients: Pulmonary fibrosis, Posterior leukoencephalopathy syndrome, Loss of deep tendon reflexes, dysarthria, Lhermitte’s sign, cranial nerve palsies, fasciculations, convulsion, RPLS, Deafness, Laryngospasm, colitis, metabolic acidosis, ileus, intestinal obstruction, pancreatitis; veno-occlusive disease of liver, perisinusoidal fibrosis, Hemolytic uremic syndrome, Acute tubular necrosis, acute interstitial nephritis, acute renal failure, Pulmonary fibrosis, interstitial lung diseases, Rhabdomyolysis, Septic shock


    FAQs for Kemocarb 450mg Injection

     Is Kemocarb 450mg (Carboplatin 450mg) Injection safe during pregnancy?

    No, taking Kemocarb 450mg Injection during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

    Can Kemocarb 450mg Injection be taken while breastfeeding?

    No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Kemocarb 450mg Injection can also pass via breastfeeding.

    Can Kemocarb 450mg Injection be taken while alcohol consumption?

    The interaction is unknown but Kemocarb 450mg Injection causes side effects. Thus, consult your physician.

    Can I take a drive or operate heavy machineries while on Kemocarb 450mg Injection?

    Kemocarb 450mg Injection causes side effects thus caution is used while driving or operating machineries.

    Can you smoke or use tobacco while using Kemocarb 450mg Injection?

    No, smoking and tobacco use causes interaction with Kemocarb 450mg Injection thus should be avoided.


    Precautions and general warning of Kemocarb 450mg Injection

    Alcohol

    Intake of alcohol with Kemocarb 450mg Injection causes side effects thus caution is required. consult your physician

    Driving or operating machinery

    Driving or operating heavy machinery with Kemocarb 450mg Injection causes side effects thus caution is required. consult your physician

    Pregnancy

    Using Carboplatin during pregnancy may cause embryo-fetal toxicity. Consult your physician

    Breast Feeding

    Using Carboplatin during Breastfeeding may cause side effects similar to adults. Consult your physician

    Kidney Problem

    impaired renal clearance

    Liver Disease

    impaired liver enzymes


    How to Take Kemocarb 450mg Injection

    This injection is used only in the presence of physician; Do not shake medicine containing vial while diluting or infusing; It is compatible with D5W; Do not use NS or chloride containing solutions; It is infused into 250-500ml of D5W and administered as slow infusion; Refrigerate unopened or opened 8?C

    After therapy has been initiated, do not take more or less of this drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing your dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.


    Use of Kemocarb 450mg Injection in Adult

    If you are pregnant or breastfeeding inform your physician as they are not advisable.


    Use of Kemocarb 450mg Injection in children

    This injection is not recommended in children less than 2 years of age. If used to be done so only with caution.


    Use of Kemocarb 450mg Injection in Elderly Patients

    This injection has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.


    Other general warnings

    • Allergic reactions - It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
    • Renal toxicity – impaired renal clearance
    • Neurotoxicity – causes tremors
    • Avoid cold food/air for next 4 days
    • Pulmonary toxicity – pulmonary fibrosis
    • Gastrointestinal effects -
    • Cardiotoxic – MI/CHF/AF/bradycardia/prolonged QT syndrome
    • Electrolyte imbalance – hypokalemia
    • Reversible posterior leukoencephalopathy syndrome
    • Rhabdomyolysis
    • Hepatotoxic – impaired liver enzymes
    • Pregnancy – causes embryo-fetal toxicity
    • Breast feeding – causes side effects similar to adults
    • Alcohol intake or Driving or operating heavy machinery – Kemocarb 450mg Injection causes side effects thus caution is required. consult your physician


    Talk to your doctor if

    If you have any allergy

    If you have a liver problem

    If you have a kidney problem

    If you have a neurological problem

    If you are pregnant or breastfeeding


    General instructions

    This injection is was given intravenously in the presence of a physician. It must be kept at 8°C. Do not store after a single-use.


    Drug Interaction of Kemocarb 450mg Injection

    Drug-Drug Interaction

    Severity of adverse effects is increased by Allopurinol, Beclomethasone

    Severity of adverse effects is increased by Carboplatin combined with Arsenic trioxide, Doxorubicin

    Severity of nephrotoxicity is increased byAceclofenac, Acyclovir, Etoposide, Mefenamic acid

    Severity of ototoxicity and nephrotoxicity is increased by Capreomycin, Dihydrostreptomycin, Gentamicin

    Severity of bleeding is increased by Abciximab, Antithrombin Alfa

    Drug-Food Interaction

    This medication can be taken with any type of food, if doubts arise kindly refer to your physician. It generally causes side effects thus it is advised not to be taken with alcohol. It is preferred to drive or operate heavy machinery with caution. Do not smoke while taking this medication. Do not use tobacco while taking this medication.

    Drug-Disease Interaction

    • Cardiac disorders – used with caution in QTc prolongation. Consult a physician before use
    • Hematological disorders – used with caution in bleeding disorders like thrombosis. Consult a physician before use
    • Bone disorders – used with caution in osteonecrosis. Consult a physician before use.
    • Liver disorders – used with caution in severe liver diseases. Consult a physician before use
    • Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
    • Respiratory disorders – used with caution in respiratory distress and interstitial lung disorder. Consult a physician before use


    Over Dose

    In the case of Overdosage with this injection Contact your physician.


    Missed Dose

    Consult your physician immediately.


    Storage and Disposal

    Keep the medication out of children’s reach

    Keep the medication away from pets

    Once expired dispose immediately

    Store at 8°C


    Fast Tag

    Kemocarb 450mg Injection is an antineoplastic drug

    Carboplatin is an alkylating agent

    This injection is used to control and treat ovarian cancer

    Do not use this medication while pregnant and lactation period.

    Don’t use this medication with liver disease or renal diseases