Lamistar 30 Tablet
Brand Name | Lamistar 30 Tablet |
Salt Composition |
Lamivudine (150mg) + Stavudine (30mg) |
Strength | 150mg + 30mg |
Product Form | Tablet |
Pack | 30 Tablet(s) in Bottle |
Storage | Store below 30°C |
Category |
HIV |
SubCategory |
HIV |
Country of Origin | India |
Manufacturer |
Hetero Healthcare Ltd |
Manufacturer/Marketer Address | Hetero Healthcare Ltd, S.no: 80-84, Melange towers, PatrikaNagar,Madhapur,Hyderabad. Telangana-500081. |
You Save : Rs.63.34 Inclusive of all taxes
- if you are allergic to Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet and its contents
- if you are pregnant
- if you are breastfeeding
- if you have a liver disorder like hepatitis B or C or Child-Pugh disease
- if you have neurologic disorders
- if you have pancreatitis
- if you have renal diseases
- if you are diabetic
- Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
- Pancreatitis
- Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
- New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
- Accumulation or Redistribution of body fat or
- immune reconstitution syndrome.
- Any sign of infection – fever or lymph node enlargement
- Liver disorders – used with caution in severe liver diseases. Consult a physician before use
- Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
- Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
- Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
- Pancreases disorders – used with caution in pancreatitis. Consult a physician before use
Medical Description of Lamistar 30 Tablet
Lamistar 30 Tablet contains Lamivudine 150mg and stavudine 30mg. Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Lamistar 30 tablet is a nucleoside reverse transcriptase inhibitor. Lamistar 30 tablet works by reducing the viral load of HIV in your body. It improves your immune system and reduces the risk of conditions associated with HIV infection.
Lamistar 30 Tablet Uses
Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is used to treat adults and children above 12 years of age who are infected by HIV-1. Lamistar 30 tablet can be taken in combination with other anti-HIV medicines. Your doctor will discuss which combination of medicines is best for you.
Lamistar 30 Tablet Benefits
Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is used with other anti-HIV medicines to help control HIV infection. Lamistar 30 tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Lamistar 30 tablet is nucleoside reverse transcriptase inhibitor. It is not a cure for HIV infection, it improves immunity that results in longevity of life. It is not recommended for use in children less than 12 years of age due to the increased risk of serious side effects.
Lamistar 30 Tablet Indication
Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is used with other anti-HIV medicines to help control HIV infection. Lamistar 30 tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Lamistar 30 tablet is nucleoside reverse transcriptase inhibitor. It is not a cure for HIV infection, it improves immunity that results in longevity of life. It is not recommended for use in children less than 12 years of age due to the increased risk of serious side effects.
Mechanism of action of Lamistar 30 Tablet
Lamistar 30 tablet contains Lamivudine 150mg and Stavudine 30mg. Lamivudine present in Lamistar 30 tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Lamivudine is phosphorylated to its active forms lamivudine triphosphate that is incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Stavudine is a nucleoside reverse transcriptase inhibitor that is phosphorylated into stavudine -5- triphosphate. Stavudine-5-triphosphate battle with deoxythymidine triphosphate and incorporate themselves into the DNA of HIV molecular structure. After they incorporate within the DNA of HIV molecule the further process such as transcription, reverse transcriptase enzyme is inhibited. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.
How Lamistar 30 Tablet works
Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Lamistar 30 tablet inhibits the action of HIV-1 reverse transcriptase enzyme by incorporating themselves into the nucleotide sequence thus inhibits the action of the reverse transcriptase of HIV-1, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection and improves immunity.
Lamistar 30 Tablet Contraindication
Absolute contraindication:
Relative contraindication:
Lamistar 30 Tablet Side Effects
Common side effects that occur 1:10 patients: Headache, Cough, nausea, vomiting, abdominal pain or cramps, diarrhoea, Rash, alopecia, Arthralgia, Myalgia, Fatigue, malaise, fever, Back pain. Neutropenia, Thrombocytopenia, increase in AST, ALT bilirubin levels.
Uncommon side effects that occur 1:100 patients: anaemia, Insomnia, Anxiety, Depression, Pancreatitis, Peripheral neuropathy
Rare side effects that occur 1:1000 patients: Pure red cell aplasia, Lactic acidosis, Pancreatitis, elevations in serum amylase, Hepatitis, Angioedema, Rhabdomyolysis, cardiomyopathy, convulsions, lipodystrophy, lactic acidosis
Very rare side effects that occur 1:10,000 patients: erythema multiform, Stevens–Johnson syndrome, toxic epidermal necrolysis, hepatic failure
FAQs for Lamistar 30 Tablet
Is Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet safe during pregnancy?
No, taking Lamistar 30 tablet during is not recommended unless the pros outweigh the cons. Consult your physician.
Can Lamistar 30 tablet be taken while breastfeeding?
No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.
Can Lamistar 30 tablet be taken while alcohol consumption?
The interaction is unknown but this medication causes side effects. Thus, consult your physician.
Can I take a drive or operate heavy machineries while on Lamistar 30 tablet?
This medication causes side effects thus caution is used while driving or operating machineries.
Is Lamistar 30 tablet habit forming?
No, Lamistar 30 tablet is not habit-forming.
Precautions and general warning of Lamistar 30 Tablet
Alcohol
Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, Consult your physician.
Driving or operating machinery
It is preferred to drive or operate heavy machinery with caution as Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet causes side effects. For further queries, consult your physician.
Pregnancy
The use of Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is not recommended during pregnancy unless the pros outweigh the cons.
Breast Feeding
The use of Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.
Kidney Problem
Renal filtration impairment – monitor function.
Liver Disease
Liver disorders and diseases like hepatitis B or C, Child-Pugh disease
Monitor liver function before and during therapy
How to Take Lamistar 30 Tablet
Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is taken orally without food.
Lamistar 30 tablets must be taken at the same time every day as prescribed by your physician.
Lamistar 30 tablets can be taken with other antivirals.
After therapy has been initiated, do not take more or less of Lamistar 30 medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing Lamistar 30 tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.
Use of Lamistar 30 Tablet in Adult
If you are pregnant or breastfeeding inform your physician as they are not advisable.
The recommended dosage for Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is one tablet taken twice per day
Lamistar 30 tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake
Use of Lamistar 30 Tablet in children
The recommended dosage is one tablet of Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet taken twice a day on empty stomach.
Lamistar 30 tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake
Caution is used in cases where the creatine clearance rate is <50ml/min
Use of Lamistar 30 Tablet in Elderly Patients
Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.
Other general warnings
Talk to your doctor if
If you have any allergy
If you have a liver problem
If you have a kidney problem
If you are pregnant or breastfeeding
General instructions
Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is taken with other antivirals orally as prescribed dosage at a specific time regularly.
Drug Interaction of Lamistar 30 Tablet
Drug-Drug Interaction
Serum concentration decreased by Acetazolamide, Potassium citrate
Serum concentration increased by Aceclofenac, Acetaminophen, Alprazolam
severity of adverse effects is increased by Acyclovir, Amphotericin B, Baclofen
Drug-Food Interaction
Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Lamistar 30 tablet generally causes side effects thus it is advised not to be taken with alcohol.
Drug-Disease Interaction
Over Dose
Contact your doctor, pharmacist or nurse immediately.
Missed Dose
If you take twice a day dosage, then the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Always take with other antivirals Don’t take a double dose for a forgotten dose.
Storage and Disposal
Keep the medication out of children’s reach
Keep the medication away from pets
Once expired dispose immediately
Store at 30°C
Fast Tag
Lamistar 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is a nucleoside reverse transcriptase inhibitor.
Lamistar 30 tablet is used to control and treat HIV infection with other antivirals
Do not use this medication while pregnant or lactation period.
Don’t use this medication with liver disease and kidney diseases.
This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.