Lamivir S 30 Tablet

Lamivir S 30 Tablet contains Lamivudine 150mg and stavudine 30mg. Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Lamivir S 30 tablet is a nucleoside reverse transcriptase inhibitor. Lamivir S 30 tablet works by reducing the viral load of HIV in your body. It improves your immune system and reduces the risk of conditions associated with HIV infection.

Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is used to treat adults and children above 12 years of age who are infected by HIV-1. Lamivir S 30 tablet can be taken in combination with other anti-HIV medicines. Your doctor will discuss which combination of medicines is best for you.

Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is used with other anti-HIV medicines to help control HIV infection. Lamivir S 30 tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Lamivir S 30 tablet is nucleoside reverse transcriptase inhibitor. It is not a cure for HIV infection, it improves immunity that results in longevity of life. It is not recommended for use in children less than 12 years of age due to the increased risk of serious side effects.

Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. Lamivir S 30 tablet is used with other antiviral medications to boost the immunity of the affected hosts. Lamivir S 30 tablet is indicated in ages above 12 years of age.

Lamivir S 30 tablet contains Lamivudine 150mg and Stavudine 30mg. Lamivudine present in Lamivir S 30 tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Lamivudine is phosphorylated to its active forms lamivudine triphosphate that is incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Stavudine is a nucleoside reverse transcriptase inhibitor that is phosphorylated into stavudine -5- triphosphate. Stavudine-5-triphosphate battle with deoxythymidine triphosphate and incorporate themselves into the DNA of HIV molecular structure. After they incorporate within the DNA of HIV molecule the further process such as transcription, reverse transcriptase enzyme is inhibited. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.

Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Lamivir S 30 tablet inhibits the action of HIV-1 reverse transcriptase enzyme by incorporating themselves into the nucleotide sequence thus inhibits the action of the reverse transcriptase of HIV-1, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection and improves immunity.

Absolute contraindication:

• if you are allergic to Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet and its contents
• if you are pregnant
• if you are breastfeeding

Relative contraindication:

• if you have a liver disorder like hepatitis B or C or Child-Pugh disease
• if you have neurologic disorders
• if you have pancreatitis
• if you have renal diseases
• if you are diabetic

Common side effects that occur 1:10 patients: Headache, Cough, nausea, vomiting, abdominal pain or cramps, diarrhoea, Rash, alopecia, Arthralgia, Myalgia, Fatigue, malaise, fever, Back pain. Neutropenia, Thrombocytopenia, increase in AST, ALT bilirubin levels.

Uncommon side effects that occur 1:100 patients: anaemia, Insomnia, Anxiety, Depression, Pancreatitis, Peripheral neuropathy

Rare side effects that occur 1:1000 patients: Pure red cell aplasia, Lactic acidosis, Pancreatitis, elevations in serum amylase, Hepatitis, Angioedema, Rhabdomyolysis, cardiomyopathy, convulsions, lipodystrophy, lactic acidosis

Very rare side effects that occur 1:10,000 patients: erythema multiform, Stevens–Johnson syndrome, toxic epidermal necrolysis, hepatic failure

Is Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet safe during pregnancy?

No, taking Lamivir S 30 tablet during is not recommended unless the pros outweigh the cons. Consult your physician.

Can Lamivir S 30 tablet be taken while breastfeeding?

No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.

Can Lamivir S 30 tablet be taken while alcohol consumption?

The interaction is unknown but this medication causes side effects. Thus, consult your physician.

Can I take a drive or operate heavy machineries while on Lamivir S 30 tablet?

This medication causes side effects thus caution is used while driving or operating machineries.

Is Lamivir S 30 tablet habit forming?

No, Lamivir S 30 tablet is not habit-forming.

Alcohol

Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, Consult your physician.

Driving or operating machinery

It is preferred to drive or operate heavy machinery with caution as Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet causes side effects. For further queries, consult your physician.

Pregnancy

The use of Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is not recommended during pregnancy unless the pros outweigh the cons.

Breast Feeding

The use of Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.

Kidney Problem

Renal filtration impairment – monitor function.

Liver Disease

Liver disorders and diseases like hepatitis B or C, Child-Pugh disease

Monitor liver function before and during therapy

Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is taken orally without food.

Lamivir S 30 tablet must be taken at the same time every day as prescribed by your physician.

Lamivir S 30 tablet can be taken with other antivirals.

After therapy has been initiated, do not take more or less of Lamivir-S medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing Lamivir S 30 tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.

If you are pregnant or breastfeeding inform your physician as they are not advisable.

The recommended dosage for Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is one tablet taken twice per day

Lamivir S 30 tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake

The recommended dosage is one tablet of Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet taken twice a day on empty stomach.

Lamivir S 30 tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake

Caution is used in cases where the creatine clearance rate is <50ml/min

Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.

• Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
• Pancreatitis
• Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
• New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
• Accumulation or Redistribution of body fat or
• immune reconstitution syndrome.
• Any sign of infection – fever or lymph node enlargement

If you have any allergy

If you have a liver problem

If you have a kidney problem

If you are pregnant or breastfeeding

Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is taken with other antivirals orally as prescribed dosage at a specific time regularly.

Drug-Drug Interaction

Serum concentration decreased by Acetazolamide, Potassium citrate

Serum concentration increased by Aceclofenac, Acetaminophen, Alprazolam

severity of adverse effects is increased by Acyclovir, Amphotericin B, Baclofen

Drug-Food Interaction

Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Lamivir S 30 tablet generally causes side effects thus it is advised not to be taken with alcohol.

Drug-Disease Interaction

• Liver disorders – used with caution in severe liver diseases. Consult a physician before use
• Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
• Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
• Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
• Pancreases disorders – used with caution in pancreatitis. Consult a physician before use

Contact your doctor, pharmacist or nurse immediately.

If you take twice a day dosage, then the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Always take with other antivirals Don’t take a double dose for a forgotten dose.

Keep the medication out of children’s reach

Keep the medication away from pets

Once expired dispose immediately

Store at 30°C

Lamivir S 30 (Lamivudine (150mg) + Stavudine (30mg)) tablet is a nucleoside reverse transcriptase inhibitor.

Lamivir S 30 tablet is used to control and treat HIV infection with other antivirals

Do not use this medication while pregnant or lactation period.

Don’t use this medication with liver disease and kidney diseases.

This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.