Lamivir S 40 Tablet
Brand Name | Lamivir S 40 Tablet |
Salt Composition |
Lamivudine (150mg) + Stavudine (40mg) |
Strength | 150mg + 40mg |
Product Form | Tablet |
Pack | 60 Tablet(s) in 1 Bottle |
Storage | Store below 30°C |
Category |
HIV |
SubCategory |
HIV |
Country of Origin | India |
Manufacturer |
Cipla Ltd |
Manufacturer/Marketer Address | Cipla Ltd,Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013. |
You Save : Rs.176.55 Inclusive of all taxes
- if you are allergic to Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet and its contents
- if you are pregnant
- if you are breastfeeding
- if you have a liver disorder like hepatitis B or C or Child-Pugh disease
- if you have neurologic disorders
- if you have pancreatitis
- if you have renal diseases
- if you are diabetic
- Skin reactions - It can be mild to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
- Pancreatitis
- Musculoskeletal problems - Osteonecrosis that causes joint stiffness and pain in larger joints like shoulder, hip, and knee
- New onset diabetes mellitus or hyperglycemia – Monitor blood glucose and insulin levels. When needed add oral hypoglycemic and insulin
- Accumulation or Redistribution of body fat or
- immune reconstitution syndrome.
- Any sign of infection – fever or lymph node enlargement
- Liver disorders – used with caution in severe liver diseases. Consult a physician before use
- Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
- Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
- Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
- Pancreases disorders – used with caution in pancreatitis. Consult a physician before use
Medical Description of Lamivir S 40 Tablet
Lamivir S 40 Tablet contains Lamivudine 150mg and stavudine 40mg. Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Lamivir S 40 tablet is a nucleoside reverse transcriptase inhibitor. Lamivir S 40 tablet works by reducing the viral load of HIV in your body. It improves your immune system and reduces the risk of conditions associated with HIV infection.
Lamivir S 40 Tablet Uses
Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is used to treat adults and children above 12 years of age who are infected by HIV-1. Lamivir S 40 tablet can be taken in combination with other anti-HIV medicines. Your doctor will discuss which combination of medicines is best for you.
Lamivir S 40 Tablet Benefits
Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is used with other anti-HIV medicines to help control HIV infection. Lamivir S 40 tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Lamivir S 40 tablet is nucleoside reverse transcriptase inhibitor. It is not a cure for HIV infection, it improves immunity that results in longevity of life. It is not recommended for use in children less than 12 years of age due to the increased risk of serious side effects.
Lamivir S 40 Tablet Indication
Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. Lamivir S 40 tablet is used with other antiviral medications to boost the immunity of the affected hosts. Lamivir S 40 tablet is indicated in ages above 12 years of age.
Mechanism of action of Lamivir S 40 Tablet
Lamivir S 40 tablet contains Lamivudine 150mg and Stavudine 40mg. Lamivudine present in Lamivir S 40 tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Lamivudine is phosphorylated to its active forms lamivudine triphosphate that is incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Stavudine is a nucleoside reverse transcriptase inhibitor that is phosphorylated into stavudine -5- triphosphate. Stavudine-5-triphosphate battle with deoxythymidine triphosphate and incorporate themselves into the DNA of HIV molecular structure. After they incorporate within the DNA of HIV molecule the further process such as transcription, reverse transcriptase enzyme is inhibited. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.
How Lamivir S 40 Tablet works
Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Lamivir S 40 tablet inhibits the action of HIV-1 reverse transcriptase enzyme by incorporating themselves into the nucleotide sequence thus inhibits the action of the reverse transcriptase of HIV-1, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection and improves immunity.
Lamivir S 40 Tablet Contraindication
Absolute contraindication:
Relative contraindication:
Lamivir S 40 Tablet Side Effects
Common side effects that occur 1:10 patients: Headache, Cough, nausea, vomiting, abdominal pain or cramps, diarrhoea, Rash, alopecia, Arthralgia, Myalgia, Fatigue, malaise, fever, Back pain. Neutropenia, Thrombocytopenia, increase in AST, ALT bilirubin levels.
Uncommon side effects that occur 1:100 patients: anaemia, Insomnia, Anxiety, Depression, Pancreatitis, Peripheral neuropathy
Rare side effects that occur 1:1000 patients: Pure red cell aplasia, Lactic acidosis, Pancreatitis, elevations in serum amylase, Hepatitis, Angioedema, Rhabdomyolysis, cardiomyopathy, convulsions, lipodystrophy, lactic acidosis
Very rare side effects that occur 1:10,000 patients: erythema multiform, Stevens–Johnson syndrome, toxic epidermal necrolysis, hepatic failure
FAQs for Lamivir S 40 Tablet
Is Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet safe during pregnancy?
No, taking Lamivir S 40 tablet during is not recommended unless the pros outweigh the cons. Consult your physician.
Can Lamivir S 40 tablet be taken while breastfeeding?
No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.
Can Lamivir S 40 tablet be taken while alcohol consumption?
The interaction is unknown but this medication causes side effects. Thus, consult your physician.
Can I take a drive or operate heavy machineries while on Lamivir S 40 tablet?
This medication causes side effects thus caution is used while driving or operating machineries.
Is Lamivir S 40 tablet habit forming?
No, Lamivir S 40 tablet is not habit-forming.
Precautions and general warning of Lamivir S 40 Tablet
Alcohol
Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, Consult your physician.
Driving or operating machinery
It is preferred to drive or operate heavy machinery with caution as Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet causes side effects. For further queries, consult your physician.
Pregnancy
The use of Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is not recommended during pregnancy unless the pros outweigh the cons.
Breast Feeding
The use of Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.
Kidney Problem
Renal filtration impairment – monitor function.
Liver Disease
Liver disorders and diseases like hepatitis B or C, Child-Pugh disease
Monitor liver function before and during therapy
How to Take Lamivir S 40 Tablet
Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is taken orally without food.
Lamivir S 40 tablet must be taken at the same time every day as prescribed by your physician.
Lamivir S 40 tablet can be taken with other antivirals.
After therapy has been initiated, do not take more or less of Lamivir S 40 medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing Lamivir S 40 tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.
Use of Lamivir S 40 Tablet in Adult
If you are pregnant or breastfeeding inform your physician as they are not advisable.
The recommended dosage for Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is one tablet taken twice per day
Lamivir S 40 tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake
Use of Lamivir S 40 Tablet in children
The recommended dosage is one tablet of Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet taken twice a day on empty stomach.
Lamivir S 40 tablet can be taken with other antivirals as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake
Caution is used in cases where the creatine clearance rate is <50ml/min
Use of Lamivir S 40 Tablet in Elderly Patients
Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.
Other general warnings
Talk to your doctor if
If you have any allergy
If you have a liver problem
If you have a kidney problem
If you are pregnant or breastfeeding
General instructions
Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is taken with other antivirals orally as prescribed dosage at a specific time regularly.
Drug Interaction of Lamivir S 40 Tablet
Drug-Drug Interaction
Serum concentration decreased by Acetazolamide, Potassium citrate
Serum concentration increased by Aceclofenac, Acetaminophen, Alprazolam
severity of adverse effects is increased by Acyclovir, Amphotericin B, Baclofen
Drug-Food Interaction
Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. Lamivir S 40 tablet generally causes side effects thus it is advised not to be taken with alcohol.
Drug-Disease Interaction
Over Dose
Contact your doctor, pharmacist or nurse immediately.
Missed Dose
If you take twice a day dosage, then the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Always take with other antivirals Don’t take a double dose for a forgotten dose.
Storage and Disposal
Keep the medication out of children’s reach
Keep the medication away from pets
Once expired dispose immediately
Store at 30°C
Fast Tag
Lamivir S 40 (Lamivudine (150mg) + Stavudine (40mg)) tablet is a nucleoside reverse transcriptase inhibitor.
Lamivir S 40 tablet is used to control and treat HIV infection with other antivirals
Do not use this medication while pregnant or lactation period.
Don’t use this medication with liver disease and kidney diseases.
This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury etc.