Lamostad N Tablet
Brand Name | Lamostad N Tablet |
Salt Composition |
Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg) |
Strength | 150mg + 30mg + 200mg |
Product Form | Tablet |
Pack | 60 Tablet(s) in 1 Bottle |
Storage | Store below 30°C |
Category |
HIV |
SubCategory |
HIV |
Country of Origin | India |
Manufacturer |
Alkem Laboratories Limited |
Manufacturer/Marketer Address | Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013. |
You Save : Rs.257.40 Inclusive of all taxes
- if you are allergic to Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet and its contents
- if you are pregnant
- if you are breastfeeding
- children <12 years of age.
- if you have a liver disorder like hepatitis B or C or Child-Pugh disease
- if you have neurologic disorders
- if you have pancreatitis
- if you have renal diseases or filtration impairment
- Pancreatitis
- Accumulation or Redistribution of body fat or
- immune reconstitution syndrome.
- Any sign of infection – fever or lymph node enlargement
- Liver disorders – used with caution in severe liver diseases. Consult a physician before use
- Kidney disorders – used with caution in severe kidney diseases. Consult a physician before use
- Cardiac disorders – used with caution in heart failure and MI. Consult a physician before use
- Respiratory disorders – used with caution in respiratory distress. Consult a physician before use
- Pancreases disorders – used with caution in pancreatitis. Consult a physician before use
Medical Description of Lamostad N Tablet
Lamostad N tablet contains Lamivudine 150mg, stavudine 30mg and nevirapine 200mg. Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV) – 1 infection. Lamostad N tablet is a nucleoside analogue. Lamostad N tablet works by reducing the viral load of HIV in your body. Lamostad N tablet improves your immune system and reduces the risk of conditions associated with HIV infection.
Lamostad N Tablet Uses
Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is used to treat adults and adolescence >50 kgs of weight or >12 years of age who are infected by HIV-1. Caution is used in cases of liver and renal impairment.
Lamostad N Tablet Benefits
Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is used with other anti-HIV medication to help control HIV infection. Lamostad N tablet helps to decrease the amount of HIV in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Lamostad N tablet is a nucleoside analogue. Lamostad N tablet is not a cure for HIV infection, it improves immunity that results in longevity of life. It is not recommended for use in children less than 12 years of age or less than 50 kgs of weight due to the increased risk of serious side effects.
Lamostad N Tablet Indication
Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is indicated in the treatment of HIV-1 infection that causes AIDS in humans. Lamostad N tablet is used to boost the immunity of the affected hosts. Lamostad N tablet is indicated in ages above 12 years of age who weigh more than 50 Kgs.
Mechanism of action of Lamostad N Tablet
Lamostad N tablet contains Lamivudine 150mg, stavudine 30mg and nevirapine 200mg. Lamivudine is HIV-1 nucleoside reverse transcriptase inhibitor. Lamivudine is phosphorylated to its active forms lamivudine triphosphate that is incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Stavudine is a nucleoside reverse transcriptase inhibitor that is phosphorylated into stavudine -5- triphosphate. Stavudine-5-triphosphate battle with deoxythymidine triphosphate and incorporate themselves into the DNA of HIV molecular structure. After they incorporate within the DNA of HIV molecule the further process such as transcription, reverse transcriptase enzyme is inhibited. Nevirapine is a non-nucleoside reverse transcriptase inhibitor that binds to reverse transcriptase of HIV-1 particle thus blocks RNA and DNA dependant DNA polymerase actions that is required for replication of HIV-1. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.
How Lamostad N Tablet works
Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is HIV-1 nucleoside reverse transcriptase inhibitor. Lamostad N tablet inhibits the action of HIV-1 reverse transcriptase enzyme by incorporating themselves into the nucleotide sequence thus inhibits the action of the reverse transcriptase of HIV-1, thereby preventing the formation of mature virus particles into infectious virions that spreads the infection and improves immunity.
Lamostad N Tablet Contraindication
Absolute contraindication:
Relative contraindication:
Lamostad N Tablet Side Effects
Very common side effect that occurs in more than 1:10 patients: rash
Common side effects that occur 1:10 patients: Headache, Cough, nausea, vomiting, abdominal pain, diarrhea, alopecia, Arthralgia, Myalgia, Fatigue, malaise, fever, Back pain. Neutropenia, Thrombocytopenia, increase in AST, ALT bilirubin levels, granulocytopenia, hepatitis
Uncommon side effects that occur 1:100 patients: anemia, Insomnia, Anxiety, Depression, Pancreatitis, Peripheral neuropathy, difficulty breathing, anaphylactic shock, jaundice, Stevens-Johnson Syndrome/toxic epidermal necrolysis, urticaria, angioedema, arthralgia, myalgia, decreased blood phosphorus, increased blood pressure
Rare side effects that occur 1:1000 patients: Pure red cell aplasia, Lactic acidosis, Pancreatitis, elevations in serum amylase, Angioedema, Rhabdomyolysis, cardiomyopathy, convulsions, lipodystrophy, lactic acidosis, fulminant hepatitis, drug reaction with eosinophilia, decrease in skin sensations
FAQs for Lamostad N Tablet
Is Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet safe during pregnancy?
No, taking Lamostad N tablet during is not recommended. Consult your physician.
Can Lamostad N tablet be taken while breastfeeding?
No, in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding.
Can Lamostad N tablet be taken while alcohol consumption?
The interaction is unknown but this medication causes neurological side effects. Thus, consult your physician.
Can I take drive or operate heavy machineries while on Lamostad N tablet?
This medication causes neurological side effects thus caution is used while driving or operating machineries.
What is the most common side effect of Lamostad N tablet?
Lamostad N tablet causes rash (skin manifestation) and jaundice (systemic manifestation)
Precautions and general warning of Lamostad N Tablet
Alcohol
Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.
Driving or operating machinery
It is preferred to drive or operate heavy machinery with caution as Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet causes side effects. For further queries, consult your physician.
Pregnancy
The use of Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is not recommended during pregnancy. It causes serious fatal toxicity and fetal death.
Breast Feeding
The use of Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.
Kidney Problem
Renal filtration impairment – monitor function of creatinine clearance rate before and during treatment. caution is used in case creatinine clearance is <50ml/min.
Liver Disease
Liver disorders and diseases like hepatitis B or C, hepatic steatosis
Monitor liver function like AST, ALT and bilirubin levels before and during therapy
How to Take Lamostad N Tablet
Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is taken orally without food.
Lamostad N tablet must be taken at the same time every day as prescribed by your physician.
After therapy has been initiated, do not take more or less of Lamostad N medicine than prescribed or stop taking it without your physicians’ approval. Skipping or changing Lamostad N tablet dose without approval may cause the amount of the virus to increase making the infection more difficult to treat, or worsen side effects.
Use of Lamostad N Tablet in Adult
If you are pregnant or breastfeeding inform your physician as they are not advisable.
The recommended age for the use of Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is >18 years who are >60 kgs
Follow the instructions provided above.
Use of Lamostad N Tablet in children
The recommended age for the use of Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is >12 years who are >50 kgs
The lead-in period for Lamostad N tablet to build tolerance is 14 days.
The recommended dosage is one tablet of Lamostad N tablet taken once a day followed by an oral dose of Lamivudine 150mg and Stavudine 30mg after 12 hours.
After the lead-in period the tolerance is checked (skin rash occurrence/ liver and kidney/ blood workup) the recommended maintenance dosage for Lamostad N tablet taken twice a day orally
Lamostad N tablet should be taken as prescribed by the physician without fail. These medicines must be taken without food on a regular time basis either 2 hours before food or 2 hours after food intake
Use of Lamostad N Tablet in Elderly Patients
Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet has only been used in few patients 65 years or older. Dosage and usage are similar to adults. Discuss with your physician before usage.
Other general warnings
Talk to your doctor if
If you have any allergy
If you have a liver problem
If you have a kidney problem
If you have a blood disorder
If you are pregnant or breastfeeding
General instructions
Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is taken with other antivirals orally as prescribed dosage at a specific time regularly.
Drug Interaction of Lamostad N Tablet
Drug-Drug Interaction
Serum concentration decreased by Acetazolamide, Potassium citrate
Serum concentration increased by Aceclofenac, Acetaminophen, Ketoconazole, Itraconazole
Severity of adverse effects is increased by Acyclovir, Dopamine, Histamine, Metformin
Drug-Food Interaction
Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet can be safely taken with any type of food, if doubts arise kindly refer to your physician. It is best to take Lamostad N tablet on an empty stomach either 2 hrs before or after food. Lamostad N tablet generally causes side effects thus it is advised not to be taken with alcohol.
Drug-Disease Interaction
Over Dose
Contact your doctor, pharmacist or nurse immediately.
Missed Dose
If you take twice a day dosage, then the missed dosage if you notice within 6 hours. If it is more than 6 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.
Storage and Disposal
Keep the medication out of children’s reach
Keep the medication away from pets
Once expired dispose immediately
Store at 30°C
Fast Tag
Lamostad N (Lamivudine (150mg) + Stavudine (30mg) + Nevirapine (200mg)) tablet is a nucleoside analogue.
Lamostad N tablet is used to control and treat HIV infection with other antivirals
Do not use this medication while pregnant or lactation period.
Don’t use this medication with liver disease and kidney diseases.
This medication doesn’t stop the spread of HIV infection from person to person thus use caution and precaution while sexual contact, needle injury, etc.