Lapatem 250mg Tablet
Brand Name | Lapatem 250mg Tablet |
Salt Composition |
Lapatinib (250mg) |
Strength | 250mg |
Product Form | Tablet |
Pack | 30 Tablet(s) in Bottle |
Storage | Store below 30°C |
Category |
Anti-Cancer |
SubCategory |
Breast Cancer |
Country of Origin | India |
Manufacturer |
Emcure Pharmaceuticals Ltd |
Manufacturer/Marketer Address | Emcure Pharmaceuticals Ltd./Add:255/2, Hinjawadi, Pune - 411057, India |
You Save : Rs.1,349.00 Inclusive of all taxes
- Do not take this medicine if you are allergic to Lapatinib
- It is contraindicated to use this medicine in patients who are having a cardiac disorder
- Diarrhea
- Anemia
- Increased Lived function test
- Rash
- Vomiting, nausea
- Pain
- Neutropenia
- Thrombocytopenia
- Mucositis
- Stomatitis
- Dyspnea
- Dyspepsia
- Insomnia
- Can Lapatem 250mg Tablet be given in combination with other anti-cancer drug?
- How should I manage diarrhea while taking Lapatem 250mg Tablet?
- How long after Lapatem 250mg Tablet can I plan pregnancy?
- The use of this medicine may cause diarrhea
- Therapy should be administered with caution in patients who are having a history of severe hepatic impairment
- The useof lapatinib along with QT-prolonging drug may increase the risk for developing QT-prolongation
- The use of this medicine may cause severe cutaneous reactions
- ‘The use of this medicine may decrease the left ventricular ejection fraction
- The use of this medicine may increase the risk for developing interstitial lung disease and pneumonitis and cardiac events
- You are not responding to the treatment
- You have experienced any allergic reaction like rashes and itching
- You have a receiving any concomitant medication and disease
- Stored at 10-30°C room temperature.
- Protect from light and heat.
- Keep away from children and pets. Otherwise, it becomes toxic to them.
- Disposed of properly in a suitable bag.
- Lapatem 250mg Tablet contains Lapatinib 250mg used to treat breast cancer by inhibiting the growth of cancer cell and it also used along with other combination to cure advanced-stage breast cancer. It shrinks and stops the progression of abnormal cancer cells. This medication is recommended only for adults.
- Take this medicine 1 hour before or 2 hours after your meal
- The use of this medicine can make your skin sensitive so apply sunscreen and wear protective clothing
- Kindly inform your doctor if you have experienced headache, stomach pain and blood in your stool and urine while you are receiving this medicine.
Medical Description of Lapatem 250mg Tablet
Lapatem 250mg Tablet contains Lapatinib 250mg used to treat breast cancer by inhibiting the growth of cancer cell and it also used along with other combination to cure advanced-stage breast cancer. It shrinks and stops the progression of abnormal cancer cells. This medication is recommended only for adults.
Lapatem 250mg Tablet Uses
It is used in the treatment of the following conditions as breast cancer.
Lapatem 250mg Tablet Benefits
Breast cancer
It is a type of cancer that forms in the breast cells. It is common among women. Symptoms include breast lump, change in breast size, redness, pitting of the skin, color change, and peeling surrounding the breast skin or nipple. This medicine helps to inhibit the multiplication of cancer cells.
Lapatem 250mg Tablet Indication
The Lapatem 250mg Tablet is prescribed in the following indications as breast cancer and it also used as an orphan drug for treatment of gastric and esophageal cancer.
Mechanism of action of Lapatem 250mg Tablet
Lapatem 250mg Tablet contains Lapatinib 250mg is an anti-cancer agent called atyrosine kinase inhibitor. It produces its effect by attaching to epidermal growth factor receptors type 1 and 2. Lapatinib 250mg inhibits signalling process required for angiogenesis and proliferation of abnormal cells are inhibited. It shrinks the abnormal cells and minimises metastasis thus treats and controls cancers or tumors.
How Lapatem 250mg Tablet works
Lapatem 250mg Tablet contains Lapatinib 250mg is an anti-cancer agent called tyrosine kinase inhibitor. It produces its effect by inhibiting the human epidermal growth factor receptor protein receptor and epidermal growth factor receptor which are responsible for over-production of cells and it also inhibit the growth of cancer cells that cause downstrean signaling pathways.
Lapatem 250mg Tablet Contraindication
Lapatem 250mg Tablet Side Effects
FAQs for Lapatem 250mg Tablet
Yes, this medicine can be used along with other anticancer drug Capecitabine to treat advanced breast cancer in patients who are having who are already treated with chemotherapy. It is also used along with letrozole to treat breast cancer in post-menopausal women.
If you are suffering from diarrhea drink plenty of fluids like water, sports drink, or clear liquids. You should eat low-fat, high protein rich foods instead of fatty and spicy foods. Kindly avoid consuming milk and milk products.
Use effective contraceptive to avoid pregnancy while you are receiving this medicine for at least one week after the last dose.
Precautions and general warning of Lapatem 250mg Tablet
Alcohol
It is not clear that consuming alcohol is safe while you are receiving this medicine. Kindly consult with your doctor.
Driving or operating machinery
It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.
Pregnancy
The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects. Kindly consult with your doctor
Breast Feeding
The use of this medicine is considered unsafe during breastfeeding because it may produce any harmful effects. Kindly consult with your doctor
Kidney Problem
The medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.
Liver Disease
The medicine should be used with caution in patients with hepatic impairment. The use of this medicine required dose modification. Kindly consult with your doctor.
How to Take Lapatem 250mg Tablet
Lapatem 250mg Tablet is taken orally with or without food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.
Use of Lapatem 250mg Tablet in Adult
It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor
Use of Lapatem 250mg Tablet in children
Safety and efficacy were not established in children who are below 18 years old. Kindly consult with your doctor.
Use of Lapatem 250mg Tablet in Elderly Patients
Lapatem 250mg Tablet should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.
Other general warnings
Talk to your doctor if
General instructions
Lapatinib 250mg used to treat breast cancer. Lapatinib 250mg is an anti-cancer agent called tyrosine kinase inhibitor. It produces its effect by inhibiting the human epidermal growth factor receptor protein receptor and epidermal growth factor receptor which are responsible for over-production of cells and it also inhibit the growth of cancer cells that cause downstrean signaling pathways.
Drug Interaction of Lapatem 250mg Tablet
Drug-Drug Interaction
Dihydroergotamine
The use of this medicine is contraindicated because the us of lapatinib will increase the effect of dihydroergotamine by affecting its hepatic and intestinal enzyme metabolism
Everolimus
The use of this medicine is contraindicated because the use of lapatinib will increase the effect of everolimus by P-glycoprotein efflux transporter.
Pimozide
The use of this medicine is contraindicated because the use of lapatinib will increase the effect of pimozide by decreasing its metabolism and it also increase the risk for developing QT interval prolongation
Amiodarone
Use alternative drug because the combination of this medicine increase QTc interval
Apalutamide
Therapy should be admi9nstered with caution because the use of apalutamide decrease the effect of lapatinib by increasing its metabolism.
Cimetidine
Therapy should be administered with caution because the use of cimetidine will decrease the effect of laptinib by increasing its gastric Ph.
Drug-Food Interaction
Lapatinib 250mg should be taken on an empty stomach one hour before the meal or 2 hours after the meal. You should also avoid grapefruit juice while you are receiving this medicine it may increase the Lapatinib in blood levels.
Drug-Disease Interaction
Cardiomyopathy
Therapy should be administered with caution in patients who are having a history of left ventricular function because the use of EGFR inhibitor may cause cardiomyopathy
Dermatologic toxicities
The use of EGFR inhibitors may cause cutaneous reaction. Kindly wear sunscreen and hats to avoid sun exposure while receiving this therapy
Pulmonary toxicity
Therapy should be administered with caution in patients with a history of interstitial pneumonitis and pulmonary fibrosis, pulmonary symptoms such as dyspnea, cough and fever because the use of EGFR inhibitors itself associated with pulmonary toxicity.
Thrombocytopenia
Patients who are having a history of decreased platelet count and patients on anti-coagulant treatment because the use of this medicine may cause thrombocytopenia
Congestive heart failure
Therapy should be administered with caution in patients who are having a history of previous heart conditions because the use of this medicine may decrease the left ventricular ejection fraction and cause congestive heart failure.
Over Dose
Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.
Missed Dose
Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).
Storage and Disposal
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