Macromycin Tablet

Macromycin Tablet contain Spiramycin (3 Million IU) used to treat bacterial and parasitic infections such as severe bacterial infections as Bacterial infections, Toxoplasmosis during pregnancy, and Gonorrhoea. Spiramycin is an antibiotic used to treat a parasitic infection called Toxoplasmosis in pregnant women and it also helps to reduce the risk of transmission of toxoplasma infection from the mother to the fetus and it is also used to treat gonorrhea in patients who are allergic to penicillin. Mainly this bacterial infection targets the respiratory tract, buccal cavity, skin and skin structures, and sexually transmitted infections. This medicine is not used for common flu and cold symptoms that occur due to viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial and parasitic infections.

It is used in the treatment of the following conditions as Bacterial infections, Toxoplasmosis during pregnancy, and Gonorrhoea

Bacterial infections

Bacterial infection occurs when bacteria enter your body and start multiplying which may cause tissue damage and make you sick. Mostly it is caused by Staphylococcus and Streptococcus organisms. The bacterial diseases are cholera, bacterial meningitis, tetanus, gonorrhea, pneumonia, and syphilis. Symptoms include fever, chills, and sweats, inflamed lymph nodes, headache, diarrhea, abdominal pain

Toxoplasmosis during pregnancy

It is caused by the Toxoplasma gondi parasite. It usually occurs by eating undercooked contaminated meat, infected cat feces, or mother-to-child transmission during pregnancy. It may lead to miscarriage, stillbirth, and preterm birth. This medicine helps pregnant women to prevent toxoplasma infections (chances of transmission of infection to the fetus). Used as a second-line treatment drug for toxoplasmosis during pregnancy.

Gonorrhea

It is a sexually transmitted infection that infects both men and women caused by Neisseria gonorrhea bacteria. This medicine is used to treat this bacterial infection who are allergic to penicillin treatment.

The Macromycin Tablet is prescribed in the following indications as Bacterial infections, Toxoplasmosis during pregnancy, and Gonorrhoea

Macromycin Tablet contains Spiramycin is a macrolide antibiotic that produces its action by preventing the protein synthesis which is essential for the bacteria to function and it also prevents the infection from spreading.

Macromycin Tablet contains Spiramycin is a macrolide antibiotic that produces its action by preventing the protein synthesis which is essential for the bacteria to function and it also prevents the infection from spreading.

• Do not take this medicine if you are allergic to Spiramycin
• It is contraindicated to use this medicine in patients who are having Bacterial meningitis and Toxoplasma encephalitis
• Kindly avoid taking this medicine if you have a history of cholestatic jaundice or any hepatic dysfunction

• Diarrhea
• Abnormal liver function
• Skin rash
• Swelling of eyelids, face, lips, tongue
• Peeling and skin blisters
• Vasculitis
• Burning and stinging
• Irregular heart rate
• Abnormal blood counts
• Hypotension

• Can the use of Macromycin Tablets cause infertility?

There is no scientific information that the use of this medicine will cause infertility in both male and female

• How long should I take the Macromycin Tablet?

Normally the duration of this medicine depends upon the severity of the disease. You should take this according to your doctor advice

• Is the Macromycin Tablet is effective?

Yes, it is considered effective when you have taken the medication as per the dose and duration advised by the doctor. If you stop the medicine without completing the course of treatment it may worsen the conditions

Alcohol

The use of alcohol does not produce harmful effects while you are receiving this treatment. Kindly consult with your doctor.

Driving or operating machinery

It is considered safe to drive while you are receiving this medicine it does not affect your ability to drive. Kindly consult with your doctor.

Pregnancy

The use of this medicine is considered safe during pregnancy because it does not produce any harmful effects on the fetus. Kindly consult with your doctor

Breast Feeding

Limited information is available regarding the use of this medicine during breastfeeding. Kindly consult with your doctor

Kidney Problem

It is considered safe to use this medicine in patients who are having kidney diseases and it does not require dose modification. Kindly consult with your doctor.

Liver Disease

Limited information is available regarding the use of this medicine to patients who are having hepatic impairment. Kindly consult with your doctor:

The Tablet is taken orally with or without food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor.

Maromycin tablet is considered unsafe to use this medicine in children who are below 3 months old. Kindly consult with your doctor.

Macromycin Tablets should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

• Therapy should be administered with caution because it is associated with QT interval prolongation and arrhythmias
• The use of this medicine may cause hepatic dysfunction like increased liver enzyme activity, hepatocellular and cholestatic hepatitis with or without jaundice.
• Kindly discontinue the treatment if you have noticed dark urine, tender abdomen, jaundice, anorexia, and pruritus
• The use of this medicine may cause Clostridium difficile associated diarrhea

• You have a history of gastrointestinal disease
• You are not responding to the treatment
• You have experienced any allergic reaction like rashes and itching

Macromycin Tablets contain Spiramycin used to treat bacterial and parasitic infections such as severe bacterial infections as Bacterial infections, Toxoplasmosis during pregnancy, and Gonorrhoea. Spiramycin is an antibiotic used to treat a parasitic infection called Toxoplasmosis in pregnant women and it also helps to reduce the risk of transmission of toxoplasma infection from the mother to the fetus and it is also used to treat gonorrhea in patients who are allergic to penicillin. Mainly this bacterial infection targets the respiratory tract, buccal cavity, skin and skin structures, and sexually transmitted infections.

Drug-Drug Interaction

BCG vaccine live

The use of this drug is contraindicated because the use of medicine decreases the effect of the BCG vaccine live by pharmacodynamic antagonism

Cabergoline

The use of this medicine is contraindicated because the use of Spiramycin may increase the effect of cabergoline by decreasing its metabolism.

Chloroquine

The use of this medicine is contraindicated because the use of chloroquine increases the toxicity of Spiramycin by QTc interval

Lovastatin

The use of Spiramycin will increase the effect of lovastatin by P-glycoprotein efflux transporter

Aripiprazole

Use alternative drugs because the use of Spiramycin will increase the effect of aripiprazole by affecting hepatic or intestinal enzyme metabolism

Digoxin

Therapy should be administered with caution because the use of Spiramycin will increase the effect of digoxin by P-glycoprotein efflux transporter

Drug-Food Interaction

The use of grape juice along with Spiramycin may affect gastrointestinal absorption and it also inhibits the metabolism of Spiroomycin.

Drug-Disease Interaction

Gastrointestinal diseases

It should be used with caution in patients with gastrointestinal diseases, particularly colitis (infection to the inner lining of the colon). It will lead to worsening the patient’s health condition. If you are noticed severe diarrhea, abdominal pain, blood in stools, etc. immediately inform the doctor. Based on the patient clinical condition, dose adjustment is needed.

QT Prolongation

Therapy should be administered with caution because the use of Spiramycin may cause prolonged cardiac repolarization, QT interval in patients who are having a history of congenital long QT syndrome, bradyarrhythmias, proarrhythmic conditions such as uncorrected hypokalemia, hypomagnesemia

Renal dysfunction

Spiramycin should be administered with caution because the use of this medicine gets eliminated by the kidney. It is not necessary to adjust the dose in patients with mild to moderate renal impairment.

Electrolyte imbalance

It should be used with caution in patients with electrolyte imbalance or fluid retention. It leads to worsening patient health conditions. Based on the patient clinical condition, dose adjustment or replacement is needed.

Cross-resistance

This medicine doesn’t show effectiveness in the treatment of infections where resistance developed by causative bacteria due to the usage of erythromycin. It is called cross-resistance. It leads to worsening the patient health condition

Myasthenia gravis

Therapy should be administered with caution in patients with a history of myasthenia gravis because the use of macrolide antibiotics may worsen the conditions

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 10-30°C room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

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• Spiramycin is a macrolide antibiotic used to treat bacterial infections. It eradicates bacterial growth by preventing the synthesis of essential proteins required by bacteria to carry out vital functions.
• This medicine is not used for common flu and cold symptoms. And not treat viral infections. This medicine is commonly prescribed for cough and colds caused by bacterial and parasitic infections.
• This medicine is contraindicated to allergic symptoms such as skin rash, itching, swelling and breathing difficulties, bacterial meningitis, and toxoplasma encephalitis.