Brand Name Markdryl Syrup
Salt Composition

Metronidazole (100mg) + Norfloxacin (100mg)

Strength 100mg + 100mg
Product Form Syrup
Pack 1 x 100ml in 1 Bottle
Storage Store below 30°C
Category

Antibiotic

SubCategory

Anti-Biotic

Country of Origin India
Manufacturer

Glenmark Pharmaceuticals Ltd

Manufacturer/Marketer Address Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
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M.R.P : Rs.10.00       Price : Rs.9.00

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1 x 100ml in 1 Bottle

Availability : Banned For Sale

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    Medical Description of Markdryl Syrup

    Markdryl Syrup contains Metronidazole 100mg and Norfloxacin 100mg used to treat both bacterial and parasitic infection and it is also used to treat diarrhea and dysentery in children. Mainly this medicine targets infections of the teeth, lungs, gastrointestinal tract, urinary tract, and genital tract. Norfloxacin 100mg is an antibiotic that helps to inhibit the growth of infection. Mainly this bacterial infection targets the urinary tract, nose, throat, skin and soft tissues, and lungs. Metronidazole 100mg is antihelmintic which kills the parasites and anaerobic bacteria. This combination of medicine helps to kill microorganisms.


    Markdryl Syrup Uses

    It is used in the treatment of the following conditions as both bacterial and parasitic infection and it is also used to treat diarrhea and dysentery in children.


    Markdryl Syrup Benefits

    Bacterial infections

    Bacterial infection occurs when bacteria enter your body and start multiplying which may cause tissue damage and make you sick. Mostly it is caused by Staphylococcus and Streptococcus organisms. The bacterial diseases are cholera, bacterial meningitis, tetanus, gonorrhea, pneumonia, and syphilis. Symptoms include fever, chills, and sweats, inflamed lymph nodes, headache, diarrhea, abdominal pain

    Parasitic infections

    It is an organism that lives in another organism like your body for its food and place to survive. You can get a parasitic infection from contaminated water, food, bug bites o sexual contact. It is a one-celled organism called protozoa which can be seen in the naked eye. Symptoms include stomach pain, nausea, vomiting, dehydration, weight loss, inflamed lymph nodes, constipation, diarrhea, rashes, eczema, hives, muscle, and joint pain.

    Diarrhea

    Infection to the digestive tract leads to increased frequency of bowel movements or loose watery bowel movements caused by bacteria called diarrhea. It leads to worsening the patient’s health condition. This medicine is used to treat this bacterial infection.

    Dysentery

    It is also called infectious diarrhea. Inflammation of the gut (intestine) leads to bloody stools or watery stools. It is most often caused by shigella bacteria (shigellosis) or an amoeba (parasite), spreading through contaminated food or water. This medicine is used to treat this bacterial infection.


    Markdryl Syrup Indication

    The Markdryl Syrup is prescribed in the following indications as both bacterial and parasitic infection and it is also used to treat diarrhea and dysentery in children.


    Mechanism of action of Markdryl Syrup

    Markdryl Syrup contains Metronidazole 100mg and Norfloxacin 100mg is a combination of two medicines. Norfloxacin 100mg is a quinolone antibiotic that produces its action by inhibiting the activity of a bacterial enzyme called DNA gyrase and preventing the bacterial cell from reproduction and repairing themselves and killing the bacteria which is responsible for the infection. Metronidazole 100mg is antihelmintic that produces its action by damaging their DNA and killing the parasites and anaerobic bacteria which is responsible for infections.


    How Markdryl Syrup works

    Markdryl Syrup contains Metronidazole 100mg and Norfloxacin 100mg is a combination of two medicines. Norfloxacin 100mg is a quinolone antibiotic that produces its action by inhibiting the activity of a bacterial enzyme called DNA gyrase and preventing the bacterial cell from reproduction and repairing themselves and killing the bacteria which is responsible for the infection. Metronidazole 100mg is antihelmintic that produces its action by damaging their DNA and killing the parasites and anaerobic bacteria which is responsible for infections.


    Markdryl Syrup Contraindication

    • Do not take this medicine if you are allergic to Norfloxacin and Metronidazole
    • It is contraindicated to use the medicine that may prolong the QT interval
    • The use of Fluoroquinolones associated with some serious adverse reactions includes tendinitis, tendon rupture, peripheral neuropathy, and CNS effects


    Markdryl Syrup Side Effects

    • Photosensitivity
    • Tendon rupture
    • Thrombocythemia
    • Platelets increased
    • Neutropenia
    • Dizziness
    • Increased transaminases
    • Headache
    • Constipation
    • Dyspepsia
    • Dizziness


    FAQs for Markdryl Syrup

    • Can Markdryl Syrup be given along with cough and cold medicines?

    No, you do not take this medicine along with cold and cough medicines because it may interact with alcohol present in the cough syrups. This may result in disulfiram reactions such as nausea, vomiting, flushing, and dizziness.

    • My child is having a genetic deficiency of the GP6D enzyme. Is it safe to give Markdryl Syrup?

    Before initiating the treatment kindly inform your doctor about your child’s condition. It is better to avoid this medicine if your child has GP6D deficiency because it may break down the blood cells which results in anemia.

    • Can I get my child vaccinated while on treatment with Markdryl Syrup?

    The use of antibiotics does not interfere with the ingredients in the vaccines. But as a preventive measure do not vaccinate your children until they recover from the illness.


    Precautions and general warning of Markdryl Syrup

    Alcohol

    Since it is used in children's no information is available regarding the use of this medicine. Kindly consult with your doctor

    Driving or operating machinery

    Since it is used in children's no information is available regarding the use of this medicine. Kindly consult with your doctor

    Pregnancy

    Since it is used in children's no information is available regarding the use of this medicine. Kindly consult with your doctor

    Breast Feeding

    Since it is used in children's no information is available regarding the use of this medicine. Kindly consult with your doctor

    Kidney Problem

    The medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

    Liver Disease

    The medicine should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.


    How to Take Markdryl Syrup

    Markdryl Syrup is taken orally with or without food. You can measure the dose with the help of a measuring cup and shake well before using this suspension. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.


    Use of Markdryl Syrup in Adult

    It is considered to be safe to use this medicine in an adult patient if the drug is prescribed by a doctor. Kindly consult with your doctor.


    Use of Markdryl Syrup in children

    It is considered unsafe to use this medicine in children who are below 3 years old. Kindly consult with your doctor.


    Use of Markdryl Syrup in Elderly Patients

    Since it is used in children's no information is available regarding the use of this medicine. Kindly consult with the doctor


    Other general warnings

    • At long-term treatment seizure and aseptic meningitis were reported
    • The use of this medicine may cause encephalopathy and peripheral neuropathy
    • Kindly avoid using this medicine in absence of any suspected bacterial or parasitic infection because it increases the risk of developing drug-resistant bacteria and parasites
    • Therapy should be administered with caution in patients who are having hepatic and renal impairment, heart failure, and H.pylori infection
    • Use this medicine with care in patients who are having a history of blood dyscrasia, agranulocytosis, leucopenia, and neutropenia
    • Kindly avoid receiving this medicine along with antiandrogen because it may cause gynecomastia
    • Long-term use may cause superinfection
    • It should not be the first drug of choice to pediatrics due to the increased risk for developing adverse effect
    • The use of fluoroquinolones is associated with an increased risk for developing tendinitis and tendon rupture
    • Kindly avoid using fluoroquinolones in patients who are with a history of myasthenia gravis because the use of this medicine may cause muscle weakness
    • The use of this medicine may cause CNS effects to include convulsions, increased intracranial pressure, and toxic psychosis

                     Tendinitis and Tendon rupture (Muscle damage)

    • This medicine causes tendinitis and tendon rupture, which mainly affects your shoulder, hands, ankles, or other joint parts of your body. And muscle damage also occurs usually on the tendons surrounding the muscles. It may experience pain, numbness, or tingling sensations in your muscles. It should be a risk in patients of more than 60 years of age or undergone a transplant of kidney, heart, or lung. If necessary, then needs dose adjustment or replacement

                   Diarrhea

    • This medicine kills the good helpful bacteria in your stomach or intestine and causes diarrhea. It leads to worsening the patient’s health condition. Better to take probiotics with this medicine to avoid diarrhea.

                  Antibiotic resistance

    • Finish the complete course of antibiotics even if you feel better. Otherwise, it will lead to Antibiotic resistance (the bacteria may be resistant to antibiotics)

                   Dialysis

    • Using this medicine doesn’t show effects in patients on dialysis. This medicine should be scheduled before or after the dialysis procedure.


    Talk to your doctor if

    • You have a history of gastrointestinal disease
    • You are not responding to the treatment
    • You have experienced any allergic reaction like rashes and itching
    • You have a history of joint issues
    • You have a Glucose-6 phosphate dehydrogenase


    General instructions

    Metronidazole 100mg and Norfloxacin 100mg are used to treat both bacterial and parasitic infections and are also used to treat diarrhea and dysentery in children. Mainly this medicine targets infections of the teeth, lungs, gastrointestinal tract, urinary tract, and genital tract. Norfloxacin 100mg is a quinolone antibiotic that produces its action by inhibiting the activity of a bacterial enzyme called DNA gyrase and preventing the bacterial cell from reproduction and repairing themselves and killing the bacteria which is responsible for the infection.  Metronidazole 100mg is antihelmintic that produces its action by damaging their DNA and killing the parasites and anaerobic bacteria which is responsible for infections.


    Drug Interaction of Markdryl Syrup

    Drug-Drug Interaction

    BCG vaccine live

    The use of this drug is contraindicated because the use of medicine decreases the effect of the BCG vaccine live by pharmacodynamic antagonism

    Aluminum hydroxide

    Use alternative drugs because the use of aluminum hydroxide decreases the effect of norfloxacin by inhibiting the GI absorption

    Escitalopram

    Therapy should be administered with caution because the use of escitalopram increase the toxicity of norfloxacin by QTc interval

    Estradiol

    Therapy should be administered with caution because the use of norfloxacin decreases the effect of estradiol by altering the intestinal flora and it also lowers the risk of contraceptive failure.

    Anti-diabetic drug

    Therapy should be administered with caution because the use of norfloxacin increases the effect of glimepiride by pharmacodynamic synergism.

    Haloperidol

    It should be administered with caution because the combination of this medicine increases the QTc interval.

    Dronabinol

    The use of this drug is contraindicated because the use of metronidazole increases the toxicity of dronabinol by inhibiting aldehyde dehydrogenase

    Ketoconazole

    Use alternative drugs because the use of ketoconazole increases the effect of metronidazole by affecting its hepatic or intestinal metabolism

    Drug-Food Interaction

    No interaction was found while using this medicine

    Drug-Disease Interaction

    Central nervous system disorders

    Using this medicine is needs caution in patients with seizures, other central nervous system abnormalities, or fits. It causes hallucinations, anxiety, confusion, and restlessness, etc. Inform the doctor, then will do dose adjustment or replacement is needed. If necessary to take this medicine with seizure medications.

    Colitis

    This medicine kills the good helpful bacteria in your stomach or intestine and causes diarrhea. This drug should be used caution in patients with gastrointestinal disease, especially colitis (swelling of the colon inner lining). It leads to worsening the patient’s health condition.

    QT prolongation

    This drug should be used with caution in patients with heart-related problems such as irregular heart rate, in which this drug alters the heart rate.

    Neurologic toxicity

    Using this medicine should be cautious in patients with neurological toxicity (convulsions and peripheral neuropathy) leads to develop numbness, tingling, or burning sensation of hands and feet like neurological effects leads to worsening the patient health condition.

    Blood Dyscrasias

    Using this medicine should be cautious in patients with blood Dyscrasias (low blood count) leads to a decrease in the blood cell count tends to develop leukopenia, thrombocytopenia, and bone marrow aplasia. It leads to worsening the patient's health condition.

    Kidney diseases

    It should be used with caution in a patient with renal impairment or kidney disease. Then it develops the risk of kidney damage. Inform your doctor and then take. Based on the patient's health condition, dose adjustment or replacement of medicine is needed.

    Liver diseases

    It should be used with caution in a patient with hepatic impairment or liver disease. Then it develops a risk of liver damage. Inform your doctor and then take. Based on the patient's health condition, dose adjustment or replacement of medicine is needed


    Over Dose

    Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.


    Missed Dose

    Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).


    Storage and Disposal

    • Stored at 10-30°C room temperature.
    • Protect from light and heat.
    • Keep away from children and pets. Otherwise, it becomes toxic to them.
    • Disposed of properly in a suitable bag.


    Fast Tag

    Markdryl Syrup contains Metronidazole 100mg and Norfloxacin 100mg used to treat both bacterial and parasitic infection and it is also used to treat diarrhea and dysentery in children. Mainly this medicine targets infections of the teeth, lungs, gastrointestinal tract, urinary tract, and genital tract.

    Norfloxacin 100mg is a quinolone antibiotic used to treat bacterial infection by preventing bacteria reproduction and repairing themselves. Metronidazole 100mg is an antihelmintic used to kill other infectious microorganisms in addition to bacteria by binding their DNA. This drug combination prevents bacterial infections effectively.

    Kindly avoid this medicine if you are constipated and inform your doctor if you have experienced any pain in your tendons, numbness, or tingling sensation.