Meflotas 250mg Tablet

Meflotas 250mg Tablet contains Mefloquine (250mg) used to treat parasitic infections such as Malaria. Mefloquine is an antimalarial drug that results in interacting with certain substances which are required for the malarial parasitic cells present in our blood for their vital functions. It is usually effective against plasmodium vivax, and Plasmodium ovale strains of malarial parasites and it is also used to treat the infections caused by chloroquine-resistant strains of malarial parasites. It produces its action by killing the parasite that causes infection and also helps to prevent the infections.

It is used in the treatment of the following conditions as parasitic infections such as Malaria

Parasitic infections

It is an organism that lives in another organism like your body for its food and place to survive. You can get a parasitic infection from contaminated water, food, bug bites o sexual contact. It is a one-celled organism called protozoa which can be seen in the naked eye. Symptoms include stomach pain, nausea, vomiting, dehydration, weight loss, inflamed lymph nodes, constipation, diarrhea, rashes, eczema, hives, muscle, and joint pain.

Malaria

It is also called plasmodium infection. It spread to humans through infected mosquito bites. It is caused by a single-celled parasite called Plasmodium. Symptoms include fever, chills, headache, diarrhea, abdominal pain, fatigue, rapid breathing, rapid heart rate, cough, and muscle pain.

The Meflotas 250mg Tablet is prescribed in the following indications as Malaria

The Meflotas 250mg Tablet containing Mefloquine is an antimalarial drug that produces its action by increasing the time (a toxic substance to parasites) in your blood. This kills the parasite that is present in your blood and inhibits the growth of bacteria that cause infections.

The Meflotas 250mg Tablet containing Mefloquine is an antimalarial drug that produces its action by increasing the time (a toxic substance to parasites) in your blood. This kills the parasite that is present in your blood and inhibits the growth of bacteria that cause infections.

• Do not take this medicine if you are allergic to Mefloquine
• It is contraindicated to use this medicine as a prophylaxis in patients who are having a history of depression, generalized anxiety disorder, psychosis, schizophrenia, and convulsions

• Dizziness
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Sinus bradycardia (slow heartbeat)
• Anxiety
• Hallucinations
• Decreased blood cell count
• Vision disturbances

• How long should I take the Meflotas 250mg Tablet?

Normally the duration of this medicine depends upon the severity of the disease. You should take this according to your doctor advice

• Is the Meflotas 250mg Tablet is safe?

Yes, it is considered safe when you have taken the medication as per the dose and duration advised by the doctor. If you stop the medicine without completing the course of treatment it may worsen the conditions

• What if I do not get better after using the Meflotas 250mg Tablet?

If you do not feel better after completing the full course of treatment kindly inform your doctor.

Alcohol

The use of alcohol may produce harmful effects while you are receiving this treatment. Kindly consult with your doctor.

Driving or operating machinery

It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

Pregnancy

The use of this medicine is considered unsafe during pregnancy because it may produce any harmful effects on the fetus. Kindly consult with your doctor

Breast Feeding

The use of this medicine is considered safe during breastfeeding because it does not excrete via breast milk. Kindly consult with your doctor

Kidney Problem

Limited information is available regarding the use of this medicine in patients who are having a renal impairment. Kindly consult with your doctor.

Liver Disease

The medicine should be used with caution in patients with hepatic impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

The Tablet is taken orally with or without food. You should not chew, cut or crush the tablet. Initially start with a low dose and slowly increase the dose once every week. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by your doctor. Kindly consult with your doctor.

It is considered unsafe to use this medicine in children who are below 6 months old. Kindly consult with your doctor.

Meflota tablets should be used with caution in patients with an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

• Therapy should be administered with caution because the use of this medicine may increase the QT interval
• Long-term use may cause neuropsychiatric effects
• Therapy should be administered with caution in patients who are having a hepatic impairment
• The use of this medicine may cause agranulocytosis and aplastic anemia
• The use of this medicine may cause psychiatric and neurological side effects and it also causes suicidal ideation
• The use of this medicine may increase the risk of developing epilepsy

Ophthalmic effects

It leads to develop ophthalmic abnormalities (vision changes, retina abnormalities, etc.), leading to worsening the patient's health conditions. Regularly monitoring the ophthalmic examination is needed in patients using this medicine.

Preventive use

If you noticed symptoms of malaria again after administration of this medicine, immediately stop taking the medicine, and start treatment with other antimalarial drugs.

Drug resistance

You may develop resistance to the drug if you withdraw the drug without completing the full course of treatment.

Quinine associated blackwater fever

Therapy should not be recommended in patients with blackwater fever (a complication of malaria infection) associated quinine drug, leading to worsening the patient's health conditions.

 

• You have a history of gastrointestinal disease
• You are not responding to the treatment
• You have experienced any allergic reaction like rashes and itching
• You are having a concomitant disease or taking any medications

• Meflotas 250mg Tablets consist of Mefloquine is used to treat Malaria diseases (caused by Plasmodium falciparum, and plasmodium vivax strains of malarial parasite).
• Mefloquine is an antimalarial drug, helpful in eradicating malarial infection. Also, used to treat the infections caused by chloroquine-resistant strains of malarial parasites.

Drug-Drug Interaction

BCG vaccine live

The use of this drug is contraindicated because the use of medicine decreases the effect of the BCG vaccine live by pharmacodynamic antagonism

Lefamulin

The use of this drug is contraindicated because the use of lefamulin will increase the effect of Mefloquine by affecting its hepatic and intestinal enzyme metabolism.

Afatinib

Use alternative drug because the use of mefloquine increases the effect of afatinib by P-glycoprotein efflux transporter

Apomorphine

Use alternative drug because the combination of this drug increases the QTc interval

Dapsone

Use alternative drug because the use of mefloquine increases the toxicity of the dapsone by unspecified interaction mechanism and it also increases the risk for developing hemolytic reactions

Drug-Food Interaction

Food may increase the effect of mefloquine in your body. So take the medicine as soon you complete your meal.

Drug-Disease Interaction

Hematological toxicity

Therapy should be used with caution in patients with hematological toxicity (leads to developing anemia, leukemia, thrombocytopenia, etc.), which leads to worsening the patient's health conditions. Based on the patient's health conditions, dose adjustment, or replacement is needed.

Liver diseases

Therapy should be used with caution in a patient with hepatic impairment or liver diseases. Then it leads to the risk of liver damage. Based on the patient clinical conditions, dose adjustment or replacement is needed.

Psychiatric disorders

Therapy should be used with caution in patients with psychiatric disorders (depression, agitation, anxiety, psychoses), which leads to worsening the patient's health conditions. Based on the patient's health conditions, dose adjustment, or replacement is needed.

Heart diseases

Therapy should be used with caution in patients with heart diseases (QT Prolongation, irregular heartbeat, breathing difficulty, arrhythmia, etc.), which leads to worsening the patient's health conditions. Based on the patient's health conditions, dose adjustment, or replacement is needed.

Cutaneous toxicity

Therapy should be used with caution in patients with cutaneous toxicity (skin diseases), which leads to worsening the patient's health conditions. Based on the patient's health conditions, dose adjustment, or replacement is needed.

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose of this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 10-30°C room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

Mefloquine is an antimalarial drug, results in interacting with certain substances (required for vital functions of the malarial parasite cell) present in the blood. Then it eradicates the malarial infection (caused by Plasmodium falciparum, and plasmodium vivax strains of malarial parasite). Also, used to treat the infections caused by chloroquine-resistant strains of malarial parasites.