Naprosyn D 500 Tablet

Naprosyn D 500 Tablet contains Naproxen 500mg and Domperidone 10mg is a pain-relieving medicine used to prevent migraine. The combination of this medicine produces its action by preventing the pain signals to reach the brain to reduce pain and it also inhibits the certain substances which are present in the brain that induces nausea or vomiting during headaches.

It is used in the treatment of migraine

Migraine

It is a type of headache that causes severe throbbing pain or pulsing sensation on one side of the head. Migraine is usually triggered by hormonal changes in women, drinks, stress, sleep changes, physical factor, weather changes, medication like oral contraceptives, and vasodilators. People may experience dizziness, light-headedness, malaise, nausea, and vomiting.

The Naprosyn D 500 Tablet is prescribed for the following indications Migraine

Naprosyn D 500 Tablet contains Naproxen 500mg and Domperidone 10mg is a pain-relieving medicine. Naproxen is an analgesic it produces its action by the release of chemical messengers which is responsible for pain

Domperidone is a prokinetic agent that produces its action by increasing the movement of the stomach and intestines and allowing the food to move easily through the stomach. Thus it reduces nausea and vomiting that occurs during migraine.

Naprosyn D 500 Tablet contains Naproxen 500mg and Domperidone 10mg is a pain-relieving medicine. Naproxen is an analgesic it produces its action by the release of chemical messengers which is responsible for pain

Domperidone is a prokinetic agent that produces its action by increasing the movement of the stomach and intestines and allowing the food to move easily through the stomach. Thus it reduces nausea and vomiting that occurs during migraine.

• Do not take this medicine if you are allergic to Naproxen and Domperidone
• It is contraindicated to use this medicine in patients with bleeding disorders, delayed esophageal transit, liver disease, peptic ulcer, kidney disease, and late pregnancy.

• Abdominal pain
• Constipation
• Dizziness
• Drowsiness
• Headache
• Heartburn
• GI bleeding
• Lightheadedness
• Fluid retention
• Diarrhea
• Edema

• Can Naprosyn D 500 Tablet damage your kidneys?

Yes, long-term use of this medicine may damage your kidney. Normally kidneys produce chemicals called prostaglandins that protect our kidneys from damage. But the use of this pain killer decreases the level of prostaglandins in your body and damages your kidney.

• Can I discontinue the medicine when my pain is relieved?

This medicine is usually used for the short term and it can be discontinued when your pain is relieved. You can withdraw the medicine as per your doctor's suggestions.

• Can the use of this Naprosyn D 500 Tablet cause dry mouth?

Yes, the use of this medicine may cause dry mouth. Drink plenty of water if you have experienced a dry mouth.

Alcohol

It is considered unsafe to consume alcohol while taking this medication. Kindly consult with your doctor

Driving or operating machinery

It is considered unsafe to drive while you are receiving this medicine it may affect your ability to drive. Kindly consult with your doctor.

Pregnancy

It is considered unsafe during pregnancy because it may produce harmful effects on the fetus. Kindly consult with your doctor.

Breast Feeding

It is considered safe during breastfeeding it does not excrete via breast milk. Kindly consult with your doctor.

Kidney Problem

The tablet should be used with caution in patients with renal impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

Liver Disease

The tablet should be used with caution in patients with severe liver impairment. The use of this medicine required dose modification. Kindly consult with your doctor.

The tablet is taken orally with or without food but it is better to take this medicine at a fixed time. You should not chew, cut or crush the tablet. Take this medicine as per the dose and duration advised by your doctor. Follow the direction mentioned within the label if you probably did not understand the appliance kindly ask your doctor or pharmacist to elucidate in detail. Do not withdraw the medicine when you feel better kindly complete the course of treatment to avoid reoccurrence.

It is considered to be safe to use this medicine in an adult patient if the medicine is prescribed by a doctor. Kindly consult with your doctor.

It is considered safe to use this medicine in children. Kindly consult with your doctor.

Naprosyn D 500 Tablet should be used with caution in patients in an elderly age group, which leads to developing further medical problems, leads to worsening the patient's health conditions. Kindly consult with your doctor. Dose modification or replacement is required based on the medical conditions of the patient.

• Nonsteroidal anti-inflammatory drugs may increase the risk of developing cardiovascular thrombotic events, myocardial infarction, and stroke
• Therapy should be administered with caution in patients with a history of bronchospasm, cardiac diseases, hypertension, hepatic or renal impairment
• Long-term use of this medicine may cause renal papillary necrosis and retinal disturbances
• The use of this medicine may increase the risk of epilepsy, fluid retention, and Parkinson's disease
• The use of this medicine decrease platelet aggregation and may prolong the bleeding time
• Therapy should be administered with caution in patients with blood dyscrasias, and bone marrow depression
• The use of this medicine may increase the risk of hyperkalemia and aseptic meningitis

• You have a history of gastrointestinal disease
• You are not responding to the treatment
• You have experienced any allergic reactions like rashes and itching
• You are suffering from anemia
• You have watery diarrhea, stomach pain, and fever

Naproxen 500mg and Domperidone 10mg is a pain-relieving medicine used to prevent migraine. The combination of this medicine produces its action by preventing the pain signals to reach the brain to reduce pain and it also inhibits the certain substances which are present in the brain that induces nausea or vomiting during headaches.

Drug-Drug Interaction

Ketorolac

It is contraindicated to use this medicine because the combination of this medicine either increases the toxicity of the other by pharmacodynamic synergism

Apixaban

The use of this drug is contraindicated because the combination of this drug increases the effect of anticoagulation

Captopril

Use alternative drug because the use of the non-steroidal anti-inflammatory drug may decrease the effectiveness of the antihypertensive drug and the combination of these drugs also decrease the renal functions

Aliskiren

Therapy should be administered with caution because the use of naproxen will decrease the effect of aliskiren on other

Asenapine

Therapy should be administered with caution because the use of naproxen decreases the effect of asenapine by pharmacodynamic synergism

Drug-Food Interaction

Alcohol

The use of alcohol should be avoided in patients who are taking NSAIDs because it may increase the risk of bleeding in the stomach which includes tarry, bloody stools, or coughing up blood while vomiting.  Do not withdraw the medication without consulting with the doctor

Drug-Disease Interaction

Asthma

Therapy should be administered with caution in patients who are having asthma because the use of the non-steroidal anti-inflammatory drug (NSAIDs) in asthma patients may cause nasal polyposis, pansinusitis, eosinophilia, and rhinitis. Before initiating the therapy ask the patients whether they are allergic to salicylate salts.

Heart failure

Therapy should be administered with caution in patients with heart failure because the use of NSAIDs may cause fluid retention and edema

Hepatotoxicity

Therapy should be administered with caution in a patient with liver diseases because the use of NSAIDs may increase the serum transaminases, LDH, and alkaline phosphatase. And in rare cases, it may cause hepatotoxicity including liver cirrhosis, jaundice, and hepatic failure

Hypertension

Therapy should be administered with caution in patients with hypertension because the use of NSAIDs may increase blood pressure and cardiovascular events. During this course of treatment monitor the patient blood pressure

Renal toxicities

Therapy should be administered with caution in a patient with renal diseases because the use of NSAIDs may increase the serum creatinine, BUN, tubular necrosis, glomerulus, renal papillary necrosis, nephrotic syndrome, and cause renal failure.

Take the medicine as directed by the doctor don’t overdose on the medicine. If you have taken an overdose on this medicine immediately meet the doctor and rush to the nearby hospital.

Take the medicine as directed by the doctor. Do not skip the medicine, if you forgot to take the medicine or missed the dose. It is almost time for your next dose, skip the missed dose and go back to your regular schedule. Don’t take the extra dose take the regular dose immediately. Don’t use the two-dose at one time (Double Dose).

• Stored at 10-30°C room temperature.
• Protect from light and heat.
• Keep away from children and pets. Otherwise, it becomes toxic to them.
• Disposed of properly in a suitable bag.

• Naprosyn D 500 Tablet contains Naproxen 500mg and Domperidone 10mg is a pain-relieving medicine used to prevent migraine.
• The combination of this medicine produces its action by preventing the pain signals to reach the brain to reduce pain and it also inhibits the certain substances which are present in the brain that induces nausea or vomiting during headaches.
• Avoid consuming alcohol while you are receiving this medicine because it may worsen your headache
• The use of this medicine may cause sleepiness so do not drive while you are receiving this medicine